ATE384549T1 - Mikronadel-vorrichtungen und verfahren zur herstellung - Google Patents

Mikronadel-vorrichtungen und verfahren zur herstellung

Info

Publication number
ATE384549T1
ATE384549T1 AT02794032T AT02794032T ATE384549T1 AT E384549 T1 ATE384549 T1 AT E384549T1 AT 02794032 T AT02794032 T AT 02794032T AT 02794032 T AT02794032 T AT 02794032T AT E384549 T1 ATE384549 T1 AT E384549T1
Authority
AT
Austria
Prior art keywords
microneedle
microneedles
cover
microneedle devices
methods
Prior art date
Application number
AT02794032T
Other languages
English (en)
Inventor
Patrick R Fleming
Michael D Delmore
Luther E Erickson
Richard H Ferber
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Application granted granted Critical
Publication of ATE384549T1 publication Critical patent/ATE384549T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150572—Pierceable protectors, e.g. shields, caps, sleeves or films, e.g. for hygienic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150694—Procedure for removing protection means at the time of piercing
    • A61B5/150717—Procedure for removing protection means at the time of piercing manually removed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Optics & Photonics (AREA)
  • Manufacturing & Machinery (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT02794032T 2002-01-15 2002-11-26 Mikronadel-vorrichtungen und verfahren zur herstellung ATE384549T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/051,745 US6908453B2 (en) 2002-01-15 2002-01-15 Microneedle devices and methods of manufacture

Publications (1)

Publication Number Publication Date
ATE384549T1 true ATE384549T1 (de) 2008-02-15

Family

ID=21973131

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02794032T ATE384549T1 (de) 2002-01-15 2002-11-26 Mikronadel-vorrichtungen und verfahren zur herstellung

Country Status (8)

Country Link
US (2) US6908453B2 (de)
EP (1) EP1465698B1 (de)
JP (1) JP4382492B2 (de)
AT (1) ATE384549T1 (de)
AU (1) AU2002359490A1 (de)
DE (1) DE60224842T2 (de)
IL (1) IL162554A0 (de)
WO (1) WO2003059431A1 (de)

