ES2642074T3 - Compuestos útiles como inmunomoduladores - Google Patents
Compuestos útiles como inmunomoduladores Download PDFInfo
- Publication number
- ES2642074T3 ES2642074T3 ES14766086.4T ES14766086T ES2642074T3 ES 2642074 T3 ES2642074 T3 ES 2642074T3 ES 14766086 T ES14766086 T ES 14766086T ES 2642074 T3 ES2642074 T3 ES 2642074T3
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- phenylbenzonitrile
- dimethoxyphenoxymethyl
- amino
- dmso
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 title claims description 8
- 239000002955 immunomodulating agent Substances 0.000 title 1
- 229940121354 immunomodulator Drugs 0.000 title 1
- 102000008096 B7-H1 Antigen Human genes 0.000 claims description 8
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 230000003993 interaction Effects 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 238000011282 treatment Methods 0.000 claims description 2
- -1 {4 - [(2-cyano-3-phenylphenyl) methoxy] -2,6-dimethoxyphenyl} methyl Chemical group 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- WIPLIOVSJOEWFD-SANMLTNESA-N (2S)-1-[[4-[(2-cyano-3-phenylphenyl)methoxy]-2,6-dimethoxyphenyl]methyl]piperidine-2-carboxylic acid Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCCC[C@H]1C(O)=O WIPLIOVSJOEWFD-SANMLTNESA-N 0.000 claims 1
- BNGQQIPGCOKIDI-UHFFFAOYSA-N CCN(Cc1ccncc1)Cc1c(OC)cc(OCc2cccc(-c3ccccc3)c2C#N)cc1OC Chemical compound CCN(Cc1ccncc1)Cc1c(OC)cc(OCc2cccc(-c3ccccc3)c2C#N)cc1OC BNGQQIPGCOKIDI-UHFFFAOYSA-N 0.000 claims 1
- WJZZOTQYDJBATG-UHFFFAOYSA-N CNCc1c(OC)cc(OCc2cccc(-c3ccccc3)c2C#N)cc1OC Chemical compound CNCc1c(OC)cc(OCc2cccc(-c3ccccc3)c2C#N)cc1OC WJZZOTQYDJBATG-UHFFFAOYSA-N 0.000 claims 1
- RLERFXIAHSTVIC-UHFFFAOYSA-N COC=1C=C(OCC2=C(C#N)C(=CC=C2)C2=CC=CC=C2)C=C(C=1CNCCCN1C(CCC1)=O)OC Chemical compound COC=1C=C(OCC2=C(C#N)C(=CC=C2)C2=CC=CC=C2)C=C(C=1CNCCCN1C(CCC1)=O)OC RLERFXIAHSTVIC-UHFFFAOYSA-N 0.000 claims 1
- AJXZPCIOBVYETD-UHFFFAOYSA-N COCCNCc1c(OC)cc(OCc2cccc(-c3ccccc3)c2C#N)cc1OC Chemical compound COCCNCc1c(OC)cc(OCc2cccc(-c3ccccc3)c2C#N)cc1OC AJXZPCIOBVYETD-UHFFFAOYSA-N 0.000 claims 1
- JPKMBXLSPLEASY-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1C(C)CCC1C Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1C(C)CCC1C JPKMBXLSPLEASY-UHFFFAOYSA-N 0.000 claims 1
- SWFHZGGDTJIWSZ-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCC1 Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCC1 SWFHZGGDTJIWSZ-UHFFFAOYSA-N 0.000 claims 1
- QHXJQISIDOZJGJ-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCCC(C1)C(O)=O Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCCC(C1)C(O)=O QHXJQISIDOZJGJ-UHFFFAOYSA-N 0.000 claims 1
- KXYPOJZVZOGBNM-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCCC(CO)C1 Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCCC(CO)C1 KXYPOJZVZOGBNM-UHFFFAOYSA-N 0.000 claims 1
- LFGLHVLFNPRWNU-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCCC(O)C1 Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCCC(O)C1 LFGLHVLFNPRWNU-UHFFFAOYSA-N 0.000 claims 1
- FDGUMKDXNMDZDZ-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCCC1 Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCCC1 FDGUMKDXNMDZDZ-UHFFFAOYSA-N 0.000 claims 1
- XWUQRTVSRZAOHT-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCCC1C Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCCC1C XWUQRTVSRZAOHT-UHFFFAOYSA-N 0.000 claims 1
- VOUQQSDINWYWOT-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCCN(CC1)C(C)=O Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCCN(CC1)C(C)=O VOUQQSDINWYWOT-UHFFFAOYSA-N 0.000 claims 1
- HOWNMIDVPXVJME-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCN(CC1)C(C)=O Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCN(CC1)C(C)=O HOWNMIDVPXVJME-UHFFFAOYSA-N 0.000 claims 1
- JCRRGWHYBLZCAI-QHCPKHFHSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CC[C@@H](C1)NC(C)=O Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CC[C@@H](C1)NC(C)=O JCRRGWHYBLZCAI-QHCPKHFHSA-N 0.000 claims 1
- HXEHEBWGBFEGHH-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNC(C)C Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNC(C)C HXEHEBWGBFEGHH-UHFFFAOYSA-N 0.000 claims 1
- AAJPIEJWNVYMGO-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNC1(CO)CCCC1 Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNC1(CO)CCCC1 AAJPIEJWNVYMGO-UHFFFAOYSA-N 0.000 claims 1
- GVKRIBKIAGEUGE-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNC1CCC(O)CC1 Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNC1CCC(O)CC1 GVKRIBKIAGEUGE-UHFFFAOYSA-N 0.000 claims 1
- WYHIHFMIMJWJKF-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNC1CCC1 Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNC1CCC1 WYHIHFMIMJWJKF-UHFFFAOYSA-N 0.000 claims 1
