HK1036800A1 - Pyrrolo(2,3-d)pyrimidine compounds, its composition and use thereof - Google Patents

Pyrrolo(2,3-d)pyrimidine compounds, its composition and use thereof

Info

Publication number
HK1036800A1
HK1036800A1 HK01107740A HK01107740A HK1036800A1 HK 1036800 A1 HK1036800 A1 HK 1036800A1 HK 01107740 A HK01107740 A HK 01107740A HK 01107740 A HK01107740 A HK 01107740A HK 1036800 A1 HK1036800 A1 HK 1036800A1
Authority
HK
Hong Kong
Prior art keywords
pyrrolo
composition
pyrimidine compounds
pyrimidine
compounds
Prior art date
Application number
HK01107740A
Other languages
English (en)
Inventor
Todd Andrew Blumenkopf
Mark Edward Flanagan
Matthew Frank Brown
Paul Steven Changelian
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of HK1036800A1 publication Critical patent/HK1036800A1/xx

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK01107740A 1998-06-19 2001-11-06 Pyrrolo(2,3-d)pyrimidine compounds, its composition and use thereof HK1036800A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8988698P 1998-06-19 1998-06-19
PCT/IB1999/001110 WO1999065909A1 (en) 1998-06-19 1999-06-14 PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS

Publications (1)

Publication Number Publication Date
HK1036800A1 true HK1036800A1 (en) 2002-01-18

Family

ID=22220084

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01107740A HK1036800A1 (en) 1998-06-19 2001-11-06 Pyrrolo(2,3-d)pyrimidine compounds, its composition and use thereof

Country Status (47)

Country Link
US (2) US6635762B1 (ru)
EP (1) EP1087971B1 (ru)
JP (1) JP3497823B2 (ru)
KR (1) KR100452054B1 (ru)
CN (1) CN1125070C (ru)
AP (1) AP1157A (ru)
AR (1) AR016498A1 (ru)
AT (1) ATE270673T1 (ru)
AU (1) AU758427B2 (ru)
BG (1) BG65063B1 (ru)
BR (1) BR9912171A (ru)
CA (1) CA2335186C (ru)
CO (1) CO5320601A1 (ru)
CZ (1) CZ20004726A3 (ru)
DE (1) DE69918552T2 (ru)
DK (1) DK1087971T3 (ru)
EA (2) EA006034B1 (ru)
EG (1) EG23758A (ru)
ES (1) ES2223172T3 (ru)
GE (1) GEP20084336B (ru)
GT (1) GT199900091A (ru)
HK (1) HK1036800A1 (ru)
HN (1) HN1999000083A (ru)
HR (1) HRP20000886B1 (ru)
HU (1) HUP0103472A3 (ru)
ID (1) ID27595A (ru)
IL (2) IL139598A0 (ru)
IS (2) IS2395B (ru)
MA (1) MA26653A1 (ru)
MY (1) MY125802A (ru)
NO (2) NO318786B1 (ru)
NZ (1) NZ508034A (ru)
OA (1) OA11571A (ru)
PA (1) PA8474101A1 (ru)
PE (1) PE20000639A1 (ru)
PL (1) PL198639B1 (ru)
PT (1) PT1087971E (ru)
SA (1) SA99200285B1 (ru)
SI (1) SI1087971T1 (ru)
SK (1) SK286685B6 (ru)
TN (1) TNSN99125A1 (ru)
TR (1) TR200003720T2 (ru)
TW (1) TW542834B (ru)
UA (1) UA63013C2 (ru)
WO (1) WO1999065909A1 (ru)
YU (1) YU79700A (ru)
ZA (1) ZA994003B (ru)

Families Citing this family (167)

