ATE254115T1 - Endothelinantagonisten: n- 2'- (4,5-dimethyl-3- isoxazolyl) amino)sulfonyl)-4-(2-oxazolyl) 1,1'- biphenyl)-2-yl)methyl) -n,3,3-trimethylbutanamid und n-(4,5-dimethyl-3-isoxazolyl) -2'- (3,3- dimethyl-2-oxo-1-pyrrolidinyl) methyl) -4'-(2- oxazolyl) 1,1'-biphenyl)-2-sulfonamid und salze davon - Google Patents

Endothelinantagonisten: n- 2'- (4,5-dimethyl-3- isoxazolyl) amino)sulfonyl)-4-(2-oxazolyl) 1,1'- biphenyl)-2-yl)methyl) -n,3,3-trimethylbutanamid und n-(4,5-dimethyl-3-isoxazolyl) -2'- (3,3- dimethyl-2-oxo-1-pyrrolidinyl) methyl) -4'-(2- oxazolyl) 1,1'-biphenyl)-2-sulfonamid und salze davon

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Publication number
ATE254115T1
ATE254115T1 AT98906005T AT98906005T ATE254115T1 AT E254115 T1 ATE254115 T1 AT E254115T1 AT 98906005 T AT98906005 T AT 98906005T AT 98906005 T AT98906005 T AT 98906005T AT E254115 T1 ATE254115 T1 AT E254115T1
Authority
AT
Austria
Prior art keywords
dimethyl
isoxazolyl
oxazolyl
biphenyl
methyl
Prior art date
Application number
AT98906005T
Other languages
English (en)
Inventor
Natesan Murugesan
Joel C Barrish
Zhengxiang Gu
Richard A Morrison
Original Assignee
Bristol Myers Squibb Co
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Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE254115T1 publication Critical patent/ATE254115T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98906005T 1997-01-30 1998-01-26 Endothelinantagonisten: n- 2'- (4,5-dimethyl-3- isoxazolyl) amino)sulfonyl)-4-(2-oxazolyl) 1,1'- biphenyl)-2-yl)methyl) -n,3,3-trimethylbutanamid und n-(4,5-dimethyl-3-isoxazolyl) -2'- (3,3- dimethyl-2-oxo-1-pyrrolidinyl) methyl) -4'-(2- oxazolyl) 1,1'-biphenyl)-2-sulfonamid und salze davon ATE254115T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3583297P 1997-01-30 1997-01-30
PCT/US1998/001490 WO1998033780A1 (en) 1997-01-30 1998-01-26 Endothelin antagonists: n-[[2'-[ [(4,5-dimethyl-3-isoxazolyl) amino]sulfonyl]-4-(2-oxazolyl) [1,1'-biphenyl]-2-yl]methyl] -n,3,3-trimethylbutanamide and n-(4,5-dimethyl-3-isoxazolyl) -2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl) methyl] -4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide and salts thereof

Publications (1)

Publication Number Publication Date
ATE254115T1 true ATE254115T1 (de) 2003-11-15

Family

ID=21885049

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98906005T ATE254115T1 (de) 1997-01-30 1998-01-26 Endothelinantagonisten: n- 2'- (4,5-dimethyl-3- isoxazolyl) amino)sulfonyl)-4-(2-oxazolyl) 1,1'- biphenyl)-2-yl)methyl) -n,3,3-trimethylbutanamid und n-(4,5-dimethyl-3-isoxazolyl) -2'- (3,3- dimethyl-2-oxo-1-pyrrolidinyl) methyl) -4'-(2- oxazolyl) 1,1'-biphenyl)-2-sulfonamid und salze davon

Country Status (22)

Country Link
US (1) US6043265A (de)
EP (1) EP0996618B1 (de)
JP (1) JP2002513397A (de)
KR (1) KR20000070584A (de)
CN (1) CN1117738C (de)
AR (1) AR015358A1 (de)
AT (1) ATE254115T1 (de)
AU (1) AU730111B2 (de)
BR (1) BR9807098A (de)
CA (1) CA2279178A1 (de)
CZ (1) CZ236299A3 (de)
DE (1) DE69819729T2 (de)
ES (1) ES2205451T3 (de)
HU (1) HUP0001310A3 (de)
IL (1) IL130622A (de)
NO (1) NO313142B1 (de)
NZ (1) NZ336380A (de)
PL (1) PL334773A1 (de)
RU (1) RU2183632C2 (de)
TW (1) TW536540B (de)
WO (1) WO1998033780A1 (de)
ZA (1) ZA98759B (de)

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EP0996618B1 (de) 2003-11-12
EP0996618A1 (de) 2000-05-03
WO1998033780A1 (en) 1998-08-06
JP2002513397A (ja) 2002-05-08
AU730111B2 (en) 2001-02-22
EP0996618A4 (de) 2000-05-03
DE69819729T2 (de) 2004-09-23
RU2183632C2 (ru) 2002-06-20
IL130622A0 (en) 2000-06-01
BR9807098A (pt) 2000-04-18
ZA98759B (en) 1999-07-29
IL130622A (en) 2003-01-12
CN1117738C (zh) 2003-08-13
NO993691D0 (no) 1999-07-29
HUP0001310A2 (hu) 2001-06-28
US6043265A (en) 2000-03-28
TW536540B (en) 2003-06-11
CA2279178A1 (en) 1998-08-06
AR015358A1 (es) 2001-05-02
DE69819729D1 (de) 2003-12-18
NO313142B1 (no) 2002-08-19
AU6134998A (en) 1998-08-25
NZ336380A (en) 2001-04-27
CZ236299A3 (cs) 1999-11-17
PL334773A1 (en) 2000-03-13
KR20000070584A (ko) 2000-11-25
HUP0001310A3 (en) 2001-07-30
NO993691L (no) 1999-07-29
ES2205451T3 (es) 2004-05-01
CN1244862A (zh) 2000-02-16

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