UA63013C2 - Pyrolo[2,3-d]pyrimidin derivatives, a pharmaceutical composition (alternatives), a method for inhibition of protein tyrosine kinases such as janus kinase 3 in mammals (alternatives) and a method for treatment (alternatives) - Google Patents
Pyrolo[2,3-d]pyrimidin derivatives, a pharmaceutical composition (alternatives), a method for inhibition of protein tyrosine kinases such as janus kinase 3 in mammals (alternatives) and a method for treatment (alternatives) Download PDFInfo
- Publication number
- UA63013C2 UA63013C2 UA2000127301A UA2000127301A UA63013C2 UA 63013 C2 UA63013 C2 UA 63013C2 UA 2000127301 A UA2000127301 A UA 2000127301A UA 2000127301 A UA2000127301 A UA 2000127301A UA 63013 C2 UA63013 C2 UA 63013C2
- Authority
- UA
- Ukraine
- Prior art keywords
- alkyl
- pyrrolo
- heteroaryl
- daryl
- cio
- Prior art date
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- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 title claims abstract description 12
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 title claims description 72
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title claims description 71
- 241000124008 Mammalia Species 0.000 title claims description 20
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 7
- 230000005764 inhibitory process Effects 0.000 title claims description 5
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- 108010019421 Janus Kinase 3 Proteins 0.000 title abstract 2
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- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 48
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8988698P | 1998-06-19 | 1998-06-19 | |
| PCT/IB1999/001110 WO1999065909A1 (en) | 1998-06-19 | 1999-06-14 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS |
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| UA63013C2 true UA63013C2 (en) | 2004-01-15 |
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| UA2000127301A UA63013C2 (en) | 1998-06-19 | 1999-06-14 | Pyrolo[2,3-d]pyrimidin derivatives, a pharmaceutical composition (alternatives), a method for inhibition of protein tyrosine kinases such as janus kinase 3 in mammals (alternatives) and a method for treatment (alternatives) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2598072C2 (ru) * | 2011-06-29 | 2016-09-20 | Мерк Шарп И Доум Корп. | Новые кристаллические формы ингибиторов дипептидилпептидазы-iv |
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