HK6392A - Podophyllotoxin derivatives - Google Patents

Podophyllotoxin derivatives Download PDF

Info

Publication number
HK6392A
HK6392A HK63/92A HK6392A HK6392A HK 6392 A HK6392 A HK 6392A HK 63/92 A HK63/92 A HK 63/92A HK 6392 A HK6392 A HK 6392A HK 6392 A HK6392 A HK 6392A
Authority
HK
Hong Kong
Prior art keywords
substd
alkyl
opt
aralkyl
cycloalkyl
Prior art date
Application number
HK63/92A
Other languages
English (en)
Inventor
G Saulnier Mark
D Senter Peter
F Kadow John
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HK6392A publication Critical patent/HK6392A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
HK63/92A 1987-08-04 1992-01-16 Podophyllotoxin derivatives HK6392A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (1)

Publication Number Publication Date
HK6392A true HK6392A (en) 1992-01-17

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
HK63/92A HK6392A (en) 1987-08-04 1992-01-16 Podophyllotoxin derivatives

Country Status (34)

Country Link
US (3) US4904768A (cg-RX-API-DMAC10.html)
JP (1) JPH0699465B2 (cg-RX-API-DMAC10.html)
KR (1) KR900006230B1 (cg-RX-API-DMAC10.html)
CN (1) CN1027169C (cg-RX-API-DMAC10.html)
AT (1) AT398974B (cg-RX-API-DMAC10.html)
BE (1) BE1002982A4 (cg-RX-API-DMAC10.html)
CA (1) CA1310637C (cg-RX-API-DMAC10.html)
CH (1) CH676716A5 (cg-RX-API-DMAC10.html)
CY (1) CY1625A (cg-RX-API-DMAC10.html)
CZ (1) CZ286893B6 (cg-RX-API-DMAC10.html)
DD (2) DD299067A5 (cg-RX-API-DMAC10.html)
DE (1) DE3826562A1 (cg-RX-API-DMAC10.html)
DK (2) DK169344B1 (cg-RX-API-DMAC10.html)
ES (1) ES2010775A6 (cg-RX-API-DMAC10.html)
FI (1) FI87790C (cg-RX-API-DMAC10.html)
FR (1) FR2622193B1 (cg-RX-API-DMAC10.html)
GB (1) GB2207674B (cg-RX-API-DMAC10.html)
GR (1) GR1000490B (cg-RX-API-DMAC10.html)
HK (1) HK6392A (cg-RX-API-DMAC10.html)
HU (3) HU202547B (cg-RX-API-DMAC10.html)
IE (1) IE61040B1 (cg-RX-API-DMAC10.html)
IL (1) IL87290A (cg-RX-API-DMAC10.html)
IT (1) IT1226825B (cg-RX-API-DMAC10.html)
LU (2) LU87290A1 (cg-RX-API-DMAC10.html)
MX (1) MX173843B (cg-RX-API-DMAC10.html)
MY (1) MY104321A (cg-RX-API-DMAC10.html)
NL (2) NL192683C (cg-RX-API-DMAC10.html)
NO (4) NO170284C (cg-RX-API-DMAC10.html)
NZ (1) NZ225615A (cg-RX-API-DMAC10.html)
PT (1) PT88186B (cg-RX-API-DMAC10.html)
SE (1) SE502214C2 (cg-RX-API-DMAC10.html)
SG (1) SG101291G (cg-RX-API-DMAC10.html)
SK (1) SK279325B6 (cg-RX-API-DMAC10.html)
YU (3) YU143688A (cg-RX-API-DMAC10.html)

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US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (cg-RX-API-DMAC10.html) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
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US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
JP2005511550A (ja) * 2001-10-26 2005-04-28 サントル・ナショナル・ドゥ・ラ・ルシェルシュ・シャンティフィク エトポシドおよび類似体の誘導体、ならびにそれを含有する医薬組成物
DE60335383D1 (de) 2002-07-15 2011-01-27 Univ Texas Antikörper mit bindung an anionische phospholipide und aminophospholipide und ihre verwendung bei der behandlung von virusinfektionen
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FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
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CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH481097A (de) * 1966-12-13 1969-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
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FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
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Also Published As