Families Citing this family (217)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
JP2005533625A (ja) * 2002-07-19 2005-11-10 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルデバイスおよびマイクロニードル送達装置
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
WO2005020912A2 (en) * 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
KR20060115722A (ko) * 2003-08-26 2006-11-09 알자 코포레이션 진피내 세포 이식용 장치 및 방법
US7378451B2 (en) * 2003-10-17 2008-05-27 3M Innovative Properties Co Surfactant composition having stable hydrophilic character
EP1740256A4 (de) * 2003-11-10 2011-06-29 Agency Science Tech & Res Mikronadeln und mikronadelherstellung
EP1713533A4 (de) * 2003-11-21 2008-01-23 Univ California Verfahren und/oder vorrichtung zur punktierung einer fläche zur extraktion, in-situ-analyse und/oder substanzzufuhr unter verwendung von mikronadeln
US7361182B2 (en) * 2003-12-19 2008-04-22 Lightnix, Inc. Medical lancet
AU2004311977A1 (en) * 2003-12-29 2005-07-21 3M Innovative Properties Company Medical devices and kits including same
US7150726B2 (en) * 2004-01-23 2006-12-19 Norfolk Medical Device for subcutaneous infusion of fluids
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US8551391B2 (en) * 2004-02-17 2013-10-08 Avery Dennison Corporation Method of making microneedles
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
WO2005087305A1 (en) * 2004-03-12 2005-09-22 Agency For Science, Technology And Research Methods and moulds for use in fabricating side-ported microneedles
CA2562643A1 (en) * 2004-04-12 2005-11-24 Allergan, Inc. Multi-site injection system
US20080039805A1 (en) * 2004-06-10 2008-02-14 Frederickson Franklyn L Patch Application Device and Kit
WO2006022933A2 (en) * 2004-08-05 2006-03-02 Apogee Technologies, Inc. System and method for drug delivery and microfluidic applications using microneedles
US8696619B2 (en) * 2004-08-10 2014-04-15 Robert P. Schnall Drug delivery devices
EP1790375A4 (de) * 2004-08-12 2009-06-17 Hisamitsu Pharmaceutical Co Transdermale arzneimittelverabreichungsvorrichtung mit mikronadel
DE602005025138D1 (de) 2004-08-16 2011-01-13 Fuctional Microstructures Ltd Verfahren zur herstellung einer mikronadel oder eines mikroimplantats
AR050608A1 (es) * 2004-08-19 2006-11-08 Alza Corp Aparato y metodo para administracion transdermica de factores de crecimiento endotelial vascular
CA2588080C (en) * 2004-11-18 2013-01-08 3M Innovative Properties Company Masking method for coating a microneedle array
ATE504328T1 (de) 2004-11-18 2011-04-15 3M Innovative Properties Co Mikronadelanordungsapplikator und halter
CA2587505C (en) 2004-11-18 2013-01-08 3M Innovative Properties Company Low-profile microneedle array applicator
KR101246015B1 (ko) 2004-11-18 2013-03-20 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로니들 어레이를 접촉 코팅하는 방법
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
US20080009801A1 (en) * 2004-12-02 2008-01-10 Nickel Janice H Method for dispensing material into a drug delivery device
ATE468961T1 (de) 2004-12-07 2010-06-15 3M Innovative Properties Co Verfahren zum formen einer mikronadel
MX2007006742A (es) * 2004-12-10 2007-07-25 3M Innovative Properties Co Dispositivo medico.
JP4793806B2 (ja) * 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
WO2006105233A1 (en) * 2005-03-28 2006-10-05 Alza Corporation Microprojections with capillary control features and method
WO2006105146A2 (en) * 2005-03-29 2006-10-05 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
EP1871459B1 (de) 2005-04-07 2019-06-19 3M Innovative Properties Company SYSTEM ZUR ERFASSUNG DER WERKZEUGRüCKMELDUNG
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US7442029B2 (en) 2005-05-16 2008-10-28 Asml Netherlands B.V. Imprint lithography
US20080195035A1 (en) * 2005-06-24 2008-08-14 Frederickson Franklyn L Collapsible Patch and Method of Application
EP2474338B1 (de) * 2005-06-27 2013-07-24 3M Innovative Properties Company Vorrichtung zum Aufbringen einer Mikronadelanordnung
US20100256568A1 (en) * 2005-06-27 2010-10-07 Frederickson Franklyn L Microneedle cartridge assembly and method of applying
