JO3102B1 - صيغ صيدلانية لوسائل استنشاق بها مسحوق جاف تشتمل على مكون فعال بقوة منخفضة الجرعة - Google Patents
صيغ صيدلانية لوسائل استنشاق بها مسحوق جاف تشتمل على مكون فعال بقوة منخفضة الجرعةInfo
- Publication number
- JO3102B1 JO3102B1 JOP/2005/0029A JOP20050029A JO3102B1 JO 3102 B1 JO3102 B1 JO 3102B1 JO P20050029 A JOP20050029 A JO P20050029A JO 3102 B1 JO3102 B1 JO 3102B1
- Authority
- JO
- Jordan
- Prior art keywords
- low
- active ingredient
- dosage strength
- dry powder
- pharmaceutical formulations
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title abstract 4
- 239000000843 powder Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000011859 microparticle Substances 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- 102100029469 WD repeat and HMG-box DNA-binding protein 1 Human genes 0.000 abstract 1
- 101710097421 WD repeat and HMG-box DNA-binding protein 1 Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
Abstract
يقدم الاختراع صيغه يتم تناولها في صورة مسحوق جاف للاستنشاق ومناسبة للتوصيل الفعال للمكونات الفعالة منخفضة الفاعلية الى القناة التنفسية السفلى للمرضى. وبصفة خاصة يقدم الاختراع الحالي صيغة تحتوى على جسيمات دقيقة للغاية مكونة من جسيمات المكون الفعال منخفض الفاعلية، وجسيمات احد السواغات حيث يتراوح القطر المتوسط للكتلة( MMD) للجسيمات الدقيقة للغاية بين 2 و 15 ميكرون، وتكون نسبة 10% على الاقل من الجسيمات الدقيقة للغاية لها قطر كتلة ( MD) اكبر من 0.5 ميكرون، وتتراوح النسبة بين المكون الفعال والسواغ بين 1: 5 و 1 : 100 كما يقدم الاختراع عملية لتحضيرها
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04006430 | 2004-03-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
JO3102B1 true JO3102B1 (ar) | 2017-09-20 |
Family
ID=34962706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2005/0029A JO3102B1 (ar) | 2004-03-17 | 2005-03-14 | صيغ صيدلانية لوسائل استنشاق بها مسحوق جاف تشتمل على مكون فعال بقوة منخفضة الجرعة |
Country Status (20)
Country | Link |
---|---|
US (1) | US8153104B2 (ar) |
EP (1) | EP1729728B1 (ar) |
KR (1) | KR20060130216A (ar) |
CN (1) | CN1942172B (ar) |
AR (1) | AR049010A1 (ar) |
AU (1) | AU2005224008B2 (ar) |
BR (1) | BRPI0508170A (ar) |
CA (1) | CA2560226C (ar) |
ES (1) | ES2566618T3 (ar) |
HK (1) | HK1101346A1 (ar) |
JO (1) | JO3102B1 (ar) |
MA (1) | MA28514B1 (ar) |
MX (1) | MXPA06010593A (ar) |
NO (1) | NO342481B1 (ar) |
NZ (1) | NZ549870A (ar) |
PE (1) | PE20060716A1 (ar) |
RU (1) | RU2371171C2 (ar) |
TN (1) | TNSN06277A1 (ar) |
WO (1) | WO2005089717A1 (ar) |
ZA (1) | ZA200607700B (ar) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1944018A1 (en) * | 2007-01-10 | 2008-07-16 | CHIESI FARMACEUTICI S.p.A. | Micronised particles of low-dosage strength active agents for powder formulations for inhalation |
EP2124915A2 (en) * | 2007-02-19 | 2009-12-02 | Cipla Limited | Pharmaceutical combinations of at least two bronchodilators or of a bronchodilator with a corticosteroid |
EP2191821A1 (en) * | 2008-11-26 | 2010-06-02 | CHIESI FARMACEUTICI S.p.A. | Microparticles comprising a salt of 8-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone having improved adhesion properties for dry powder inhalation |
TWI491416B (zh) * | 2008-12-24 | 2015-07-11 | Daiichi Sankyo Co Ltd | 吸入用乾燥粉末醫藥組成物 |
