HRP20160241T1 - Postupci i intermedijeri za pripravu jak inhibitora - Google Patents
Postupci i intermedijeri za pripravu jak inhibitora Download PDFInfo
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- HRP20160241T1 HRP20160241T1 HRP20160241TT HRP20160241T HRP20160241T1 HR P20160241 T1 HRP20160241 T1 HR P20160241T1 HR P20160241T T HRP20160241T T HR P20160241TT HR P20160241 T HRP20160241 T HR P20160241T HR P20160241 T1 HRP20160241 T1 HR P20160241T1
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- Prior art keywords
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- 238000000034 method Methods 0.000 title claims 27
- 229940122245 Janus kinase inhibitor Drugs 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 23
- 150000003839 salts Chemical class 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 14
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 9
- 238000006243 chemical reaction Methods 0.000 claims 6
- 238000010511 deprotection reaction Methods 0.000 claims 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 4
- RROBIDXNTUAHFW-UHFFFAOYSA-N benzotriazol-1-yloxy-tris(dimethylamino)phosphanium Chemical group C1=CC=C2N(O[P+](N(C)C)(N(C)C)N(C)C)N=NC2=C1 RROBIDXNTUAHFW-UHFFFAOYSA-N 0.000 claims 4
- 239000003638 chemical reducing agent Substances 0.000 claims 4
- 239000007822 coupling agent Substances 0.000 claims 4
- 239000012458 free base Substances 0.000 claims 4
- 238000004821 distillation Methods 0.000 claims 3
- 238000010438 heat treatment Methods 0.000 claims 3
- 238000010992 reflux Methods 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- KZMGYPLQYOPHEL-UHFFFAOYSA-N Boron trifluoride etherate Chemical compound FB(F)F.CCOCC KZMGYPLQYOPHEL-UHFFFAOYSA-N 0.000 claims 2
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims 2
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 2
- 239000001361 adipic acid Substances 0.000 claims 2
- 235000011037 adipic acid Nutrition 0.000 claims 2
- 239000012141 concentrate Substances 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- -1 sodium triacetoxyborohydride Chemical compound 0.000 claims 2
- 239000012321 sodium triacetoxyborohydride Substances 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 150000001279 adipic acids Chemical class 0.000 claims 1
- 239000000908 ammonium hydroxide Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical group [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (23)
1. Postupak, naznačen time da obuhvaća reakciju spoja Formule III:
[image]
ili njegove soli, sa spojem Formule IV:
[image]
u prisustvu sredstva za redukciju tako da nastane spoj Formule II:
[image]
ili njegove soli, pod uvjetom da sredstvo za redukciju nije natrijev cijanoborodeuterid; pri čemu je P1 zaštitna skupina.
2. Postupak prema patentnom zahtjevu 1, naznačen time da je spomenuta zaštitna skupina –CH2OCH2CH2Si(CH3)3.
3. Postupak prema bilo kojem od patentnih zahtjeva od 1 do 2, naznačen time da je spomenuto sredstvo za redukciju odabrano od natrijevog cijanoborohidrida i natrijevog triacetoksiborohidrida.
4. Postupak prema bilo kojem od patentnih zahtjeva od 1 do 2, naznačen time da je spomenuto redukcijsko sredstvo natrijev triacetoksiborohidrid.
5. Postupak prema bilo kojem od patentnih zahtjeva od 1 do 4, naznačen time da je svaki od spojeva Formula II, III i IV slobodna baza.
6. Postupak prema bilo kojem od patentnih zahtjeva od 1 do 5, naznačen time da nadalje uključuje uklanjanje zaštite spoja Formule II, ili njegove soli, za formiranje spoja Formule I:
[image]
ili njegove soli.
7. Postupak prema patentnom zahtjevu 6, naznačen time da spomenuto uklanjanje zaštite obuhvaća tretman sa bor trifluorid eteratom, iza kojega slijedi tretiranje sa otopinom amonijevog hidroksida.
8. Postupak prema bilo kojem od patentnih zahtjeva od 6 do 8, naznačen time da spomenuti postupak nadalje uključuje reakcije spoja Formule I sa adipinskom kiselinom tako da nastaje adipinska sol.
9. Postupak prema bilo kojem od patentnih zahtjeva od 6 do 8, naznačen time da je svaki od spojeva formule I, II, III i IV slobodna baza.
10. Postupak prema bilo kojem od patentnih zahtjeva od 6 do 7, naznačen time da spomenuti postupak nadalje obuhvaća:
(a) grijanje spoja Formule I u metanolu na refluksu tako da nastane smjesa;
(b) nakon (a), dodavanje metil izobutil ketona smjesi;
(c) nakon (b), uklanjanje dijela otapala destilacijom na unutrašnjoj temperaturi od 40°C do 50°C tako da nastane koncentrirana smjesa;
(d) nakon (c), dodavanje metanola koncentriranoj smjesi da tvori razrijeđenu smjesu;
(e) nakon (d), grijanje razrijeđene smjese na refluksu da tvori smjesu;
(f) nakon (e), dodavanje metil izobutil ketona smjesi;
(g) nakon (f), uklanjanje dijela otapala destilacijom na unutrašnjoj temperaturi od 40°C do 50°C tako da tvori koncentrat smjese;
(h) nakon (g), dodavanje adipinske kiseline i metanola koncentriranoj smjesi;
(i) nakon (h), grijanje smjese na refluksu; i
(j) nakon (i), uklanjanje dijela otapala destilacijom na unutrašnjoj temperaturi od 40°C do 50°C tako da koncentrat smjese;
(k) nakon (j), dodavanje heptana smjesi; i
(l) nakon (k) miješanje smjese na sobnoj temperaturi tako da tvori soli adipinske kiseline spoja Formule I.
