GB961641A - A diuretic dihydrobenzothiadiazine, processes for the preparation thereof and compositions containing the same - Google Patents

A diuretic dihydrobenzothiadiazine, processes for the preparation thereof and compositions containing the same

Info

Publication number
GB961641A
GB961641A GB29474/62A GB2947462A GB961641A GB 961641 A GB961641 A GB 961641A GB 29474/62 A GB29474/62 A GB 29474/62A GB 2947462 A GB2947462 A GB 2947462A GB 961641 A GB961641 A GB 961641A
Authority
GB
United Kingdom
Prior art keywords
compound
excipient
fluorophenylethyl
chloro
sulphamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB29474/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DAUSSE LAB
Original Assignee
DAUSSE LAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DAUSSE LAB filed Critical DAUSSE LAB
Publication of GB961641A publication Critical patent/GB961641A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
    • C07D285/26—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals
    • C07D285/30—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals with hydrocarbon radicals, substituted by hetero atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26B—HAND-HELD CUTTING TOOLS NOT OTHERWISE PROVIDED FOR
    • B26B19/00—Clippers or shavers operating with a plurality of cutting edges, e.g. hair clippers, dry shavers
    • B26B19/38—Details of, or accessories for, hair clippers, or dry shavers, e.g. housings, casings, grips, guards

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Forests & Forestry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises 3-p-fluorophenylmethyl -6- chloro -7- sulphamoyl-3, 4-dihydrobenzo-1, 2, 4-thiadiazine-1, 1-dioxide and its preparation by reacting 5-chloro-2, 4-disulphamoyl-aniline with a b -p-fluorophenylethyl compound such as p-fluorophenylethyl alcohol and simultaneously oxidising, e.g. by boiling with chromic acid in an aqueous medium, to effect ring closure between the amino group and the nitrogen of the 2-sulphamoyl group by means of the a -carbon atom of the fluorophenylethyl compound. Reference has been directed by the Comptroller to Specification 861,367.ALSO:Pharmaceutical preparations having diuretic activity, for the treatment of cardiac, cardiorenal and renal oedemas, hypertension, ascitic cirrhoses, neurohormonal oedemas, obesity and angina pectoris, comprise the compound 3-p-fluorophenylmethyl - 7 - sulphamoyl - 6 - chloro-3,4 - dihydro - 1,2,4 - benzothiadiazene - 1,1-dioxide (see Division C2), together with an inert diluent or excipient, or with one or more Rauwolfia alkaloids and, optionally, an inert diluent or excipient. The preparations may be liquid or solid and are preferably administered orally. Examples describe tablets containing the benzothiadiazine compound with (a) an inert solid excipient, and (b) reserpine, rescinnamine, raupine, ajmaline, methyl yohimbate and an inert solid excipient. Reference has been directed by the Comptroller to Specification 861,367.
GB29474/62A 1961-07-31 1962-07-31 A diuretic dihydrobenzothiadiazine, processes for the preparation thereof and compositions containing the same Expired GB961641A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR869626A FR1374M (en) 1961-07-31 1961-07-31 Diuretic drug based on a benzo-thiadiazine derivative.

Publications (1)

Publication Number Publication Date
GB961641A true GB961641A (en) 1964-06-24

Family

ID=8760452

Family Applications (1)

Application Number Title Priority Date Filing Date
GB29474/62A Expired GB961641A (en) 1961-07-31 1962-07-31 A diuretic dihydrobenzothiadiazine, processes for the preparation thereof and compositions containing the same

Country Status (4)

Country Link
BE (1) BE620829A (en)
FR (1) FR1374M (en)
GB (1) GB961641A (en)
NL (2) NL126491C (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
ES2382009T3 (en) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company N - ((3-Benzyl) -2,2- (bis-phenyl -) - propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
CN105143203A (en) 2013-04-17 2015-12-09 辉瑞大药厂 N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof

Also Published As

Publication number Publication date
BE620829A (en) 1962-11-16
NL281593A (en)
FR1374M (en) 1962-06-25
NL126491C (en)

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