GB927288A - 1-and 7-(basically-substituted-alkyl) xanthine derivatives, a process for their manufacture and pharmaceutical compositions containing them - Google Patents

1-and 7-(basically-substituted-alkyl) xanthine derivatives, a process for their manufacture and pharmaceutical compositions containing them

Info

Publication number
GB927288A
GB927288A GB31890/59A GB3189059A GB927288A GB 927288 A GB927288 A GB 927288A GB 31890/59 A GB31890/59 A GB 31890/59A GB 3189059 A GB3189059 A GB 3189059A GB 927288 A GB927288 A GB 927288A
Authority
GB
United Kingdom
Prior art keywords
radical
alkyl
basically
substituted
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31890/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHEMIEWERK HOMBURG ZWEIGNIEDER
Evonik Operations GmbH
Original Assignee
CHEMIEWERK HOMBURG ZWEIGNIEDER
Deutsche Gold und Silber Scheideanstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHEMIEWERK HOMBURG ZWEIGNIEDER, Deutsche Gold und Silber Scheideanstalt filed Critical CHEMIEWERK HOMBURG ZWEIGNIEDER
Publication of GB927288A publication Critical patent/GB927288A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0927288/IV(a)/1> wherein X represents a 1-theobromine or 7-theophylline radical, A is a straight or branched chain alkylene radical, R1 is an alkyl radical of 1-3 carbon atoms and R2 is an aryl, e.g. phenyl radical, together with acid addition salts thereof, and comprises also the preparation of those compounds by reacting a haloalkyl-xanthine X-A-Halogen with an aralkylamine of the formula H2N-CH(R1)-CH2-R2, preferably at 70 DEG -170 DEG C. in an inert solvent such as toluene in the presence of an acid-binding agent such as potassium carbonate. Pharmaceutical preparations having central nervous system stimulant action comprise the above compounds of the invention, suitably in the form of a salt such as the hydrochloride, and a diluent or excipient. Specified preparations comprise granules, tablets and dragees containing 7-(b -phenylisopropylaminoethyl)-theophylline hydrochloride as the active constituent.
GB31890/59A 1958-10-18 1959-09-18 1-and 7-(basically-substituted-alkyl) xanthine derivatives, a process for their manufacture and pharmaceutical compositions containing them Expired GB927288A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1958C0017685 DE1123329B (en) 1958-10-18 1958-10-18 Process for the preparation of basic substituted alkylxanthine derivatives.

Publications (1)

Publication Number Publication Date
GB927288A true GB927288A (en) 1963-05-29

Family

ID=7016288

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31890/59A Expired GB927288A (en) 1958-10-18 1959-09-18 1-and 7-(basically-substituted-alkyl) xanthine derivatives, a process for their manufacture and pharmaceutical compositions containing them

Country Status (4)

Country Link
CH (1) CH379511A (en)
DE (1) DE1123329B (en)
FR (1) FR479M (en)
GB (1) GB927288A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3245994A (en) * 1966-04-12 Theophylline derivatives
DE1221641B (en) * 1962-03-30 1966-07-28 Degussa Process for the preparation of basic substituted theophylline derivatives
DE1237578B (en) * 1963-05-10 1967-03-30 Knoll Ag Process for the preparation of basic substituted xanthine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1011424B (en) * 1954-04-17 1957-07-04 Chemiewerk Homburg Ag Process for the preparation of basic substituted 7-alkyl-xanthine derivatives or their salts

Also Published As

Publication number Publication date
CH379511A (en) 1964-07-15
FR479M (en) 1961-05-02
DE1123329B (en) 1962-02-08

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