HUP0300499A2 - Pharmaceutical formulations for dry powder inhalers - Google Patents

Pharmaceutical formulations for dry powder inhalers

Info

Publication number
HUP0300499A2
HUP0300499A2 HU0300499A HUP0300499A HUP0300499A2 HU P0300499 A2 HUP0300499 A2 HU P0300499A2 HU 0300499 A HU0300499 A HU 0300499A HU P0300499 A HUP0300499 A HU P0300499A HU P0300499 A2 HUP0300499 A2 HU P0300499A2
Authority
HU
Hungary
Prior art keywords
particle size
dry powder
mixture
weight
material particles
Prior art date
Application number
HU0300499A
Other languages
English (en)
Inventor
Gaetano Brambilla
Lorenzo Ferrarini
Rajbir Gill
David Alexander Vodden Morton
Rossella Musa
John Nicholas Staniforth
Original Assignee
Vectura Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26071084&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0300499(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB0009469.8A external-priority patent/GB0009469D0/en
Application filed by Vectura Ltd filed Critical Vectura Ltd
Publication of HUP0300499A2 publication Critical patent/HUP0300499A2/hu
Publication of HU229270B1 publication Critical patent/HU229270B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

A találmány tárgya por száraz por inhalátorban való alkalmazásra, apor i) fiziológiailag elfogadható segédanyag és adalékanyagkeverékének finom részecskeméretű frakcióját, amely keverék közepesrészecskemérete 35 mm -nél kisebb; ii) fiziológiailag elfogadhatóhordozó durva részecskeméretű frakcióját, amelynek a részecskeméretelegalább 90 mm; és iii) legalább egy hatóanyagot tartalmaz; az i)keverék legalább 99 tömeg% segédanyag-részecskét és legalább 1 tömeg%adalékanyagot tartalmaz, és a finom segédanyag-részecskék és a durvahordozóanyag-részecskék aránya 1:99 és 40:60 tömeg% közötti. Atalálmány belégzés útján, száraz por formájában adagolandókészítményekre vonatkozik, amelyek alkalmasak a hatóanyagoknak apulmonális betegségektől, így például asztmától szenvedő betegek alsólégzőtraktusába való hatékony eljuttatására. Ó
HU0300499A 2000-04-17 2001-04-17 Pharmaceutical formulations for dry powder inhalers HU229270B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0009469.8A GB0009469D0 (en) 2000-04-17 2000-04-17 Improvements in or relating to formalities for use in inhaler devices
EP00113608 2000-06-27
PCT/GB2001/001751 WO2001078695A2 (en) 2000-04-17 2001-04-17 Pharmaceutical formulations for dry powder inhalers

Publications (2)

Publication Number Publication Date
HUP0300499A2 true HUP0300499A2 (en) 2003-07-28
HU229270B1 HU229270B1 (en) 2013-10-28

Family

ID=26071084

Family Applications (4)

Application Number Title Priority Date Filing Date
HU0300593A HU229797B1 (en) 2000-04-17 2001-04-17 Pharmaceutical formulations for dry powder inhalers in the form of hard-pellets
HU0300490A HUP0300490A2 (en) 2000-04-17 2001-04-17 Formulations for use in inhaler devices
HU0300499A HU229270B1 (en) 2000-04-17 2001-04-17 Pharmaceutical formulations for dry powder inhalers
HU1300117A HU230464B1 (hu) 2000-04-17 2001-04-17 Kemény pelletként kialakított gyógyászati készítmény száraz porral működő inhalátorhoz

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HU0300593A HU229797B1 (en) 2000-04-17 2001-04-17 Pharmaceutical formulations for dry powder inhalers in the form of hard-pellets
HU0300490A HUP0300490A2 (en) 2000-04-17 2001-04-17 Formulations for use in inhaler devices

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU1300117A HU230464B1 (hu) 2000-04-17 2001-04-17 Kemény pelletként kialakított gyógyászati készítmény száraz porral működő inhalátorhoz

Country Status (32)

Country Link
US (4) US8182791B2 (hu)
EP (6) EP1719505B1 (hu)
JP (2) JP2003530425A (hu)
KR (1) KR20030069047A (hu)
CN (1) CN1424909A (hu)
AT (5) ATE521340T1 (hu)
AU (3) AU784719B2 (hu)
BR (3) BR0110301A (hu)
CA (3) CA2405767C (hu)
CY (1) CY1107315T1 (hu)
CZ (1) CZ301904B6 (hu)
DE (3) DE60123031T2 (hu)
DK (3) DK1276472T3 (hu)
DZ (1) DZ3315A1 (hu)
EE (1) EE05257B1 (hu)
ES (3) ES2272473T3 (hu)
GB (2) GB2363988A (hu)
HU (4) HU229797B1 (hu)
IL (1) IL152306A0 (hu)
MA (1) MA26892A1 (hu)
MX (3) MXPA02010213A (hu)
MY (1) MY129384A (hu)
NO (4) NO342999B1 (hu)
NZ (1) NZ521887A (hu)
PE (1) PE20011227A1 (hu)
PL (3) PL358640A1 (hu)
PT (3) PT1719505E (hu)
SA (1) SA01220062B1 (hu)
SI (2) SI1274406T1 (hu)
SK (1) SK284248B6 (hu)
TN (1) TNSN01060A1 (hu)
WO (3) WO2001078693A2 (hu)

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