MX2019002307A - Anticuerpos multiespecificos que facilitan el emparejamiento selectivo de cadenas ligeras. - Google Patents
Anticuerpos multiespecificos que facilitan el emparejamiento selectivo de cadenas ligeras.Info
- Publication number
- MX2019002307A MX2019002307A MX2019002307A MX2019002307A MX2019002307A MX 2019002307 A MX2019002307 A MX 2019002307A MX 2019002307 A MX2019002307 A MX 2019002307A MX 2019002307 A MX2019002307 A MX 2019002307A MX 2019002307 A MX2019002307 A MX 2019002307A
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies
- chain pairing
- light chain
- relates
- multispecific antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/247—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Generalmente, la presente invención se refiere al campo de anticuerpos. En particular, se refiere a anticuerpos multiespecíficos, por ejemplo, anticuerpos biespecíficos, que se modifican de manera que el emparejamiento de cadenas deseado tiene lugar y/o puede seleccionarse. Específicamente, esto se consigue usando diferentes dominios de dimerización para el emparejamiento de cadenas ligeras. La invención se refiere además a ácidos nucleicos que codifican estos anticuerpos, vectores de expresión que comprenden estos ácidos nucleicos, células que los expresan, y además a composiciones farmacéuticas que comprenden los anticuerpos. La invención también se refiere a métodos para aislar los anticuerpos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16306087 | 2016-08-26 | ||
PCT/EP2017/071375 WO2018037092A1 (en) | 2016-08-26 | 2017-08-24 | Multispecific antibodies facilitating selective light chain pairing |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019002307A true MX2019002307A (es) | 2019-07-04 |
Family
ID=57130307
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019002307A MX2019002307A (es) | 2016-08-26 | 2017-08-24 | Anticuerpos multiespecificos que facilitan el emparejamiento selectivo de cadenas ligeras. |
Country Status (14)
Country | Link |
---|---|
US (1) | US11820809B2 (es) |
EP (1) | EP3504233B1 (es) |
JP (2) | JP7366742B2 (es) |
CN (1) | CN109641949B (es) |
AR (1) | AR109425A1 (es) |
AU (1) | AU2017315146A1 (es) |
BR (1) | BR112019003601A2 (es) |
CA (1) | CA3034768A1 (es) |
MX (1) | MX2019002307A (es) |
RS (1) | RS65405B1 (es) |
SG (1) | SG11201901557XA (es) |
TW (1) | TW201819410A (es) |
UY (1) | UY37377A (es) |
WO (1) | WO2018037092A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10982008B2 (en) * | 2014-12-05 | 2021-04-20 | Merck Patent Gmbh | Domain-exchanged antibody |
CN108601830B (zh) * | 2015-12-18 | 2023-02-03 | 比奥根Ma公司 | 双特异性抗体平台 |
CN111315767A (zh) | 2017-08-22 | 2020-06-19 | 萨纳生物有限责任公司 | 可溶性干扰素受体及其用途 |
US11965030B2 (en) | 2018-12-24 | 2024-04-23 | Sanofi | Multispecific binding proteins with mutant fab domains |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020062010A1 (en) * | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
BRPI0714893A2 (pt) * | 2006-09-05 | 2013-05-28 | Medarex Inc | anticorpo monoclonal isolado ou uma porÇço de ligaÇço ao seu antÍgeno, um fragmento de anticorpo, um anticorpo mimÉtico, imunoconjugado, composiÇço molÉcula de Ácido nuclÉico isolada, vetor de expressço, cÉlula hospedeira, mÉtodo para preparar um anticorpo anti-bmp2 ou anti-bmp4, mÉtodo para tratar ou prevenir uma doenÇa associada com formaÇço àssea normal e ossificaÇço, hibridoma e metodo para preparar o anticorpo |
EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
AU2009212747B2 (en) * | 2008-01-31 | 2013-11-07 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Engineered antibody constant domain molecules |
EP2210902A1 (en) | 2009-01-14 | 2010-07-28 | TcL Pharma | Recombinant monovalent antibodies |
DE102009047243A1 (de) * | 2009-11-27 | 2011-06-01 | Orgentec Diagnostika Gmbh | Monospezifische Polypeptidreagenzien |
PT2519543T (pt) | 2009-12-29 | 2016-10-07 | Emergent Product Dev Seattle | Proteínas de ligação de heterodímero e suas utilizações |
SI3095871T1 (sl) | 2010-02-08 | 2019-06-28 | Regeneron Pharmaceuticals, Inc. | Miš z navadno lahko verigo |
TWI622597B (zh) | 2011-03-28 | 2018-05-01 | 賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
