GB897440A - Improvements in or relating to sulfonamides - Google Patents
Improvements in or relating to sulfonamidesInfo
- Publication number
- GB897440A GB897440A GB2917260A GB2917260A GB897440A GB 897440 A GB897440 A GB 897440A GB 2917260 A GB2917260 A GB 2917260A GB 2917260 A GB2917260 A GB 2917260A GB 897440 A GB897440 A GB 897440A
- Authority
- GB
- United Kingdom
- Prior art keywords
- isoxazole
- methyl
- acetylsulphanilamido
- sulfonamides
- relating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises 3-N1-acetylsulphanilamido-5-methyl-isoxazole and its preparation by reacting 3 - sulphanilamido - 5 - methyl - isoxazole or a metal salt thereof with acetic anhydride in an inert organic solvent such as acetone, benzene or pyridine, preferably at a temperature not above 90 DEG C. and more preferably not above 60 DEG C. At temperatures above 60 DEG C. the N4-acetyl compound is formed simultaneously and is removed by treatment with alkali. Specification 814,276 is referred to.ALSO:Pharmaceutical preparations having anti-bacterial activity comprise 3-N1-acetylsulphanilamido - 5 - methyl - isoxazole (see Group IV (b)) suitably in the form of tablets, pills, powders or liquid preparations containing excipients and/or other sulpha drugs or antibiotics.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1897760 | 1960-02-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB897440A true GB897440A (en) | 1962-05-30 |
Family
ID=11986671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2917260A Expired GB897440A (en) | 1960-02-08 | 1960-08-23 | Improvements in or relating to sulfonamides |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB897440A (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5514696A (en) * | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
US5760038A (en) * | 1995-02-06 | 1998-06-02 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
US5856507A (en) * | 1997-01-21 | 1999-01-05 | Bristol-Myers Squibb Co. | Methods for the preparation of biphenyl isoxazole sulfonamides |
US5939446A (en) * | 1996-04-09 | 1999-08-17 | Bristol-Myers Squibb Co. | Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists |
US6043265A (en) * | 1997-01-30 | 2000-03-28 | Bristol-Myers Squibb Co. | Isoxazolyl endothelin antagonists |
US6080774A (en) * | 1995-10-11 | 2000-06-27 | Bristol-Myers Squibb Company | Substituted biphenylsulfonamide endothelin antagonists |
US6313308B1 (en) | 1999-03-19 | 2001-11-06 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
US6515136B1 (en) | 1996-02-20 | 2003-02-04 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
US6639082B2 (en) | 2000-10-17 | 2003-10-28 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
-
1960
- 1960-08-23 GB GB2917260A patent/GB897440A/en not_active Expired
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5514696A (en) * | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
US6107320A (en) * | 1992-05-06 | 2000-08-22 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
US5827869A (en) * | 1994-08-26 | 1998-10-27 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
US5760038A (en) * | 1995-02-06 | 1998-06-02 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
US6080774A (en) * | 1995-10-11 | 2000-06-27 | Bristol-Myers Squibb Company | Substituted biphenylsulfonamide endothelin antagonists |
US6271248B1 (en) | 1995-10-11 | 2001-08-07 | Bristol-Myers Squibb Company | Substituted biphenysulfonamide endothelin antagonists |
US6515136B1 (en) | 1996-02-20 | 2003-02-04 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
US5939446A (en) * | 1996-04-09 | 1999-08-17 | Bristol-Myers Squibb Co. | Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists |
US5856507A (en) * | 1997-01-21 | 1999-01-05 | Bristol-Myers Squibb Co. | Methods for the preparation of biphenyl isoxazole sulfonamides |
US6043265A (en) * | 1997-01-30 | 2000-03-28 | Bristol-Myers Squibb Co. | Isoxazolyl endothelin antagonists |
US6313308B1 (en) | 1999-03-19 | 2001-11-06 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
US6639082B2 (en) | 2000-10-17 | 2003-10-28 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
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