DE60224842T2 - Mikronadel-vorrichtungen und verfahren zur herstellung - Google Patents

Mikronadel-vorrichtungen und verfahren zur herstellung Download PDF

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Publication number
DE60224842T2
DE60224842T2 DE60224842T DE60224842T DE60224842T2 DE 60224842 T2 DE60224842 T2 DE 60224842T2 DE 60224842 T DE60224842 T DE 60224842T DE 60224842 T DE60224842 T DE 60224842T DE 60224842 T2 DE60224842 T2 DE 60224842T2
Authority
DE
Germany
Prior art keywords
substrate
microneedle
cover
microneedles
capillary volume
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60224842T
Other languages
German (de)
English (en)
Other versions
DE60224842D1 (de
Inventor
Patrick R. Saint Paul Fleming
Michael D. Saint Paul Delmore
Luther E. Saint Paul ERICKSON
Richard H. Saint Paul FERBER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Application granted granted Critical
Publication of DE60224842D1 publication Critical patent/DE60224842D1/de
Publication of DE60224842T2 publication Critical patent/DE60224842T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150572—Pierceable protectors, e.g. shields, caps, sleeves or films, e.g. for hygienic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150694—Procedure for removing protection means at the time of piercing
    • A61B5/150717—Procedure for removing protection means at the time of piercing manually removed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Optics & Photonics (AREA)
  • Manufacturing & Machinery (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60224842T 2002-01-15 2002-11-26 Mikronadel-vorrichtungen und verfahren zur herstellung Expired - Lifetime DE60224842T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51745 2002-01-15
US10/051,745 US6908453B2 (en) 2002-01-15 2002-01-15 Microneedle devices and methods of manufacture
PCT/US2002/037920 WO2003059431A1 (en) 2002-01-15 2002-11-26 Microneedle devices and methods of manufacture

Publications (2)

Publication Number Publication Date
DE60224842D1 DE60224842D1 (de) 2008-03-13
DE60224842T2 true DE60224842T2 (de) 2009-01-22

Family

ID=21973131

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60224842T Expired - Lifetime DE60224842T2 (de) 2002-01-15 2002-11-26 Mikronadel-vorrichtungen und verfahren zur herstellung

Country Status (8)

Country Link
US (2) US6908453B2 (https=)
EP (1) EP1465698B1 (https=)
JP (1) JP4382492B2 (https=)
AT (1) ATE384549T1 (https=)
AU (1) AU2002359490A1 (https=)
DE (1) DE60224842T2 (https=)
IL (1) IL162554A0 (https=)
WO (1) WO2003059431A1 (https=)

Families Citing this family (236)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
KR20120087197A (ko) * 2002-07-19 2012-08-06 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로 니들 장치, 마이크로 니들 장치를 사용하는 방법 및 마이크로 니들 장치를 송출하는 방법
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
WO2005020912A2 (en) * 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
CA2536443A1 (en) * 2003-08-26 2005-03-03 Alza Corporation Device and method for intradermal cell implantation
US7378451B2 (en) * 2003-10-17 2008-05-27 3M Innovative Properties Co Surfactant composition having stable hydrophilic character
WO2005044364A1 (en) * 2003-11-10 2005-05-19 Agency For Science, Technology And Research Microneedles and microneedle fabrication
WO2005060621A2 (en) * 2003-11-21 2005-07-07 The Regents Of The University Of California Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles
US7361182B2 (en) * 2003-12-19 2008-04-22 Lightnix, Inc. Medical lancet
US20070083151A1 (en) * 2003-12-29 2007-04-12 Carter Chad J Medical devices and kits including same
US7150726B2 (en) * 2004-01-23 2006-12-19 Norfolk Medical Device for subcutaneous infusion of fluids
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US8551391B2 (en) * 2004-02-17 2013-10-08 Avery Dennison Corporation Method of making microneedles
EP1718452A1 (en) * 2004-02-23 2006-11-08 3M Innovative Properties Company Method of molding for microneedle arrays
JP4500851B2 (ja) * 2004-03-12 2010-07-14 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 横穴付きマイクロ針の製造に使用するための方法および型
JP4981660B2 (ja) * 2004-04-12 2012-07-25 アラーガン、インコーポレイテッド マルチサイト注射システム
EP1773444B1 (en) * 2004-06-10 2017-09-20 3M Innovative Properties Company Patch application device and kit
