PE20090624A1 - Diaminopirimidinas - Google Patents
DiaminopirimidinasInfo
- Publication number
- PE20090624A1 PE20090624A1 PE2008000379A PE2008000379A PE20090624A1 PE 20090624 A1 PE20090624 A1 PE 20090624A1 PE 2008000379 A PE2008000379 A PE 2008000379A PE 2008000379 A PE2008000379 A PE 2008000379A PE 20090624 A1 PE20090624 A1 PE 20090624A1
- Authority
- PE
- Peru
- Prior art keywords
- pyrimidin
- amino
- compounds
- metoxy
- alcoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE DIAMINOPIRIMIDINAS DE FORMULA (I) DONDE R1 ES ALCOXI(C1-C6), HIDROXI O HALOGENO; R2 ES ALCOXI(C1-C6), HALOGENO, ALQUILSULFONILO(C1-C6) O AMINOSULFONILO. SON COMPUESTOS PREFERIDOS: 2-[4-AMINO-5-(5-YODO-2-ISOPROPIL-4-METOXI-FENOXI)-PIRIMIDIN-2-ILAMINO]-PROPANO-1,3-DIOL, 5-[4-AMINO-2-(2-HIDROXI-1-HIDROXIMETIL-ETILAMINO)-PIRIMIDIN-5-ILOXI]-4-ISOPROPIL-2-METOXI-BENCENOSULFONAMIDA, 2-[4-AMINO-5-(4-CLORO-5-YODO-2-ISOPROPIL-FENOXI)-PIRIMIDIN-2-ILAMINO]-PROPANO-1,3-DIOL, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCESO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LOS RECEPTORES PURINERGICOS P2X SIENDO UTILES EN EL TRATAMIENTO DE INCONTINENCIA, HIPERTROFIA BENIGNA DE PROSTATA, VEJIGA HIPERACTIVA, CISTITIS, NEURALGIAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90407907P | 2007-02-28 | 2007-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090624A1 true PE20090624A1 (es) | 2009-05-16 |
Family
ID=39297415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000379A PE20090624A1 (es) | 2007-02-28 | 2008-02-25 | Diaminopirimidinas |
Country Status (6)
Country | Link |
---|---|
US (1) | US20080207655A1 (es) |
AR (1) | AR065477A1 (es) |
CL (1) | CL2008000554A1 (es) |
PE (1) | PE20090624A1 (es) |
TW (1) | TW200845995A (es) |
WO (1) | WO2008104474A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2009003257A (es) * | 2006-10-04 | 2009-04-07 | Hoffmann La Roche | Procedimiento para la sintesis de derivados de fenoxi diaminopirimidina. |
WO2013184827A1 (en) | 2012-06-05 | 2013-12-12 | Pastine Stefan J | Synthesis of and compositions containing diaminoacetals and diaminoketals |
MY195728A (en) * | 2013-08-23 | 2023-02-07 | Afferent Pharmaceuticals Inc | Diaminopyrimidine P2x3 and P2x 2/3 Receptor Modulators for Treatment of Acute, Sub-Acute or Chronic Cough |
HRP20230445T1 (hr) * | 2015-09-29 | 2023-07-21 | Afferent Pharmaceuticals Inc. | Modulatori diaminopirimidin p2x3 i p2x2/3 receptora za primjenu u liječenju kašlja |
WO2017160569A1 (en) | 2016-03-14 | 2017-09-21 | Afferent Pharmaceuticals Inc. | Pyrimidines and variants thereof, and uses therefor |
BR112018069105A2 (pt) | 2016-03-25 | 2019-01-29 | Afferent Pharmaceuticals Inc | pirimidinas e variantes das mesmas, e usos para tais |
US10676444B2 (en) * | 2016-12-20 | 2020-06-09 | Afferent Pharmaceuticals, Inc. | Crystalline salts and polymorphs of a P2X3 antagonist |
US10919839B2 (en) | 2017-07-11 | 2021-02-16 | Aditya Birla Chemicals (Usa) Llc | Silicon-containing compositions and their methods of use |
SG11202111960PA (en) * | 2019-04-30 | 2021-12-30 | Beijing Tide Pharmaceutical Co Ltd | Method for treating endometriosis-associated pain by using diaminopyrimidine compound |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1930135B (zh) * | 2004-03-05 | 2011-12-28 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x3和p2x2/3拮抗剂的二氨基嘧啶 |
BRPI0615040A2 (pt) * | 2005-09-01 | 2011-04-26 | Hoffmann La Roche | diaminopirimidinas como moduladores de p2x3 e p2x2/3 |
EP1924566B1 (en) * | 2005-09-01 | 2016-01-13 | F.Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
JP4850911B2 (ja) * | 2005-09-01 | 2012-01-11 | エフ.ホフマン−ラ ロシュ アーゲー | P2x3およびp2x2/3モジュレーターとしてのジアミノピリミジン |
-
2008
- 2008-02-18 WO PCT/EP2008/051944 patent/WO2008104474A1/en active Application Filing
- 2008-02-25 TW TW097106480A patent/TW200845995A/zh unknown
- 2008-02-25 PE PE2008000379A patent/PE20090624A1/es not_active Application Discontinuation
- 2008-02-25 CL CL200800554A patent/CL2008000554A1/es unknown
- 2008-02-26 AR ARP080100785A patent/AR065477A1/es unknown
- 2008-02-27 US US12/072,664 patent/US20080207655A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20080207655A1 (en) | 2008-08-28 |
CL2008000554A1 (es) | 2008-08-29 |
TW200845995A (en) | 2008-12-01 |
AR065477A1 (es) | 2009-06-10 |
WO2008104474A1 (en) | 2008-09-04 |
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