- MLGYDLQNIZYLAH-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNC1CCCC1 Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNC1CCCC1 MLGYDLQNIZYLAH-UHFFFAOYSA-N 0.000 claims 1
- IOUNFTFULVKAND-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNC1CCCCC1 Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNC1CCCCC1 IOUNFTFULVKAND-UHFFFAOYSA-N 0.000 claims 1
- FKVGEVWPIYZSRP-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNCCC(N)=O Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNCCC(N)=O FKVGEVWPIYZSRP-UHFFFAOYSA-N 0.000 claims 1
- FOQIRHYDHROHMG-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNCCN(C)C Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNCCN(C)C FOQIRHYDHROHMG-UHFFFAOYSA-N 0.000 claims 1
- KXDLFZSSQMCMOM-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNCCNC(C)=O Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNCCNC(C)=O KXDLFZSSQMCMOM-UHFFFAOYSA-N 0.000 claims 1
- CRXMIYGHZKOKII-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNCCO Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNCCO CRXMIYGHZKOKII-UHFFFAOYSA-N 0.000 claims 1
- AVTPGUBVEFQMJW-UHFFFAOYSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNCCc1ccccn1 Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNCCc1ccccn1 AVTPGUBVEFQMJW-UHFFFAOYSA-N 0.000 claims 1
- SGRJFBMMKOAXCG-FQEVSTJZSA-N COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNC[C@@H](O)CC(O)=O Chemical compound COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CNC[C@@H](O)CC(O)=O SGRJFBMMKOAXCG-FQEVSTJZSA-N 0.000 claims 1
- XKPLUFKYCZERKI-QFIPXVFZSA-N OC[C@H]1N(CCC1)CC1=C(C=C(OCC2=C(C#N)C(=CC=C2)C2=CC=CC=C2)C=C1OC)OC Chemical compound OC[C@H]1N(CCC1)CC1=C(C=C(OCC2=C(C#N)C(=CC=C2)C2=CC=CC=C2)C=C1OC)OC XKPLUFKYCZERKI-QFIPXVFZSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- VLJNHYLEOZPXFW-UHFFFAOYSA-N pyrrolidine-2-carboxamide Chemical compound NC(=O)C1CCCN1 VLJNHYLEOZPXFW-UHFFFAOYSA-N 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 116
- 238000005160 1H NMR spectroscopy Methods 0.000 description 61
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 15
- 238000002868 homogeneous time resolved fluorescence Methods 0.000 description 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 5
- 239000012131 assay buffer Substances 0.000 description 5
- 238000000159 protein binding assay Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 229910001868 water Inorganic materials 0.000 description 4
- 238000009739 binding Methods 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 229910052693 Europium Inorganic materials 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 2
- 230000027455 binding Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- OKKJLVBELUTLKV-MZCSYVLQSA-N Deuterated methanol Chemical compound [2H]OC([2H])([2H])[2H] OKKJLVBELUTLKV-MZCSYVLQSA-N 0.000 description 1
- 208000005176 Hepatitis C Diseases 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 1
- 108010004469 allophycocyanin Proteins 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- XLNZTFSHKDNRBE-UHFFFAOYSA-N n,n-diaminoacetamide Chemical compound CC(=O)N(N)N XLNZTFSHKDNRBE-UHFFFAOYSA-N 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
Classifications
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Families Citing this family (247)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2707323T3 (es) | 2012-12-07 | 2019-04-03 | Chemocentryx Inc | Diazol lactamas |
| US9850225B2 (en) * | 2014-04-14 | 2017-12-26 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| RS62809B1 (sr) | 2015-05-21 | 2022-02-28 | Chemocentryx Inc | Modulatori ccr2 |
| US10464896B2 (en) | 2015-06-11 | 2019-11-05 | Basilea Pharmaceutica International AG | Efflux-pump inhibitors and therapeutic uses thereof |
| US10745382B2 (en) | 2015-10-15 | 2020-08-18 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| WO2017070089A1 (en) | 2015-10-19 | 2017-04-27 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| DK3377488T3 (da) * | 2015-11-19 | 2022-10-03 | Incyte Corp | Heterocykliske forbindelser som immunomodulatorer |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| MA44075A (fr) * | 2015-12-17 | 2021-05-19 | Incyte Corp | Dérivés de n-phényl-pyridine-2-carboxamide et leur utilisation en tant que modulateurs des interactions protéine/protéine pd-1/pd-l1 |
| MY199705A (en) * | 2015-12-22 | 2023-11-20 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| EP3190103A1 (en) | 2016-01-08 | 2017-07-12 | Rijksuniversiteit Groningen | Inhibitors of the pd-1/pd-l1 protein/protein interaction |
| WO2017176965A1 (en) | 2016-04-07 | 2017-10-12 | Chemocentryx, Inc. | Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors |
| TW201808950A (zh) | 2016-05-06 | 2018-03-16 | 英塞特公司 | 作為免疫調節劑之雜環化合物 |
| KR102400592B1 (ko) * | 2016-05-23 | 2022-05-20 | 인스티튜드 오브 머테리아 메디카, 차이니스 아케데미 오브 메디컬 싸이언시스 | 페닐레이트 유도체, 그의 제조 방법, 및 그의 약학적 조성물 및 용도 |
| US20170342060A1 (en) * | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| SG11201811414TA (en) | 2016-06-20 | 2019-01-30 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| CN109415366B (zh) * | 2016-06-23 | 2022-02-22 | 豪夫迈·罗氏有限公司 | [1,2,3]三唑并[4,5-d]嘧啶衍生物 |
| WO2018005374A1 (en) * | 2016-06-27 | 2018-01-04 | Chemocentryx, Inc. | Immunomodulator compounds |
| EP3483142B1 (en) * | 2016-07-05 | 2025-10-15 | Beijing Maxinovel Pharmaceuticals Co., Ltd. | Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof |
| AU2017292758A1 (en) * | 2016-07-08 | 2019-02-21 | Bristol-Myers Squibb Company | 1,3-dihydroxy-phenyl derivatives useful as immunomodulators |
| EP3484866B1 (en) | 2016-07-14 | 2022-09-07 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| SI3798217T1 (sl) | 2016-07-28 | 2023-05-31 | Idorsia Pharmaceuticals Ltd | Piperidinski modulatorji cxcr7 receptorja |
| EP3493804A1 (en) * | 2016-08-03 | 2019-06-12 | Arising International, Inc. | Symmetric or semi-symmetric compounds useful as immunomodulators |
| MA46045A (fr) | 2016-08-29 | 2021-04-28 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| US10144706B2 (en) * | 2016-09-01 | 2018-12-04 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| SG11201901991QA (en) * | 2016-09-06 | 2019-04-29 | Incelldx Inc | Methods of detecting per cell pd-l1 expression and uses thereof |
| US11726089B2 (en) | 2016-09-06 | 2023-08-15 | Incelldx, Inc. | Methods of assaying neoplastic and neoplasia-related cells and uses thereof |
| US12298309B2 (en) | 2016-09-06 | 2025-05-13 | Incelldx, Inc. | Methods of assaying neoplastic and neoplasia-related cells and uses thereof |
| BR112019007450A2 (pt) | 2016-10-14 | 2020-07-07 | Precision Biosciences, Inc. | meganucleases modificadas específicas para sequências de reconhecimento no genoma do vírus da hepatite b |
| WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
| CN110072860B (zh) * | 2016-12-20 | 2022-09-02 | 百时美施贵宝公司 | 可用作免疫调节剂的化合物 |
| WO2018119221A1 (en) * | 2016-12-22 | 2018-06-28 | Incyte Corporation | Pyridine derivatives as immunomodulators |
| US20180179202A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| WO2018119266A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Benzooxazole derivatives as immunomodulators |
| KR102641030B1 (ko) * | 2016-12-22 | 2024-02-29 | 인사이트 코포레이션 | Pd-l1 내재화 유도제로서의 테트라하이드로 이미다조[4,5-c]피리딘 유도체 |
| US20180177784A1 (en) * | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| WO2018119236A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
| AU2017384900B2 (en) | 2016-12-28 | 2020-12-10 | GC Cell Corporation | Chimeric antigen receptor and natural killer cells expressing same |
| US10654815B2 (en) | 2016-12-29 | 2020-05-19 | Shenzhen Chipscreen Biosciences Co., Ltd. | Urea compound and preparation method and application thereof |
| EP3565841A1 (en) | 2017-01-06 | 2019-11-13 | Crescendo Biologics Limited | Single domain antibodies to programmed cell death (pd-1) |
| KR20190133714A (ko) * | 2017-03-27 | 2019-12-03 | 브리스톨-마이어스 스큅 컴퍼니 | 면역조정제로서 유용한 치환된 이소퀴놀린 유도체 |
| JOP20180040A1 (ar) * | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
| US11130740B2 (en) | 2017-04-25 | 2021-09-28 | Arbutus Biopharma Corporation | Substituted 2,3-dihydro-1H-indene analogs and methods using same |
| LT3625222T (lt) | 2017-05-18 | 2021-11-10 | Idorsia Pharmaceuticals Ltd | Fenilo dariniai, kaip pge2 receptoriaus moduliatoriai |
| PT3625228T (pt) | 2017-05-18 | 2021-09-16 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores dos recetores de pge2 |
| CN110621671A (zh) | 2017-05-18 | 2019-12-27 | 爱杜西亚药品有限公司 | 作为pge2受体调节剂的苯并呋喃及苯并噻吩衍生物 |
| LT3625224T (lt) | 2017-05-18 | 2021-10-25 | Idorsia Pharmaceuticals Ltd | N-pakeistieji indolo dariniai |
| TW201900180A (zh) | 2017-05-18 | 2019-01-01 | 瑞士商愛杜西亞製藥有限公司 | 嘧啶衍生物 |
| WO2018223004A1 (en) | 2017-06-01 | 2018-12-06 | Xencor, Inc. | Bispecific antibodies that bind cd20 and cd3 |
| WO2018223002A1 (en) | 2017-06-01 | 2018-12-06 | Xencor, Inc. | Bispecific antibodies that bind cd 123 cd3 |
| WO2019008154A1 (en) | 2017-07-07 | 2019-01-10 | Rijksuniversiteit Groningen | 3- (AZOLYLMETHOXY) BIPHENYL DERIVATIVES AS INHIBITORS OF PROTEIN / PROTEIN INTERACTION PD-1 / PD-L1 |
| WO2019008152A1 (en) | 2017-07-07 | 2019-01-10 | Rijksuniversiteit Groningen | 3-CYANOTHIOPHENE DERIVATIVES AS INHIBITORS OF PROTEIN / PROTEIN INTERACTION PD-1 / PD-L1 |
| WO2019008156A1 (en) | 2017-07-07 | 2019-01-10 | Rijksuniversiteit Groningen | INHIBITORS OF PROTEIN / PROTEIN INTERACTION PD-1 / PD-L1 |