Publication number Publication date
HUT47303A (en) 1989-02-28
FI883596A0 (fi) 1988-08-01
DK434088D0 (da) 1988-08-03
NL8801934A (nl) 1989-03-01
HU202547B (en) 1991-03-28
CZ541288A3 (cs) 1999-12-15
FR2622193A1 (fr) 1989-04-28
NO920277D0 (no) 1992-01-22
GB2207674B (en) 1991-09-11
NO920665D0 (no) 1992-02-20
IL87290A (en) 1993-01-31
NO883299D0 (no) 1988-07-26
AU2030688A (en) 1989-06-08
NO1998002I1 (no) 1998-01-14
NO883299L (no) 1989-02-24
SK541288A3 (en) 1998-10-07
FR2622193B1 (fr) 1993-12-17
DK11992D0 (da) 1992-01-31
BE1002982A4 (fr) 1991-10-15
FI883596A7 (fi) 1989-02-05
FI87790C (fi) 1993-02-25
CA1310637C (en) 1992-11-24
YU10390A (en) 1990-06-30
IT8821535A0 (it) 1988-07-28
YU10490A (en) 1990-06-30
DD299067A5 (de) 1992-03-26
DK11992A (da) 1992-01-31
HU208147B (en) 1993-08-30
SG101291G (en) 1992-01-17
IE882378L (en) 1989-02-04
NO170284B (no) 1992-06-22
HU905862D0 (en) 1991-03-28
KR890003790A (ko) 1989-04-18
GR880100512A (en) 1989-05-25
AT398974B (de) 1995-02-27
NO172440C (no) 1993-07-21
DD274423A5 (de) 1989-12-20
PT88186A (pt) 1989-06-30
NL970042I1 (nl) 1998-03-02
CY1625A (en) 1992-07-10
GR1000490B (el) 1992-07-30
NO920665L (no) 1989-02-24
SE8802815D0 (sv) 1988-08-03
YU143688A (en) 1990-04-30
CH676716A5 (cg-RX-API-DMAC10.html) 1991-02-28
SK279325B6 (sk) 1998-10-07
IT1226825B (it) 1991-02-19
SE502214C2 (sv) 1995-09-18
CN1027169C (zh) 1994-12-28
DK169344B1 (da) 1994-10-10
MX9202851A (es) 1992-06-30
PT88186B (pt) 1995-07-03
FI87790B (fi) 1992-11-13
CN1061225A (zh) 1992-05-20
USRE35524E (en) 1997-06-03
ES2010775A6 (es) 1989-12-01
DE3826562A1 (de) 1989-02-16
SE8802815L (sv) 1989-02-05
NL970042I2 (cg-RX-API-DMAC10.html) 2005-06-01
KR900006230B1 (ko) 1990-08-27
ATA195588A (de) 1994-07-15
US4904768A (en) 1990-02-27
CZ286893B6 (cs) 2000-07-12
NL192683B (cg-RX-API-DMAC10.html) 1997-08-01
IE61040B1 (en) 1994-09-07
HU211960A9 (en) 1996-01-29
NZ225615A (en) 1991-06-25
JPH01100188A (ja) 1989-04-18
NO172440B (no) 1993-04-13
NO170284C (no) 1992-09-30
MY104321A (en) 1994-03-31
DK434088A (da) 1989-02-05
DE3826562C2 (cg-RX-API-DMAC10.html) 1993-04-08
JPH0699465B2 (ja) 1994-12-07
GB2207674A (en) 1989-02-08
AU610619B2 (en) 1991-05-23
GB8818462D0 (en) 1988-09-07
NO920277L (no) 1989-02-24
LU87290A1 (fr) 1990-02-07
US5041424A (en) 1991-08-20
LU90138I2 (fr) 1997-11-26
MX173843B (es) 1994-03-30
NL192683C (nl) 1997-12-02
IL87290A0 (en) 1989-01-31

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