* Cited by examiner, โ€  Cited by third party
Publication number Priority date Publication date Assignee Title
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
EP1065207A1 (en) * 1999-07-02 2001-01-03 Aventis Pharma Deutschland GmbH Naphthyridine derivatives, processes for their preparation, their use, and pharmaceutical compositions comprising them
MXPA02003436A (es) * 1999-10-07 2002-08-20 Amgen Inc Inhibidores de triazina cinasa.
DE19948417A1 (de) * 1999-10-07 2001-04-19 Morphochem Ag Imidazol-Derivate und ihre Verwendung als Arzneimittel
CN1195755C (zh) 1999-12-10 2005-04-06 ่พ‰็‘žไบงๅ“ๅ…ฌๅธ ๅกๅ’ฏๅนถ[2,3๏ผd]ๅ˜งๅ•ถๅŒ–ๅˆ็‰ฉ
EP1250137B1 (en) * 2000-01-24 2007-08-15 Genzyme Corporation Jak/stat pathway inhibitors and the use thereof for the treatment of primary generalized osteoarthritis
EP1875900A3 (en) * 2000-01-24 2010-07-21 Genzyme Corporation JAK/STAT pathway inhibitors and the use thereof for the treatment of osteoarthritis
MY137020A (en) * 2000-04-27 2008-12-31 Abbott Lab Diazabicyclic central nervous system active agents
MXPA03000068A (es) * 2000-06-26 2003-09-25 Pfizer Prod Inc Compuestos de pirrolo (2,3-d)pirimidina como agentes inmunosupresores.
US6881737B2 (en) 2001-04-11 2005-04-19 Amgen Inc. Substituted triazinyl acrylamide derivatives and methods of use
US6864255B2 (en) 2001-04-11 2005-03-08 Amgen Inc. Substituted triazinyl amide derivatives and methods of use
US7301023B2 (en) 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
KR100875380B1 (ko) * 2001-06-23 2008-12-23 ์•„๋ฒคํ‹ฐ์Šค ํŒŒ๋งˆ์Šˆํ‹ฐ์นผ์Šค ์ธํฌ. ๋‹จ๋ฐฑ์งˆ ํ‚ค๋‚˜์ œ ์–ต์ œ์ œ๋กœ์„œ์˜ ํ”ผ๋กค๋กœํ”ผ๋ฆฌ๋ฏธ๋”˜
GB0115393D0 (en) * 2001-06-23 2001-08-15 Aventis Pharma Ltd Chemical compounds
US7323469B2 (en) 2001-08-07 2008-01-29 Novartis Ag 7H-pyrrolo[2,3-d]pyrimidine derivatives
GB0119249D0 (en) 2001-08-07 2001-10-03 Novartis Ag Organic compounds
GT200200234A (es) 2001-12-06 2003-06-27 Compuestos cristalinos novedosos
US6642381B2 (en) 2001-12-27 2003-11-04 Hoffman-La Roche Inc. Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
DE60305446T4 (de) 2002-01-07 2009-07-09 Eisai R&D Management Co., Ltd. Desazapurine und deren verwendung
GB0202679D0 (en) * 2002-02-05 2002-03-20 Glaxo Group Ltd Novel compounds
EP1388541A1 (en) * 2002-08-09 2004-02-11 Centre National De La Recherche Scientifique (Cnrs) Pyrrolopyrazines as kinase inhibitors
PL378246A1 (pl) 2002-11-26 2006-03-20 Pfizer Products Inc. Sposรณb leczenia odrzucania przeszczepu
WO2004093812A2 (en) * 2003-04-22 2004-11-04 Irm Llc Compounds that induce neuronal differentiation in embryonic stem cells
US7169918B2 (en) * 2003-10-27 2007-01-30 Genelabs Technologies, Inc. Methods for preparing 7-(2โ€ฒ-substituted-ฮฒ-D-ribofuranosyl)-4-(NR2R3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives
WO2005067546A2 (en) * 2004-01-13 2005-07-28 Ambit Biosciences Corporation Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
GB0403606D0 (en) 2004-02-18 2004-03-24 Novartis Ag Organic compounds
EP1750727A2 (en) * 2004-04-23 2007-02-14 Exelixis, Inc. Kinase modulators and methods of use
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
AU2005260032A1 (en) 2004-06-29 2006-01-12 Amgen Inc. Pyrrolo[2,3-d]pyrimidines that modulate ACK1 and LCK activity
TW200615268A (en) 2004-08-02 2006-05-16 Osi Pharm Inc Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds
UY29177A1 (es) 2004-10-25 2006-05-31 Astex Therapeutics Ltd Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen mรฉtodos para su preparaciรณn y sus usos
