HRP20120958T1 - Postupci za pripremanje supstituirane gama-aminokiseline - Google Patents
Postupci za pripremanje supstituirane gama-aminokiseline Download PDFInfo
- Publication number
- HRP20120958T1 HRP20120958T1 HRP20120958AT HRP20120958T HRP20120958T1 HR P20120958 T1 HRP20120958 T1 HR P20120958T1 HR P20120958A T HRP20120958A T HR P20120958AT HR P20120958 T HRP20120958 T HR P20120958T HR P20120958 T1 HRP20120958 T1 HR P20120958T1
- Authority
- HR
- Croatia
- Prior art keywords
- reaction
- temperature
- sodium hypochlorite
- alkali metal
- molar equivalents
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 15
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 6
- 239000005708 Sodium hypochlorite Substances 0.000 claims 5
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims 5
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims 4
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 claims 3
- 229960001233 pregabalin Drugs 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- NPDKTSLVWGFPQG-SSDOTTSWSA-N (3r)-3-(2-amino-2-oxoethyl)-5-methylhexanoic acid Chemical compound CC(C)C[C@H](CC(N)=O)CC(O)=O NPDKTSLVWGFPQG-SSDOTTSWSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (13)
1. Postupak za pripremanje pregabalina formule I:
[image]
naznačen time, da navedeni postupak obuhvaća reakciju (R)-(-)-3-(karbamoilmetil)-5-metilheksanojeve kiseline formule II:
[image]
s natrijevim hipokloritom pri temperaturi od 50°C do 70°C.
2. Postupak prema patentnom zahtjevu 1, naznačen time, da temperatura jest 60°C.
3. Postupak prema patentnom zahtjevu 1, naznačen time, da količina natrijevog hipoklorita jest manja od 1,3 molarna ekvivalenta.
4. Postupak prema patentnom zahtjevu 3, naznačen time, da količina natrijevog hipoklorita jest od 0,90 molarnih ekvivalenata do 1,1 molarnih ekvivalenata.
5. Postupak prema patentnom zahtjevu 4, naznačen time, da količina natrijevog hipoklorita jest 0,95 molarnih ekvivalenata.
6. Postupak prema bilo kojem od patentnih zahtjeva 1-5, naznačen time, da se reakcija provodi u otapalu koje sadrži vodu.
7. Postupak prema bilo kojem od patentnih zahtjeva 1-5, naznačen time, da se reakcija provodi u prisutnosti hidroksida alkalijskog metala.
8. Postupak prema patentnom zahtjevu 6, naznačen time, da se reakcija provodi u prisutnosti hidroksida alkalijskog metala.
9. Postupak prema patentnom zahtjevu 7, naznačen time, da hidroksid alkalijskog metala jest natrijev hidroksid.
10. Postupak prema patentnom zahtjevu 8, naznačen time, da hidroksid alkalijskog metala jest natrijev hidroksid.
11. Postupak prema bilo kojem od patentnih zahtjeva 1-5, naznačen time, da nadalje sadrži korak dovođenja u kontakt spoja formule II s natrijevim hipokloritom pri temperaturi od 5°C do 10°C prije reakcije pri temperaturi od 50°C do 70°C.
12. Postupak prema bilo kojem od patentnih zahtjeva 1-5, naznačen time, da nadalje sadrži korak izoliranja pregabalina tretiranjem reakcijske smjese s mineralnom kiselinom uz održavanje temperature na 30°C do 35°C, da bi se dobio pH od 5,0 do 5,5.