EP1789127A2 (en) * 2004-08-05 2007-05-30 Apogee Technology, Inc. System and method for drug delivery and microfluidic applications using microneedles
WO2006016364A2 (en) * 2004-08-10 2006-02-16 Hellman De Picciotto, Tania Drug delivery devices
EP1790375A4 (en) * 2004-08-12 2009-06-17 Hisamitsu Pharmaceutical Co TRANSDERMAL MEDICINE ADMINISTRATION WITH MICRONADEL
EP2272430A1 (en) 2004-08-16 2011-01-12 Functional Microstructures Limited Method of producing a microneedle or microimplant
AR050608A1 (es) * 2004-08-19 2006-11-08 Alza Corp Aparato y metodo para administracion transdermica de factores de crecimiento endotelial vascular
KR20130026511A (ko) 2004-11-18 2013-03-13 쓰리엠 이노베이티브 프로퍼티즈 컴파니 로우-프로파일 미세 바늘 어레이 인가 장치
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
AU2005306429B2 (en) 2004-11-18 2011-04-14 3M Innovative Properties Company Microneedle array applicator and retainer
EP2388078B1 (en) 2004-11-18 2013-03-20 3M Innovative Properties Co. Method of contact coating a microneedle array
KR101224257B1 (ko) * 2004-11-18 2013-01-18 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로니들 어레이를 코팅하기 위한 마스킹 방법
US20080009801A1 (en) * 2004-12-02 2008-01-10 Nickel Janice H Method for dispensing material into a drug delivery device
WO2006062974A2 (en) 2004-12-07 2006-06-15 3M Innovative Properties Company Method of molding a microneedle
US20080108958A1 (en) 2004-12-10 2008-05-08 3M Innovative Properties Company Medical Device
JP4793806B2 (ja) * 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
EP1898807A1 (en) * 2005-03-28 2008-03-19 Alza Corporation Microprojections with capillary control features and method
WO2006105146A2 (en) * 2005-03-29 2006-10-05 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
EP1871459B1 (en) 2005-04-07 2019-06-19 3M Innovative Properties Company System for tool feedback sensing
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US7442029B2 (en) * 2005-05-16 2008-10-28 Asml Netherlands B.V. Imprint lithography
US20080195035A1 (en) * 2005-06-24 2008-08-14 Frederickson Franklyn L Collapsible Patch and Method of Application
WO2007002521A2 (en) * 2005-06-27 2007-01-04 3M Innovative Properties Company Microneedle array applicator device
ATE477833T1 (de) * 2005-06-27 2010-09-15 3M Innovative Properties Co Mikronadelkartuschenanordnung
US20070004989A1 (en) * 2005-06-29 2007-01-04 Parvinder Dhillon Device for transdermal sampling
EP1925336A4 (en) 2005-09-15 2011-01-19 Tti Ellebeau Inc ROD TYPE IONTOPHORESIS APPARATUS
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
WO2007038028A1 (en) * 2005-09-28 2007-04-05 Tti Ellebeau, Inc. Iontophoresis apparatus and method to deliver active agents to biological interfaces
JP2009509685A (ja) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 損傷組織の治癒を増強するための血管新生因子の送達のためのイオントフォレーシス装置及び方法
JP2009509677A (ja) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 小胞封入活性物質のイオントフォレーシス送達
JP2009509657A (ja) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 生体界面への活性物質の送達のイオントフォレーシス装置及び方法
CA2629193C (en) * 2005-11-18 2016-03-29 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
US20080319404A1 (en) * 2005-12-21 2008-12-25 Pekurovsky Mikhail L Microneedle Devices
US7848801B2 (en) * 2005-12-30 2010-12-07 Tti Ellebeau, Inc. Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
ATE532553T1 (de) * 2006-02-10 2011-11-15 Hisamitsu Pharmaceutical Co Transdermales arzneiverabreichungsgerät mit mikronadeln
EP1820441A1 (de) * 2006-02-16 2007-08-22 Roche Diagnostics GmbH Mikronadelanordnung mit Sensor basierend auf der abgeschwächten Totalreflexion (ATR)
US7699819B2 (en) 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
WO2007123707A1 (en) * 2006-03-30 2007-11-01 Tti Ellebeau, Inc. Controlled release membrane and methods of use
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
DE102006028782A1 (de) * 2006-06-23 2007-12-27 Robert Bosch Gmbh Vorrichtung zur Aufbewahrung und Transport von Mikronadeln und ein Verfahren zur Verabreichung von Wirkstoffen mittels einer solchen Vorrichtung
US8250729B2 (en) * 2006-07-12 2012-08-28 University Of Utah Research Foundation 3D fabrication of needle tip geometry and knife blade