CA2770714A1 (en) * | 2009-08-27 | 2011-03-17 | Stc.Unm | Methods and systems for dosing and coating inhalation powders onto carrier particles |
EP2360147A1 (en) * | 2010-02-22 | 2011-08-24 | CHIESI FARMACEUTICI S.p.A. | Process for preparing crystalline particles of a salt of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino] ethyl]-2(1H)-quinolinone (carmoterol) |
MX336414B (es) * | 2010-04-01 | 2016-01-19 | Chiesi Farma Spa | Proceso de preparacion de particulas portadoras para polvos secos para inhalacion. |
DE102011102614A1 (de) * | 2011-05-27 | 2012-11-29 | Roland Nied | Verfahren zum Betrieb einer Strahlmühle sowie Strahlmühle |
WO2013077830A1 (en) * | 2011-11-25 | 2013-05-30 | Mahmut Bilgic | Synergistilly active combinations of roflumilast and carmoterol |
LT3412277T (lt) * | 2012-01-25 | 2023-04-25 | Chiesi Farmaceutici S.P.A. | Sausų miltelių pavidalo vaisto forma, apimanti kortikosteridą ir beta adrenerginį vaistą, skirta įvedimui inhaliacijos būdu |
SG10201703243QA (en) * | 2012-02-28 | 2017-06-29 | Iceutica Holdings Inc | Inhalable pharmaceutical compositions |
BR112014025518B1 (pt) | 2012-04-13 | 2022-05-24 | Glaxosmithkline Intellectual Property Development Limited | Partículas agregadas de umeclidinium, vilanterol e fluticasona, composição em pó, inalador, processo para a preparação de partículas agregadas, e, uso de estearato de magnésio em partículas agregadas |
JP5087182B1 (ja) * | 2012-06-13 | 2012-11-28 | クリニプロ株式会社 | 吸入用パウダーの製造方法 |
MX2015012931A (es) | 2013-03-13 | 2016-07-20 | Forest Lab Holdings Ltd | Composiciones farmaceuticas micronizadas. |
GB201305825D0 (en) | 2013-03-28 | 2013-05-15 | Vectura Ltd | New use |
HUE053957T2 (hu) * | 2013-07-11 | 2021-08-30 | Chiesi Farm Spa | Antikolinerg, kortikoszteroid és béta-adrenerg anyagot tartalmazó száraz porkészítmény inhalálással történõ beadásra |
US9427376B2 (en) * | 2013-10-10 | 2016-08-30 | Chiesi Farmaceutici S.P.A. | Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient |
CN104800192A (zh) * | 2014-01-27 | 2015-07-29 | 成都英诺新科技有限公司 | 一种罗氟司特吸入粉雾剂及制备方法 |
MA40617B1 (fr) | 2014-09-09 | 2020-05-29 | Vectura Ltd | Formulation comprenant glycopyrrolate, procédé et appareil |
US10583085B2 (en) * | 2017-05-17 | 2020-03-10 | Chiesi Farmaceutici S.P.A. | Carrier particles for dry powder formulations for inhalation |
CN109200034A (zh) * | 2017-06-30 | 2019-01-15 | 正大天晴药业集团股份有限公司 | 一种可吸入干粉形式的组合物及其制备方法 |
GB201911517D0 (en) * | 2019-08-12 | 2019-09-25 | Verona Pharma Plc | Pharmaceutical composition |
US20230034390A1 (en) * | 2019-12-16 | 2023-02-02 | Seagen Inc. | High performance liquid chromatography quantification of excipients |
US20210353650A1 (en) * | 2020-05-18 | 2021-11-18 | Cai Gu Huang | Pharmaceutical formulation containing remdesivir and its active metabolites for dry powder inhalation |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0441740T3 (da) * | 1990-01-29 | 1993-11-08 | Ciba Geigy Ag | Fremgangsmåde og apparat til dosering af et firkornet pulver |
US6673335B1 (en) * | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
IS1796B (is) | 1993-06-24 | 2001-12-31 | Ab Astra | Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband |
SE9700135D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