| AU2018306619B2 (en) * | 2017-07-28 | 2022-06-02 | Chemocentryx, Inc. | Immunomodulator compounds |
| KR102670486B1 (ko) * | 2017-08-08 | 2024-05-28 | 케모센트릭스, 인크. | 마크로사이클릭 면역조절제 |
| JP7110325B2 (ja) | 2017-08-17 | 2022-08-01 | イドーシア ファーマシューティカルズ リミテッド | インドールアミン 2,3-ジオキシゲナーゼ及び/又はトリプトファン 2,3-ジオキシゲナーゼの阻害剤 |
| CN109400522B (zh) * | 2017-08-18 | 2023-04-28 | 上海轶诺药业有限公司 | 一种具有pd-l1抑制活性的化合物、其制备方法及用途 |
| IL273428B2 (en) | 2017-09-22 | 2023-09-01 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
| US11304952B2 (en) | 2017-09-25 | 2022-04-19 | Chemocentryx, Inc. | Combination therapy using a chemokine receptor 2 (CCR2) antagonist and a PD-1/PD-L1 inhibitor |
| CN109665968B (zh) * | 2017-10-16 | 2022-02-22 | 四川科伦博泰生物医药股份有限公司 | 并环化合物及其制备方法和用途 |
| CN111225915B (zh) | 2017-10-18 | 2023-03-07 | 朱比兰特埃皮帕德有限公司 | 作为pad抑制剂的咪唑并吡啶化合物 |
| CN109721527B (zh) * | 2017-10-27 | 2024-03-12 | 广州丹康医药生物有限公司 | 一种新型抗pd-l1化合物、其应用及含其的组合物 |
| BR112020008851A2 (pt) * | 2017-11-06 | 2020-10-20 | Jubilant Prodel LLC | composto da fórmula i, processo de preparação de compostos da fórmula i, composição farmacêutica, método para o tratamento e/ou prevenção de várias doenças, uso, método para o tratamento de câncer, método de tratamento de câncer e método para o tratamento e/ou prevenção de câncer e doenças infecciosas |
| CN111315398A (zh) | 2017-11-10 | 2020-06-19 | 阿尔莫生物科技股份有限公司 | 白介素-10与免疫检查点途径抑制剂的组合的组合物和使用方法 |
| KR20200080304A (ko) | 2017-11-13 | 2020-07-06 | 크레센도 바이오로직스 리미티드 | Cd137에 결합하는 단일 도메인 항체 |
| US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| CN111655732B (zh) | 2017-11-14 | 2023-09-12 | Gc细胞治疗 | 抗her2抗体或其抗原结合片段及包含其的嵌合抗原受体 |
| JP7368369B2 (ja) | 2017-11-24 | 2023-10-24 | ジュビラント・エピスクライブ・エルエルシー | Prmt5阻害剤としてのヘテロ環式化合物 |
| EP3728282B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| CN111566120B (zh) | 2017-12-20 | 2023-09-29 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的3’3’环状二核苷酸 |
| CN109956898B (zh) * | 2017-12-22 | 2021-03-26 | 上海海雁医药科技有限公司 | 免疫调节剂及其制法与医药上的用途 |
| WO2019128918A1 (zh) | 2017-12-29 | 2019-07-04 | 广州再极医药科技有限公司 | 芳香乙烯或芳香乙基类衍生物、其制备方法、中间体、药物组合物及应用 |
| EP3737367B1 (en) | 2018-01-08 | 2024-10-02 | ChemoCentryx, Inc. | Ccr2 antagonists for the treatment of cutaneous t-cell lymphoma |
| US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| ES2983284T3 (es) | 2018-01-09 | 2024-10-22 | Shuttle Pharmaceuticals Inc | Inhibidores selectivos de histona deacetilasa para el tratamiento de enfermedades humanas |
| PL3737684T3 (pl) | 2018-01-10 | 2023-02-27 | Idorsia Pharmaceuticals Ltd | Pochodne 2,4,6,7-tetrahydropirazolo[4,3-d]pirymidyn-5-onu i związki pokrewne jako modulatory receptorów c5a do leczenia zapalenia naczyń i chorób zapalnych |
| JP7217279B2 (ja) | 2018-01-15 | 2023-02-02 | イドーシア ファーマシューティカルズ リミテッド | インドールアミン 2,3-ジオキシゲナーゼ及び/又はトリプトファン 2,3-ジオキシゲナーゼの阻害剤 |
| US11685729B2 (en) | 2018-01-19 | 2023-06-27 | Idorsia Pharmaceuticals Ltd. | C5a receptor modulators |
| CN111615513A (zh) | 2018-01-19 | 2020-09-01 | 爱杜西亚药品有限公司 | C5a受体调节剂 |
| ES2998139T3 (en) | 2018-01-23 | 2025-02-19 | Bristol Myers Squibb Co | 2,8-diacyl-2,8-diazaspiro[5.5]undecane compounds useful as immunomodulators |
| BR112020015024A2 (pt) | 2018-01-26 | 2021-01-19 | Idorsia Pharmaceuticals Ltd | Forma cristalina, composição farmacêutica, uso de uma forma cristalina, e, método de profilaxia ou tratamento de câncer, distúrbios autoimunes, doenças inflamatórias, rejeição a transplante ou fibrose |
| CN110092779B (zh) * | 2018-01-29 | 2022-07-12 | 广州丹康医药生物有限公司 | 一种取代的苯基化合物及其应用 |
| CN110092740B (zh) * | 2018-01-29 | 2022-10-14 | 广州丹康医药生物有限公司 | 一种稠环化合物及其应用 |
| ES3035608T3 (en) | 2018-02-05 | 2025-09-05 | Abbisko Therapeutics Co Ltd | Biaryl derivatives and their pharmaceutical application for the treatment of pd-1/pd-l1 signal pathway-mediated diseases |
| CN111712494A (zh) * | 2018-02-13 | 2020-09-25 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
| EP3755311A4 (en) | 2018-02-22 | 2021-11-10 | ChemoCentryx, Inc. | INDANAMINE AS PD-L1 ANTAGONISTS |
| CA3091142C (en) | 2018-02-26 | 2023-04-11 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds and uses thereof |
| US11578054B2 (en) | 2018-03-01 | 2023-02-14 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| CN110240587B (zh) * | 2018-03-08 | 2022-01-04 | 中国科学院上海药物研究所 | 一类芳基二氟苄基醚类化合物、制备方法及用途 |
| CN111788193B (zh) * | 2018-03-13 | 2023-04-04 | 广东东阳光药业有限公司 | Pd-1/pd-l1类小分子抑制剂及其在药物中的应用 |
| JP7279063B6 (ja) * | 2018-03-13 | 2024-02-15 | ジュビラント プローデル エルエルシー | Pd1/pd-l1相互作用/活性化の阻害剤としての二環式化合物 |
| FI3774791T3 (fi) | 2018-03-30 | 2023-03-21 | Incyte Corp | Heterosyklisiä yhdisteitä immunomodulaattoreina |