US20090326441A1 (en) * 2006-08-01 2009-12-31 Agency For Science ,Technology And Research Ultrasonic Enhanced Microneedles
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
ATE547985T1 (de) 2006-09-04 2012-03-15 Hoffmann La Roche Verpackung für hydrophile medizinische instrumente
US20080097352A1 (en) * 2006-09-12 2008-04-24 Beck Patricia A Methods of fabricating microneedles with bio-sensory functionality
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
PT2468300T (pt) 2006-09-26 2018-01-30 Infectious Disease Res Inst Composição para vacina contendo adjuvante sintético
JP4954656B2 (ja) * 2006-09-28 2012-06-20 凸版印刷株式会社 針状体および針状体の製造方法
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
EP2069013A2 (en) 2006-10-02 2009-06-17 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
WO2008062832A1 (en) * 2006-11-22 2008-05-29 Toppan Printing Co., Ltd. Microneedle array and process for production thereof
US8062783B2 (en) 2006-12-01 2011-11-22 Tti Ellebeau, Inc. Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
JP5297595B2 (ja) * 2007-03-20 2013-09-25 凸版印刷株式会社 針状体および針状体製造方法
US8439861B2 (en) * 2007-04-24 2013-05-14 Velcro Industries B.V. Skin penetrating touch fasteners
TW200841866A (en) * 2007-04-25 2008-11-01 Micro Base Technology Corp Cosmetic or medical patch structure
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
US20090053673A1 (en) * 2007-08-23 2009-02-26 Zimmer, Inc. Method for localized treatment of periodontal tissue
US9549746B2 (en) * 2007-09-28 2017-01-24 The Queen's University Of Belfast Delivery device and method
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
EP2247527A4 (en) 2008-02-07 2014-10-29 Univ Queensland MANUFACTURE OF TRANSDERMAL STAMP
US8398397B2 (en) * 2008-03-12 2013-03-19 Ultradent Products, Inc. Dental intraligamentary injection needles and related methods of manufacture
US20090259176A1 (en) * 2008-04-09 2009-10-15 Los Gatos Research, Inc. Transdermal patch system
US8012329B2 (en) 2008-05-09 2011-09-06 3M Innovative Properties Company Dimensional control in electroforms
AU2009250341A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection using a needle projection patch
WO2010022326A2 (en) * 2008-08-22 2010-02-25 Us Worldmeds Llc Transdermal delivery of apomorphine using microneedles
JP2012509106A (ja) 2008-11-18 2012-04-19 スリーエム イノベイティブ プロパティズ カンパニー 中空のマイクロニードルアレイ及び方法
RU2514896C2 (ru) 2008-12-02 2014-05-10 Аллерган, Инк. Устройство для инъекций
US8615295B2 (en) 2009-03-17 2013-12-24 Cardiothrive, Inc. External defibrillator
US8781576B2 (en) 2009-03-17 2014-07-15 Cardiothrive, Inc. Device and method for reducing patient transthoracic impedance for the purpose of delivering a therapeutic current
KR101033514B1 (ko) * 2009-06-02 2011-05-09 (주)마이티시스템 유연한 미세바늘 패치 시스템 및 그 제작방법
CN102481312B (zh) 2009-06-05 2015-07-15 传染性疾病研究院 合成的吡喃葡萄糖脂佐剂
US8062568B2 (en) * 2009-08-27 2011-11-22 Korea University Research And Business Foundation Nano pattern writer
US20110319742A1 (en) * 2009-09-08 2011-12-29 SensiVida Medical Technologies, Inc. Spatial imaging methods for biomedical monitoring and systems thereof
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
AU2010313487A1 (en) 2009-10-26 2012-05-24 Emkinetics, Inc. Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
DE102009046581A1 (de) 2009-11-10 2011-05-12 Robert Bosch Gmbh Herstellungsverfahren für eine poröse Mikronadelanordnung und entsprechende poröse Mikronadelanordnung und entsprechender Substratverbund
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
USD619245S1 (en) 2010-01-08 2010-07-06 Ratio, Inc. Drug delivery device
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
USD638534S1 (en) 2010-01-08 2011-05-24 Ratio, Inc. Drug delivery device
GB2478363A (en) * 2010-03-05 2011-09-07 Ndm Technologies Ltd Microneedle patch and method of manufacture
JP5423522B2 (ja) * 2010-03-25 2014-02-19 日本電気株式会社 モジュール及びモジュール製造方法
EP2563455A4 (en) 2010-04-28 2014-02-19 Kimberly Clark Co METHOD FOR INCREASING THE PERMEABILITY OF AN EPITHELIAL BARRIER
CA2797204C (en) 2010-04-28 2018-06-12 Kimberly-Clark Worldwide, Inc. Device for delivery of rheumatoid arthritis medication
MX2012012317A (es) 2010-04-28 2012-11-21 Kimberly Clark Co Arreglo de microagujas moldeado por inyeccion y metodo para formar el arreglo de microagujas.