US20070004989A1 (en) * 2005-06-29 2007-01-04 Parvinder Dhillon Device for transdermal sampling
WO2007032446A1 (ja) 2005-09-15 2007-03-22 Tti Ellebeau, Inc. ロッド型イオントフォレーシス装置
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
WO2007038028A1 (en) * 2005-09-28 2007-04-05 Tti Ellebeau, Inc. Iontophoresis apparatus and method to deliver active agents to biological interfaces
WO2007041434A2 (en) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Iontophoresis apparatus and method for delivery of angiogenic factors to enhance healing of injured tissue
CA2664589A1 (en) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Iontophoretic device and method of delivery of active agents to biological interface
JP2009509677A (ja) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 小胞封入活性物質のイオントフォレーシス送達
EP1948139A4 (de) * 2005-11-18 2012-04-04 3M Innovative Properties Co Überziehbare zusammensetzungen, daraus erhaltene überzüge und mikroanordnungen mit diesen überzügen
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
US20080319404A1 (en) * 2005-12-21 2008-12-25 Pekurovsky Mikhail L Microneedle Devices
WO2007079193A2 (en) * 2005-12-30 2007-07-12 Tti Ellebeau, Inc. Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
WO2007091608A1 (ja) * 2006-02-10 2007-08-16 Hisamitsu Pharmaceutical Co., Inc. マイクロニードル付き経皮薬物投与装置
EP1820441A1 (de) * 2006-02-16 2007-08-22 Roche Diagnostics GmbH Mikronadelanordnung mit Sensor basierend auf der abgeschwächten Totalreflexion (ATR)
US7699819B2 (en) 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US20080004564A1 (en) * 2006-03-30 2008-01-03 Transcutaneous Technologies Inc. Controlled release membrane and methods of use
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
DE102006028782A1 (de) * 2006-06-23 2007-12-27 Robert Bosch Gmbh Vorrichtung zur Aufbewahrung und Transport von Mikronadeln und ein Verfahren zur Verabreichung von Wirkstoffen mittels einer solchen Vorrichtung
US8250729B2 (en) * 2006-07-12 2012-08-28 University Of Utah Research Foundation 3D fabrication of needle tip geometry and knife blade
EP2049173A4 (de) * 2006-08-01 2013-09-11 Agency Science Tech & Res Ultraschallverstärkte mikronadeln
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
ATE547985T1 (de) 2006-09-04 2012-03-15 Hoffmann La Roche Verpackung für hydrophile medizinische instrumente
US20080097352A1 (en) * 2006-09-12 2008-04-24 Beck Patricia A Methods of fabricating microneedles with bio-sensory functionality
EP2468300B1 (de) 2006-09-26 2017-12-20 Infectious Disease Research Institute Impfstoffzusammensetzung mit einem synthetischen Adjuvans
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
JP4954656B2 (ja) * 2006-09-28 2012-06-20 凸版印刷株式会社 針状体および針状体の製造方法
AU2007303223C1 (en) 2006-10-02 2013-01-10 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
JPWO2008062832A1 (ja) * 2006-11-22 2010-03-04 凸版印刷株式会社 マイクロニードルアレイ及びマイクロニードルアレイの製造方法
KR20090106492A (ko) 2006-12-01 2009-10-09 티티아이 엘뷰 가부시키가이샤 경피성 전달 장치와 같은 장치에 전력을 제공하거나 제어하기 위한 시스템, 장치, 및 방법
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
JP5297595B2 (ja) * 2007-03-20 2013-09-25 凸版印刷株式会社 針状体および針状体製造方法
US8439861B2 (en) * 2007-04-24 2013-05-14 Velcro Industries B.V. Skin penetrating touch fasteners
TW200841866A (en) * 2007-04-25 2008-11-01 Micro Base Technology Corp Cosmetic or medical patch structure
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
US20090053673A1 (en) * 2007-08-23 2009-02-26 Zimmer, Inc. Method for localized treatment of periodontal tissue
ES2612061T3 (es) * 2007-09-28 2017-05-11 The Queen's University Of Belfast Dispositivo y método de suministro
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
CA2745339C (en) 2007-12-24 2016-06-28 The University Of Queensland Coating method
CA2749347C (en) * 2008-02-07 2018-03-27 The University Of Queensland Patch production
US8398397B2 (en) * 2008-03-12 2013-03-19 Ultradent Products, Inc. Dental intraligamentary injection needles and related methods of manufacture
US20090259176A1 (en) * 2008-04-09 2009-10-15 Los Gatos Research, Inc. Transdermal patch system
US8012329B2 (en) 2008-05-09 2011-09-06 3M Innovative Properties Company Dimensional control in electroforms