| WO2019195181A1 (en) | 2018-04-05 | 2019-10-10 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis b virus protein x |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | 2,2,─環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| EP4600247A3 (en) | 2018-04-19 | 2025-11-19 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| WO2019211799A1 (en) | 2018-05-03 | 2019-11-07 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide |
| BR112020022936A2 (pt) | 2018-05-11 | 2021-02-02 | Incyte Corporation | derivados de tetra-hidro-imidazo[4,5-c]piridina como imunomoduladores de pd-l1 |
| CN118130807A (zh) | 2018-05-31 | 2024-06-04 | 小野药品工业株式会社 | 用于确定免疫检查点抑制剂的有效性的生物标志物 |
| US20210205449A1 (en) | 2018-06-01 | 2021-07-08 | Novartis Ag | Dosing of a bispecific antibody that bind cd123 and cd3 |
| US20210347842A1 (en) | 2018-06-19 | 2021-11-11 | Eli Lilly And Company | Compositions and methods of use of il-10 agents in conjunction with chimeric antigen receptor cell therapy |
| KR20230159715A (ko) | 2018-07-13 | 2023-11-21 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| CN109305934A (zh) * | 2018-08-07 | 2019-02-05 | 成都海博锐药业有限公司 | 苯醚类衍生物及可药用盐、医药上的用途 |
| CN108997172B (zh) * | 2018-08-08 | 2020-12-15 | 中国人民解放军总医院 | 抗肿瘤化合物 |
| CN110872275A (zh) * | 2018-08-31 | 2020-03-10 | 深圳微芯生物科技股份有限公司 | 作为免疫调节剂的联苯化合物及其用途 |
| TWI855000B (zh) | 2018-10-11 | 2024-09-11 | 日商小野藥品工業股份有限公司 | Sting促效化合物 |
| AU2019366355B2 (en) * | 2018-10-24 | 2022-10-13 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| CN117105933A (zh) | 2018-10-31 | 2023-11-24 | 吉利德科学公司 | 具有hpk1抑制活性的取代的6-氮杂苯并咪唑化合物 |
| CN113227089B (zh) | 2018-10-31 | 2024-07-05 | 吉利德科学公司 | 作为hpk1抑制剂的取代的6-氮杂苯并咪唑化合物 |
| AU2019373702A1 (en) | 2018-11-02 | 2021-06-24 | Shanghai Maxinovel Pharmaceuticals Co., Ltd. | Diphenyl-like compound, intermediate thereof, preparation method therefor, pharmaceutical composition thereof and uses thereof |
| CN109456284A (zh) * | 2018-11-13 | 2019-03-12 | 南方医科大学 | 一种含取代联苯的查尔酮及其应用 |
| CN109438263A (zh) * | 2018-11-28 | 2019-03-08 | 南方医科大学 | 一种含取代联苯的萘及其应用 |
| CN109503546A (zh) * | 2019-01-10 | 2019-03-22 | 南方医科大学 | 一种间苯二酚二苯甲醚及其应用 |
| CN113454458A (zh) | 2019-02-05 | 2021-09-28 | 文塔纳医疗系统公司 | 用于评估iv期结直肠癌中免疫细胞浸润的方法和系统 |
| CN112313220B (zh) | 2019-02-21 | 2023-11-03 | 厦门宝太生物科技股份有限公司 | Pd-l1拮抗剂化合物 |
| EP3935065A1 (en) | 2019-03-07 | 2022-01-12 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| EP3934757B1 (en) | 2019-03-07 | 2023-02-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| US20220143061A1 (en) | 2019-03-07 | 2022-05-12 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| US20220168268A1 (en) | 2019-03-22 | 2022-06-02 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd. | Small-molecule inhibitor of pd-1/pd-l1, pharmaceutical composition thereof with pd-l1 antibody, and application of same |
| JP2022526960A (ja) | 2019-03-28 | 2022-05-27 | ブリストル-マイヤーズ スクイブ カンパニー | 腫瘍を処置する方法 |
| EP3946625A1 (en) | 2019-03-28 | 2022-02-09 | Bristol-Myers Squibb Company | Methods of treating tumor |
| CN111747927B (zh) * | 2019-03-29 | 2023-08-18 | 广州丹康医药生物有限公司 | 作为免疫调节剂的化合物及其应用 |
| EP3946434A1 (en) | 2019-04-02 | 2022-02-09 | Immunetune B.V. | Immune-stimulatory compositions and use thereof |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| WO2020225077A1 (en) | 2019-05-03 | 2020-11-12 | Idorsia Pharmaceuticals Ltd | Pyrimido[4,5-b]indol derivatives as pdhk1 inhibitors |
| WO2020228649A1 (zh) * | 2019-05-10 | 2020-11-19 | 上海海雁医药科技有限公司 | 取代的苯基丙烯基吡啶类衍生物,其制法与医药上的用途 |
| MX2021013819A (es) | 2019-05-15 | 2022-02-10 | Chemocentryx Inc | Compuestos de triarilo para el tratamiento de enfermedades asociadas a pd-l1. |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| CN114174538A (zh) | 2019-05-30 | 2022-03-11 | 百时美施贵宝公司 | 适合于免疫肿瘤学疗法的多肿瘤基因特征 |
| EP3977132A1 (en) | 2019-05-30 | 2022-04-06 | Bristol-Myers Squibb Company | Cell localization signature and combination therapy |
| KR20220016155A (ko) | 2019-05-30 | 2022-02-08 | 브리스톨-마이어스 스큅 컴퍼니 | 면역-종양학 (i-o) 요법에 적합한 대상체를 확인하는 방법 |
| CN112028870B (zh) * | 2019-06-04 | 2021-11-05 | 中国科学院上海药物研究所 | 一种具有苄氧基芳环结构的化合物,其制备方法和用途 |
| EP3980413B1 (en) * | 2019-06-07 | 2023-07-19 | Janssen Sciences Ireland Unlimited Company | Heterocyclic immunomodulators as pdl1 checkpoint inhibitor |
| CN113557236B (zh) * | 2019-06-10 | 2022-05-10 | 中国科学院广州生物医药与健康研究院 | 一种双功能免疫调节剂及其在药学上可接受的盐、药物组合物 |
| EP3982922A1 (en) | 2019-06-12 | 2022-04-20 | Technical University of Denmark | Dissacharide formulations for controlled drug release |
| BR112021023750A2 (pt) | 2019-06-20 | 2022-01-11 | Chemocentryx Inc | Compostos para tratamento de doenças pd-l1 |
| CN112121169B (zh) * | 2019-06-24 | 2023-10-24 | 广州再极医药科技有限公司 | 用于治疗具有高间质压力的肿瘤受试者的癌症的小分子抑制剂 |
