CL2008002826A1 - Compuestos derivados de pirimidina alquiltio sustituidas, antagonista crth2; composicion farmaceutica que comprende a dicho compuestos; y uso para tratar una enfermedad alergica, asma, dermatitis atopica, psoriasis, colitis ulcerantes, sinusitis, leucemia basofilica, entre otras. - Google Patents

Compuestos derivados de pirimidina alquiltio sustituidas, antagonista crth2; composicion farmaceutica que comprende a dicho compuestos; y uso para tratar una enfermedad alergica, asma, dermatitis atopica, psoriasis, colitis ulcerantes, sinusitis, leucemia basofilica, entre otras.

Info

Publication number
CL2008002826A1
CL2008002826A1 CL2008002826A CL2008002826A CL2008002826A1 CL 2008002826 A1 CL2008002826 A1 CL 2008002826A1 CL 2008002826 A CL2008002826 A CL 2008002826A CL 2008002826 A CL2008002826 A CL 2008002826A CL 2008002826 A1 CL2008002826 A1 CL 2008002826A1
Authority
CL
Chile
Prior art keywords
compounds
sinusitis
psoriasis
asthma
pharmaceutical composition
Prior art date
Application number
CL2008002826A
Other languages
English (en)
Inventor
Wei Ly Tai
D Raaum Erik
Chantal Siu-Ying Tran Marie
Original Assignee
Actimis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actimis Pharmaceuticals Inc filed Critical Actimis Pharmaceuticals Inc
Publication of CL2008002826A1 publication Critical patent/CL2008002826A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/58—Two sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)

Abstract

Compuestos derivados de pirimidina alquiltio sustituidas, antagonista crth2; composición farmacéutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de una enfermedad alérgica, asma, dermatitis atópica, psoriasis, colitis ulcerante, sinusitis, leucemia basofílica, entre otras.
CL2008002826A 2007-09-25 2008-09-24 Compuestos derivados de pirimidina alquiltio sustituidas, antagonista crth2; composicion farmaceutica que comprende a dicho compuestos; y uso para tratar una enfermedad alergica, asma, dermatitis atopica, psoriasis, colitis ulcerantes, sinusitis, leucemia basofilica, entre otras. CL2008002826A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99538607P 2007-09-25 2007-09-25

Publications (1)

Publication Number Publication Date
CL2008002826A1 true CL2008002826A1 (es) 2009-08-07

Family

ID=40039984

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008002826A CL2008002826A1 (es) 2007-09-25 2008-09-24 Compuestos derivados de pirimidina alquiltio sustituidas, antagonista crth2; composicion farmaceutica que comprende a dicho compuestos; y uso para tratar una enfermedad alergica, asma, dermatitis atopica, psoriasis, colitis ulcerantes, sinusitis, leucemia basofilica, entre otras.

Country Status (25)

Country Link
US (1) US8324229B2 (es)
EP (1) EP2205569B1 (es)
JP (1) JP5524847B2 (es)
KR (1) KR20100061747A (es)
CN (1) CN101874023A (es)
AR (1) AR068632A1 (es)
AT (1) ATE547407T1 (es)
AU (1) AU2008305632B2 (es)
BR (1) BRPI0817319A2 (es)
CA (1) CA2700524C (es)
CL (1) CL2008002826A1 (es)
CY (1) CY1112720T1 (es)
DK (1) DK2205569T3 (es)
ES (1) ES2383249T3 (es)
HR (1) HRP20120377T1 (es)
IL (1) IL205647A0 (es)
MX (1) MX2010003182A (es)
NZ (1) NZ584352A (es)
PL (1) PL2205569T3 (es)
PT (1) PT2205569E (es)
RU (1) RU2491280C2 (es)
SI (1) SI2205569T1 (es)
TW (1) TW200922587A (es)
WO (1) WO2009042138A1 (es)
ZA (1) ZA201002173B (es)

