SG10201800072YA - Microneedle Patches Comprising Corticosteroid - Google Patents

Microneedle Patches Comprising Corticosteroid

Info

Publication number
SG10201800072YA
SG10201800072YA SG10201800072YA SG10201800072YA SG10201800072YA SG 10201800072Y A SG10201800072Y A SG 10201800072YA SG 10201800072Y A SG10201800072Y A SG 10201800072YA SG 10201800072Y A SG10201800072Y A SG 10201800072YA SG 10201800072Y A SG10201800072Y A SG 10201800072YA
Authority
SG
Singapore
Prior art keywords
corticosteroid
dissolving
substrate
matrix material
microneedles
Prior art date
Application number
SG10201800072YA
Inventor
Chee Yen Lim
Hong Liang Tey
Original Assignee
Micropoint Tech Pte Ltd
Nat Skin Centre Singapore Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micropoint Tech Pte Ltd, Nat Skin Centre Singapore Pte Ltd filed Critical Micropoint Tech Pte Ltd
Priority to SG10201800072YA priority Critical patent/SG10201800072YA/en
Priority to CN201980001702.2A priority patent/CN111683713A/en
Priority to US16/500,203 priority patent/US11590331B2/en
Priority to PCT/SG2019/050014 priority patent/WO2019135717A1/en
Publication of SG10201800072YA publication Critical patent/SG10201800072YA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • A61M2207/10—Device therefor

Abstract

In the preferred embodiment of the present invention, a patch of dissolving microneedles loaded with active ingredients to be applied to skin for treating skin conditions is provided. As seen in Fig. 1, the dissolving microneedle patch 10 comprises a substrate 12 and a plurality of microneedles 14 which extends from the substrate. The dissolving microneedle patch 10 is made of a matrix material and at least one active ingredient such as a corticosteroid, namely triamcinolone (TAC). The matrix material is made of bio-compatible materials such as hyaluronic acid (HA), polyvinylpyrrolidone (PVP), or mixture of them, which dissolve rapidly when they are in contact with the inner skin. The active ingredient is loaded onto individual patches with the desirable dosage ranging from 0.01mg - 1.0mg.
SG10201800072YA 2018-01-03 2018-01-03 Microneedle Patches Comprising Corticosteroid SG10201800072YA (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
SG10201800072YA SG10201800072YA (en) 2018-01-03 2018-01-03 Microneedle Patches Comprising Corticosteroid
CN201980001702.2A CN111683713A (en) 2018-01-03 2019-01-10 Dissolving corticosteroid-containing microneedle patches
US16/500,203 US11590331B2 (en) 2018-01-03 2019-01-10 Dissolving microneedle patches comprising corticosteroid
PCT/SG2019/050014 WO2019135717A1 (en) 2018-01-03 2019-01-10 Dissolving microneedle patches comprising corticosteroid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SG10201800072YA SG10201800072YA (en) 2018-01-03 2018-01-03 Microneedle Patches Comprising Corticosteroid

Publications (1)

Publication Number Publication Date
SG10201800072YA true SG10201800072YA (en) 2019-08-27

Family

ID=67143723

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201800072YA SG10201800072YA (en) 2018-01-03 2018-01-03 Microneedle Patches Comprising Corticosteroid

Country Status (4)

Country Link
US (1) US11590331B2 (en)
CN (1) CN111683713A (en)
SG (1) SG10201800072YA (en)
WO (1) WO2019135717A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111035628B (en) * 2020-01-19 2022-12-30 广东药科大学 Self-dissolving microneedle for treating scar
USD939090S1 (en) 2020-02-05 2021-12-21 Peace Out Inc. Microneedling patch
NL2026264B1 (en) * 2020-08-13 2022-04-13 Versailles B V Microneedle applicator with active ingredient for treatment of skin lesions
CN117159443B (en) * 2023-10-19 2024-04-19 暨南大学 In-situ supermolecule gel microneedle patch and preparation method and application thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5901707A (en) * 1995-05-19 1999-05-11 Hpl Biomedical, Inc. Silicone mask for cryosurgery and method
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
CA2530531A1 (en) * 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
US20060105029A1 (en) * 2004-11-12 2006-05-18 Jie Zhang Instant patch for dermal drug delivery
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
JP2007001938A (en) * 2005-06-24 2007-01-11 Daikyo Yakuhin Kogyo Kk Plaster with microneedle
WO2008130587A2 (en) * 2007-04-16 2008-10-30 Corium International, Inc. Solvent-cast microneedle arrays containing active
JP5538897B2 (en) * 2007-11-21 2014-07-02 株式会社バイオセレンタック Preparation for body surface application, and preparation holding sheet for body surface application
JP5472673B2 (en) * 2008-09-29 2014-04-16 コスメディ製薬株式会社 Microneedle array
JP2010233674A (en) 2009-03-30 2010-10-21 Fujifilm Corp Microneedle sheet, its use method and method for producing the same
US20120184916A1 (en) * 2009-08-07 2012-07-19 Medrx Co., Ltd. Applicator device of pinholder type microneedle
AU2010200556B2 (en) * 2010-02-15 2012-02-02 Oncobeta International Gmbh Brachytherapy method of treating skin tumours using a tailor-made radioactive source
WO2011115272A1 (en) * 2010-03-19 2011-09-22 コスメディ製薬株式会社 Proteoglycan-containing microneedle array
JP2013032324A (en) * 2011-08-03 2013-02-14 Bioserentack Co Ltd Rapid-acting microneedle array patch preparation including local anesthetic
JP6003338B2 (en) * 2012-07-26 2016-10-05 凸版印刷株式会社 Acicular package
WO2015122838A1 (en) * 2014-02-14 2015-08-20 Chee Yen Lim Rapidly dissolvable microneedles with drug-impregnated tips
JP6265774B2 (en) 2014-02-18 2018-01-24 久光製薬株式会社 Patch
MA41818A (en) * 2015-03-27 2018-01-30 Leo Pharma As MICRO-NEEDLE STAMP FOR ADMINISTRATION OF AN ACTIVE SUBSTANCE TO THE SKIN
JP6682783B2 (en) * 2015-09-08 2020-04-15 凸版印刷株式会社 Transdermal administration device and method of manufacturing transdermal administration device

Also Published As

Publication number Publication date
US20200206488A1 (en) 2020-07-02
CN111683713A (en) 2020-09-18
WO2019135717A1 (en) 2019-07-11
US11590331B2 (en) 2023-02-28

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