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
AR054416A1 (es) 2004-12-22 2007-06-27 Incyte Corp Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas.
FR2880626B1 (fr) * 2005-01-13 2008-04-18 Aventis Pharma Sa Derives de la purine, compositions les contenant et utilisation
WO2006091450A1 (en) * 2005-02-18 2006-08-31 Lexicon Genetics Incorporated 4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds
MX2007014066A (es) 2005-05-13 2008-02-11 Irm Llc Compuestos y composiciones como inhibidores de cinasa de proteina.
JP5071374B2 (ja) 2005-07-14 2012-11-14 ใ‚ขใ‚นใƒ†ใƒฉใ‚น่ฃฝ่–ฌๆ ชๅผไผš็คพ ใƒ˜ใƒ†ใƒญ็’ฐใƒคใƒŒใ‚นใ‚ญใƒŠใƒผใ‚ผ๏ผ“้˜ปๅฎณๅ‰ค
EP2251341A1 (en) 2005-07-14 2010-11-17 Astellas Pharma Inc. Heterocyclic Janus kinase 3 inhibitors
CA2621261C (en) 2005-09-22 2014-05-20 Incyte Corporation Azepine inhibitors of janus kinases
EP2532667A1 (en) * 2005-09-30 2012-12-12 Vertex Pharmaceuticals Incorporated Deazapurines useful as inhibitors of janus kinases
PT3184526T (pt) 2005-12-13 2018-12-19 Incyte Holdings Corp Derivados de pirrolo[2,3-d]pirimidina como inibidores da cinase janus
AU2015201850B2 (en) * 2005-12-13 2017-03-02 Incyte Holdings Corporation Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
EP2007767B1 (en) * 2006-03-11 2011-11-02 Vernalis (R&D) Ltd Pyrrolopyrimidine derivatives used as hsp90 inhibitors
AU2007235487A1 (en) * 2006-04-05 2007-10-18 Vertex Pharmaceuticals Incorporated Deazapurines useful as inhibitors of janus kinases
GB0608176D0 (en) * 2006-04-25 2006-06-07 Astex Therapeutics Ltd Pharmaceutical Compounds
DK3421471T3 (da) * 2006-04-25 2021-06-14 Astex Therapeutics Ltd Purin- og deazapurinderivater som farmaceutiske forbindelser
WO2008012635A2 (en) * 2006-07-26 2008-01-31 Pfizer Products Inc. Amine derivatives useful as anticancer agents
EP2061772A4 (en) * 2006-09-11 2011-06-29 Curis Inc MULTIFUNCTIONAL SMALL MOLECULES AS PROLIFERATION-ACTIVE ACTIVE SUBSTANCES
WO2008033745A2 (en) * 2006-09-11 2008-03-20 Curis, Inc. Fused bicyclic pyrimidines as ptk inhibitors containing a zinc binding moiety
WO2008075007A1 (en) * 2006-12-21 2008-06-26 Cancer Research Technology Limited Morpholino-substituted bicycloheteroaryl compounds and their use as anti cancer agents
AR064416A1 (es) * 2006-12-21 2009-04-01 Cancer Rec Tech Ltd Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas.
EP2121692B1 (en) 2006-12-22 2013-04-10 Incyte Corporation Substituted heterocycles as janus kinase inhibitors
WO2008084861A1 (ja) 2007-01-12 2008-07-17 Astellas Pharma Inc. ็ธฎๅˆใƒ”ใƒชใ‚ธใƒณๅŒ–ๅˆ็‰ฉ
EP2142550A1 (en) * 2007-04-02 2010-01-13 Palau Pharma, S.A. Pyrrolopyrimidine derivatives as jak3 inhibitors
UA99284C2 (ru) 2007-05-11 2012-08-10 ะ•ะปั– ะ›ั–ะปะปั– ะ•ะฝะด ะšะพะผะฟะฐะฝั– ะ˜ะะ“ะ˜ะ‘ะ˜ะขะžะ ะซ ั€70 S6-ะšะ˜ะะะ—ะซ
US20080312259A1 (en) 2007-06-13 2008-12-18 Incyte Corporation SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
GB0713602D0 (en) * 2007-07-12 2007-08-22 Syngenta Participations Ag Chemical compounds
EP2185562B1 (en) * 2007-07-27 2015-12-02 Janssen Pharmaceutica, N.V. Pyrrolopyrimidines useful for the treatment of proliferative diseases
ES2557931T3 (es) 2007-08-08 2016-01-29 Lexicon Pharmaceuticals, Inc. (7H-Pirrolo[2,3-d]pirimidin-4-il)-piperazinas como inhibidores de cinasas para el tratamiento de cรกncer e inflamaciรณn
WO2009030871A1 (en) * 2007-09-07 2009-03-12 Vernalis R & D Ltd Pyrrolopyrimidine derivatives having hsp90 inhibitory activity
