ECSP21012501A - Combinaciones para tratamiento de ehna/ehgna y enfermedades relacionadas - Google Patents

Combinaciones para tratamiento de ehna/ehgna y enfermedades relacionadas

Info

Publication number
ECSP21012501A
ECSP21012501A ECSENADI202112501A ECDI202112501A ECSP21012501A EC SP21012501 A ECSP21012501 A EC SP21012501A EC SENADI202112501 A ECSENADI202112501 A EC SENADI202112501A EC DI202112501 A ECDI202112501 A EC DI202112501A EC SP21012501 A ECSP21012501 A EC SP21012501A
Authority
EC
Ecuador
Prior art keywords
nash
treatment
nafld
combinations
related diseases
Prior art date
Application number
ECSENADI202112501A
Other languages
English (en)
Inventor
Trenton Thomas Ross
William Paul Esler
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ECSP21012501A publication Critical patent/ECSP21012501A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describe en la presente la combinación de (S)-2-(5-((3-etoxi-piridin-2-il)oxi)piridin-3-il)-N-(tetrahidrofuran-3-il)pirimidina-5-carboxamida, o una sal farmacéuticamente aceptable de la misma, y ácido 4-(4-(1-isopropil-7-oxo-1,4,6,7-tetrahidrospiro-[indazol-5,4’-piperidina]-1’-carbonil)-6-metoxipiridin-2-il)benzoico, o sal farmacéuticamente aceptable del mismo, para tratamiento de enfermedades, incluyendo esteatohepatitis no alcohólica (EHNA), en mamíferos.
ECSENADI202112501A 2018-08-31 2021-02-23 Combinaciones para tratamiento de ehna/ehgna y enfermedades relacionadas ECSP21012501A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862726172P 2018-08-31 2018-08-31
US201962883860P 2019-08-07 2019-08-07

Publications (1)

Publication Number Publication Date
ECSP21012501A true ECSP21012501A (es) 2021-03-31

Family

ID=68165623

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202112501A ECSP21012501A (es) 2018-08-31 2021-02-23 Combinaciones para tratamiento de ehna/ehgna y enfermedades relacionadas

Country Status (22)

Country Link
US (2) US11254660B2 (es)
EP (1) EP3843740A1 (es)
JP (1) JP7161605B2 (es)
KR (1) KR102614808B1 (es)
CN (1) CN112955147A (es)
AU (1) AU2019329884B2 (es)
BR (1) BR112021003039A2 (es)
CA (1) CA3110601C (es)
CL (1) CL2021000491A1 (es)
CO (1) CO2021002230A2 (es)
CR (1) CR20210110A (es)
DO (1) DOP2021000036A (es)
EC (1) ECSP21012501A (es)
IL (1) IL281093A (es)
MA (1) MA53496A (es)
MX (1) MX2021002428A (es)
PH (1) PH12021550339A1 (es)
SG (1) SG11202101503RA (es)
TW (1) TWI718644B (es)
UY (1) UY38351A (es)
WO (1) WO2020044266A1 (es)
ZA (1) ZA202101090B (es)

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JP2022058085A (ja) * 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
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US20220089578A1 (en) * 2020-08-21 2022-03-24 Terns Pharmaceuticals, Inc. Compounds as glp-1r agonists
CN112635049A (zh) * 2020-12-23 2021-04-09 无锡市第二人民医院 一种研究HSD17B13 rs72613567基因变异和肾功能损伤之间关系的方法
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Publication number Publication date
TW202026292A (zh) 2020-07-16
IL281093A (en) 2021-04-29
WO2020044266A1 (en) 2020-03-05
MX2021002428A (es) 2023-01-02
UY38351A (es) 2020-03-31
US20200071306A1 (en) 2020-03-05
PH12021550339A1 (en) 2021-10-04
CN112955147A (zh) 2021-06-11
CA3110601C (en) 2023-09-05
CA3110601A1 (en) 2020-03-05
ZA202101090B (en) 2022-06-29
TWI718644B (zh) 2021-02-11
KR20210053929A (ko) 2021-05-12
KR102614808B1 (ko) 2023-12-19
CO2021002230A2 (es) 2021-03-08
BR112021003039A2 (pt) 2021-05-18
CR20210110A (es) 2021-05-13
MA53496A (fr) 2021-12-08
JP2021535126A (ja) 2021-12-16
AU2019329884B2 (en) 2022-01-27
CL2021000491A1 (es) 2021-08-20
EP3843740A1 (en) 2021-07-07
US11254660B2 (en) 2022-02-22
US20220023299A1 (en) 2022-01-27
SG11202101503RA (en) 2021-03-30
DOP2021000036A (es) 2021-04-15
AU2019329884A1 (en) 2021-03-11
JP7161605B2 (ja) 2022-10-26

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