| TWI867008B (zh) | 2019-07-09 | 2024-12-21 | 瑞士商愛杜西亞製藥有限公司 | 包含四氫吡唑并嘧啶酮化合物之醫藥組合物 |
| MX2022000318A (es) | 2019-07-10 | 2022-02-10 | Chemocentryx Inc | Indanos como inhibidores de pd-l1. |
| JP2022540146A (ja) | 2019-07-11 | 2022-09-14 | イドーシア ファーマシューティカルズ リミテッド | インドールアミン 2,3-ジオキシゲナーゼ及び/又はトリプトファン 2,3-ジオキシゲナーゼの阻害剤 |
| WO2021025554A1 (en) | 2019-08-02 | 2021-02-11 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Combination comprising an activator of the glucocorticoid receptor and an inhibitor of ifg-1 signaling for carcinoma treatment |
| WO2021025031A1 (ja) | 2019-08-05 | 2021-02-11 | 小野薬品工業株式会社 | 免疫チェックポイント阻害薬の有効性判定バイオマーカー |
| US11753406B2 (en) | 2019-08-09 | 2023-09-12 | Incyte Corporation | Salts of a PD-1/PD-L1 inhibitor |
| EP4017476A1 (en) | 2019-08-19 | 2022-06-29 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
| CN111909108B (zh) * | 2019-09-02 | 2023-05-02 | 中国药科大学 | 联苯类化合物及其制备方法和医药用途 |
| BR112022004316A2 (pt) | 2019-09-22 | 2022-06-21 | Bristol Myers Squibb Co | Caracterização espacial quantitativa para terapia de antagonista lag-3 |
| CN112574183B (zh) * | 2019-09-29 | 2022-07-08 | 南京华威医药科技集团有限公司 | 一种pd-1抑制剂及其制备方法和用途 |
| JP2022550427A (ja) | 2019-09-30 | 2022-12-01 | メッドシャイン ディスカバリー インコーポレイテッド | Pd-1/pd-l1小分子阻害剤としての化合物及びその使用 |
| HRP20241379T1 (hr) | 2019-09-30 | 2024-12-20 | Gilead Sciences, Inc. | Cjepiva za hbv i postupci za liječenje hbv |
| MX2022003578A (es) | 2019-09-30 | 2022-05-30 | Incyte Corp | Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores. |
| EP4037776A1 (en) * | 2019-10-04 | 2022-08-10 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| WO2021076565A1 (en) | 2019-10-16 | 2021-04-22 | Corcept Therapeutics Incorporated | Method of normalizing the neutrophil to lymphocyte ratio in cancer patients with a selective glucocorticoid receptor antagonist |
| MX2022004450A (es) | 2019-10-16 | 2022-05-03 | Chemocentryx Inc | Aminas de heteroaril-bifenilo para el tratamiento de enfermedades pd-l1. |
| CN114585359B (zh) | 2019-10-16 | 2025-08-12 | 凯莫森特里克斯股份有限公司 | 用于治疗pd-l1疾病的杂芳基联苯酰胺 |
| US20220280499A1 (en) | 2019-10-21 | 2022-09-08 | Stichting Het Nederlands Kanker Instituue-Antoni van Leeuwenhoek Ziekenhuis | Novel drug combinations for treatment of a carcinoma |
| KR20220093349A (ko) | 2019-11-08 | 2022-07-05 | 브리스톨-마이어스 스큅 컴퍼니 | 흑색종에 대한 lag-3 길항제 요법 |
| BR112022009031A2 (pt) | 2019-11-11 | 2022-10-11 | Incyte Corp | Sais e formas cristalinas de um inibidor de pd-1/pd-l1 |
| ES3022990T3 (en) | 2019-12-06 | 2025-05-29 | Prec Biosciences Inc | Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome |
| MX2022008016A (es) * | 2019-12-26 | 2022-07-27 | Adlai Nortye Biopharma Co Ltd | Compuesto antagonista de pd-l1. |
| CN113348170B (zh) | 2020-01-03 | 2023-12-22 | 上海翰森生物医药科技有限公司 | 联苯类衍生物抑制剂、其制备方法和应用 |
| CN111187172B (zh) * | 2020-01-20 | 2021-10-29 | 中国药科大学 | 硝基苯醚类化合物、其制备方法和药物组合物与用途 |
| EP4096663A4 (en) | 2020-01-29 | 2023-10-25 | Corcept Therapeutics Incorporated | TREATMENT OF CORTICOSADRENAL CARCINOMA USING SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS (SGRM) AND ANTIBODY CHECKPOINT INHIBITORS |
| WO2021171264A1 (en) | 2020-02-28 | 2021-09-02 | Novartis Ag | Dosing of a bispecific antibody that binds cd123 and cd3 |
| CA3175848A1 (en) * | 2020-03-11 | 2021-09-16 | Purdue Research Foundation | Compounds with immunomodulatory activity and therapeutic uses thereof |
| TWI845826B (zh) | 2020-03-20 | 2024-06-21 | 美商基利科學股份有限公司 | 4'-c-經取代-2-鹵基-2'-去氧腺苷核苷之前藥及其製造與使用方法 |
| CN111303122A (zh) * | 2020-04-07 | 2020-06-19 | 南方医科大学 | 一种泊马度胺衍生物及其用途 |
| JPWO2021205631A1 (OSRAM) | 2020-04-10 | 2021-10-14 | ||
| WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
| CN111333629B (zh) * | 2020-04-10 | 2021-03-05 | 颜建发 | 苯基-1h-吡唑类衍生物及其在抗肿瘤药物中的应用 |
| CN111559981B (zh) * | 2020-04-15 | 2023-08-01 | 杭州庆正鸿科技有限公司 | 一种联苯-嘧啶偶联物及其制备方法和应用 |
| EP4143344A1 (en) | 2020-04-27 | 2023-03-08 | Agendia N.V. | Treatment of her2 negative, mammaprint high risk 2 breast cancer |
| CN113563260A (zh) * | 2020-04-28 | 2021-10-29 | 药康众拓(江苏)医药科技有限公司 | 苯甲酰胺类化合物、制备方法及用途 |
| CN113582971B (zh) * | 2020-04-30 | 2023-10-20 | 北京康辰药业股份有限公司 | 一种小分子免疫抑制剂、其制备方法及其应用 |
| CN113943330A (zh) * | 2020-07-17 | 2022-01-18 | 中国科学院上海药物研究所 | 一类含糖结构化合物、其制备方法、药物组合物和用途 |
| CN114075123B (zh) * | 2020-08-11 | 2023-06-06 | 中国人民解放军军事科学院军事医学研究院 | 苄胺类衍生物及其制备方法与用途 |
| MX2023002332A (es) | 2020-08-28 | 2023-03-21 | Bristol Myers Squibb Co | Terapia con antagonistas del gen 3 de activacion de linfocitos (lag-3) para carcinoma hepatocelular. |
| CA3190660A1 (en) | 2020-08-31 | 2022-03-03 | George C. Lee | Cell localization signature and immunotherapy |
| WO2022052926A1 (zh) | 2020-09-09 | 2022-03-17 | 广州再极医药科技有限公司 | 芳香乙烯类化合物、其制备方法、中间体、药物组合物及其应用 |