AU2008309383B2 (en) 2007-10-11 2012-04-19 Astrazeneca Ab Pyrrolo [2, 3 -D] pyrimidin derivatives as protein kinase B inhibitors
EA020777B1 (ru) 2007-11-16 2015-01-30 ะ˜ะฝัะฐะนั‚ ะšะพั€ะฟะพั€ะตะนัˆะฝ 4-ะฟะธั€ะฐะทะพะปะธะป-n-ะฐั€ะธะปะฟะธั€ะธะผะธะดะธะฝ-2-ะฐะผะธะฝั‹, 4-ะฟะธั€ะฐะทะพะปะธะป-n-ะฟะธั€ะฐะทะพะปะธะปะฟะธั€ะธะผะธะดะธะฝ-2-ะฐะผะธะฝั‹ ะธ 4-ะฟะธั€ะฐะทะพะปะธะป-n-ะฟะธั€ะธะดะธะปะฟะธั€ะธะผะธะดะธะฝ-2-ะฐะผะธะฝั‹ ะฒ ะบะฐั‡ะตัั‚ะฒะต ะธะฝะณะธะฑะธั‚ะพั€ะพะฒ ะบะธะฝะฐะท janus
TWI444382B (zh) 2008-03-11 2014-07-11 Incyte Corp ไฝœ็‚บ๏ฝŠ๏ฝ๏ฝ‹ๆŠ‘ๅˆถๅŠ‘ไน‹ๆฐฎ้›œ็’ฐไธ็ƒทๅŠ็’ฐไธ็ƒท่ก็”Ÿ็‰ฉ
AU2009239500B2 (en) 2008-04-21 2014-01-30 Lexicon Pharmaceuticals, Inc. LIMK2 inhibitors, compositions comprising them, and methods of their use
JP2011518836A (ja) 2008-04-24 2011-06-30 ใ‚คใƒณใ‚ตใ‚คใƒˆใƒปใ‚ณใƒผใƒใƒฌใ‚คใ‚ทใƒงใƒณ ๅคง็’ฐ็ŠถๅŒ–ๅˆ็‰ฉใŠใ‚ˆใณใใ‚Œใ‚‰ใฎใ‚ญใƒŠใƒผใ‚ผ้˜ปๅฎณๅ‰คใจใ—ใฆใฎไฝฟ็”จ
PT2384326E (pt) 2008-08-20 2014-06-09 Zoetis Llc Compostos de pirrolo[2,3-d]pirimidina
US8385364B2 (en) * 2008-09-24 2013-02-26 Nec Laboratories America, Inc. Distributed message-passing based resource allocation in wireless systems
CL2009001884A1 (es) * 2008-10-02 2010-05-14 Incyte Holdings Corp Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composiciรณn que lo comprende para el tratamiento del ojo seco.
JOP20190231A1 (ar) 2009-01-15 2017-06-16 Incyte Corp ุทุฑู‚ ู„ุงุตู„ุงุญ ู…ุซุจุทุงุช ุงู†ุฒูŠู… jak ูˆ ุงู„ู…ุฑูƒุจุงุช ุงู„ูˆุณูŠุทุฉ ุงู„ู…ุชุนู„ู‚ุฉ ุจู‡
DE102009005193A1 (de) * 2009-01-20 2010-07-22 Merck Patent Gmbh Neue heterocyclische Verbindungen als MetAP-2 Inhibitoren
WO2010085597A1 (en) 2009-01-23 2010-07-29 Incyte Corporation Macrocyclic compounds and their use as kinase inhibitors
EP2396004A4 (en) 2009-02-11 2012-07-25 Reaction Biology Corp SELECTIVE KINASE HEMMER
AU2010239396B2 (en) 2009-04-20 2016-06-23 Auspex Pharmaceuticals, Llc Piperidine inhibitors of Janus Kinase 3
ES2487542T3 (es) * 2009-05-22 2014-08-21 Incyte Corporation Derivados de N-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de cinasas Janus
CN106967070A (zh) 2009-05-22 2017-07-21 ๅ› ๅกž็‰นๆŽง่‚กๅ…ฌๅธ ไฝœไธบjakๆŠ‘ๅˆถๅ‰‚็š„ๅŒ–ๅˆ็‰ฉ
CA2767079A1 (en) * 2009-07-08 2011-01-13 Leo Pharma A/S Heterocyclic compounds as jak receptor and protein tyrosine kinase inhibitors
TWI466885B (zh) * 2009-07-31 2015-01-01 Japan Tobacco Inc ๅซๆฐฎ่žบ็’ฐๅŒ–ๅˆ็‰ฉๅŠๅ…ถ้†ซ่—ฅ็”จ้€”
TW201111385A (en) * 2009-08-27 2011-04-01 Biocryst Pharm Inc Heterocyclic compounds as janus kinase inhibitors
AR078012A1 (es) 2009-09-01 2011-10-05 Incyte Corp Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus
AU2010289321A1 (en) 2009-09-04 2012-04-05 The Regents Of The University Of Michigan Compositions and methods for treatment of leukemia
JP5699149B2 (ja) 2009-09-04 2015-04-08 ใƒใ‚คใ‚ชใ‚ธใ‚งใƒณใƒปใ‚ขใ‚คใƒ‡ใƒƒใ‚ฏใƒปใ‚จใƒ ใ‚จใ‚คใƒปใ‚คใƒณใ‚ณใƒผใƒใƒฌใ‚คใƒ†ใƒƒใƒ‰ ๏ผข๏ฝ’๏ฝ•๏ฝ”๏ฝ๏ฝŽๅž‹ใƒใƒญใ‚ทใƒณใ‚ญใƒŠใƒผใ‚ผ้˜ปๅฎณ่–ฌ
BR112012008267B1 (pt) 2009-10-09 2022-10-04 Incyte Holdings Corporation Derivados hidroxila, ceto e glucuronida de 3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1- il)-3-ciclopentilpropanonitrila
KR20120083452A (ko) * 2009-10-15 2012-07-25 ํ™”์ด์ž ์ธ์ฝ”ํฌ๋ ˆ์ดํ‹ฐ๋“œ ํ”ผ๋กค๋กœ๏ผป2,3-๏ฝ„๏ผฝํ”ผ๋ฆฌ๋ฏธ๋”˜ ํ™”ํ•ฉ๋ฌผ
US9074143B2 (en) * 2009-12-11 2015-07-07 Uop Llc Process for producing hydrocarbon fuel
WO2011075334A1 (en) 2009-12-18 2011-06-23 Pfizer Inc. Pyrrolo[2,3-d]pyrimidine compounds
