JP7242300B2 - ニコチン粒子カプセル - Google Patents
ニコチン粒子カプセル Download PDFInfo
- Publication number
- JP7242300B2 JP7242300B2 JP2018530623A JP2018530623A JP7242300B2 JP 7242300 B2 JP7242300 B2 JP 7242300B2 JP 2018530623 A JP2018530623 A JP 2018530623A JP 2018530623 A JP2018530623 A JP 2018530623A JP 7242300 B2 JP7242300 B2 JP 7242300B2
- Authority
- JP
- Japan
- Prior art keywords
- capsule
- nicotine
- particles
- single opening
- flavor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/241—Extraction of specific substances
- A24B15/243—Nicotine
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/186—Treatment of tobacco products or tobacco substitutes by coating with a coating composition, encapsulation of tobacco particles
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F15/00—Receptacles or boxes specially adapted for cigars, cigarettes, simulated smoking devices or cigarettes therefor
- A24F15/01—Receptacles or boxes specially adapted for cigars, cigarettes, simulated smoking devices or cigarettes therefor specially adapted for simulated smoking devices or cigarettes therefor
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
- A24F42/20—Devices without heating means
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
- A24F42/60—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Description
Claims (10)
- ニコチンを含む粒子を含み、かつ内部容積を画定するカプセルであって、直径が約0.5mm~約1.5mmである単一の開口部のみが前記カプセルを通して延び、前記単一の開口部が、前記単一の開口部を形成するように使用される貫通要素が前記単一の開口部から引き出されると、ニコチンを含み、かつ空気動力学的中央粒子径が約0.5マイクロメートル~約4マイクロメートルである粒子の部分量を5回以上の吸煙にわたって、従来的な喫煙方法の気流量である約5L/分未満で提供するようなサイズとされており、
前記カプセルの前記内部容積が約0.2mL~約0.45mLであり、
前記単一の開口部の開放表面積が、前記カプセルの内部容積1mL当たり約0.7平方mm~約7平方mmの範囲である、カプセル。 - ニコチンを含む前記粒子が空気動力学的中央粒子径を有し、かつ前記単一の開口部が直径を有し、前記単一の開口部の前記直径と、ニコチンを含む前記粒子の前記空気動力学的中央粒子径との比が約200~約800である、請求項1に記載のカプセル。
- 前記ニコチンがニコチン塩またはニコチン塩水和物を含む、請求項1~2のいずれか一項に記載のカプセル。
- ニコチンを含む前記粒子が、ロイシンまたはL-ロイシンなどのアミノ酸を含む、請求項1~3のいずれか一項に記載のカプセル。
- 前記カプセルが、風味を含む粒子を含み、この粒子が約20マイクロメートル以上、または約50マイクロメートル~約150マイクロメートルの範囲の中央粒子径を有する、請求項1~4のいずれか一項に記載のカプセル。
- 前記単一の開口部の開放表面積が約0.2平方mm~約1平方mmである、請求項1~5のいずれか一項に記載のカプセル。
- 前記カプセルが約10mg~約200mgの乾燥粉末を含む、請求項1~6のいずれか一項に記載のカプセル。
- 前記単一の開口部が前記カプセルの長軸方向軸で入射する、請求項1~7のいずれか一項に記載のカプセル。
- 請求項1~8のいずれか一項に記載のカプセルを備える、乾燥粉末吸入器。
- 前記カプセルがカプセル空洞の中で安定性を有して回転できるように構成される前記カプセル空洞内に、前記カプセルが配置される、請求項9に記載の乾燥粉末吸入器。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15202712 | 2015-12-24 | ||
EP15202712.4 | 2015-12-24 | ||
EP16201580 | 2016-11-30 | ||
EP16201580.4 | 2016-11-30 | ||
PCT/IB2016/057792 WO2017109678A1 (en) | 2015-12-24 | 2016-12-19 | Nicotine particle capsule |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019508015A JP2019508015A (ja) | 2019-03-28 |
JP7242300B2 true JP7242300B2 (ja) | 2023-03-20 |
Family
ID=57822002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018530623A Active JP7242300B2 (ja) | 2015-12-24 | 2016-12-19 | ニコチン粒子カプセル |
Country Status (18)
Country | Link |
---|---|
US (1) | US10960152B2 (ja) |
EP (1) | EP3393565B1 (ja) |
JP (1) | JP7242300B2 (ja) |
KR (1) | KR20180096611A (ja) |
CN (1) | CN108430551A (ja) |
AU (1) | AU2016376033A1 (ja) |
BR (1) | BR112018010830B1 (ja) |
CA (1) | CA3008996A1 (ja) |
ES (1) | ES2948157T3 (ja) |
IL (1) | IL259910A (ja) |
MX (1) | MX2018007512A (ja) |
PH (1) | PH12018501199A1 (ja) |
PL (1) | PL3393565T3 (ja) |
RU (1) | RU2720573C2 (ja) |
SG (1) | SG11201805204WA (ja) |
UA (1) | UA123586C2 (ja) |
WO (1) | WO2017109678A1 (ja) |
ZA (1) | ZA201803662B (ja) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2762860C2 (ru) | 2017-02-28 | 2021-12-23 | Филип Моррис Продактс С.А. | Устройство, генерирующее аэрозоль, содержащее исполнительный элемент для деагломерирования порошка |
WO2019003118A1 (en) * | 2017-06-28 | 2019-01-03 | Philip Morris Products S.A. | CONTAINER WITH PARTICLES FOR USE WITH INHALER |
EP3700611B1 (en) * | 2017-10-25 | 2021-12-01 | Philip Morris Products S.A. | Piercing accessory for inhaler article and system |