| WO2022055542A1 (en) | 2020-09-10 | 2022-03-17 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing pd-1 antagonist prodrugs useful in the treatment of cancer and methods thereof |
| CA3196496A1 (en) | 2020-10-23 | 2022-04-28 | Laurence David TOMS | Lag-3 antagonist therapy for lung cancer |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
| TW202233615A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | Pd—1/pd—l1抑制劑之結晶形式 |
| MX2023005362A (es) | 2020-11-06 | 2023-06-22 | Incyte Corp | Proceso para hacer un inhibidor de proteina de muerte programada 1 (pd-1)/ligando de muerte programada 1 (pd-l1) y sales y formas cristalinas del mismo. |
| CN114507227B (zh) * | 2020-11-17 | 2024-06-21 | 中国医学科学院药物研究所 | 苯并异噻唑类化合物、及其制法和药物组合物与用途 |
| EP4251772A1 (en) | 2020-11-26 | 2023-10-04 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Personalized tumor markers |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| JP2024504923A (ja) | 2021-01-11 | 2024-02-02 | シンセカイン インコーポレイテッド | 受容体ペア形成に関する組成物および方法 |
| CN117677634A (zh) | 2021-03-05 | 2024-03-08 | 利达提斯有限公司 | 三聚体多肽及其在治疗癌症中的用途 |
| CN116981660A (zh) * | 2021-03-22 | 2023-10-31 | 南京明德新药研发有限公司 | 氟代乙烯基联苯衍生物及其应用 |
| CN113105431B (zh) * | 2021-03-24 | 2022-10-28 | 河北康泰药业有限公司 | 一种蛋白水解靶向嵌合体及其应用 |
| JP2024514245A (ja) | 2021-03-29 | 2024-03-29 | ジュノー セラピューティクス インコーポレイテッド | チェックポイント阻害剤療法とcar t細胞療法との組合せを用いた投薬および処置のための方法 |
| JP2024516194A (ja) * | 2021-04-22 | 2024-04-12 | ジュビラント・プロデル・エルエルシー | Pd1/pd-l1阻害剤としての化合物及びその方法 |
| CN113135895A (zh) * | 2021-04-30 | 2021-07-20 | 中国药科大学 | 一种新型联苯类衍生物及其制备方法与医药用途 |
| KR20240004801A (ko) * | 2021-05-05 | 2024-01-11 | 브리스톨-마이어스 스큅 컴퍼니 | 면역조절제로서 유용한 락톤 및 락탐 함유 화합물 |
| TW202348237A (zh) | 2021-05-13 | 2023-12-16 | 美商基利科學股份有限公司 | TLR8調節化合物及抗HBV siRNA療法之組合 |
| AU2022291381B2 (en) | 2021-06-11 | 2025-04-24 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-cancer agents |
| EP4351657A1 (en) | 2021-06-11 | 2024-04-17 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-body drug conjugates |
| WO2022266236A1 (en) * | 2021-06-18 | 2022-12-22 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
| CN117480155A (zh) | 2021-06-23 | 2024-01-30 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| EP4359415A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| CN117377671A (zh) | 2021-06-23 | 2024-01-09 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| JP7686091B2 (ja) | 2021-06-23 | 2025-05-30 | ギリアード サイエンシーズ, インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| IT202100016775A1 (it) * | 2021-06-25 | 2022-12-25 | Univ Degli Studi Milano | Derivati triazinici per il trattamento dei tumori e di disturbi neurodegenerativi |
| EP4370139A4 (en) | 2021-07-14 | 2025-10-15 | Synthekine Inc | METHODS AND COMPOSITIONS FOR USE IN CELL THERAPY FOR NEOPLASTIC DISEASE |
| CN114437051A (zh) * | 2021-09-18 | 2022-05-06 | 药康众拓(江苏)医药科技有限公司 | 一类联苯类化合物、其制备方法和用途 |
| WO2023057548A1 (en) | 2021-10-07 | 2023-04-13 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
| WO2023072924A1 (en) | 2021-10-26 | 2023-05-04 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
| KR20240090693A (ko) | 2021-10-28 | 2024-06-21 | 이도르시아 파마슈티컬스 리미티드 | Ccr6 수용체 조절인자 |
| CN118176214A (zh) | 2021-10-29 | 2024-06-11 | 百时美施贵宝公司 | 血液癌症的lag-3拮抗剂疗法 |
| WO2023080788A1 (en) | 2021-11-05 | 2023-05-11 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Tryptophan depletion induces production and presentation of tryptophan to phenylalanine substitutions |
| US20250144253A1 (en) | 2021-12-06 | 2025-05-08 | Helmholtz-Zentrum Dresden-Rossendorf E.V. | 3-((3-([1,1'-biphenyl]-3-ylmethoxy)phenoxy)methyl)benzonitrile derivatives and the use thereof |
| MX2024008831A (es) | 2022-01-26 | 2024-07-25 | Bristol Myers Squibb Co | Terapia combinada para carcinoma hepatocelular. |
| CN116768870A (zh) * | 2022-03-08 | 2023-09-19 | 中国科学院上海药物研究所 | 具有苄氧基芳基醚结构的化合物及其制备方法和用途 |
| WO2023192946A1 (en) | 2022-03-31 | 2023-10-05 | Ventana Medical Systems, Inc. | Methods and systems for predicting response to pd-1 axis directed therapeutics in colorectal tumors with deficient mismatch repair |
| CN119731651A (zh) | 2022-04-08 | 2025-03-28 | 百时美施贵宝公司 | 三级淋巴结构的机器学习标识、分类和量化 |
| WO2023224487A1 (en) | 2022-05-19 | 2023-11-23 | Agendia N.V. | Prediction of response to immune therapy in breast cancer patients |
| EP4282448A1 (en) | 2022-05-23 | 2023-11-29 | Danmarks Tekniske Universitet | Porous expanding biocompatible scaffolds |
| EP4282435A1 (en) | 2022-05-23 | 2023-11-29 | Danmarks Tekniske Universitet | Formulations of active pharmaceutical ingredients and excipients in icells via hydrophobic ion pairing |
| IL318949A (en) | 2022-08-23 | 2025-04-01 | Ono Pharmaceutical Co | Bispecific antibody |