EP2531508A1 (en) 2010-02-05 2012-12-12 Pfizer Inc. Pyrrolo [ 2, 3 - d]pyrimidine urea compounds as jak inhibitors
CA2790070C (en) * 2010-02-18 2018-03-06 Incyte Corporation Cyclobutane and methylcyclobutane derivatives as janus kinase inhibitors
TWI766281B (zh) 2010-03-10 2022-06-01 ็พŽๅ•†่‹ฑๅกž็‰นๆŽง่‚กๅ…ฌๅธ ไฝœ็‚บjak1ๆŠ‘ๅˆถๅŠ‘ไน‹ๅ“Œๅ•ถ-4-ๅŸบไธ‰ไบž็”ฒไบž่ƒบ่ก็”Ÿ็‰ฉ
PE20130216A1 (es) 2010-05-21 2013-02-27 Incyte Corp Formulacion topica para un inhibidor de jak
TW201204732A (en) * 2010-07-09 2012-02-01 Leo Pharma As Novel homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof
WO2012022045A1 (en) * 2010-08-20 2012-02-23 Hutchison Medipharma Limited Pyrrolopyrimidine compounds and uses thereof
CN102372717B (zh) * 2010-08-20 2014-06-18 ๅ’Œ่ฎฐ้ป„ๅŸ”ๅŒป่ฏ๏ผˆไธŠๆตท๏ผ‰ๆœ‰้™ๅ…ฌๅธ ๅกๅ’ฏๅนถๅ˜งๅ•ถ็ฑปๅŒ–ๅˆ็‰ฉๅŠๅ…ถ็”จ้€”
SG187742A1 (en) 2010-08-20 2013-03-28 Hutchison Medipharma Ltd Pyrrolopyrimidine compounds and uses thereof
TWI401258B (zh) * 2010-09-08 2013-07-11 Hutchison Medipharma Ltd ๅกๅ’ฏไธฆๅ˜งๅ•ถ้กžๅŒ–ๅˆ็‰ฉๅŠๅ…ถ็”จ้€”
JP5917544B2 (ja) 2010-11-19 2016-05-18 ใ‚คใƒณใ‚ตใ‚คใƒˆใƒปใƒ›ใƒผใƒซใƒ‡ใ‚ฃใƒณใ‚ฐใ‚นใƒปใ‚ณใƒผใƒใƒฌใ‚คใ‚ทใƒงใƒณ๏ผฉ๏ฝŽ๏ฝƒ๏ฝ™๏ฝ”๏ฝ… ๏ผจ๏ฝ๏ฝŒ๏ฝ„๏ฝ‰๏ฝŽ๏ฝ‡๏ฝ“ ๏ผฃ๏ฝ๏ฝ’๏ฝ๏ฝ๏ฝ’๏ฝ๏ฝ”๏ฝ‰๏ฝ๏ฝŽ ๏ผช๏ฝ๏ฝ‹้˜ปๅฎณๅ‰คใจใ—ใฆใฎ่ค‡็ด ็’ฐ็ฝฎๆ›ใƒ”ใƒญใƒญใƒ”ใƒชใ‚ธใƒณใŠใ‚ˆใณใƒ”ใƒญใƒญใƒ”ใƒชใƒŸใ‚ธใƒณ
AR083933A1 (es) 2010-11-19 2013-04-10 Incyte Corp Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak
US9045485B2 (en) 2010-12-16 2015-06-02 Convergence Pharmaceuticals Limited ASK 1 inhibiting pyrrolopyrimidine derivatives
WO2012088682A1 (en) * 2010-12-29 2012-07-05 Shanghai Fochon Pharmaceutical Co Ltd. 2-(3-aminopiperidin-1-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7(3h,6h)-dione derivates as dipeptidyl peptidase iv(dpp-iv) inhibitors
EP2661436B1 (en) 2011-01-07 2016-04-13 Leo Pharma A/S Novel sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof
DE102011008352A1 (de) * 2011-01-12 2012-07-12 Merck Patent Gmbh 5-([1,2,3]Triazol-4-yl)-7H-pyrrolo-[2,3-d]pyrimidinderivate
JP5813785B2 (ja) 2011-02-04 2015-11-17 ใƒ‡ใƒฅใ‚ฑใ‚คใƒณ ใƒฆใƒ‹ใƒใƒผใ‚ทใƒ†ใ‚ฃใƒผ ใ‚ชใƒ– ใ‚ถ ใƒ›ใƒชใƒผ ใ‚นใƒ”ใƒชใƒƒใƒˆ ๆŠ—ใƒใƒฅใƒผใƒ–ใƒชใƒณๆดปๆ€งใ‚’ๆœ‰ใ™ใ‚‹ไบŒ็’ฐๅผใŠใ‚ˆใณไธ‰็’ฐๅผใฎใƒ”ใƒชใƒŸใ‚ธใƒณใƒใƒญใ‚ทใƒณใ‚ญใƒŠใƒผใ‚ผ้˜ปๅฎณๅ‰คใชใ‚‰ใณใซๆ‚ฃ่€…ใฎๅ‡ฆ็ฝฎๆ–นๆณ•
US9993480B2 (en) 2011-02-18 2018-06-12 Novartis Pharma Ag mTOR/JAK inhibitor combination therapy
US9115133B2 (en) 2011-03-22 2015-08-25 Advinus Therapeutics Limited Substituted fused tricyclic compounds, compositions and medicinal applications thereof
SG193505A1 (en) 2011-04-01 2013-10-30 Astrazeneca Ab Therapeutic treatment
EA201490042A1 (ru) 2011-06-20 2014-10-30 ะ˜ะฝัะฐะนั‚ ะšะพั€ะฟะพั€ะตะนัˆะฝ ะะทะตั‚ะธะดะธะฝะธะป-ั„ะตะฝะธะป-, ะฟะธั€ะธะดะธะป- ะธะปะธ ะฟะธั€ะฐะทะธะฝะธะปะบะฐั€ะฑะพะบัะฐะผะธะดะฝั‹ะต ะฟั€ะพะธะทะฒะพะดะฝั‹ะต ะบะฐะบ ะธะฝะณะธะฑะธั‚ะพั€ั‹ jak
KR20140034861A (ko) * 2011-06-29 2014-03-20 ๋จธํฌ ์ƒคํ”„ ์•ค๋“œ ๋” ์ฝ”ํฌ๋ ˆ์ด์…˜ ๋””ํŽฉํ‹ฐ๋”œ ํŽฉํ‹ฐ๋‹ค์ œ-iv ์–ต์ œ์ œ์˜ ์‹ ๊ทœํ•œ ๊ฒฐ์ •์งˆ ํ˜•ํƒœ
KR20140058543A (ko) * 2011-07-08 2014-05-14 ๋…ธํŒŒ๋ฅดํ‹ฐ์Šค ์•„๊ฒŒ ์‹ ๊ทœ ํ”ผ๋กค๋กœ ํ”ผ๋ฆฌ๋ฏธ๋”˜ ์œ ๋„์ฒด
WO2013023119A1 (en) 2011-08-10 2013-02-14 Novartis Pharma Ag JAK P13K/mTOR COMBINATION THERAPY
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp ไฝœ็‚บ๏ฝŠ๏ฝ๏ฝ‹ๆŠ‘ๅˆถๅŠ‘ไน‹็’ฐๅทฑๅŸบๆฐฎ้›œ็’ฐไธ็ƒท่ก็”Ÿ็‰ฉ
UA111854C2 (uk) 2011-09-07 2016-06-24 ะ†ะฝัะฐะนั‚ ะฅะพะปะดั–ะฝะณั ะšะพั€ะฟะพั€ะตะนัˆะฝ ะกะฟะพัะพะฑะธ ั– ะฟั€ะพะผั–ะถะฝั– ัะฟะพะปัƒะบะธ ะดะปั ะพั‚ั€ะธะผะฐะฝะฝั ั–ะฝะณั–ะฑั–ั‚ะพั€ั–ะฒ jak