CA2760680A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection by microneedle patch with analyte selective reagents
WO2010022326A2 (en) * 2008-08-22 2010-02-25 Us Worldmeds Llc Transdermal delivery of apomorphine using microneedles
EP3300765A1 (de) * 2008-11-18 2018-04-04 3M Innovative Properties Co. Hohlmikronadelfeld
AU2009322463B2 (en) 2008-12-02 2015-10-08 Allergan, Inc. Injection device
US8781576B2 (en) 2009-03-17 2014-07-15 Cardiothrive, Inc. Device and method for reducing patient transthoracic impedance for the purpose of delivering a therapeutic current
US8615295B2 (en) 2009-03-17 2013-12-24 Cardiothrive, Inc. External defibrillator
KR101033514B1 (ko) * 2009-06-02 2011-05-09 (주)마이티시스템 유연한 미세바늘 패치 시스템 및 그 제작방법
CN102481312B (zh) 2009-06-05 2015-07-15 传染性疾病研究院 合成的吡喃葡萄糖脂佐剂
US8062568B2 (en) * 2009-08-27 2011-11-22 Korea University Research And Business Foundation Nano pattern writer
US20110319742A1 (en) * 2009-09-08 2011-12-29 SensiVida Medical Technologies, Inc. Spatial imaging methods for biomedical monitoring and systems thereof
US8834423B2 (en) * 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
EP2493551A4 (de) 2009-10-26 2013-04-17 Emkinetics Inc Verfahren und vorrichtung zur elektromagnetischen stimulation von nerven, muskeln und körpergewebe
DE102009046581A1 (de) 2009-11-10 2011-05-12 Robert Bosch Gmbh Herstellungsverfahren für eine poröse Mikronadelanordnung und entsprechende poröse Mikronadelanordnung und entsprechender Substratverbund
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
GB2478363A (en) * 2010-03-05 2011-09-07 Ndm Technologies Ltd Microneedle patch and method of manufacture
JP5423522B2 (ja) * 2010-03-25 2014-02-19 日本電気株式会社 モジュール及びモジュール製造方法
KR101794376B1 (ko) 2010-04-28 2017-11-06 킴벌리-클라크 월드와이드, 인크. ｓｉＲＮＡ 전달용 의료 기구
WO2011135532A2 (en) 2010-04-28 2011-11-03 Kimberly-Clark Worldwide, Inc. Composite microneedle array including nanostructures thereon
MX2012012567A (es) 2010-04-28 2012-11-21 Kimberly Clark Co Metodo para aumentar la permeabilidad de una barrera epitelial.
FR2959599B1 (fr) * 2010-04-28 2013-12-20 Commissariat Energie Atomique Dispositif et procede de texturation mecanique d'une plaquette de silicium destinee a constituer une cellule photovoltaique, plaquette de silicium obtenue
EP2563450B1 (de) 2010-04-28 2017-07-26 Kimberly-Clark Worldwide, Inc. Vorrichtung zur verabreichung eines medikaments gegen rheumatoide arthritis
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
US20120089118A1 (en) * 2010-10-08 2012-04-12 A Nevada Corporation Delivery of bisphosphonates by microinjection systems
WO2012061556A1 (en) 2010-11-03 2012-05-10 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
EA027236B1 (ru) 2011-04-08 2017-07-31 Иммьюн Дизайн Корп. Иммуногенные композиции и способы применения таких композиций для индукции гуморального и клеточного иммунного ответа
US8636696B2 (en) * 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
JP2014236758A (ja) * 2011-09-30 2014-12-18 テルモ株式会社 センサ
EP2765927B1 (de) 2011-10-12 2021-02-24 Vaxxas Pty Limited Abgabegerät
EP3574950B1 (de) 2011-10-27 2021-02-17 Sorrento Therapeutics, Inc. Transdermale freisetzung von hochviskosen bioaktiven wirkstoffen
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
ES2729967T3 (es) 2012-02-07 2019-11-07 Infectious Disease Res Inst Formulaciones de adyuvante mejoradas que comprenden agonistas de TLR4 y métodos para usar las mismas
US9944019B2 (en) 2012-05-01 2018-04-17 University of Pittsburgh—of the Commonwealth System of Higher Education Tip-loaded microneedle arrays for transdermal insertion
EP3388835B1 (de) 2012-05-16 2020-04-01 Immune Design Corp. Impfstoffe gegen hsv-2
JP5903016B2 (ja) * 2012-06-27 2016-04-13 コスメディ製薬株式会社 マイクロニードルパッチの保護離型シート
EP2872222B1 (de) * 2012-07-06 2023-05-31 The General Hospital Corporation System und vorrichtung zur dermatologischen behandlung
EP2951560B1 (de) 2013-01-29 2019-03-20 Hewlett-Packard Development Company, L.P. Vorrichtung mit oberflächenverstärkten spektroskopieelementen auf einer äusseren oberfläche