WO2013156054A1 (en) | 2012-04-16 | 2013-10-24 | Universität Stuttgart | The igm and ige heavy chain domain 2 as covalently linked homodimerization modules for the generation of fusion proteins with dual specificity |
JP6196661B2 (ja) | 2012-04-20 | 2017-09-13 | スリップチップ, エルエルシー | サンプル調製または自律分析のための流体デバイスおよびシステム |
BR112016006929A2 (pt) * | 2013-10-11 | 2017-09-19 | Hoffmann La Roche | Anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, métodos de preparação de anticorpo, de tratamento de pacientes e de geração de um anticorpo, composição farmacêutica e uso do anticorpo |
US20180194861A1 (en) * | 2015-07-10 | 2018-07-12 | Abbvie Inc. | IgM- or IgE-Modified Binding Proteins and Uses Thereof |
CN108601830B (zh) * | 2015-12-18 | 2023-02-03 | 比奥根Ma公司 | 双特异性抗体平台 |
GB201610198D0 (en) * | 2016-06-10 | 2016-07-27 | Ucb Biopharma Sprl | Anti-ige antibodies |
-
2017
- 2017-08-24 UY UY0001037377A patent/UY37377A/es not_active Application Discontinuation
- 2017-08-24 MX MX2019002307A patent/MX2019002307A/es unknown
- 2017-08-24 WO PCT/EP2017/071375 patent/WO2018037092A1/en unknown
- 2017-08-24 JP JP2019511358A patent/JP7366742B2/ja active Active
- 2017-08-24 EP EP17758138.6A patent/EP3504233B1/en active Active
- 2017-08-24 SG SG11201901557XA patent/SG11201901557XA/en unknown
- 2017-08-24 RS RS20240436A patent/RS65405B1/sr unknown
- 2017-08-24 CA CA3034768A patent/CA3034768A1/en not_active Abandoned
- 2017-08-24 CN CN201780052194.1A patent/CN109641949B/zh active Active
- 2017-08-24 AU AU2017315146A patent/AU2017315146A1/en not_active Abandoned
- 2017-08-24 BR BR112019003601-6A patent/BR112019003601A2/pt not_active IP Right Cessation
- 2017-08-25 TW TW106128777A patent/TW201819410A/zh unknown
- 2017-08-25 AR ARP170102367A patent/AR109425A1/es unknown
- 2017-08-25 US US15/687,055 patent/US11820809B2/en active Active
-
2022
- 2022-02-28 JP JP2022028783A patent/JP2022071047A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN109641949B (zh) | 2023-09-15 |
EP3504233A1 (en) | 2019-07-03 |
JP2022071047A (ja) | 2022-05-13 |
WO2018037092A1 (en) | 2018-03-01 |
CN109641949A (zh) | 2019-04-16 |
AR109425A1 (es) | 2018-11-28 |
UY37377A (es) | 2018-03-23 |
TW201819410A (zh) | 2018-06-01 |
AU2017315146A1 (en) | 2019-04-11 |
EP3504233C0 (en) | 2024-01-17 |
JP2019533986A (ja) | 2019-11-28 |
SG11201901557XA (en) | 2019-03-28 |
JP7366742B2 (ja) | 2023-10-23 |
US11820809B2 (en) | 2023-11-21 |
CA3034768A1 (en) | 2018-03-01 |
BR112019003601A2 (pt) | 2019-05-21 |
RS65405B1 (sr) | 2024-05-31 |
EP3504233B1 (en) | 2024-01-17 |
US20180057567A1 (en) | 2018-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2019002946A (es) | Anticuerpos anti-pd-1 y sus usos. | |
PH12019501357A1 (en) | Anti-ox40 antibodies and their uses | |
MX2018003936A (es) | Anticuerpos anti proteina de muerte celular programada 1 (pd-1) y composiciones. | |
PH12018500711A1 (en) | Anti-pd1 antibodies and methods of use | |
PH12018502456A1 (en) | Anti-cd04 antibodies and their uses | |
PH12019500923A1 (en) | Anti-pd-1 antibodies and compositions | |
PH12018500707A1 (en) | Anti-human cd19 antibodies with high affinity | |
MX2017006802A (es) | Animales no humanos que expresan el complejo cd3 humanizado. | |
MX2019010922A (es) | Anticuerpos anti-phf-tau y usos de estos. | |
EA201890285A1 (ru) | Антитела против pd-1, активируемые антитела против pd-1 и способы их применения | |
MX2017003847A (es) | Proteinas biespecificas activables por proteasas. | |
MX2018003183A (es) | Proteinas de enlace de antigeno biespecifico y tetraespecifico tetravalentes y usos de las mismas. | |
GB2547587A (en) | Transgenic mice | |
MX2016016883A (es) | Anticuerpo anti-axl. | |
MX2022001085A (es) | Anticuerpos anti-c1s humanizados y metodos para usarlos. | |
EA201892820A1 (ru) | Способ стабилизации белков | |
MX2019002307A (es) | Anticuerpos multiespecificos que facilitan el emparejamiento selectivo de cadenas ligeras. | |
JOP20210010A1 (ar) | بروتينات مخصصة ل baff و b7rp1 وإستخداماتها | |
MX2019013124A (es) | Proteinas de fusion de inhibidor de tripsina urinaria (uti). | |
PH12017502277A1 (en) | Multi-specific binding proteins | |
MX2019005933A (es) | Polipeptidos biespecificos para gitr y ctla-4. |