AU2012321110B2 (en) 2011-11-30 2014-10-23 Astrazeneca Ab Combination treatment
US9089574B2 (en) 2011-11-30 2015-07-28 Emory University Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
EP2788000B1 (en) * 2011-12-06 2018-05-30 Merck Sharp & Dohme Corp. Pyrrolopyrimidines as janus kinase inhibitors
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
AR091079A1 (es) 2012-05-18 2014-12-30 Incyte Corp Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak
AR091273A1 (es) 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
CN105732639A (zh) * 2012-06-29 2016-07-06 ่พ‰็‘žๅคง่ฏๅŽ‚ ไฝœไธบLRRK2ๆŠ‘ๅˆถๅ‰‚็š„4-(ๅ–ไปฃ็š„ๆฐจๅŸบ)-7H-ๅกๅ’ฏๅนถใ€”2,3-dใ€•ๅ˜งๅ•ถ็ฑป
AU2013312477B2 (en) * 2012-09-06 2018-05-31 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US9593115B2 (en) 2012-09-21 2017-03-14 Advinus Therapeutics Ltd. Substituted fused tricyclic compounds, compositions, and medicinal applications thereof
US20150284394A1 (en) * 2012-10-26 2015-10-08 Hoffmann-La Roche Inc. Inhibitors of bruton's tyrosine kinase
CN102936251A (zh) * 2012-11-05 2013-02-20 ไธŠๆตทๆฏ•ๅพ—ๅŒป่ฏ็ง‘ๆŠ€ๆœ‰้™ๅ…ฌๅธ ไธ€็งๅกๅ’ฏๅนถ[2,3-d]ๅ˜งๅ•ถ่ก็”Ÿ็‰ฉ็š„ๅˆถๅค‡ๆ–นๆณ•
SG11201503695XA (en) 2012-11-15 2015-06-29 Incyte Corp Sustained-release dosage forms of ruxolitinib
ES2647525T3 (es) 2013-02-22 2017-12-22 Pfizer Inc. Derivados de pirrolo[2,3-d]pirimidina como inhibidores de janus cinasas (JAK)
HUE057262T2 (hu) 2013-03-06 2022-04-28 Incyte Holdings Corp Eljรกrรกs รฉs kรถztitermรฉkek JAK inhibitor elรตรกllรญtรกsรกra
US9650375B2 (en) 2013-03-14 2017-05-16 Merck Sharp & Dohme Corp. Indole derivatives useful as anti-diabetic agents
US9655854B2 (en) 2013-08-07 2017-05-23 Incyte Corporation Sustained release dosage forms for a JAK1 inhibitor
UA117040C2 (uk) * 2013-12-05 2018-06-11 ะŸั„ะฐะนะทะตั€ ะ†ะฝะบ. ะŸะ†ะ ะžะ›ะž[2,3-d]ะŸะ†ะ ะ˜ะœะ†ะ”ะ˜ะะ†ะ›-, ะŸะ†ะ ะžะ›ะž[2,3-b]ะŸะ†ะ ะะ—ะ˜ะะ†ะ›- ะขะ ะŸะ†ะ ะžะ›ะž[2,3-d]ะŸะ†ะ ะ˜ะ”ะ˜ะะ†ะ›ะะšะ ะ˜ะ›ะะœะ†ะ”ะ˜
EP3083618B1 (en) 2013-12-17 2018-02-21 Pfizer Inc Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
US9498467B2 (en) 2014-05-30 2016-11-22 Incyte Corporation Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
JP6585158B2 (ja) 2014-08-12 2019-10-02 ใƒ•ใ‚กใ‚คใ‚ถใƒผใƒปใ‚คใƒณใ‚ฏ ใƒคใƒŒใ‚นใ‚ญใƒŠใƒผใ‚ผใฎ้˜ปๅฎณใซๆœ‰็”จใชใƒ”ใƒญใƒญ๏ผป๏ผ’๏ผŒ๏ผ“โˆ’๏ฝ„๏ผฝใƒ”ใƒชใƒŸใ‚ธใƒณ่ช˜ๅฐŽไฝ“
WO2016040330A1 (en) 2014-09-09 2016-03-17 The Regents Of The University Of Michigan Thienopyrimidine and thienopyridine compounds and methods of use thereof
CN105524067A (zh) * 2014-09-28 2016-04-27 ๆฑŸ่‹ๆŸฏ่ฒๅนณๅŒป่ฏ่‚กไปฝๆœ‰้™ๅ…ฌๅธ 4-ๅ–ไปฃๅกๅ’ฏๅนถ[2,3-d]ๅ˜งๅ•ถๅŒ–ๅˆ็‰ฉๅŠๅ…ถ็”จ้€”
CA2984183C (en) 2015-05-01 2021-11-09 Pfizer Inc. Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof
TWI703150B (zh) 2015-06-04 2020-09-01 ็พŽๅ•†ๅบซๆ‹‰่…ซ็˜คๆŠ€่ก“่‚กไปฝๆœ‰้™ๅ…ฌๅธ ็”จๆ–ผๆŠ‘ๅˆถ๏ฝ๏ฝ…๏ฝŽ๏ฝ‰๏ฝŽๅŠ๏ฝ๏ฝŒ๏ฝŒ่›‹็™ฝไน‹ไบคไบ’ไฝœ็”จ็š„ๆ–นๆณ•ๅŠ็ต„ๅˆ็‰ฉ
US10588907B2 (en) 2015-06-04 2020-03-17 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
AU2016302302B2 (en) * 2015-07-31 2019-12-19 Taiho Pharmaceutical Co., Ltd. Pyrrolo[2,3-d]pyrimidine compound or salt thereof
KR101771219B1 (ko) * 2015-08-21 2017-09-05 ์–‘์ง€ํ™”ํ•™ ์ฃผ์‹ํšŒ์‚ฌ ์•ผ๋ˆ„์Šค ํ‚ค๋‚˜์ œ 1 ์„ ํƒ์  ์–ต์ œ์ œ ๋ฐ ๊ทธ ์˜์•ฝ ์šฉ๋„
JP6873980B2 (ja) 2015-09-14 2021-05-19 ใƒ•ใ‚กใ‚คใ‚ถใƒผใƒปใ‚คใƒณใ‚ฏ ๏ผฌ๏ผฒ๏ผฒ๏ผซ๏ผ’้˜ปๅฎณ่–ฌใจใ—ใฆใฎๆ–ฐ่ฆใฎใ‚คใƒŸใƒ€ใ‚พ๏ผป๏ผ”๏ผŒ๏ผ•โˆ’๏ฝƒ๏ผฝใ‚ญใƒŽใƒชใƒณใŠใ‚ˆใณใ‚คใƒŸใƒ€ใ‚พ๏ผป๏ผ”๏ผŒ๏ผ•โˆ’๏ฝƒ๏ผฝ๏ผป๏ผ‘๏ผŒ๏ผ•๏ผฝใƒŠใƒ•ใƒใƒชใ‚ธใƒณ่ช˜ๅฐŽไฝ“
