DK2573121T3 - Antistoffer, der binder IL-4 og/eller IL-13, og anvendelser deraf - Google Patents
Antistoffer, der binder IL-4 og/eller IL-13, og anvendelser deraf Download PDFInfo
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- DK2573121T3 DK2573121T3 DK12006790.5T DK12006790T DK2573121T3 DK 2573121 T3 DK2573121 T3 DK 2573121T3 DK 12006790 T DK12006790 T DK 12006790T DK 2573121 T3 DK2573121 T3 DK 2573121T3
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Claims (17)
1. Bispecifikt antistof eller antistoffragment deraf, der binder specifikt til IL-13 og IL-4, hvor det bispecifikke antistof eller antistoffragmentet deraf indeholder to lette kæder med strukturen N-VLhB-Bi3-linker-VLh8D4-8-CL-C og to tunge kæder med strukturen N-VHhB-Bi3-linker-VHh8D4-8-CHl-CH2-CH3-C, hvor CL er den lette kædes konstante region, VLhB-Bi3 er et humaniseret variabelt domæne af let kæde af anti-IL-13-antistof B-B13, VLh8D4-8 er et humaniseret variabelt domæne af let kæde af anti-IL-4-antistof 8D4-8, VHhB-Bi3 er et humaniseret variabelt domæne af tung kæde af anti-IL-13-antistof B-B13, og VHh8D4-8 er et humaniseret variabelt domæne af tung kæde af anti-IL-4-antistof 8D4-8; hvor: (i) VLhB-Bi3 omfatter aminosyresekvensen ifølge SEQ ID NO: 1, VLh8D4-8 omfatter aminosyresekvensen ifølge SEQ ID NO: 3, VHhB-Bi3 omfatter aminosyresekvensen ifølge SEQ ID NO: 2, og VHh8D4-8 omfatter aminosyresekvensen ifølge SEQ ID NO: 4; eller (ii) VLhB-Bi3 omfatter aminosyresekvensen ifølge SEQ ID NO: 1, VLh8D4-8 omfatter aminosyresekvensen ifølge SEQ ID NO: 3, VHhB-Bi3 omfatter aminosyresekvensen ifølge SEQ ID NO: 2, og VHh8D4-8 omfatter aminosyresekvensen ifølge SEQ ID NO: 5.
2. Bispecifikt antistof eller antistoffragment deraf ifølge krav 1, hvor linkerne kan ens eller forskellige fra hinanden mellem og inden for det tunge kædepolypeptid og det lette kædepolypeptid.
3. Bispecifikt antistof eller antistoffragment deraf ifølge krav 1 eller 2, hvor linkerne har en længde på 1 til 20 aminosyrer.
4. Bispecifikt antistof eller antistoffragment deraf ifølge et hvilket som helst af kravene 1 til 3, hvor linkerne omfatter peptidlinkerenheden med sekvensen [GGGGS].
5. Bispecifikt antistof eller antistoffragment deraf ifølge krav 4, hvor antallet af linkerenheder i den tunge kæde og i den lette kæde er ens (symmetrisk orden) eller forskelligt fra hinanden (asymmetrisk orden).
6. Bispecifikt antistof eller antistoffragment deraf ifølge et hvilket som helst af kravene 1 til 5, der yderligere omfatter domæner af konstant region, hvor domænerne af konstant region fortrinsvis består af CHI, CH2, CH3 og CL.
7. Bispecifikt antistof eller antistoffragment deraf ifølge et hvilket som helst af kravene 1 til 6, hvor antistoffet eller antistoffragmentet deraf neutraliserer IL-4- og/eller IL-13-aktivitet.
8. Bispecifikt antistof eller antistoffragment deraf ifølge et hvilket som helst af kravene 1 til 7, der er yderligere konjugeret til et effektormolekyle, hvor effektormolekylet fortrinsvis er valgt fra gruppen, der består af heterologe polypeptider, lægemidler, radioaktive nukleotider og toksiner.