FR2959599B1 (fr) * 2010-04-28 2013-12-20 Commissariat Energie Atomique Dispositif et procede de texturation mecanique d'une plaquette de silicium destinee a constituer une cellule photovoltaique, plaquette de silicium obtenue
JP5860033B2 (ja) 2010-04-28 2016-02-16 キンバリー クラーク ワールドワイド インコーポレイテッド ｓｉＲＮＡ送達用の医療デバイス
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
US20120089118A1 (en) * 2010-10-08 2012-04-12 A Nevada Corporation Delivery of bisphosphonates by microinjection systems
US8668675B2 (en) 2010-11-03 2014-03-11 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
WO2012141984A1 (en) 2011-04-08 2012-10-18 Immune Design Corp. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
US8636696B2 (en) * 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
JP2014236758A (ja) * 2011-09-30 2014-12-18 テルモ株式会社 センサ
WO2013053022A1 (en) 2011-10-12 2013-04-18 The University Of Queensland Delivery device
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
MX343262B (es) 2011-10-27 2016-10-28 Kimberly Clark Co Administración transdérmica de agentes bioactivos de alta viscosidad.
PL2811981T3 (pl) 2012-02-07 2019-09-30 Infectious Disease Research Institute Ulepszone formulacje adiuwantowe zawierające agonistę TLR4 oraz sposoby ich zastosowania
EP4112112A1 (en) 2012-05-01 2023-01-04 University of Pittsburgh - Of the Commonwealth System of Higher Education Tip-loaded microneedle arrays for transdermal insertion
KR102136433B1 (ko) 2012-05-16 2020-07-22 이뮨 디자인 코포레이션 Hsv-2 백신
JP5903016B2 (ja) * 2012-06-27 2016-04-13 コスメディ製薬株式会社 マイクロニードルパッチの保護離型シート
EP2872222B1 (en) 2012-07-06 2023-05-31 The General Hospital Corporation Method and apparatus for dermatological treatment
US9675288B2 (en) 2013-01-29 2017-06-13 Hewlett-Packard Development Company, L.P. Apparatus having surface-enhanced spectroscopy elements on an exterior surface
CN103157178B (zh) * 2013-02-05 2014-12-31 北京化工大学 精确控制微针插入长度的印章式工具
EP2958533B8 (en) 2013-02-20 2022-02-16 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
ITMI20130586A1 (it) * 2013-04-11 2014-10-12 Azienda Ospedaliero Universitaria P Isana Microago e matrice di microaghi per uso medicale, e processo di produzione di detta matrice
EP2986303B1 (en) 2013-04-18 2020-02-26 Immune Design Corp. Gla monotherapy for use in cancer treatment
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
KR20160019944A (ko) * 2013-06-13 2016-02-22 마이크로데믹스 인코퍼레이티드 금속 마이크로니들
US10279189B2 (en) 2013-06-14 2019-05-07 Cardiothrive, Inc. Wearable multiphasic cardioverter defibrillator system and method
US10149973B2 (en) 2013-06-14 2018-12-11 Cardiothrive, Inc. Multipart non-uniform patient contact interface and method of use
US9656094B2 (en) 2013-06-14 2017-05-23 Cardiothrive, Inc. Biphasic or multiphasic pulse generator and method
US9616243B2 (en) 2013-06-14 2017-04-11 Cardiothrive, Inc. Dynamically adjustable multiphasic defibrillator pulse system and method
US9907970B2 (en) 2013-06-14 2018-03-06 Cardiothrive, Inc. Therapeutic system and method using biphasic or multiphasic pulse waveform
US9833630B2 (en) 2013-06-14 2017-12-05 Cardiothrive, Inc. Biphasic or multiphasic pulse waveform and method
EP3030175B1 (en) 2013-08-09 2023-10-04 Cytrellis Biosystems, Inc. Apparatuses for skin treatment using non-thermal tissue ablation
KR101511850B1 (ko) * 2013-10-10 2015-04-16 (주)엠큐어 멀티니들허브를 갖는 피부재생기
US10953143B2 (en) 2013-12-19 2021-03-23 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
CA2935722A1 (en) 2014-01-21 2015-07-30 Immune Design Corp. Compositions for use in the treatment of allergic conditions
WO2015129894A1 (ja) 2014-02-27 2015-09-03 凸版印刷株式会社 マイクロニードルユニット、および、マイクロニードル用容器
KR20160138152A (ko) * 2014-03-26 2016-12-02 니혼샤신 인사츠 가부시키가이샤 추체상 돌기 시트의 곤포체 및 그 제조 방법
CN106163607B (zh) * 2014-04-30 2018-03-27 金伯利-克拉克环球有限公司 披盖的微针阵列
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
US9987427B1 (en) 2014-06-24 2018-06-05 National Technology & Engineering Solutions Of Sandia, Llc Diagnostic/drug delivery “sense-respond” devices, systems, and uses thereof
US10321858B2 (en) 2014-08-18 2019-06-18 Proteadx, Inc. Apparatus and methods for transdermal sensing of analytes in interstitial fluid and associated data transmission systems