WO2019082056A1 (en) * | 2017-10-25 | 2019-05-02 | Philip Morris Products S.A. | INHALER WITH DELIMITATION ELEMENT |
BR112020010021A2 (pt) * | 2017-12-28 | 2020-11-03 | Philip Morris Products S.A. | inalador com túnel de vórtice |
WO2019159123A1 (en) * | 2018-02-19 | 2019-08-22 | Philip Morris Products S.A. | Dry powder inhaler |
JP7458985B2 (ja) | 2018-03-26 | 2024-04-01 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 複合多孔性支持要素を備えた吸入器 |
JP7249354B2 (ja) * | 2018-03-26 | 2023-03-30 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 開口部付きの多孔性支持要素を備えた吸入器 |
US11964099B2 (en) | 2018-03-26 | 2024-04-23 | Philip Morris Products, S.A. | Inhaler with vortex capsule cavity |
Citations (4)
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JP2011505905A (ja) | 2007-12-05 | 2011-03-03 | ノバルティス アーゲー | エアロゾル化可能な薬物製剤用レセプタクル |
WO2015166344A1 (en) | 2014-04-28 | 2015-11-05 | Philip Morris Products S.A. | Nicotine powder inhaler |
WO2015166350A2 (en) | 2014-04-28 | 2015-11-05 | Philip Morris Products S.A. | Flavoured nicotine powder inhaler |
WO2015193498A1 (en) | 2014-06-20 | 2015-12-23 | Philip Morris Products S.A. | Nicotine powder delivery system with airflow management means |
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2016
- 2016-12-19 ES ES16826768T patent/ES2948157T3/es active Active
- 2016-12-19 PL PL16826768.0T patent/PL3393565T3/pl unknown
- 2016-12-19 AU AU2016376033A patent/AU2016376033A1/en not_active Abandoned
- 2016-12-19 RU RU2018126867A patent/RU2720573C2/ru active
- 2016-12-19 UA UAA201803894A patent/UA123586C2/uk unknown
- 2016-12-19 SG SG11201805204WA patent/SG11201805204WA/en unknown
- 2016-12-19 WO PCT/IB2016/057792 patent/WO2017109678A1/en active Application Filing
- 2016-12-19 US US16/064,177 patent/US10960152B2/en active Active
- 2016-12-19 CA CA3008996A patent/CA3008996A1/en not_active Abandoned
- 2016-12-19 EP EP16826768.0A patent/EP3393565B1/en active Active
- 2016-12-19 MX MX2018007512A patent/MX2018007512A/es unknown
- 2016-12-19 CN CN201680071326.0A patent/CN108430551A/zh active Pending
- 2016-12-19 KR KR1020187016263A patent/KR20180096611A/ko active IP Right Grant
- 2016-12-19 JP JP2018530623A patent/JP7242300B2/ja active Active
- 2016-12-19 BR BR112018010830-8A patent/BR112018010830B1/pt active IP Right Grant
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2018
- 2018-06-01 ZA ZA2018/03662A patent/ZA201803662B/en unknown
- 2018-06-06 PH PH12018501199A patent/PH12018501199A1/en unknown
- 2018-06-10 IL IL259910A patent/IL259910A/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011505905A (ja) | 2007-12-05 | 2011-03-03 | ノバルティス アーゲー | エアロゾル化可能な薬物製剤用レセプタクル |
WO2015166344A1 (en) | 2014-04-28 | 2015-11-05 | Philip Morris Products S.A. | Nicotine powder inhaler |
WO2015166350A2 (en) | 2014-04-28 | 2015-11-05 | Philip Morris Products S.A. | Flavoured nicotine powder inhaler |
WO2015193498A1 (en) | 2014-06-20 | 2015-12-23 | Philip Morris Products S.A. | Nicotine powder delivery system with airflow management means |
Also Published As
Publication number | Publication date |
---|---|
MX2018007512A (es) | 2018-09-17 |
JP2019508015A (ja) | 2019-03-28 |
PH12018501199A1 (en) | 2019-01-28 |
ZA201803662B (en) | 2019-07-31 |
ES2948157T3 (es) | 2023-09-01 |
BR112018010830A2 (pt) | 2018-11-27 |
IL259910A (en) | 2018-07-31 |
BR112018010830B1 (pt) | 2023-04-11 |
SG11201805204WA (en) | 2018-07-30 |
CN108430551A (zh) | 2018-08-21 |
RU2720573C2 (ru) | 2020-05-12 |
RU2018126867A (ru) | 2020-01-24 |
UA123586C2 (uk) | 2021-04-28 |
US10960152B2 (en) | 2021-03-30 |
WO2017109678A1 (en) | 2017-06-29 |
PL3393565T3 (pl) | 2023-09-11 |
EP3393565A1 (en) | 2018-10-31 |
EP3393565B1 (en) | 2023-05-24 |
KR20180096611A (ko) | 2018-08-29 |
AU2016376033A1 (en) | 2018-06-28 |
CA3008996A1 (en) | 2017-06-29 |
US20190001084A1 (en) | 2019-01-03 |
RU2018126867A3 (ja) | 2020-03-17 |
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