13. Postupak prema bilo kojem od patentnih zahtjeva 1-5, naznačen time, da nadalje sadrži korak kristaliziranja dobivenog pregabalina iz smjese izopropanola i vode.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US498207P | 2007-11-30 | 2007-11-30 | |
PCT/IB2008/003232 WO2009068967A1 (en) | 2007-11-30 | 2008-11-25 | Processes for preparing a substituted gamma-amino acid |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20120958T1 true HRP20120958T1 (hr) | 2013-01-31 |
Family
ID=40404504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20120958AT HRP20120958T1 (hr) | 2007-11-30 | 2012-11-23 | Postupci za pripremanje supstituirane gama-aminokiseline |
Country Status (14)
Country | Link |
---|---|
US (1) | US8071808B2 (hr) |
EP (1) | EP2225198B1 (hr) |
CN (1) | CN101910111B (hr) |
AR (1) | AR071259A1 (hr) |
CA (1) | CA2706381C (hr) |
CY (1) | CY1113780T1 (hr) |
DK (1) | DK2225198T3 (hr) |
ES (1) | ES2397416T3 (hr) |
HR (1) | HRP20120958T1 (hr) |
IL (1) | IL205491A (hr) |
PL (1) | PL2225198T3 (hr) |
PT (1) | PT2225198E (hr) |
SI (1) | SI2225198T1 (hr) |
WO (1) | WO2009068967A1 (hr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140243412A1 (en) * | 2013-02-28 | 2014-08-28 | Dr. Reddy's Laboratories Ltd. | Process for preparation of pregabalin |
CN103922950B (zh) * | 2014-04-08 | 2016-06-01 | 浙江美诺华药物化学有限公司 | 一种普瑞巴林的制备方法 |
CN104710320A (zh) * | 2015-03-30 | 2015-06-17 | 浙江华海药业股份有限公司 | 一种制备普瑞巴林的方法 |
CN109678737B (zh) * | 2019-02-18 | 2021-12-24 | 常州制药厂有限公司 | 一种普瑞巴林的制备方法 |
CN113801031B (zh) | 2021-10-26 | 2023-12-26 | 浙江华海药业股份有限公司 | 一种普瑞巴林的纯化方法 |
CN117417272B (zh) * | 2023-10-19 | 2024-08-13 | 上海海皋科技有限公司 | 一种Boc-D-异亮氨酸的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5616793A (en) | 1995-06-02 | 1997-04-01 | Warner-Lambert Company | Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
CA2604600A1 (en) | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Pregabalin free of isobutylglutaric acid and a process for preparation thereof |
-
2008
- 2008-11-25 CN CN2008801232668A patent/CN101910111B/zh not_active Expired - Fee Related
- 2008-11-25 WO PCT/IB2008/003232 patent/WO2009068967A1/en active Application Filing
- 2008-11-25 EP EP08855671A patent/EP2225198B1/en active Active
- 2008-11-25 PL PL08855671T patent/PL2225198T3/pl unknown
- 2008-11-25 ES ES08855671T patent/ES2397416T3/es active Active
- 2008-11-25 SI SI200830827T patent/SI2225198T1/sl unknown
- 2008-11-25 DK DK08855671.7T patent/DK2225198T3/da active
- 2008-11-25 US US12/745,413 patent/US8071808B2/en active Active
- 2008-11-25 CA CA2706381A patent/CA2706381C/en active Active
- 2008-11-25 PT PT88556717T patent/PT2225198E/pt unknown
- 2008-11-25 AR ARP080105101A patent/AR071259A1/es unknown
-
2010
- 2010-05-02 IL IL205491A patent/IL205491A/en not_active IP Right Cessation
-
2012
- 2012-11-23 HR HRP20120958AT patent/HRP20120958T1/hr unknown
-
2013
- 2013-01-30 CY CY20131100087T patent/CY1113780T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP2225198B1 (en) | 2012-11-07 |
US8071808B2 (en) | 2011-12-06 |
WO2009068967A1 (en) | 2009-06-04 |
SI2225198T1 (sl) | 2013-02-28 |
EP2225198A1 (en) | 2010-09-08 |
CA2706381A1 (en) | 2009-06-04 |
AR071259A1 (es) | 2010-06-09 |
PL2225198T3 (pl) | 2013-04-30 |
CN101910111B (zh) | 2013-06-12 |
CA2706381C (en) | 2016-11-01 |
CY1113780T1 (el) | 2016-07-27 |
ES2397416T3 (es) | 2013-03-06 |
IL205491A0 (en) | 2010-12-30 |
IL205491A (en) | 2014-01-30 |
PT2225198E (pt) | 2013-01-25 |
CN101910111A (zh) | 2010-12-08 |
DK2225198T3 (da) | 2013-02-11 |
US20100305359A1 (en) | 2010-12-02 |
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