US9933387B1 (en) 2014-09-07 2018-04-03 Biolinq, Inc. Miniaturized sub-nanoampere sensitivity low-noise potentiostat system
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
JP6906885B2 (ja) 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
KR102670286B1 (ko) 2014-11-14 2024-05-30 사이트렐리스 바이오시스템즈, 인크. 피부 절제를 위한 디바이스 및 방법
WO2016121499A1 (ja) * 2015-01-27 2016-08-04 凸版印刷株式会社 経皮投与デバイス
AU2016214968B2 (en) 2015-02-02 2021-02-25 Vaxxas Pty Limited Microprojection array applicator and method
AU2016229013B2 (en) 2015-03-10 2020-05-21 Allergan Sales, Llc Multiple needle injector
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
JP6505210B2 (ja) 2015-04-27 2019-04-24 株式会社Ｑｕａｒｒｙｍｅｎ＆Ｃｏ． シート状小片、その小片を含む発毛促進用シート、並びに、その小片を含む美白及び皺改善剤
JP6646985B2 (ja) * 2015-09-08 2020-02-14 花王株式会社 微細突起具の製造方法
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
EP3355981B1 (en) 2015-09-28 2025-11-19 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
JP6461761B2 (ja) * 2015-10-06 2019-01-30 富士フイルム株式会社 経皮吸収シートの製造方法
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
WO2017095321A1 (en) 2015-12-04 2017-06-08 Ascilion Ab A microneedle and a chip
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
AU2017245174A1 (en) 2016-03-29 2018-10-04 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
RU2725968C2 (ru) 2016-04-08 2020-07-07 Аллерган, Инк. Аспирационно-инъекционное устройство
EP3451928B1 (en) 2016-05-04 2020-04-15 midge medical GmbH Body fluid extraction device
US10092207B1 (en) 2016-05-15 2018-10-09 Biolinq, Inc. Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
DK3458475T3 (da) 2016-05-16 2022-09-12 Access To Advanced Health Inst Formulering, der indeholder tlr-agonist, og anvendelsesfremgangsmåder
US11266602B2 (en) 2016-05-16 2022-03-08 Infectious Disease Research Institute PEGylated liposomes and methods of use
AU2017273650B2 (en) 2016-06-01 2022-08-18 Access To Advanced Health Institute Nanoalum particles containing a sizing agent
JP6300864B2 (ja) * 2016-08-09 2018-03-28 ヒューレット−パッカード デベロップメント カンパニー エル．ピー．Ｈｅｗｌｅｔｔ‐Ｐａｃｋａｒｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏｍｐａｎｙ， Ｌ．Ｐ． 外面に表面増感分光法要素を有する装置
CN109922740B (zh) 2016-09-21 2022-08-23 希特利斯生物系统有限公司 用于美容皮肤重建的装置和方法
AU2017360346B2 (en) 2016-11-21 2023-11-23 Eirion Therapeutics, Inc. Transdermal delivery of large agents
KR20190070335A (ko) * 2016-11-23 2019-06-20 유니버시티 메디컬 파마슈티컬스 코퍼레이션 미세바늘 전달 시스템 및 방법
JP6977258B2 (ja) * 2016-12-20 2021-12-08 株式会社リコー 中空構造体
EP3338832A1 (en) * 2016-12-23 2018-06-27 Sanofi-Aventis Deutschland GmbH Medicament delivery device
US12109032B1 (en) 2017-03-11 2024-10-08 Biolinq Incorporated Methods for achieving an isolated electrical interface between an anterior surface of a microneedle structure and a posterior surface of a support structure
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
EP3606760B1 (en) 2017-03-31 2023-09-27 Vaxxas Pty Limited Device and method for coating surfaces
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
AU2018283973B2 (en) 2017-06-11 2025-04-24 Molecular Express, Inc. Methods and compositions for substance use disorder vaccine formulations and uses thereof
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
JP6931222B2 (ja) * 2017-07-18 2021-09-01 コスメディ製薬株式会社 マイクロニードルアレイの発泡支持体シート
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
US12599337B1 (en) 2017-08-08 2026-04-14 Biolinq Incorporated Method and system for confirmation of microneedle-based analyte-selective sensor insertion into viable tissue via electrical interrogation
US11766203B2 (en) 2017-09-13 2023-09-26 National Technology & Engineering Solutions Of Sandia, Llc Coaxial microneedle assemblies and methods thereof
TWI667016B (zh) * 2017-11-20 2019-08-01 研能科技股份有限公司 血糖監測控制系統
US12433510B2 (en) 2017-12-21 2025-10-07 Georgia Tech Research Corporation Methods and systems for improved collection of interstitial fluid
US10828500B2 (en) 2017-12-22 2020-11-10 Cardiothrive, Inc. External defibrillator
SG10201800072YA (en) * 2018-01-03 2019-08-27 Micropoint Tech Pte Ltd Microneedle Patches Comprising Corticosteroid
US10918839B2 (en) * 2018-03-13 2021-02-16 II Jaro Mayda Balloon catheter
JP7055861B2 (ja) * 2018-03-30 2022-04-18 富士フイルム株式会社 マイクロニードルアレイの製造方法
USD875254S1 (en) 2018-06-08 2020-02-11 Biolinq, Inc. Intradermal biosensor
CA3112549A1 (en) 2018-09-13 2020-03-19 Eirion Therapeutics, Inc. Uses of plasminogen activator inhibitor 1 (pai-1) inhibitors
BR112021004542A2 (pt) 2018-09-13 2021-06-08 Eirion Therapeutics, Inc. inibidores do inibidor de ativador de plasminogênio 1 (pai-1) e usos para os mesmos
AU2019353531B2 (en) 2018-10-02 2025-02-06 WearOptimo Pty Ltd Electrode arrangement
US20210338158A1 (en) 2018-10-02 2021-11-04 WearOptimo Pty Ltd Measurement system
AU2019352635B2 (en) 2018-10-02 2024-12-19 WearOptimo Pty Ltd Actuator system
WO2020069568A1 (en) 2018-10-02 2020-04-09 WearOptimo Pty Ltd Treatment delivery system
BR112021009554A2 (pt) 2018-12-03 2021-08-17 Eirion Therapeutics, Inc. aplicação melhorada de agentes grandes
JP7666887B2 (ja) * 2018-12-21 2025-04-22 ロレアル マイクロニードルシートを使用するキット及び美容方法
CA3139983A1 (en) 2019-05-14 2020-11-19 Eirion Therapeutics, Inc. Delaying peak effect and/or extending duration of response
CN111939452A (zh) * 2019-05-15 2020-11-17 微邦科技股份有限公司 微针结构及其生物可降解微针
TWI687247B (zh) * 2019-05-15 2020-03-11 微邦科技股份有限公司 微針結構及其生物可降解微針
CN113874065A (zh) 2019-05-16 2021-12-31 联邦高等教育系统匹兹堡大学 用于皮肤和非皮肤药物递送的具有底切特征的微针阵列
EP3772331A1 (fr) * 2019-08-08 2021-02-10 PKvitality Systeme de surveillance corporelle comprenant une microaiguille
CN110711312B (zh) * 2019-11-07 2021-07-30 河南大学 基于微机电系统的强促渗透皮释药微系统及其制造方法
BR112022022039A2 (pt) 2020-04-28 2022-12-13 Ticona Llc Conjunto de microagulhas
CA3163460A1 (en) 2020-07-29 2022-02-03 Joshua Ray Windmiller Continuous analyte monitoring system with microneedle array
WO2022118859A1 (ja) * 2020-12-01 2022-06-09 三井化学株式会社 マイクロニードルアレイ、マイクロニードルアレイアセンブリ、及び検査チップ
US12582337B2 (en) 2020-12-03 2026-03-24 Biolinq Incorporated Solid-state substrate-integrated reference electrode and counter electrode
CN117120087A (zh) 2020-12-23 2023-11-24 高级健康研究所 茄尼醇疫苗助剂及其制备方法
CN112858430B (zh) * 2021-01-08 2021-11-26 中山大学 一种检测植物活性小分子的传感器和制备方法
USD988160S1 (en) * 2021-03-16 2023-06-06 Biolinq Incorporated Wearable dermal sensor
SE545874C2 (en) 2021-05-08 2024-02-27 Biolinq Incorporated Fault detection for microneedle array based continuous analyte monitoring device
US20250082236A1 (en) * 2021-07-19 2025-03-13 Carnegie Mellon University Scalable Manufacturing of Microneedle Arrays Using Automated High-Throughput Manufacturing Systems and High-Capacity Molding
CN113499537A (zh) * 2021-09-03 2021-10-15 河南佳普医药科技有限公司 一种微针透皮给药装置
JP7141625B1 (ja) * 2021-09-17 2022-09-26 リンテック株式会社 マイクロニードルパッチ及びマイクロニードル構造体
USD996999S1 (en) * 2021-11-16 2023-08-29 Biolinq Incorporated Wearable sensor
USD1013544S1 (en) 2022-04-29 2024-02-06 Biolinq Incorporated Wearable sensor
USD1012744S1 (en) * 2022-05-16 2024-01-30 Biolinq Incorporated Wearable sensor with illuminated display
JP2025541386A (ja) * 2022-12-16 2025-12-18 キンデーバ ドラッグ デリバリー リミティド パートナーシップ 薬物送達デバイス
EP4658168A2 (en) 2023-02-02 2025-12-10 Biolinq, Inc. Method for improved sensor sensitivity of a microneedle-based continuous analyte monitoring system
WO2024182511A2 (en) * 2023-02-28 2024-09-06 Board Of Regents, The University Of Texas System Microneedle wound monitoring systems, devices and methods
USD1035004S1 (en) 2023-02-28 2024-07-09 Biolinq Incorporated Wearable sensor
USD1068516S1 (en) * 2023-02-28 2025-04-01 Biolinq Incorporated Wearable sensor
USD1083977S1 (en) 2023-02-28 2025-07-15 Biolinq Incorporated Display with graphical user interface for a wearable sensor
USD1083640S1 (en) 2023-05-16 2025-07-15 Biolinq Incorporated Wearable sensor
AU2024344613A1 (en) 2023-09-18 2026-04-23 Eirion Therapeutics, Inc. Topical compositions and uses of pai-1 inhibitors

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123212A (en) * 1964-03-03 Multiple disposable intracutaneous injector package
NL111907C (https=) * 1954-04-27
US3034507A (en) * 1960-05-10 1962-05-15 American Cyanamid Co Intracutaneous injection device
US3074403A (en) * 1960-05-17 1963-01-22 American Cyanamid Co Intracutaneous injector with capillary gap
US3136314A (en) * 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3246647A (en) * 1962-07-23 1966-04-19 American Cyanamid Co Disposable intracutaneous injector
US3466131A (en) * 1967-09-07 1969-09-09 Becton Dickinson Co Dispensing applicator package
US3675766A (en) * 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3688764A (en) * 1970-08-20 1972-09-05 Bard Hamilton Co Inc Intracutaneous injection system
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) * 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
DE2250293A1 (de) * 1972-10-13 1974-04-25 Bayern Freistaat Impfstempel zur cutanen pockenimpfung mittels trockenimpfstoff
OA05448A (fr) * 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
US4473083A (en) * 1981-12-14 1984-09-25 Maganias Nicholas H Device and method for allergy testing
US4921475A (en) * 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
GB2221394B (en) 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
US6090790A (en) * 1989-12-14 2000-07-18 Eriksson; Elof Gene delivery by microneedle injection
US5402798A (en) * 1991-07-18 1995-04-04 Swierczek; Remi Disposable skin perforator and blood testing device
US5342737A (en) * 1992-04-27 1994-08-30 The United States Of America As Represented By The Secretary Of The Navy High aspect ratio metal microstructures and method for preparing the same
WO1993025690A1 (en) * 1992-06-18 1993-12-23 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Recombinant pseudomonas exotoxin with increased activity
JP3211525B2 (ja) 1993-04-22 2001-09-25 オムロン株式会社 薄材メッシュ、その製造方法及びその製造装置
US5620095A (en) * 1993-06-11 1997-04-15 Minnesota Mining And Manufacturing Company Orthopedic casting material and hermetic package
US5611806A (en) * 1994-05-23 1997-03-18 Samsung Electro-Mechanics Co., Ltd. Skin perforating device for transdermal medication
DE69637994D1 (de) 1995-04-26 2009-09-24 Minnesota Mining & Mfg Ablationsverfahren durch laser-darstellung
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
WO1996037155A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
JP2725637B2 (ja) * 1995-05-31 1998-03-11 日本電気株式会社 電子回路装置およびその製造方法
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5658515A (en) * 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5657516A (en) * 1995-10-12 1997-08-19 Minnesota Mining And Manufacturing Company Dual structured fastener elements
EP0914178B1 (en) * 1996-06-18 2003-03-12 Alza Corporation Device for enhancing transdermal agent delivery or sampling
CA2259437C (en) * 1996-07-03 2006-12-05 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
US6797276B1 (en) * 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
AU722574B2 (en) * 1996-12-20 2000-08-10 Alza Corporation Device and method for enhancing transdermal agent flux
US6605332B2 (en) * 1997-07-29 2003-08-12 3M Innovative Properties Company Unitary polymer substrate having napped surface of frayed end microfibers
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
JP4061022B2 (ja) * 1997-12-11 2008-03-12 アルザ・コーポレーション 経皮輸送剤の流量促進装置
CA2313698C (en) * 1997-12-11 2008-04-15 Alza Corporation Device for enhancing transdermal agent flux
US6099682A (en) * 1998-02-09 2000-08-08 3M Innovative Properties Company Corporation Of Delaware Cold seal package and method for making the same
WO1999064580A1 (en) 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
GB9815820D0 (en) 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
DE69921489T2 (de) * 1998-08-31 2005-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
JP2002532165A (ja) * 1998-12-18 2002-10-02 メドトロニック ミニメド インコーポレイテッド 医療装置と共に使われる、微小突刺し部材を備える挿入セット及びそのような挿入セットの使用方法
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
EP1163024B1 (en) * 1999-01-28 2003-12-17 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
US6611707B1 (en) * 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
EP1187653B1 (en) 1999-06-04 2010-03-31 Georgia Tech Research Corporation Devices for enhanced microneedle penetration of biological barriers
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
AU2573801A (en) * 1999-11-02 2001-05-14 University Of Hawaii Method for fabricating arrays of micro-needles
DE60022540T2 (de) 1999-11-15 2006-06-14 Velcro Ind Befestigungselement für die haut
WO2001066065A2 (en) 2000-03-09 2001-09-13 Nanopass Ltd. Systems and methods for fluid transport through dermal barriers
US6558361B1 (en) * 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