| CN116283896B (zh) * | 2022-09-07 | 2024-10-29 | 广东晨康生物科技有限公司 | 一种具有pd-l1抑制活性的联苯类化合物及其用途 |
| CN115417870B (zh) * | 2022-09-20 | 2024-02-27 | 中国药科大学 | Pd-l1&nampt双靶点抑制剂和用途 |
| CN115477609B (zh) * | 2022-09-26 | 2024-03-12 | 浙江师范大学 | 基于疏水标签技术的pd-l1蛋白降解剂及其应用 |
| CN118265699A (zh) * | 2022-10-26 | 2024-06-28 | 西安新通药物研究股份有限公司 | 一种非对称性联苯衍生物及其制备方法与医药用途 |
| CN119768390A (zh) * | 2022-11-22 | 2025-04-04 | 西安新通药物研究股份有限公司 | 新型双环类pd-l1抑制剂及其制备方法与医药用途 |
| WO2024115549A1 (en) | 2022-11-30 | 2024-06-06 | Idorsia Pharmaceuticals Ltd | Aryl- and heteroaryl-sulfonamide derivatives as ccr8 modulators |
| KR20250116720A (ko) | 2022-12-06 | 2025-08-01 | 이도르시아 파마슈티컬스 리미티드 | Ccr6 길항제의 결정질 아디프산 염 형태 |
| WO2024137776A1 (en) | 2022-12-21 | 2024-06-27 | Bristol-Myers Squibb Company | Combination therapy for lung cancer |
| WO2024186917A2 (en) * | 2023-03-06 | 2024-09-12 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions for pd-l1 inhibition and methods of use thereof |
| WO2024183756A1 (zh) * | 2023-03-07 | 2024-09-12 | 上海再极医药科技有限公司 | 一种含苯环类化合物及其制备方法和应用 |
| WO2024196952A1 (en) | 2023-03-20 | 2024-09-26 | Bristol-Myers Squibb Company | Tumor subtype assessment for cancer therapy |
| GB202318675D0 (en) | 2023-12-06 | 2024-01-17 | Oncopeptides Ab | Novel polypeptides |
| WO2025159640A1 (en) | 2024-01-24 | 2025-07-31 | Agendia N.V. | Method for assessing a risk of breast cancer recurrence |
| WO2025198469A1 (en) | 2024-03-18 | 2025-09-25 | Agendia N.V. | Prediction of response to immune therapy in triple negative breast cancer patients. |
| CN117986158A (zh) * | 2024-04-03 | 2024-05-07 | 云南大学 | 取代联苯类化合物、制备方法及应用 |
| WO2025229177A1 (en) | 2024-05-02 | 2025-11-06 | Idorsia Pharmaceuticals Ltd | Crystalline forms of an n-substituted indole derivative |
| US20250345389A1 (en) | 2024-05-13 | 2025-11-13 | Gilead Sciences, Inc. | Combination therapies |
| WO2025240246A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| US20250345390A1 (en) | 2024-05-13 | 2025-11-13 | Gilead Sciences, Inc. | Combination therapies |
| WO2025240242A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| WO2025245489A1 (en) | 2024-05-24 | 2025-11-27 | Bristol-Myers Squibb Company | Treatment of tumors in subjects having fgl-1 positive samples |
| CN119350185A (zh) * | 2024-10-08 | 2025-01-24 | 聊城大学 | 一种联苯羟肟类衍生物及其制备方法和用途 |
| CN119350297B (zh) * | 2024-12-25 | 2025-04-04 | 浙江大学 | 一种特异性溶酶体靶向嵌合体分子及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994018167A1 (fr) * | 1993-02-01 | 1994-08-18 | Kaken Pharmaceutical Co., Ltd. | Derive de dibenzylamine substitue |
| US6297239B1 (en) * | 1997-10-08 | 2001-10-02 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| EP1481965B1 (en) | 2002-02-07 | 2015-07-29 | Hitoshi Endo | Aromatic amino acid derivatives and medicinal compositions |
| JPWO2004007439A1 (ja) | 2002-07-10 | 2005-11-10 | 住友製薬株式会社 | ビアリール誘導体 |
| US7960369B2 (en) | 2002-11-08 | 2011-06-14 | Takeda Pharmaceutical Company Limited | Receptor function regulator |
| TW200815377A (en) | 2006-04-24 | 2008-04-01 | Astellas Pharma Inc | Oxadiazolidinedione compound |
| US9321730B2 (en) * | 2007-08-21 | 2016-04-26 | The Hong Kong Polytechnic University | Method of making and administering quinoline derivatives as anti-cancer agents |
| TW200932219A (en) | 2007-10-24 | 2009-08-01 | Astellas Pharma Inc | Oxadiazolidinedione compound |
| WO2010059838A2 (en) * | 2008-11-20 | 2010-05-27 | Decode Genetics Ehf | Pde4 inhibitors selective for the long form of pde4 for treating inflammation and avoiding side effects |
| WO2011082400A2 (en) * | 2010-01-04 | 2011-07-07 | President And Fellows Of Harvard College | Modulators of immunoinhibitory receptor pd-1, and methods of use thereof |
| US9850225B2 (en) | 2014-04-14 | 2017-12-26 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
| US10745382B2 (en) | 2015-10-15 | 2020-08-18 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
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| EA201690316A1 (ru) | 2016-07-29 |
| AU2014315457A1 (en) | 2016-04-28 |
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| PE20160432A1 (es) | 2016-05-11 |
| EA029901B1 (ru) | 2018-05-31 |
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| CL2018000150A1 (es) | 2018-05-11 |
| KR102276644B1 (ko) | 2021-07-13 |
| JP2016536333A (ja) | 2016-11-24 |
| CN105705489B (zh) | 2019-04-26 |
| US9872852B2 (en) | 2018-01-23 |
| EP3041822A1 (en) | 2016-07-13 |
| CL2016000508A1 (es) | 2016-11-04 |
| AU2014315457B2 (en) | 2018-05-10 |
| BR112016004194A8 (pt) | 2020-02-11 |
| CN105705489A (zh) | 2016-06-22 |
| IL244346A0 (en) | 2016-04-21 |
| KR20160048946A (ko) | 2016-05-04 |
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