AR065477A1 - Diaminopirimidinas - Google Patents

Diaminopirimidinas

Info

Publication number
AR065477A1
AR065477A1 ARP080100785A ARP080100785A AR065477A1 AR 065477 A1 AR065477 A1 AR 065477A1 AR P080100785 A ARP080100785 A AR P080100785A AR P080100785 A ARP080100785 A AR P080100785A AR 065477 A1 AR065477 A1 AR 065477A1
Authority
AR
Argentina
Prior art keywords
halo
alkoxy
diaminopirimidins
disorder
aminosulfonyl
Prior art date
Application number
ARP080100785A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR065477A1 publication Critical patent/AR065477A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Compuestos de la formula (1) o una sal farmacéuticamente aceptable del mismo. R1 es alcoxi C1-6, hidroxi o halo; y R2 es alcoxi C1-6, halo, alquilo C1-6; alquilsulfonilo C1-6 o aminosulfonilo. Composicion farmacéutica, método para obtener (1) y parapreparar medicamento para enfermedad del tracto urinario, un estado patologico doloroso, un trastorno respiratorio o trastorno gastrointestinal.
ARP080100785A 2007-02-28 2008-02-26 Diaminopirimidinas AR065477A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90407907P 2007-02-28 2007-02-28

Publications (1)

Publication Number Publication Date
AR065477A1 true AR065477A1 (es) 2009-06-10

Family

ID=39297415

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080100785A AR065477A1 (es) 2007-02-28 2008-02-26 Diaminopirimidinas

Country Status (6)

Country Link
US (1) US20080207655A1 (es)
AR (1) AR065477A1 (es)
CL (1) CL2008000554A1 (es)
PE (1) PE20090624A1 (es)
TW (1) TW200845995A (es)
WO (1) WO2008104474A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101522641B (zh) * 2006-10-04 2012-07-04 弗·哈夫曼-拉罗切有限公司 合成苯氧基二氨基嘧啶衍生物的方法
US20150152043A1 (en) 2012-06-05 2015-06-04 Stefan J. Pastine Synthesis of and compositions containing diaminoacetals and diaminoketals
KR102196885B1 (ko) * 2013-08-23 2020-12-30 애퍼런트 파마슈티컬스 인크. 급성, 아급성 또는 만성 기침의 치료를 위한 디아미노피리미딘 p2x3 및 p2x2/3 수용체 조절제
RS64155B1 (sr) * 2015-09-29 2023-05-31 Afferent Pharmaceuticals Inc Diaminopirimidinski modulatori p2x3 i p2x2/3 receptora, za upotrebu u lečenju kašlja
KR20180122406A (ko) 2016-03-14 2018-11-12 애퍼런트 파마슈티컬스 인크. 피리미딘 및 그의 변이체, 및 그의 용도
RU2760733C2 (ru) 2016-03-25 2021-11-30 Эфферент Фармасьютикалз Инк. Пиримидины и их варианты, и их применение
MX2019007163A (es) 2016-12-20 2019-08-29 Afferent Pharmaceuticals Inc Sales cristalinas y polimorfos de un antagonista de p2x3.
US11124473B2 (en) 2017-07-11 2021-09-21 Aditya Birla Chemicals (Usa) Llc Salts of diaminoacetals and diaminoketals and their synthesis, and their transformations to diaminoacetals and diaminoketals
US20220249478A1 (en) * 2019-04-30 2022-08-11 Beijing Tide Pharmaceutical Co., Ltd. Method for treating endometriosis-associated pain by using diaminopyrimidine compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1725540T3 (pl) * 2004-03-05 2013-02-28 Hoffmann La Roche Diaminopirymidyny jako antagoniści p2x3 i p2x2/3
BRPI0615040A2 (pt) * 2005-09-01 2011-04-26 Hoffmann La Roche diaminopirimidinas como moduladores de p2x3 e p2x2/3
JP4850911B2 (ja) * 2005-09-01 2012-01-11 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３およびｐ２ｘ２／３モジュレーターとしてのジアミノピリミジン
CN101300235B (zh) * 2005-09-01 2011-12-07 弗·哈夫曼-拉罗切有限公司 作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物

Also Published As

Publication number Publication date
US20080207655A1 (en) 2008-08-28
WO2008104474A1 (en) 2008-09-04
CL2008000554A1 (es) 2008-08-29
TW200845995A (en) 2008-12-01
PE20090624A1 (es) 2009-05-16

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