9. Farmaceutisk sammensætning, der omfatter det bispecifikke antistof eller antistoffragmentet deraf ifølge et hvilket som helst af kravene 1 til 8 og et farmaceutisk acceptabelt bæremiddel.
10. Nukleinsyremolekyle, der koder for det bispecifikke antistof eller antistoffragmentet deraf ifølge et hvilket som helst af kravene 1 til 7.
11. Vektor, der omfatter nukleinsyremolekylet ifølge krav 10.
12. Værtscelle, der omfatter vektoren ifølge krav 11.
13. Fremgangsmåde til fremstilling af et bispecifikt antistof ifølge et hvilket som helst af kravene 1 til 7, der omfatter ekspression af nukleinsyremolekylet ifølge krav 10 i en egnet værtscelle.
14. Bispecifikt antistof eller antistoffragment ifølge et hvilket som helst af kravene 1 til 8 til anvendelse til behandling, suppression eller forebyggelse af en sygdom.
15. Bispecifikt antistof eller antistoffragment til anvendelse ifølge krav 14, hvor sygdommen er valgt fra gruppen, der består af en allergisk sygdom, astma, cancer, en autoimmun sygdom, sklerodermi og idiopatisk lungefibrose.
16. Anvendelse af det bispecifikke antistof eller antistoffragmentet ifølge et hvilket som helst af kravene 1 til 7 til forskning eller in vitro-diagnostiske anvendelser, hvor det bispecifikke antistof eller antistoffragmentet deraf omfatter et mærke, såsom et radioaktivt mærke, en fluorofor, en kromofor, et kontrastmiddel eller en metal-ion.
17. Kit, der omfatter det bispecifikke antistof eller antistoffragmentet deraf ifølge et hvilket som helst af kravene 1 til 8 og en brugsanvisning.
Applications Claiming Priority (3)
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EP07291259A EP2050764A1 (en) | 2007-10-15 | 2007-10-15 | Novel polyvalent bispecific antibody format and uses thereof |
US3712808P | 2008-03-17 | 2008-03-17 | |
EP08839958.9A EP2205640B1 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and/or il-13 and their uses |
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DK2573121T3 true DK2573121T3 (da) | 2017-12-04 |
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DK12006790.5T DK2573121T3 (da) | 2007-10-15 | 2008-10-14 | Antistoffer, der binder IL-4 og/eller IL-13, og anvendelser deraf |
DK12006789.7T DK2574629T3 (da) | 2007-10-15 | 2008-10-14 | Antistoffer, der binder il-4 og/eller il-13, og anvendelser deraf |
DK12006791.3T DK2574630T3 (da) | 2007-10-15 | 2008-10-14 | Antistoffer, der binder il-4 og/eller il-13, og anvendelser deraf |
DK12006797.0T DK2573119T3 (da) | 2007-10-15 | 2008-10-14 | Antistoffer, der binder IL-4 og/eller IL-13, og anvendelser deraf |
DK08839958.9T DK2205640T3 (da) | 2007-10-15 | 2008-10-14 | Antistoffer, der binder il-4 og/eller il-13, og anvendelser heraf |
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DK12006789.7T DK2574629T3 (da) | 2007-10-15 | 2008-10-14 | Antistoffer, der binder il-4 og/eller il-13, og anvendelser deraf |
DK12006791.3T DK2574630T3 (da) | 2007-10-15 | 2008-10-14 | Antistoffer, der binder il-4 og/eller il-13, og anvendelser deraf |
DK12006797.0T DK2573119T3 (da) | 2007-10-15 | 2008-10-14 | Antistoffer, der binder IL-4 og/eller IL-13, og anvendelser deraf |
DK08839958.9T DK2205640T3 (da) | 2007-10-15 | 2008-10-14 | Antistoffer, der binder il-4 og/eller il-13, og anvendelser heraf |
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