US10045981B2 (en) 2015-11-24 2018-08-14 Jakpharm, Llc Selective kinase inhibitors
CN107098908B (zh) * 2016-02-23 2021-01-08 ๆฌฃๅ‡ฏๅŒป่ฏ็ง‘ๆŠ€(ไธŠๆตท)ๆœ‰้™ๅ…ฌๅธ ไธ€็งๅกๅ’ฏๅนถๅ˜งๅ•ถ็ฑปๅŒ–ๅˆ็‰ฉ็š„ๅˆถๅค‡ๆ–นๆณ•ๅ’Œๅบ”็”จ
CN109640987B (zh) 2016-03-16 2022-12-02 ๅบ“ๆ‹‰่‚ฟ็˜คๅญฆๅ…ฌๅธ Menin-mll็š„ๆกฅ่”ๅŒ็ŽฏๆŠ‘ๅˆถๅ‰‚ๅŠไฝฟ็”จๆ–นๆณ•
CN114539284A (zh) 2016-03-16 2022-05-27 ๅบ“ๆ‹‰่‚ฟ็˜คๅญฆๅ…ฌๅธ ็ปๅ–ไปฃ็š„menin-mllๆŠ‘ๅˆถๅ‰‚ๅŠไฝฟ็”จๆ–นๆณ•
CN107513067A (zh) 2016-06-16 2017-12-26 ๅŒ—ไบฌ่ต›ๆž—ๆณฐๅŒป่ฏๆŠ€ๆœฏๆœ‰้™ๅ…ฌๅธ ๅซๆœ‰ๅ–ไปฃ็ŽฏๆˆŠๅŸบ็š„ๅกๅ’ฏๅนถๅ˜งๅ•ถๅŒ–ๅˆ็‰ฉ
CN107513069A (zh) * 2016-06-16 2017-12-26 ๆญฃๅคงๅคฉๆ™ด่ฏไธš้›†ๅ›ข่‚กไปฝๆœ‰้™ๅ…ฌๅธ ๆ‰‹ๆ€งๅกๅ’ฏๅนถๅ˜งๅ•ถๅŒ–ๅˆ็‰ฉ็š„ๅˆถๅค‡ๆ–นๆณ•
SG11201900515PA (en) 2016-07-21 2019-02-27 Biogen Ma Inc Succinate forms and compositions of bruton's tyrosine kinase inhibitors
WO2018140648A1 (en) 2017-01-25 2018-08-02 Eric Jon Jacobsen Pyrrolopyrimidine itk inhibitors for treating inflammation and cancer
WO2018141842A1 (en) * 2017-02-03 2018-08-09 Leo Pharma A/S 5-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-5-AZASPIRO[2.5]OCTANE-8-CARBOXYLIC ACID DERIVATIVES AS NOVEL JAK KINASE INHIBITORS
EP3601249A4 (en) 2017-03-24 2020-12-16 Kura Oncology, Inc. METHODS OF TREATMENT OF MALIGNANT HEMOPATHIES AND EWING'S SARCOMA
CN108794480A (zh) * 2017-04-28 2018-11-13 ๅคฉๆดฅ่ฏ็‰ฉ็ ”็ฉถ้™ขๆœ‰้™ๅ…ฌๅธ ๅกๅ’ฏๅนถๅ˜งๅ•ถ็ฑปๅŒ–ๅˆ็‰ฉใ€ๅ…ถๅˆถๅค‡ๆ–นๆณ•ๅ’Œ็”จ้€”
US11542248B2 (en) 2017-06-08 2023-01-03 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
EP3684361A4 (en) 2017-09-20 2021-09-08 Kura Oncology, Inc. MENINE-MLL SUBSTITUTE INHIBITORS AND METHODS OF USE
US10800775B2 (en) 2017-11-03 2020-10-13 Aclaris Therapeutics, Inc. Pyrazolyl pyrrolo[2,3-b]pyrmidine-5-carboxylate analogs and methods of making the same
US10981906B2 (en) 2017-11-03 2021-04-20 Aclaris Therapeutics, Inc. Substituted pyrrolopyridine JAK inhibitors and methods of making and using the same
AR113922A1 (es) 2017-12-08 2020-07-01 Incyte Corp Terapia de combinaciรณn de dosis baja para el tratamiento de neoplasias mieloproliferativas
CN112105608B (zh) 2018-01-30 2023-07-14 ๅ› ่ต›็‰นๅ…ฌๅธ ๅˆถๅค‡(1-(3-ๆฐŸ-2-(ไธ‰ๆฐŸ็”ฒๅŸบ)ๅผ‚็ƒŸ็ขฑๅŸบ)ๅ“Œๅ•ถ-4-้…ฎ)็š„ๆ–นๆณ•
AU2019245420A1 (en) 2018-03-30 2020-11-12 Incyte Corporation Treatment of hidradenitis suppurativa using JAK inhibitors
JP2021534244A (ja) 2018-08-10 2021-12-09 ใ‚ขใ‚ฏใƒฉใƒชใ‚น ใ‚ปใƒฉใƒ”ใƒฅใƒผใƒ†ใ‚ฃใ‚ฏใ‚น๏ผŒใ‚คใƒณใ‚ณใƒผใƒใƒฌใ‚คใƒ†ใƒƒใƒ‰ ใƒ”ใƒญใƒญใƒ”ใƒชใƒŸใ‚ธใƒณ๏ฝ‰๏ฝ”๏ฝ‹้˜ปๅฎณๅ‰ค
GB201818750D0 (en) * 2018-11-16 2019-01-02 Institute Of Cancer Res Royal Cancer Hospital Lox inhibitors
CN109394768B (zh) * 2018-12-10 2019-08-23 ็‰กไธนๆฑŸๅŒปๅญฆ้™ข ไธ€็งๆฒป็–—ๆนฟ็–น็š„่ฏ็‰ฉๅŠๅ…ถๅˆถๅค‡ๆ–นๆณ•
EP3946606A1 (en) * 2019-03-27 2022-02-09 Insilico Medicine IP Limited Bicyclic jak inhibitors and uses thereof
KR20220004726A (ko) 2019-05-02 2022-01-11 ์–ดํด๋ผ๋ฆฌ์Šค ์Ž„๋ผํ“จํ‹ฑ์Šค, ์ธ์ฝ”ํฌ๋ ˆ์ดํ‹ฐ๋“œ Jak ์–ต์ œ์ œ๋กœ์„œ์˜ ์น˜ํ™˜๋œ ํ”ผ๋กค๋กœํ”ผ๋ฆฌ๋”˜
WO2020232247A1 (en) 2019-05-14 2020-11-19 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
IL293085A (en) 2019-11-22 2022-07-01 Incyte Corp Combined treatment that includes an alk2 inhibitor and a jak2 inhibitor
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
US12006366B2 (en) 2020-06-11 2024-06-11 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
WO2023055731A1 (en) * 2021-09-28 2023-04-06 Sanford Burnham Prebys Medical Discovery Institute Inhibitors of serine/threonine protein kinase stk3 or stk4 and uses thereof

