HRP20201984T1 - Priprema (s)-n-(5-((r)-2-(2,5-difluorofenil)pirolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroksipirolidin-1-karboksamida - Google Patents

Priprema (s)-n-(5-((r)-2-(2,5-difluorofenil)pirolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroksipirolidin-1-karboksamida Download PDF

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Publication number
HRP20201984T1
HRP20201984T1 HRP20201984TT HRP20201984T HRP20201984T1 HR P20201984 T1 HRP20201984 T1 HR P20201984T1 HR P20201984T T HRP20201984T T HR P20201984TT HR P20201984 T HRP20201984 T HR P20201984T HR P20201984 T1 HRP20201984 T1 HR P20201984T1
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Croatia
Prior art keywords
formula
compound
image
salt
membered
Prior art date
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HRP20201984TT
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English (en)
Croatian (hr)
Inventor
Mark Reynolds
Charles Todd Eary
Stacey Spencer
Derrick JUENGST
Bruno Hache
Yutong Jiang
Julia Haas
Steven W. Andrews
Original Assignee
Loxo Oncology, Inc.
Array Biopharma Inc.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58794189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20201984(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Loxo Oncology, Inc., Array Biopharma Inc. filed Critical Loxo Oncology, Inc.
Publication of HRP20201984T1 publication Critical patent/HRP20201984T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HRP20201984TT 2016-05-18 2017-05-18 Priprema (s)-n-(5-((r)-2-(2,5-difluorofenil)pirolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroksipirolidin-1-karboksamida HRP20201984T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662338359P 2016-05-18 2016-05-18
PCT/US2017/033257 WO2017201241A1 (en) 2016-05-18 2017-05-18 Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide
EP17726442.1A EP3458456B1 (en) 2016-05-18 2017-05-18 Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

Publications (1)

Publication Number Publication Date
HRP20201984T1 true HRP20201984T1 (hr) 2021-04-16

Family

ID=58794189

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20201984TT HRP20201984T1 (hr) 2016-05-18 2017-05-18 Priprema (s)-n-(5-((r)-2-(2,5-difluorofenil)pirolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroksipirolidin-1-karboksamida
HRP20230704TT HRP20230704T1 (hr) 2016-05-18 2017-05-18 Priprava (s)-n-(5-((r)-2-(2,5-difluorfenil)pirolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroksipirolidin-1-karboksamida

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20230704TT HRP20230704T1 (hr) 2016-05-18 2017-05-18 Priprava (s)-n-(5-((r)-2-(2,5-difluorfenil)pirolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroksipirolidin-1-karboksamida

Country Status (27)

Country Link
US (1) US11214571B2 (enExample)
EP (2) EP3458456B1 (enExample)
JP (1) JP7443057B2 (enExample)
KR (1) KR102566858B1 (enExample)
CN (1) CN110049987B (enExample)
AU (1) AU2017268371B2 (enExample)
CA (1) CA3024603A1 (enExample)
CL (1) CL2018003264A1 (enExample)
CO (1) CO2018013015A2 (enExample)
DK (2) DK3800189T3 (enExample)
ES (2) ES2836222T3 (enExample)
FI (1) FI3800189T3 (enExample)
HR (2) HRP20201984T1 (enExample)
HU (2) HUE053643T2 (enExample)
IL (1) IL262964B (enExample)
LT (2) LT3800189T (enExample)
MX (1) MX392604B (enExample)
PE (1) PE20190437A1 (enExample)
PL (2) PL3800189T3 (enExample)
PT (2) PT3800189T (enExample)
RS (2) RS61463B1 (enExample)
RU (1) RU2745953C2 (enExample)
SG (1) SG11201810245WA (enExample)
SI (2) SI3458456T1 (enExample)
UA (1) UA127826C2 (enExample)
WO (1) WO2017201241A1 (enExample)
ZA (1) ZA201808534B (enExample)

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CN112457231A (zh) * 2019-09-09 2021-03-09 上海医药工业研究院 一种拉罗替尼（Larotrectinib）中间体的消旋化方法
CN110804059B (zh) * 2019-09-30 2024-03-12 郑州泰基鸿诺医药股份有限公司 氨基甲酸酯类化合物、药物组合物及其应用
CN111138437B (zh) * 2019-12-04 2021-03-05 杭州华东医药集团新药研究院有限公司 取代的吡唑并[1,5-a]嘧啶氨基酸衍生物及其用途
CN112624950A (zh) * 2020-12-10 2021-04-09 北京蓝博特科技有限公司 一种(r)-2-(2,5-二氟苯基)吡咯烷的合成方法
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CN115872905B (zh) * 2021-09-29 2024-08-09 凯特立斯（深圳）科技有限公司 一种拉罗替尼中间体的制备方法
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