US20010006939A1 (en) * | 1997-10-03 | 2001-07-05 | Ralph W. Niven | Secretory leukocyte protease inhibitor dry powder pharmaceutical compositions |
IT1309592B1 (it) * | 1999-03-05 | 2002-01-24 | Chiesi Farma Spa | Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e |
PE20011227A1 (es) * | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
EP1309312A2 (en) * | 2000-08-07 | 2003-05-14 | Inhale Therapeutic Systems, Inc. | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
US6587025B2 (en) * | 2001-01-31 | 2003-07-01 | Vishay Dale Electronics, Inc. | Side-by-side coil inductor |
EP1643974A1 (en) * | 2003-07-11 | 2006-04-12 | Glaxo Group Limited | Inhalable pharmaceutical formulations comprising a sugar ester |
EP2080508A1 (en) * | 2008-01-15 | 2009-07-22 | CHIESI FARMACEUTICI S.p.A. | Dry powder formulation comprising an anticholinergic drug |
-
2005
- 2005-03-14 JO JOP/2005/0029A patent/JO3102B1/ar active
- 2005-03-16 MX MXPA06010593A patent/MXPA06010593A/es active IP Right Grant
- 2005-03-16 ZA ZA200607700A patent/ZA200607700B/en unknown
- 2005-03-16 ES ES05716109.3T patent/ES2566618T3/es active Active
- 2005-03-16 US US10/592,701 patent/US8153104B2/en active Active
- 2005-03-16 CA CA2560226A patent/CA2560226C/en active Active
- 2005-03-16 WO PCT/EP2005/002789 patent/WO2005089717A1/en active Application Filing
- 2005-03-16 KR KR1020067018864A patent/KR20060130216A/ko not_active Application Discontinuation
- 2005-03-16 BR BRPI0508170-0A patent/BRPI0508170A/pt not_active Application Discontinuation
- 2005-03-16 RU RU2006133038/15A patent/RU2371171C2/ru active
- 2005-03-16 EP EP05716109.3A patent/EP1729728B1/en active Active
- 2005-03-16 AU AU2005224008A patent/AU2005224008B2/en active Active
- 2005-03-16 CN CN2005800109732A patent/CN1942172B/zh active Active
- 2005-03-16 NZ NZ549870A patent/NZ549870A/en unknown
- 2005-03-17 PE PE2005000304A patent/PE20060716A1/es not_active Application Discontinuation
- 2005-03-18 AR ARP050101060A patent/AR049010A1/es not_active Application Discontinuation
-
2006
- 2006-09-12 TN TNP2006000277A patent/TNSN06277A1/en unknown
- 2006-09-14 NO NO20064161A patent/NO342481B1/no unknown
- 2006-10-02 MA MA29363A patent/MA28514B1/fr unknown
-
2007
- 2007-06-07 HK HK07106112.3A patent/HK1101346A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU2005224008B2 (en) | 2010-09-16 |
NO342481B1 (no) | 2018-05-28 |
CN1942172B (zh) | 2010-10-06 |
AR049010A1 (es) | 2006-06-21 |
TNSN06277A1 (en) | 2007-12-03 |
EP1729728A1 (en) | 2006-12-13 |
HK1101346A1 (en) | 2007-10-18 |
EP1729728B1 (en) | 2016-03-16 |
US20070202053A1 (en) | 2007-08-30 |
PE20060716A1 (es) | 2006-07-25 |
CA2560226C (en) | 2013-07-23 |
MA28514B1 (fr) | 2007-04-03 |
ES2566618T3 (es) | 2016-04-14 |
CN1942172A (zh) | 2007-04-04 |
NO20064161L (no) | 2006-10-17 |
BRPI0508170A (pt) | 2007-08-07 |
WO2005089717A1 (en) | 2005-09-29 |
RU2006133038A (ru) | 2008-03-20 |
US8153104B2 (en) | 2012-04-10 |
RU2371171C2 (ru) | 2009-10-27 |
KR20060130216A (ko) | 2006-12-18 |
AU2005224008A1 (en) | 2005-09-29 |
NZ549870A (en) | 2010-05-28 |
MXPA06010593A (es) | 2007-02-16 |
ZA200607700B (en) | 2008-05-28 |
CA2560226A1 (en) | 2005-09-29 |
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