Family Cites Families (41)

* Cited by examiner, โ€  Cited by third party
Publication number Priority date Publication date Assignee Title
US3037980A (en) 1955-08-18 1962-06-05 Burroughs Wellcome Co Pyrrolopyrimidine vasodilators and method of making them
GB915303A (en) 1958-03-13 1963-01-09 Wellcome Found Pyrrolo[2,3-d]pyrimidine derivatives and the manufacture thereof
NO169490C (no) 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
JP2983254B2 (ja) 1989-06-14 1999-11-29 ๆญฆ็”ฐ่–ฌๅ“ๅทฅๆฅญๆ ชๅผไผš็คพ ใƒ”ใƒญใƒญใ€”๏ผ’๏ผŒ๏ผ“โ€•๏ฝ„ใ€•ใƒ”ใƒชใƒŸใ‚ธใƒณ่ช˜ๅฐŽไฝ“ใฎ่ฃฝ้€ ๆณ•ใŠใ‚ˆใณใใฎไธญ้–“ไฝ“
ATE197051T1 (de) * 1992-04-03 2000-11-15 Upjohn Co Pharmazeutisch wirksame bicyclisch heterocyclische amine
US6136595A (en) 1993-07-29 2000-10-24 St. Jude Children's Research Hospital Jak kinases and regulations of cytokine signal transduction
US5389509A (en) 1993-10-04 1995-02-14 Eastman Kodak Company Ultrathin high chloride tabular grain emulsions
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
DK0682027T3 (da) 1994-05-03 1998-05-04 Ciba Geigy Ag Pyrrolopyrimidinderivater med antiproliferativ virkning
PT831829E (pt) * 1995-06-07 2003-12-31 Pfizer Derivados de pirimidina heterociclicos de aneis fundidos
MX9800136A (es) 1995-07-05 1998-03-29 Du Pont Pirimidinonas fungicidas.
SK398A3 (en) * 1995-07-06 1998-07-08 Novartis Ag Pyrrolopyrimidines and processes for the preparation thereof
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
EA000072B1 (ru) 1995-11-14 1998-06-25 ะคะฐั€ะผะฐั†ะธั ะญะฝะด ะะฟะดะถะพะฝ ะก.ะŸ.ะ. ะ‘ะธั†ะธะบะปะธั‡ะตัะบะพะต ะบะพะฝะดะตะฝัะธั€ะพะฒะฐะฝะฝะพะต ะฟะธั€ะธะผะธะดะธะฝะพะฒะพะต ัะพะตะดะธะฝะตะฝะธะต ะธ ะตะณะพ ะฟั€ะธะผะตะฝะตะฝะธะต ะฒ ะบะฐั‡ะตัั‚ะฒะต ั‚ะตั€ะฐะฟะตะฒั‚ะธั‡ะตัะบะพะณะพ ะฐะณะตะฝั‚ะฐ
ATE217873T1 (de) * 1996-01-23 2002-06-15 Novartis Erfind Verwalt Gmbh Pyrrolopyrimidinen und verfahren zu deren herstellung
CH690773A5 (de) 1996-02-01 2001-01-15 Novartis Ag Pyrrolo(2,3-d)pyrimide und ihre Verwendung.
GB9604361D0 (en) * 1996-02-29 1996-05-01 Pharmacia Spa 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors
AU1794697A (en) 1996-03-06 1997-09-22 Novartis Ag 7-alkyl-pyrrolo{2,3-d}pyrimidines
WO1997049706A1 (en) 1996-06-25 1997-12-31 Novartis Ag SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
EA199900021A1 (ru) 1996-07-13 1999-08-26 ะ“ะปะฐะบัะพ, ะ“ั€ัƒะฟ ะ›ะธะผะธั‚ะตะด ะ‘ะธั†ะธะบะปะธั‡ะตัะบะธะต ะณะตั‚ะตั€ะพะฐั€ะพะผะฐั‚ะธั‡ะตัะบะธะต ัะพะตะดะธะฝะตะฝะธั ะฒ ะบะฐั‡ะตัั‚ะฒะต ะธะฝะณะธะฑะธั‚ะพั€ะพะฒ ะฟั€ะพั‚ะตะธะฝั‚ะธั€ะพะทะธะฝะบะธะฝะฐะทั‹
WO1998007726A1 (en) * 1996-08-23 1998-02-26 Novartis Ag Substituted pyrrolopyrimidines and processes for their preparation
KR20000057228A (ko) * 1996-11-27 2000-09-15 ๋””. ์ œ์ด. ์šฐ๋“œ, ์Šคํ”ผ๊ฒ” ์•Œ๋ Œ ์ œ์ด ์ถ•ํ•ฉ๋œ ๋น„์‚ฌ์ดํด๋ฆญ ํ”ผ๋ฆฌ๋ฏธ๋”˜ ์œ ๋„์ฒด
ATE391719T1 (de) 1997-02-05 2008-04-15 Warner Lambert Co Pyrido (2,3-d) pyrimidine und 4-amino-primidine als inhibitoren der zellulรคren proliferation
EP0972197A1 (en) 1997-03-24 2000-01-19 PHARMACIA & UPJOHN COMPANY Method for identifying inhibitors of jak2/cytokine receptor binding
JP2002510687A (ja) 1998-04-02 2002-04-09 ใƒ‹ใƒฅใƒผใƒญใ‚ฒใƒณ ใ‚ณใƒผใƒใƒฌใ‚คใ‚ทใƒงใƒณ ใ‚ขใƒŸใƒŽใ‚ขใƒซใ‚ญใƒซ็ฝฎๆ›ใƒ”ใƒญใƒญ๏ผป๏ผ’๏ผŒ๏ผ“โˆ’๏ฝ‚๏ผฝใƒ”ใƒชใ‚ธใƒณใŠใ‚ˆใณใƒ”ใƒญใƒญ๏ผป๏ผ’๏ผŒ๏ผ“โˆ’๏ฝ„๏ผฝใƒ”ใƒชใƒŸใ‚ธใƒณ่ช˜ๅฐŽไฝ“๏ผš๏ฝƒ๏ฝ’๏ฝ†๏ผ‘ใƒฌใ‚ปใƒ—ใ‚ฟใฎใƒขใ‚ธใƒฅใƒฌใƒผใ‚ฟ
EP1082311A1 (en) 1998-05-28 2001-03-14 Parker Hughes Institute Quinazolines for treating brain tumor
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
EA005852B1 (ru) 1998-06-19 2005-06-30 ะŸั„ะฐะนะทะตั€ ะŸั€ะพะดะฐะบั‚ั ะ˜ะฝะบ. ะŸะ˜ะ ะ ะžะ›ะž[2,3-d]ะŸะ˜ะ ะ˜ะœะ˜ะ”ะ˜ะะซ
CA2337999A1 (en) 1998-06-30 2000-01-06 Parker Hughes Institute Method for inhibiting c-jun expression using jak-3 inhibitors
HUP0103386A3 (en) 1998-08-21 2002-07-29 Parker Hughes Inst St Paul Use of quinazoline derivatives for producing pharmaceutical compositions having jak 3-inhibitor effect
PL346700A1 (en) 1998-09-18 2002-02-25 Basf Ag Pyrrolopyrimidines as protein kinase inhibitors
US6080747A (en) 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
US6664252B2 (en) * 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
CN1195755C (zh) 1999-12-10 2005-04-06 ่พ‰็‘žไบงๅ“ๅ…ฌๅธ ๅกๅ’ฏๅนถ[2,3๏ผd]ๅ˜งๅ•ถๅŒ–ๅˆ็‰ฉ
MXPA03000068A (es) 2000-06-26 2003-09-25 Pfizer Prod Inc Compuestos de pirrolo (2,3-d)pirimidina como agentes inmunosupresores.
US6680324B2 (en) * 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6673802B2 (en) * 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US7301023B2 (en) 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
GT200200234A (es) 2001-12-06 2003-06-27 Compuestos cristalinos novedosos
KR20040006555A (ko) 2002-07-12 2004-01-24 ์‚ผ์„ฑ์ „์ž์ฃผ์‹ํšŒ์‚ฌ ์•ก์ • ํ‘œ์‹œ ์žฅ์น˜

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