WO2001093930A1 (en) 2000-06-02 2001-12-13 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6537242B1 (en) * 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6589202B1 (en) * 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6440096B1 (en) * 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6749575B2 (en) * 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
CN100421653C (zh) * 2000-09-08 2008-10-01 阿尔扎公司 通过抑制通道关闭来抑制药物透皮通量减少的方法
CA2425312C (en) * 2000-10-13 2010-02-16 Alza Corporation Microprotrusion member retainer for impact applicator
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
BR0114909A (pt) * 2000-10-26 2004-02-03 Alza Corp Dispositivos de distribuição de drogas transdérmicas possuindo microprotuberâncias revestidas
US9302903B2 (en) * 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2002050584A2 (en) * 2000-12-21 2002-06-27 Biovalve Technologies, Inc. Microneedle array systems
US20020099356A1 (en) * 2001-01-19 2002-07-25 Unger Evan C. Transmembrane transport apparatus and method
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
WO2002100466A2 (en) * 2001-06-08 2002-12-19 The Regents Of The University Of California Microfabricated surgical devices and methods of making the same
US6686299B2 (en) * 2001-06-21 2004-02-03 Carlo D. Montemagno Nanosyringe array and method
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US6746590B2 (en) * 2001-09-05 2004-06-08 3M Innovative Properties Company Ultrasonically-enhanced electroplating apparatus and methods
WO2003024507A2 (en) * 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
CA2500453A1 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Microneedle with membrane
US6689100B2 (en) * 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
WO2003051284A2 (en) * 2001-10-29 2003-06-26 Becton, Dickinson And Company Method and device for the delivery of a substance
EP1451584B1 (en) * 2001-11-09 2011-05-11 3dbiosurfaces Technologies, LLC High surface area substrates for microarrays and methods to make same
AU2002357372B2 (en) * 2001-12-20 2008-11-20 Alza Corporation Skin-piercing microprojections having piercing depth control
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US20040060902A1 (en) * 2002-02-05 2004-04-01 Evans John D. Microprotrusion array and methods of making a microprotrusion
CA2478822C (en) * 2002-03-11 2016-07-12 Passport Technologies, Inc. Transdermal drug delivery patch system, method of making same and method of using same
US6780171B2 (en) * 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US6899838B2 (en) * 2002-07-12 2005-05-31 Becton, Dickinson And Company Method of forming a mold and molding a micro-device
ES2720098T3 (es) * 2002-07-22 2019-07-17 Becton Dickinson Co Dispositivo de infusión similar a un parche
WO2004019777A2 (en) * 2002-08-29 2004-03-11 Becton Dickinson And Company Substance delivery via rotating mocroabrading surface
EP1590034B1 (en) * 2002-10-07 2014-05-14 Biovalve Technologies, Inc. Microneedle array patch
WO2005000382A2 (en) * 2003-06-04 2005-01-06 Georgia Tech Research Corporation Drilling microneedle device
EP1643918A1 (en) * 2003-07-02 2006-04-12 Alza Corporation Microprojection array immunization patch and method
BRPI0413360A (pt) * 2003-08-04 2006-10-10 Alza Corp método e dispositivo para aumentar o fluxo de agentes transdérmicos
MXPA06001373A (es) * 2003-08-12 2006-05-15 Becton Dickinson Co Dispositivo de infusion similar a un parche.
CA2536443A1 (en) * 2003-08-26 2005-03-03 Alza Corporation Device and method for intradermal cell implantation
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
EP1675539A4 (en) * 2003-10-24 2007-09-12 Alza Corp METHOD AND SYSTEM FOR PRETREATMENT FOR IMPROVING TRANSDERMAL DRUG DELIVERY
CN1897899A (zh) * 2003-10-24 2007-01-17 阿尔扎公司 促进透皮药物传递的装置和方法
KR20070001886A (ko) * 2003-10-28 2007-01-04 알자 코포레이션 치료용 펩타이드 및 단백질의 폴리머 컨쥬게이트의 피복된미세돌출부를 통한 전달

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US6908453B2 (en) 2005-06-21
WO2003059431A1 (en) 2003-07-24
US20030135161A1 (en) 2003-07-17
ATE384549T1 (de) 2008-02-15
DE60224842D1 (de) 2008-03-13
IL162554A0 (en) 2005-11-20
JP2005514179A (ja) 2005-05-19
US20050187521A1 (en) 2005-08-25
AU2002359490A1 (en) 2003-07-30
JP4382492B2 (ja) 2009-12-16

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