GB824908A - Improvements in or relating to triazine derivatives - Google Patents

Improvements in or relating to triazine derivatives

Info

Publication number
GB824908A
GB824908A GB1775658A GB1775658A GB824908A GB 824908 A GB824908 A GB 824908A GB 1775658 A GB1775658 A GB 1775658A GB 1775658 A GB1775658 A GB 1775658A GB 824908 A GB824908 A GB 824908A
Authority
GB
United Kingdom
Prior art keywords
salt
amino
acid
amidinoanilinotriazine
toluoyltartrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1775658A
Inventor
Julius Nicholson Ashley
Samuel Sidney Berg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
May and Baker Ltd
Original Assignee
May and Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May and Baker Ltd filed Critical May and Baker Ltd
Priority to GB1775658A priority Critical patent/GB824908A/en
Publication of GB824908A publication Critical patent/GB824908A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises 2-amino-4:6-di-p-amidinoanilinotriazine D(-) - di - p - toluoyltartrate and the preparation thereof by reacting 2 - amino - 4:6 - di - p - amidinoanilino - s - triazine, or an acid addition salt thereof, with D(-)-di-p-toluoyl-tartaric acid or by effecting a metathetical reaction between an acid addition salt of the base and a salt of the acid.ALSO:The invention includes a pharmaceutical preparation especially useful for the treatment of trypanosomiasis which comprises 2-amino-4 : 6 - di - p - amidinoanilinotriazine D(-) - di - p-toluoyltartrate in association with a significant proportion of a pharmaceutical carrier. A preferred composition is in the form of an aqueous suspension of the active salt, containing at least 0.025% by weight of the salt for injection or at least 0.1% for oral administration.
GB1775658A 1958-06-03 1958-06-03 Improvements in or relating to triazine derivatives Expired GB824908A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1775658A GB824908A (en) 1958-06-03 1958-06-03 Improvements in or relating to triazine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1775658A GB824908A (en) 1958-06-03 1958-06-03 Improvements in or relating to triazine derivatives

Publications (1)

Publication Number Publication Date
GB824908A true GB824908A (en) 1959-12-09

Family

ID=10100669

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1775658A Expired GB824908A (en) 1958-06-03 1958-06-03 Improvements in or relating to triazine derivatives

Country Status (1)

Country Link
GB (1) GB824908A (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1180755B (en) * 1961-02-08 1964-11-05 Rhone Poulenc Sa Process for the preparation of trypanocidally active 4-melaminylphenylarsinodimercapto-succinates of 1,5-bis- (4'-amidinophenoxy) -pentane
WO1996028427A1 (en) * 1995-03-10 1996-09-19 Berlex Laboratories, Inc. Benzamidine derivatives their preparation and their use as anti-coagulants
US5691364A (en) * 1995-03-10 1997-11-25 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US5994375A (en) * 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
US6004985A (en) * 1996-10-09 1999-12-21 Berlex Laboratories, Inc. Thio acid derived monocylic N-heterocyclics as anticoagulants
US6008234A (en) * 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
US6127376A (en) * 1998-12-04 2000-10-03 Berlex Laboratories, Inc. Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
US6140351A (en) * 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
US6177473B1 (en) 1996-09-12 2001-01-23 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
US6380221B1 (en) 1997-12-19 2002-04-30 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1180755B (en) * 1961-02-08 1964-11-05 Rhone Poulenc Sa Process for the preparation of trypanocidally active 4-melaminylphenylarsinodimercapto-succinates of 1,5-bis- (4'-amidinophenoxy) -pentane
US6465459B2 (en) 1995-03-10 2002-10-15 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6306884B1 (en) 1995-03-10 2001-10-23 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6034103A (en) * 1995-03-10 2000-03-07 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
WO1996028427A1 (en) * 1995-03-10 1996-09-19 Berlex Laboratories, Inc. Benzamidine derivatives their preparation and their use as anti-coagulants
US5889005A (en) * 1995-03-10 1999-03-30 Berlex Laboratories, Inc. Benzamidine derivatives and their use for treating thrombotic diseases
US5691364A (en) * 1995-03-10 1997-11-25 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6479485B2 (en) 1995-03-10 2002-11-12 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6350746B1 (en) 1995-03-10 2002-02-26 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US5883100A (en) * 1995-03-10 1999-03-16 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US5877181A (en) * 1995-03-10 1999-03-02 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US5994375A (en) * 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
US6166088A (en) * 1996-02-12 2000-12-26 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
US6242454B1 (en) 1996-02-12 2001-06-05 Berlex Laboratories Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
US6071912A (en) * 1996-02-12 2000-06-06 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
US6177473B1 (en) 1996-09-12 2001-01-23 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
US6232325B1 (en) 1996-09-12 2001-05-15 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatves and their use as anti-coagulants
US6008234A (en) * 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
US6265404B1 (en) 1996-09-12 2001-07-24 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
US6034084A (en) * 1996-10-09 2000-03-07 Berlex Laboratories, Inc. Thio acid derived monocyclic N-heterocyclics as anticoagulants
US6221886B1 (en) 1996-10-09 2001-04-24 Berlex Laboratories, Inc. Thio acid derived monocyclic N-heterocyclics as anticoagulants
US6166014A (en) * 1996-10-09 2000-12-26 Berlex Laboratories, Inc. Thio acid derived monocyclic N-heterocyclics as anticoagulants
US6162807A (en) * 1996-10-09 2000-12-19 Berlex Laboratories, Inc. Thio acid derived monocyclic N-heterocyclics as anticoagulants
US6150382A (en) * 1996-10-09 2000-11-21 Berlex Laboratories, Inc. Thio acid derived monocyclic n-heterocyclics as anticoagulants
US6004985A (en) * 1996-10-09 1999-12-21 Berlex Laboratories, Inc. Thio acid derived monocylic N-heterocyclics as anticoagulants
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6380221B1 (en) 1997-12-19 2002-04-30 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
US6140351A (en) * 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
US6492376B2 (en) 1998-11-19 2002-12-10 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6495574B2 (en) 1998-11-19 2002-12-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6552030B2 (en) 1998-11-19 2003-04-22 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6686367B2 (en) 1998-11-19 2004-02-03 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6372751B1 (en) 1998-12-04 2002-04-16 Berlex Laboratories, Inc. Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
US6127376A (en) * 1998-12-04 2000-10-03 Berlex Laboratories, Inc. Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants

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