GB982615A - Improvements in or relating to 3-methyl-1,2,4-benzothiadiazine-1,1-dioxide - Google Patents
Improvements in or relating to 3-methyl-1,2,4-benzothiadiazine-1,1-dioxideInfo
- Publication number
- GB982615A GB982615A GB232263A GB232263A GB982615A GB 982615 A GB982615 A GB 982615A GB 232263 A GB232263 A GB 232263A GB 232263 A GB232263 A GB 232263A GB 982615 A GB982615 A GB 982615A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzothiadiazine
- dioxide
- methyl
- salt
- see division
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- FDWRKMPNEIXNOE-UHFFFAOYSA-N 3-methyl-4h-1$l^{6},2,4-benzothiadiazine 1,1-dioxide Chemical compound C1=CC=C2NC(C)=NS(=O)(=O)C2=C1 FDWRKMPNEIXNOE-UHFFFAOYSA-N 0.000 title abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- KCMKIDORSDPITL-UHFFFAOYSA-N 2-acetamidobenzenesulfonic acid Chemical compound CC(=O)NC1=CC=CC=C1S(O)(=O)=O KCMKIDORSDPITL-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229940125717 barbiturate Drugs 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 239000003701 inert diluent Substances 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940080360 rauwolfia alkaloid Drugs 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
3 - Methyl - 1,2,4 - benzothiadiazine - 1,1-dioxide is prepared by reacting a salt of o-acetylaminobenzenesulphonic acid, e.g. a salt with an alkali metal or an organic base, with phosphorus pentachloride, preferably in an inert diluent at 75-85 DEG C. and treating the product with ammonia. The compound is used pharmaceutically as a hypotensive agent (see Division A5).ALSO:Pharmaceutical preparations having hypotensive activity comprise 3-methyl-1,2,4-benzothiadiazine-1,1-dioxide (see Division C2) and a carrier, and optionally contain one or more additional substances chosen from rauwolfia alkaloids and barbiturates. Suitably the preparations are used orally and may take the form of tablets, pills, capsules, emulsions or suspensions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2233362 | 1962-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB982615A true GB982615A (en) | 1965-02-10 |
Family
ID=11194798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB232263A Expired GB982615A (en) | 1962-11-17 | 1963-01-18 | Improvements in or relating to 3-methyl-1,2,4-benzothiadiazine-1,1-dioxide |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES292054A1 (en) |
| GB (1) | GB982615A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024086252A1 (en) * | 2022-10-18 | 2024-04-25 | Rhythm Pharmaceuticals, Inc. | Novel atp-sensitive potassium channel potentiators, their preparation and use |
-
1963
- 1963-01-18 GB GB232263A patent/GB982615A/en not_active Expired
- 1963-09-28 ES ES292054A patent/ES292054A1/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024086252A1 (en) * | 2022-10-18 | 2024-04-25 | Rhythm Pharmaceuticals, Inc. | Novel atp-sensitive potassium channel potentiators, their preparation and use |
Also Published As
| Publication number | Publication date |
|---|---|
| ES292054A1 (en) | 1964-01-01 |
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