CN103157178B (zh) * 2013-02-05 2014-12-31 北京化工大学 精确控制微针插入长度的印章式工具
AU2014219240B2 (en) 2013-02-20 2018-12-20 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
ITMI20130586A1 (it) * 2013-04-11 2014-10-12 Azienda Ospedaliero Universitaria P Isana Microago e matrice di microaghi per uso medicale, e processo di produzione di detta matrice
CN105209047B (zh) 2013-04-18 2020-08-18 免疫设计股份有限公司 用于癌症治疗的gla单一疗法
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
BR112015031162A2 (pt) * 2013-06-13 2017-07-25 Microdermics Inc microagulhas metálicas
US9656094B2 (en) 2013-06-14 2017-05-23 Cardiothrive, Inc. Biphasic or multiphasic pulse generator and method
US9907970B2 (en) 2013-06-14 2018-03-06 Cardiothrive, Inc. Therapeutic system and method using biphasic or multiphasic pulse waveform
US9833630B2 (en) 2013-06-14 2017-12-05 Cardiothrive, Inc. Biphasic or multiphasic pulse waveform and method
US10149973B2 (en) 2013-06-14 2018-12-11 Cardiothrive, Inc. Multipart non-uniform patient contact interface and method of use
US10279189B2 (en) 2013-06-14 2019-05-07 Cardiothrive, Inc. Wearable multiphasic cardioverter defibrillator system and method
US9616243B2 (en) 2013-06-14 2017-04-11 Cardiothrive, Inc. Dynamically adjustable multiphasic defibrillator pulse system and method
KR102349218B1 (ko) 2013-08-09 2022-01-10 사이트렐리스 바이오시스템즈, 인크. 비-열적 조직 절제를 사용한 피부 치료를 위한 방법 및 기구
KR101511850B1 (ko) * 2013-10-10 2015-04-16 (주)엠큐어 멀티니들허브를 갖는 피부재생기
EP3082897A4 (de) 2013-12-19 2017-07-26 Cytrellis Biosystems, Inc. Verfahren und vorrichtungen zur manipulation von unterhautfett
MX2016009464A (es) 2014-01-21 2017-01-16 Immune Design Corp Composiciones para el uso en el tratamiento de afecciones alergicas.
EP3111986B1 (de) 2014-02-27 2024-03-27 Toppan Printing Co., Ltd. Mikronadeleinheit und mikronadelaufnahme
CN106456952A (zh) * 2014-03-26 2017-02-22 日本写真印刷株式会社 锥状突起片的包装体及其制造方法
WO2015168214A1 (en) * 2014-04-30 2015-11-05 Kimberly-Clark Worldwide, Inc. Draped microneedle array
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
US9987427B1 (en) 2014-06-24 2018-06-05 National Technology & Engineering Solutions Of Sandia, Llc Diagnostic/drug delivery “sense-respond” devices, systems, and uses thereof
US10321858B2 (en) 2014-08-18 2019-06-18 Proteadx, Inc. Apparatus and methods for transdermal sensing of analytes in interstitial fluid and associated data transmission systems
US9933387B1 (en) 2014-09-07 2018-04-03 Biolinq, Inc. Miniaturized sub-nanoampere sensitivity low-noise potentiostat system
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
KR102670286B1 (ko) 2014-11-14 2024-05-30 사이트렐리스 바이오시스템즈, 인크. 피부 절제를 위한 디바이스 및 방법
JP6906885B2 (ja) 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
WO2016121499A1 (ja) * 2015-01-27 2016-08-04 凸版印刷株式会社 経皮投与デバイス
AU2016214968B2 (en) 2015-02-02 2021-02-25 Vaxxas Pty Limited Microprojection array applicator and method
JP2018507771A (ja) 2015-03-10 2018-03-22 アラーガン ファーマシューティカルズ ホールディングス （アイルランド） アンリミテッド カンパニー 多針注入器
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
CN107614051B (zh) * 2015-04-27 2020-10-02 石匠株式会社 片状小片、包含该小片的生发促进用片、以及包含该小片的美白和皱纹改善剂
JP6646985B2 (ja) * 2015-09-08 2020-02-14 花王株式会社 微細突起具の製造方法
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
JP6461761B2 (ja) * 2015-10-06 2019-01-30 富士フイルム株式会社 経皮吸収シートの製造方法
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
AU2016361874B2 (en) * 2015-12-04 2019-01-03 Ascilion Ab A microneedle and a chip
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
KR20230117470A (ko) 2016-03-29 2023-08-08 사이트렐리스 바이오시스템즈, 인크. 미용 피부 리설페이싱용 디바이스 및 방법
WO2017176476A1 (en) 2016-04-08 2017-10-12 Allergan, Inc. Aspiration and injection device
EP3711670B1 (de) * 2016-05-04 2022-03-16 midge medical GmbH Vorrichtung zur entnahme von körperflüssigkeit
US10092207B1 (en) 2016-05-15 2018-10-09 Biolinq, Inc. Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
JP7195147B2 (ja) 2016-05-16 2022-12-23 アクセス ツー アドバンスト ヘルス インスティチュート Ｐｅｇ化リポソームおよび使用方法
EP4112638A1 (de) 2016-05-16 2023-01-04 Access to Advanced Health Institute Formulierung mit tlr-agonist und verfahren zur verwendung