11. Postupak prema bilo kojem od patentnih zahtjeva od 6 do 10, naznačen time da su spoj Formule IV ili njegova sol dobiveni postupkom koji obuhvaća uklanjanje zaštite spoja Formule V:
[image]
ili njegove soli.
12. Postupak prema patentnom zahtjevu 11, naznačen time da spomenuto uklanjanje zaštite obuhvaća reakciju sa razrijeđenom kiselinom.
13. Postupak prema patentnom zahtjevu 12, naznačen time da je spomenuta kiselina kloridna kiselina.
14. Postupak prema bilo kojem od patentnih zahtjeva od 11 do 13, naznačen time da je svaki od spojeva Formule I, II, III, IV i V slobodna baza.
15. Postupak prema bilo kojem od patentnih zahtjeva od 11 do 14, naznačen time da je spoj formule V ili njegove soli proizvod postupka koji obuhvaća reakciju spoja Formule VI:
[image]
sa spojem Formule VII:
[image]
u prisustvu sredstva za spajanje.
16. Postupak prema patentnom zahtjevu 15, naznačen time da je sredstvo za spajanje benzotriazol-1-iloksi-tris (dimetilamino)-fosfonijev heksafluorofosfat (BOP).
17. Postupak pripreme spoja Formule IV:
[image]
ili njegove soli, naznačen time da obuhvaća uklanjanje zaštite spoja Formule V:
[image]
ili njegove soli, za formiranje spoja Formule IV, ili njegove spomenute soli.
18. Postupak prema patentnom zahtjevu 17, naznačen time da spomenuto uklanjanje zaštite obuhvaća reakciju sa razrijeđenom kiselinom.
19. Postupak prema patentnom zahtjevu 18, naznačen time da je spomenuta kiselina kloridna kiselina.
20. Postupak prema bilo kojem od patentnih zahtjeva od 17 do 19, naznačen time da je svaki od spojeva Formule IV i V slobodna baza.
21. Postupak priprave spoja Formule V:
[image]
ili njegove soli, naznačen time da uključuje reakciju spoja Formule VI:
[image]
ili njegove soli, sa spojem Formule VII:
[image]
ili njegove soli, u prisustvu sredstva za spajanje tako da tvori spoj Formule V, ili njegove spomenute soli.
22. Postupak prema patentnom zahtjevu 21, naznačen time da je sredstvo spajanja benzotriazol-1-iloksi-tris (dimetilamino)-fosfonijum heksafluorofosfat (BOP).
23. Spoj Formule V:
[image]
ili njegove soli.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161531896P | 2011-09-07 | 2011-09-07 | |
EP12770334.6A EP2753621B1 (en) | 2011-09-07 | 2012-09-06 | Processes and intermediates for making a jak inhibitor |
PCT/US2012/053921 WO2013036611A1 (en) | 2011-09-07 | 2012-09-06 | Processes and intermediates for making a jak inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20160241T1 true HRP20160241T1 (hr) | 2016-04-08 |
Family
ID=47010724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20160241TT HRP20160241T1 (hr) | 2011-09-07 | 2016-03-08 | Postupci i intermedijeri za pripravu jak inhibitora |
Country Status (35)
Country | Link |
---|---|
US (2) | US9487521B2 (hr) |
EP (1) | EP2753621B1 (hr) |
JP (2) | JP5977354B2 (hr) |
KR (1) | KR102002277B1 (hr) |
CN (1) | CN104024256B (hr) |
AR (2) | AR087794A1 (hr) |
AU (1) | AU2012304650B2 (hr) |
BR (1) | BR112014005174B1 (hr) |
CA (1) | CA2847728C (hr) |
CL (1) | CL2014000534A1 (hr) |
CO (1) | CO6910194A2 (hr) |
CR (1) | CR20140120A (hr) |
CY (1) | CY1117276T1 (hr) |
DK (1) | DK2753621T3 (hr) |
EA (1) | EA026122B1 (hr) |
ES (1) | ES2564133T3 (hr) |
HK (1) | HK1199445A1 (hr) |
HR (1) | HRP20160241T1 (hr) |
HU (1) | HUE026497T2 (hr) |
IL (1) | IL231389A (hr) |
IN (1) | IN2014DN02177A (hr) |
ME (1) | ME02458B (hr) |
MX (1) | MX339715B (hr) |
MY (1) | MY169617A (hr) |
PE (1) | PE20142360A1 (hr) |
PL (1) | PL2753621T3 (hr) |
PT (1) | PT2753621E (hr) |
RS (1) | RS54615B1 (hr) |
SG (1) | SG11201400414XA (hr) |
SI (1) | SI2753621T1 (hr) |
SM (1) | SMT201600060B (hr) |
TW (1) | TWI577690B (hr) |
UA (1) | UA111854C2 (hr) |
WO (1) | WO2013036611A1 (hr) |
ZA (1) | ZA201402163B (hr) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT2474545T (lt) | 2005-12-13 | 2017-02-27 | Incyte Holdings Corporation | Heteroarilu pakeisti pirolo[2,3-b]piridinai ir pirolo[2,3-b]pirimidinai kaip janus kinazės inhibitoriai |
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