CR20210110A - Combinaciones para tratamiento de ehna/ehgna y enfermedades relacionadas - Google Patents

Combinaciones para tratamiento de ehna/ehgna y enfermedades relacionadas

Info

Publication number
CR20210110A
CR20210110A CR20210110A CR20210110A CR20210110A CR 20210110 A CR20210110 A CR 20210110A CR 20210110 A CR20210110 A CR 20210110A CR 20210110 A CR20210110 A CR 20210110A CR 20210110 A CR20210110 A CR 20210110A
Authority
CR
Costa Rica
Prior art keywords
nash
treatment
nafld
combinations
related diseases
Prior art date
Application number
CR20210110A
Other languages
English (en)
Inventor
William Paul Esler
Trenton Thomas Ross
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CR20210110A publication Critical patent/CR20210110A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)

Abstract

Se describe en la presente la combinación de (S)-2-(5-((3-etoxi-piridin-2-il)oxi)piridin-3-il)-N-(tetrahidrofuran-3-il)pirimidina-5-carboxamida, o una sal farmacéuticamente aceptable de la misma, y ácido 4-(4-(1-isopropil-7-oxo-1,4,6,7-tetrahidrospiro-[indazol-5,4¿-piperidina]-1¿-carbonil)-6-metoxipiridin-2-il)benzoico, o sal farmacéuticamente aceptable del mismo, para tratamiento de enfermedades, incluyendo esteatohepatitis no alcohólica (EHNA), en mamíferos.
CR20210110A 2018-08-31 2019-08-28 Combinaciones para tratamiento de ehna/ehgna y enfermedades relacionadas CR20210110A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862726172P 2018-08-31 2018-08-31
US201962883860P 2019-08-07 2019-08-07
PCT/IB2019/057259 WO2020044266A1 (en) 2018-08-31 2019-08-28 Combinations for treatment of nash/nafld and related diseases

Publications (1)

Publication Number Publication Date
CR20210110A true CR20210110A (es) 2021-05-13

Family

ID=68165623

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20210110A CR20210110A (es) 2018-08-31 2019-08-28 Combinaciones para tratamiento de ehna/ehgna y enfermedades relacionadas

Country Status (22)

Country Link
US (2) US11254660B2 (es)
EP (1) EP3843740A1 (es)
JP (1) JP7161605B2 (es)
KR (1) KR102614808B1 (es)
CN (1) CN112955147A (es)
AU (1) AU2019329884B2 (es)
BR (1) BR112021003039A2 (es)
CA (1) CA3110601C (es)
CL (1) CL2021000491A1 (es)
CO (1) CO2021002230A2 (es)
CR (1) CR20210110A (es)
DO (1) DOP2021000036A (es)
EC (1) ECSP21012501A (es)
IL (1) IL281093A (es)
MA (1) MA53496A (es)
MX (1) MX2021002428A (es)
PH (1) PH12021550339A1 (es)
SG (1) SG11202101503RA (es)
TW (1) TWI718644B (es)
UY (1) UY38351A (es)
WO (1) WO2020044266A1 (es)
ZA (1) ZA202101090B (es)

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Also Published As

Publication number Publication date
JP2021535126A (ja) 2021-12-16
AU2019329884A1 (en) 2021-03-11
SG11202101503RA (en) 2021-03-30
DOP2021000036A (es) 2021-04-15
US11254660B2 (en) 2022-02-22
BR112021003039A2 (pt) 2021-05-18
CN112955147A (zh) 2021-06-11
MX2021002428A (es) 2023-01-02
WO2020044266A1 (en) 2020-03-05
PH12021550339A1 (en) 2021-10-04
AU2019329884B2 (en) 2022-01-27
US20220023299A1 (en) 2022-01-27
US20200071306A1 (en) 2020-03-05
TW202026292A (zh) 2020-07-16
ECSP21012501A (es) 2021-03-31
UY38351A (es) 2020-03-31
ZA202101090B (en) 2022-06-29
EP3843740A1 (en) 2021-07-07
TWI718644B (zh) 2021-02-11
KR102614808B1 (ko) 2023-12-19
CL2021000491A1 (es) 2021-08-20
CO2021002230A2 (es) 2021-03-08
MA53496A (fr) 2021-12-08
CA3110601C (en) 2023-09-05
CA3110601A1 (en) 2020-03-05
KR20210053929A (ko) 2021-05-12
JP7161605B2 (ja) 2022-10-26
IL281093A (en) 2021-04-29

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