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Publication number Priority date Publication date Assignee Title
US8314116B2 (en) 2007-09-25 2012-11-20 Actimis Pharmaceuticals, Inc. 2-S-benzyl substituted pyrimidines as CRTH2 antagonists
NZ592534A (en) * 2007-10-18 2013-03-28 Boehringer Ingelheim Int Preparation of dihydrothieno [3,2-D] pyrimidines and intermediates used therein
EP2393492A1 (en) * 2009-02-09 2011-12-14 Boehringer Ingelheim International GmbH New pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
ES2545865T3 (es) * 2010-01-27 2015-09-16 Boehringer Ingelheim International Gmbh Compuestos de pirazol como antagonistas de CRTH2
EP2598145A1 (en) * 2010-07-28 2013-06-05 Boehringer Ingelheim International GmbH Pharmaceutical composition for treatment of respiratory and inflammatory diseases
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
US8759386B2 (en) 2011-01-24 2014-06-24 Boehringer Ingelheim International Gmbh Pyrazole compounds as CRTH2 antagonists
WO2012130633A1 (en) 2011-03-25 2012-10-04 Boehringer Ingelheim International Gmbh Pyrazole compounds as crth2 antagonists
GB2494277A (en) 2011-08-29 2013-03-06 Univ Heriot Watt Electro-spinning nanofibres onto a moving wire card
PL2781508T3 (pl) * 2011-11-17 2019-06-28 Kbp Biosciences Co., Ltd. Związki pierścieniowe o układzie skondensowanych pierścieni zawierające azot do zastosowania jako antagonisty CRTH2

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Publication number Priority date Publication date Assignee Title
BE790679A (fr) 1971-11-03 1973-04-27 Ici Ltd Derives de l'indole
GB9125842D0 (en) 1991-12-04 1992-02-05 Ici Plc Heterocyclic derivatives
BR9307264A (pt) * 1992-10-16 1999-05-11 Nippon Soda Co Derivados de pirimidina herbicida e fungicida
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
JP2001302667A (ja) 2000-04-28 2001-10-31 Bayer Ag イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体
US6878522B2 (en) 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
EP1413306A1 (en) 2002-10-21 2004-04-28 Warner-Lambert Company LLC Tetrahydroquinoline derivatives as CRTH2 antagonists
MXPA05006701A (es) 2002-12-20 2006-03-30 Amgen Inc Moduladores de asma y de inflacion alergica.
PT1471057E (pt) * 2003-04-25 2006-05-31 Actimis Pharmaceuticals Inc Derivados de acido pirimidinilacetico uteis para o tratamento de doencas mediadas por crth2
ATE433452T1 (de) 2004-01-31 2009-06-15 Actimis Pharmaceuticals Inc Imidazoä1,2-cüpyrimidinylessigsäurederivate
WO2007062677A1 (en) * 2005-11-30 2007-06-07 7Tm Pharma A/S Thiazolyl- and pyrimidinyl-acetic acids and their use as crth2 receptor ligands
US8314116B2 (en) 2007-09-25 2012-11-20 Actimis Pharmaceuticals, Inc. 2-S-benzyl substituted pyrimidines as CRTH2 antagonists

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Publication number Publication date
ATE547407T1 (de) 2012-03-15
RU2491280C2 (ru) 2013-08-27
WO2009042138A9 (en) 2009-10-15
US8324229B2 (en) 2012-12-04
HRP20120377T1 (hr) 2012-05-31
CN101874023A (zh) 2010-10-27
PL2205569T3 (pl) 2012-08-31
EP2205569A1 (en) 2010-07-14
US20100298361A1 (en) 2010-11-25
KR20100061747A (ko) 2010-06-08
SI2205569T1 (sl) 2012-06-29
AU2008305632A1 (en) 2009-04-02
BRPI0817319A2 (pt) 2015-03-17
AR068632A1 (es) 2009-11-25
CA2700524C (en) 2017-08-01
CY1112720T1 (el) 2016-02-10
ES2383249T3 (es) 2012-06-19
TW200922587A (en) 2009-06-01
JP5524847B2 (ja) 2014-06-18
PT2205569E (pt) 2012-05-25
NZ584352A (en) 2012-03-30
DK2205569T3 (da) 2012-05-21
IL205647A0 (en) 2011-07-31
JP2010540520A (ja) 2010-12-24
AU2008305632B2 (en) 2014-01-30
MX2010003182A (es) 2010-06-02
CA2700524A1 (en) 2009-04-02
WO2009042138A1 (en) 2009-04-02
EP2205569B1 (en) 2012-02-29
RU2010116293A (ru) 2011-11-10
ZA201002173B (en) 2011-05-25

Similar Documents

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