MX2018014399A (es) 2016-06-01 2019-06-06 Infectious Disease Res Inst Particulas de nanoalumbre que contienen un agente de dimensionamiento.
JP6300864B2 (ja) * 2016-08-09 2018-03-28 ヒューレット−パッカード デベロップメント カンパニー エル．ピー．Ｈｅｗｌｅｔｔ‐Ｐａｃｋａｒｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏｍｐａｎｙ， Ｌ．Ｐ． 外面に表面増感分光法要素を有する装置
JP2019529043A (ja) 2016-09-21 2019-10-17 サイトレリス バイオシステムズ，インコーポレーテッド 美容スキンリサーフェシング装置及び方法
JP2019535829A (ja) 2016-11-21 2019-12-12 エイリオン セラピューティクス， インコーポレイテッド 大型薬剤の経皮送達
AU2017363296A1 (en) * 2016-11-23 2019-05-30 University Medical Pharmaceuticals Corp. Microneedle delivery system and method
JP6977258B2 (ja) * 2016-12-20 2021-12-08 株式会社リコー 中空構造体
EP3338832A1 (de) * 2016-12-23 2018-06-27 Sanofi-Aventis Deutschland GmbH Medikamentenverabreichungsvorrichtung
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
ES2960937T3 (es) 2017-03-31 2024-03-07 Vaxxas Pty Ltd Dispositivo y método para recubrir superficies
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
SG11201911930SA (en) 2017-06-11 2020-01-30 Molecular Express Inc Methods and compositions for substance use disorder vaccine formulations and uses thereof
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
JP6931222B2 (ja) * 2017-07-18 2021-09-01 コスメディ製薬株式会社 マイクロニードルアレイの発泡支持体シート
AU2018309562A1 (en) 2017-08-04 2020-02-20 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
US11766203B2 (en) 2017-09-13 2023-09-26 National Technology & Engineering Solutions Of Sandia, Llc Coaxial microneedle assemblies and methods thereof
TWI667016B (zh) 2017-11-20 2019-08-01 研能科技股份有限公司 血糖監測控制系統
EP3727141A4 (de) * 2017-12-21 2021-09-01 Georgia Tech Research Corporation Verfahren und systeme zur verbesserten sammlung von interstitieller flüssigkeit
US10828500B2 (en) 2017-12-22 2020-11-10 Cardiothrive, Inc. External defibrillator
SG10201800072YA (en) * 2018-01-03 2019-08-27 Micropoint Tech Pte Ltd Microneedle Patches Comprising Corticosteroid
US10918839B2 (en) * 2018-03-13 2021-02-16 II Jaro Mayda Balloon catheter
WO2019188935A1 (ja) * 2018-03-30 2019-10-03 富士フイルム株式会社 マイクロニードルアレイの製造方法
USD875254S1 (en) 2018-06-08 2020-02-11 Biolinq, Inc. Intradermal biosensor
CN113056268A (zh) 2018-09-13 2021-06-29 艾里奥治疗公司 纤溶酶原激活物抑制剂1(pai-1)抑制剂和其用途
JP2022500452A (ja) 2018-09-13 2022-01-04 エイリオン セラピューティクス， インコーポレイテッド プラスミノーゲンアクチベーターインヒビター１（ｐｌａｓｍｉｎｏｇｅｎ ａｃｔｉｖａｔｏｒ ｉｎｈｉｂｉｔｏｒ １）（ＰＡＩ−１）阻害剤（ｉｎｈｉｂｉｔｏｒ）の使用
CA3114763A1 (en) 2018-10-02 2020-04-09 WearOptimo Pty Ltd System for performing measurements on a biological subject
AU2019353531A1 (en) 2018-10-02 2021-06-03 WearOptimo Pty Ltd Electrode arrangement
WO2020117564A1 (en) 2018-12-03 2020-06-11 Eirion Therapeutics, Inc. Improved delivery of large agents
SG11202110518XA (en) 2019-05-14 2021-10-28 Eirion Therapeutics Inc Delaying peak effect and/or extending duration of response
TWI687247B (zh) * 2019-05-15 2020-03-11 微邦科技股份有限公司 微針結構及其生物可降解微針
CN111939452A (zh) * 2019-05-15 2020-11-17 微邦科技股份有限公司 微针结构及其生物可降解微针
EP3772331A1 (de) * 2019-08-08 2021-02-10 PKvitality Körperüberwachungssystem mit einer mikronadel
CN110711312B (zh) * 2019-11-07 2021-07-30 河南大学 基于微机电系统的强促渗透皮释药微系统及其制造方法
JP7319742B2 (ja) 2020-07-29 2023-08-02 バイオリンク インコーポレイテッド 微小針アレイを伴う持続的分析物監視システム
WO2022118859A1 (ja) * 2020-12-01 2022-06-09 三井化学株式会社 マイクロニードルアレイ、マイクロニードルアレイアセンブリ、及び検査チップ
CN117120087A (zh) 2020-12-23 2023-11-24 高级健康研究所 茄尼醇疫苗助剂及其制备方法
CN112858430B (zh) * 2021-01-08 2021-11-26 中山大学 一种检测植物活性小分子的传感器和制备方法
USD988160S1 (en) * 2021-03-16 2023-06-06 Biolinq Incorporated Wearable dermal sensor
SE2330048A1 (en) 2021-05-08 2023-01-25 Biolinq Incorporated Fault detection for microneedle array based continuous analyte monitoring device
CN113499537A (zh) * 2021-09-03 2021-10-15 河南佳普医药科技有限公司 一种微针透皮给药装置
JP7141625B1 (ja) 2021-09-17 2022-09-26 リンテック株式会社 マイクロニードルパッチ及びマイクロニードル構造体
USD996999S1 (en) * 2021-11-16 2023-08-29 Biolinq Incorporated Wearable sensor
USD1013544S1 (en) * 2022-04-29 2024-02-06 Biolinq Incorporated Wearable sensor
USD1012744S1 (en) * 2022-05-16 2024-01-30 Biolinq Incorporated Wearable sensor with illuminated display
WO2024129424A1 (en) * 2022-12-16 2024-06-20 Kindeva Drug Delivery L.P. Drug delivery device

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123212A (en) * 1964-03-03 Multiple disposable intracutaneous injector package
NL113697C (de) * 1954-04-27
US3034507A (en) * 1960-05-10 1962-05-15 American Cyanamid Co Intracutaneous injection device
US3074403A (en) * 1960-05-17 1963-01-22 American Cyanamid Co Intracutaneous injector with capillary gap
US3136314A (en) * 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3246647A (en) * 1962-07-23 1966-04-19 American Cyanamid Co Disposable intracutaneous injector
US3466131A (en) * 1967-09-07 1969-09-09 Becton Dickinson Co Dispensing applicator package
US3675766A (en) * 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3688764A (en) * 1970-08-20 1972-09-05 Bard Hamilton Co Inc Intracutaneous injection system
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) * 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
DE2250293A1 (de) * 1972-10-13 1974-04-25 Bayern Freistaat Impfstempel zur cutanen pockenimpfung mittels trockenimpfstoff
OA05448A (fr) * 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
US4473083A (en) * 1981-12-14 1984-09-25 Maganias Nicholas H Device and method for allergy testing
US4921475A (en) * 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
GB2221394B (en) 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
US6090790A (en) * 1989-12-14 2000-07-18 Eriksson; Elof Gene delivery by microneedle injection
US5402798A (en) * 1991-07-18 1995-04-04 Swierczek; Remi Disposable skin perforator and blood testing device
US5342737A (en) * 1992-04-27 1994-08-30 The United States Of America As Represented By The Secretary Of The Navy High aspect ratio metal microstructures and method for preparing the same
ATE314475T1 (de) * 1992-06-18 2006-01-15 Us Gov Health & Human Serv Rekombinantes pseudomonas exotoxin mit gesteigerter aktivität
JP3211525B2 (ja) 1993-04-22 2001-09-25 オムロン株式会社 薄材メッシュ、その製造方法及びその製造装置
US5620095A (en) * 1993-06-11 1997-04-15 Minnesota Mining And Manufacturing Company Orthopedic casting material and hermetic package
JP2551742B2 (ja) * 1994-05-23 1996-11-06 三星電機株式会社 医薬品投与用皮膚傷形成装置
DE69637994D1 (de) 1995-04-26 2009-09-24 Minnesota Mining & Mfg Ablationsverfahren durch laser-darstellung
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
AU5740496A (en) * 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
JP2725637B2 (ja) * 1995-05-31 1998-03-11 日本電気株式会社 電子回路装置およびその製造方法
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5658515A (en) * 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5657516A (en) * 1995-10-12 1997-08-19 Minnesota Mining And Manufacturing Company Dual structured fastener elements
AR008242A1 (es) * 1996-06-18 1999-12-29 Alza Corp Dispositivo para atravesar el estrato corneo de una superficie corporal
US6183434B1 (en) 1996-07-03 2001-02-06 Spectrx, Inc. Multiple mechanical microporation of skin or mucosa
US6797276B1 (en) * 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
AU722574B2 (en) * 1996-12-20 2000-08-10 Alza Corporation Device and method for enhancing transdermal agent flux
US6605332B2 (en) * 1997-07-29 2003-08-12 3M Innovative Properties Company Unitary polymer substrate having napped surface of frayed end microfibers
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
KR100572539B1 (ko) * 1997-12-11 2006-04-24 알자 코포레이션 경피성 작용제 유동률을 증진시키기 위한 장치
CN1170603C (zh) * 1997-12-11 2004-10-13 阿尔扎有限公司 增强透皮物剂流量的装置
US6099682A (en) * 1998-02-09 2000-08-08 3M Innovative Properties Company Corporation Of Delaware Cold seal package and method for making the same
JP2002517300A (ja) 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション 微小針デバイスおよび製造方法ならびにそれらの使用
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
GB9815820D0 (en) 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
DE69921489T2 (de) * 1998-08-31 2005-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
CA2352974A1 (en) * 1998-12-18 2000-06-22 John H. Livingston Insertion sets with micro-piercing members for use with medical devices and methods of using the same
DE60007290T2 (de) * 1999-01-28 2004-09-23 Cyto Pulse Sciences, Inc. Einbringen von makromolekülen in zellen
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
EP1187653B1 (de) 1999-06-04 2010-03-31 Georgia Tech Research Corporation Vorrichtungen zur vergrösserten penetration von mikronadeln in biologischen hautschichten
US6611707B1 (en) * 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
WO2001033614A1 (en) * 1999-11-02 2001-05-10 University Of Hawaii Method for fabricating arrays of micro-needles
WO2001036037A2 (en) * 1999-11-15 2001-05-25 Velcro Industries B.V. Skin attachment member
WO2001066065A2 (en) 2000-03-09 2001-09-13 Nanopass Ltd. Systems and methods for fluid transport through dermal barriers
US6558361B1 (en) * 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US7473244B2 (en) * 2000-06-02 2009-01-06 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6537242B1 (en) * 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6589202B1 (en) * 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6440096B1 (en) * 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6749575B2 (en) * 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
BR0113749A (pt) * 2000-09-08 2004-06-22 Alza Corp Métodos para inibir a diminuição no fluxo de droga transdérmica por inibição do fechamento das vias
MXPA03003303A (es) * 2000-10-13 2004-12-13 Johnson & Johnson Retenedor del miembro de microprotrusion para aplicador de impacto.
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
EP2085109A3 (de) * 2000-10-26 2009-09-02 Alza Corporation Transdermale Arzneimittelverabreichungsvorrichtungen mit beschichteten Mikrovorsprüngen
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
AU2002231207A1 (en) * 2000-12-21 2002-07-01 Biovalve Technologies, Inc. Microneedle array systems
US20020099356A1 (en) * 2001-01-19 2002-07-25 Unger Evan C. Transmembrane transport apparatus and method
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
AU2002312315A1 (en) * 2001-06-08 2002-12-23 The Regents Of The University Of California Microfabricated surgical devices and methods of making the same
US6686299B2 (en) * 2001-06-21 2004-02-03 Carlo D. Montemagno Nanosyringe array and method
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US6746590B2 (en) * 2001-09-05 2004-06-08 3M Innovative Properties Company Ultrasonically-enhanced electroplating apparatus and methods
AU2002327675A1 (en) * 2001-09-19 2003-04-01 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
EP1469903A2 (de) * 2001-09-28 2004-10-27 BioValve Technologies, Inc. Mikronadel mit membran
US6689100B2 (en) * 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
EP1439870B1 (de) * 2001-10-29 2009-01-14 Becton, Dickinson and Company Vorrichtung für die abgabe einer substanz
AU2002360361A1 (en) * 2001-11-09 2003-06-10 Biomicroarrays, Inc. High surface area substrates for microarrays and methods to make same
WO2003053258A1 (en) * 2001-12-20 2003-07-03 Alza Corporation Skin-piercing microprojections having piercing depth control
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US20040060902A1 (en) * 2002-02-05 2004-04-01 Evans John D. Microprotrusion array and methods of making a microprotrusion
US7392080B2 (en) * 2002-03-11 2008-06-24 Altea Therapeutics Corporation Transdermal drug delivery patch system, method of making same and method of using same
US6780171B2 (en) * 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US6899838B2 (en) * 2002-07-12 2005-05-31 Becton, Dickinson And Company Method of forming a mold and molding a micro-device
JP4691445B2 (ja) * 2002-07-22 2011-06-01 ベクトン・ディキンソン・アンド・カンパニー パッチ状注入装置
US7422567B2 (en) * 2002-08-29 2008-09-09 Becton, Dickinson And Company Microabrader with controlled abrasion features
US20040106904A1 (en) * 2002-10-07 2004-06-03 Gonnelli Robert R. Microneedle array patch
WO2005000382A2 (en) * 2003-06-04 2005-01-06 Georgia Tech Research Corporation Drilling microneedle device
PE20050288A1 (es) * 2003-07-02 2005-04-29 Alza Corp Metodo y parche de inmunizacion por disposicion de microproyeccion
CA2534823A1 (en) * 2003-08-04 2005-02-24 Alza Corporation Method and device for enhancing transdermal agent flux
EP2609948B1 (de) * 2003-08-12 2020-01-08 Becton, Dickinson and Company Pflasterähnliche Infusionsvorrichtung
KR20060115722A (ko) * 2003-08-26 2006-11-09 알자 코포레이션 진피내 세포 이식용 장치 및 방법
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
KR20060108682A (ko) * 2003-10-24 2006-10-18 알자 코포레이션 경피 약물 전달을 증대시키기 위한 전처리 방법 및 장치
WO2005041871A2 (en) * 2003-10-24 2005-05-12 Alza Corporation Apparatus and method for enhancing transdermal drug delivery
KR20070001886A (ko) * 2003-10-28 2007-01-04 알자 코포레이션 치료용 펩타이드 및 단백질의 폴리머 컨쥬게이트의 피복된미세돌출부를 통한 전달

Also Published As

Publication number Publication date
US6908453B2 (en) 2005-06-21
EP1465698A1 (de) 2004-10-13
JP4382492B2 (ja) 2009-12-16
US20050187521A1 (en) 2005-08-25
WO2003059431A1 (en) 2003-07-24
DE60224842T2 (de) 2009-01-22
IL162554A0 (en) 2005-11-20
DE60224842D1 (de) 2008-03-13
US20030135161A1 (en) 2003-07-17
EP1465698B1 (de) 2008-01-23
AU2002359490A1 (en) 2003-07-30
JP2005514179A (ja) 2005-05-19

Similar Documents

Publication Publication Date Title
ATE384549T1 (de) Mikronadel-vorrichtungen und verfahren zur herstellung
TW200613029A (en) System and method for drug delivery and microfluidic applications using microneedles
JP2005501615A5 (de)
WO2004020015A3 (en) Microprotrusion arrays and methods for using same to deliver substances into tissue
ATE296575T1 (de) Herstellungsverfahren für eine medizinische elektrode
AR046823A1 (es) Sistema y metodo de administracion de vacuna transdermica asistida por ultrasonido
JP2012523265A (ja) 流体伝達を調節することができるマイクロニードルユニット
WO2005042054A3 (en) Pretreatment method and system for enhancing transdermal drug delivery
WO2005000382A3 (en) Drilling microneedle device
WO2002085447A3 (en) Microprojection array having a beneficial agent containing coating
WO2006116281A3 (en) Method of treating acne with stratum corneum piercing device
DE502004006613D1 (de) Vorrichtung zur transdermalen Verabreichung von Wirkstoffen
DE60213976D1 (de) Vorrichtung zur manipulation von nadeln oder polierarray
DE60124917D1 (de) Mikrovorrichtung und verfahren zur herstellung
BR0312671A (pt) Dispositivo de microagulhas, método para utilizar um dispositivo de microagulhas, e, método para aplicar um dispositivo de microagulhas
DE60225859D1 (de) Mikronadelanordnungen
TW200612867A (en) Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
WO2005102334A3 (en) Apparatus and method for transdermal delivery of fentany-based agents
US20200230389A1 (en) Micropenetrator device for penetrating a biological barrier
WO2006023684A3 (en) Microprojection array patch for transdermal delivery of vascular endothelial growth factors
CN107913458B (zh) 一种液体定量储存系统
KR102535229B1 (ko) 광치료용 니들 패치 및 이의 제조 방법
CN109833562B (zh) 一种一次性自毁式振动头组件以及应用该组件的促渗仪
WO2004100850A3 (en) Method of applying gas contact ultrasound therapy, surgery, and drug delivery
UA3737U (uk) Спосіб лікування інсульту

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties