DE60124917D1 - Mikrovorrichtung und verfahren zur herstellung - Google Patents

Mikrovorrichtung und verfahren zur herstellung

Info

Publication number
DE60124917D1
DE60124917D1 DE60124917T DE60124917T DE60124917D1 DE 60124917 D1 DE60124917 D1 DE 60124917D1 DE 60124917 T DE60124917 T DE 60124917T DE 60124917 T DE60124917 T DE 60124917T DE 60124917 D1 DE60124917 D1 DE 60124917D1
Authority
DE
Germany
Prior art keywords
support
skin
microdevice
penetrating member
skin penetrating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60124917T
Other languages
English (en)
Other versions
DE60124917T2 (de
Inventor
G Lastovich
D Evans
J Pettis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of DE60124917D1 publication Critical patent/DE60124917D1/de
Application granted granted Critical
Publication of DE60124917T2 publication Critical patent/DE60124917T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15142—Devices intended for single use, i.e. disposable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Micromachines (AREA)
  • Medicines Containing Plant Substances (AREA)
DE60124917T 2000-07-14 2001-07-11 Mikrovorrichtung und verfahren zur herstellung Expired - Lifetime DE60124917T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US616771 2000-07-14
US09/616,771 US6440096B1 (en) 2000-07-14 2000-07-14 Microdevice and method of manufacturing a microdevice
PCT/US2001/021791 WO2002005890A2 (en) 2000-07-14 2001-07-11 Microdevice and method of manufacturing a microdevice

Publications (2)

Publication Number Publication Date
DE60124917D1 true DE60124917D1 (de) 2007-01-11
DE60124917T2 DE60124917T2 (de) 2007-06-06

Family

ID=24470876

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60124917T Expired - Lifetime DE60124917T2 (de) 2000-07-14 2001-07-11 Mikrovorrichtung und verfahren zur herstellung

Country Status (8)

Country Link
US (2) US6440096B1 (de)
EP (1) EP1301237B1 (de)
JP (1) JP4892166B2 (de)
AT (1) ATE346645T1 (de)
AU (1) AU2001273340A1 (de)
DE (1) DE60124917T2 (de)
ES (1) ES2276805T3 (de)
WO (1) WO2002005890A2 (de)

Families Citing this family (265)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US9717451B2 (en) * 2000-06-08 2017-08-01 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6607513B1 (en) * 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US6603987B2 (en) * 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
US6749575B2 (en) * 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US6821281B2 (en) * 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7828827B2 (en) * 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
AU2002237703A1 (en) * 2000-11-09 2002-06-18 Biovalve Technologies, Inc. Microneedle adapter
EP1345646A2 (de) * 2000-12-14 2003-09-24 Georgia Tech Research Corporation Mikronadel-vorrichtungen und deren herstellung
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
BR0209046A (pt) * 2001-04-20 2004-11-09 Alza Corp Disposição de microprojeção que possui um agente benéfico contendo revestimento
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
DE60213976T2 (de) * 2001-06-08 2007-04-26 Becton Dickinson And Co. Vorrichtung zur manipulation von nadeln oder polierarray
CN100349629C (zh) * 2001-09-12 2007-11-21 贝克顿迪肯森公司 用于药物传送的微针为基础的笔装置和使用该装置的方法
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US6830562B2 (en) 2001-09-27 2004-12-14 Unomedical A/S Injector device for placing a subcutaneous infusion set
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US20050033197A1 (en) * 2001-12-06 2005-02-10 Cottler Patrick S Apparatus for fluid transport and related method thereof
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
AU2003209645A1 (en) * 2002-03-04 2003-09-16 Nano Pass Technologies Ltd. Devices and methods for transporting fluid across a biological barrier
BRPI0308319B1 (pt) 2002-03-11 2015-06-09 Beaver Visitec Int Us Inc Método para fabricar um dispositivo de corte de material cristalino e método para fabricar uma lâmina cirúrgica de material cristalino
US7387742B2 (en) * 2002-03-11 2008-06-17 Becton, Dickinson And Company Silicon blades for surgical and non-surgical use
US7115108B2 (en) * 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US7047070B2 (en) * 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
JP4829497B2 (ja) * 2002-06-25 2011-12-07 セラジェクト， インコーポレイテッド 薬物送達のための急速に溶解する微小穿孔器および他の適用
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
US7422567B2 (en) * 2002-08-29 2008-09-09 Becton, Dickinson And Company Microabrader with controlled abrasion features
US20040051019A1 (en) 2002-09-02 2004-03-18 Mogensen Lasse Wesseltoft Apparatus for and a method of adjusting the length of an infusion tube
AU2003275311A1 (en) * 2002-09-16 2004-04-30 Sung-Yun Kwon Solid micro-perforators and methods of use
WO2004033021A1 (en) * 2002-10-07 2004-04-22 Biovalve Technologies, Inc. Microneedle array patch
DK200201823A (da) 2002-11-26 2004-05-27 Maersk Medical As Forbindelsesstykke for en slangeforbindelse
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US20090007436A1 (en) * 2003-03-10 2009-01-08 Daskal Vadim M Silicon blades for surgical and non-surgical use
US20050155955A1 (en) * 2003-03-10 2005-07-21 Daskal Vadim M. Method for reducing glare and creating matte finish of controlled density on a silicon surface
TW566423U (en) * 2003-04-23 2003-12-11 Ind Tech Res Inst Structure for miniature gripping clip
AU2004251699A1 (en) * 2003-06-04 2005-01-06 Georgia Tech Research Corporation Drilling microneedle device
IL156374A0 (en) * 2003-06-10 2004-01-04 Danenberg Holdings 2000 Ltd N Method for removing a pigmented section of skin
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
CN1842320B (zh) * 2003-06-30 2013-06-19 阿尔扎公司 含有不挥发性平衡离子的用于经涂覆的微突出物的制剂
IL157696A0 (en) * 2003-09-01 2004-03-28 Hawk Medical Technologies Ltd Apparatus and method for removing a pigmented section of skin
JP2007514457A (ja) * 2003-09-17 2007-06-07 ベクトン・ディキンソン・アンド・カンパニー シリコンおよびその他の結晶質材料にルータを用いて直線状および非直線状の溝を作成するシステムおよび方法
US7956742B2 (en) 2003-10-30 2011-06-07 Motedata Inc. Method and system for storing, retrieving, and managing data for tags
US7388488B2 (en) * 2003-10-30 2008-06-17 Peter Lupoli Method and system for storing, retrieving, and managing data for tags
EP1699524A4 (de) * 2003-11-18 2009-07-15 Nanopass Technologies Ltd Verbessertes penetrationssystem und verfahren zum schieben von mikronadeln
US7998119B2 (en) * 2003-11-18 2011-08-16 Nano Pass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
EP1706171A1 (de) * 2003-12-29 2006-10-04 3M Innovative Properties Company Medizinprodukte und diese enthaltende sets
US8551391B2 (en) * 2004-02-17 2013-10-08 Avery Dennison Corporation Method of making microneedles
CN100540086C (zh) * 2004-03-12 2009-09-16 新加坡科技研究局 用来制造侧开口微型针的方法及模具
AU2005228145B2 (en) 2004-03-24 2011-03-03 Corium Pharma Solutions, Inc. Transdermal delivery device
WO2005092410A1 (en) 2004-03-26 2005-10-06 Unomedical A/S Infusion set
US7331953B2 (en) * 2004-04-01 2008-02-19 The Gneral Hospital Corporation Method and apparatus for dermatological treatment
CA2562643A1 (en) * 2004-04-12 2005-11-24 Allergan, Inc. Multi-site injection system
US7396484B2 (en) * 2004-04-30 2008-07-08 Becton, Dickinson And Company Methods of fabricating complex blade geometries from silicon wafers and strengthening blade geometries
CA2566032A1 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US20080039805A1 (en) * 2004-06-10 2008-02-14 Frederickson Franklyn L Patch Application Device and Kit
US8062250B2 (en) 2004-08-10 2011-11-22 Unomedical A/S Cannula device
US8192787B2 (en) * 2004-08-16 2012-06-05 Innoture Limited Method of producing a microneedle or microimplant
US7316665B2 (en) * 2004-08-25 2008-01-08 Becton, Dickinson And Company Method and device for the delivery of a substance including a covering
BRPI0517749A (pt) 2004-11-18 2008-10-21 3M Innovative Properties Co dispositivo de aplicação para aplicar um dispositivo de micro-agulha a uma superfìcie de pele, e, método para usar um dispositivo de aplicação
CA2588080C (en) * 2004-11-18 2013-01-08 3M Innovative Properties Company Masking method for coating a microneedle array
CN101060882B (zh) 2004-11-18 2010-06-16 3M创新有限公司 微针阵列施放器和保持器
WO2006054280A2 (en) * 2004-11-18 2006-05-26 Nanopass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
CN101076409B (zh) 2004-11-18 2011-11-23 3M创新有限公司 接触涂敷微针阵列的方法
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
JP4964141B2 (ja) 2004-12-10 2012-06-27 ウノメディカル アクティーゼルスカブ 挿入具
WO2006064270A1 (en) * 2004-12-17 2006-06-22 Functional Microstructures Limited Microneedle device for transdermal transport of fluid
US7985199B2 (en) * 2005-03-17 2011-07-26 Unomedical A/S Gateway system
WO2006108185A1 (en) 2005-04-07 2006-10-12 3M Innovative Properties Company System and method for tool feedback sensing
US20060253078A1 (en) * 2005-04-25 2006-11-09 Wu Jeffrey M Method of treating skin disorders with stratum corneum piercing device
US8840586B2 (en) * 2006-08-23 2014-09-23 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US8277415B2 (en) 2006-08-23 2012-10-02 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8137314B2 (en) * 2006-08-23 2012-03-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with compressible or curved reservoir or conduit
US8512288B2 (en) 2006-08-23 2013-08-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US20080097291A1 (en) * 2006-08-23 2008-04-24 Hanson Ian B Infusion pumps and methods and delivery devices and methods with same
US7905868B2 (en) 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US7955305B2 (en) 2005-05-06 2011-06-07 Medtronic Minimed, Inc. Needle inserter and method for infusion device
WO2007002523A2 (en) 2005-06-24 2007-01-04 3M Innovative Properties Company Collapsible patch with microneedle array
CA2613111C (en) 2005-06-27 2015-05-26 3M Innovative Properties Company Microneedle array applicator device and method of array application
JP2009501184A (ja) * 2005-07-13 2009-01-15 エフ．ホフマン−ラ ロシュ アーゲー ５−ｈｔ６、５−ｈｔ２４としてのベンゾイミダゾール誘導体
ES2466646T3 (es) * 2005-08-01 2014-06-10 Hawk Medical Technologies Ltd. Erradicación de pigmentación y tejido cicatrizal
CN101242869B (zh) * 2005-09-02 2010-05-26 Iomai公司 经皮递送疫苗和透皮递送药物的装置及其应用
CA2629393C (en) * 2005-09-06 2014-06-10 Theraject, Inc. Solid solution perforator containing drug particle and/or drug-adsorbed particles
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US9358033B2 (en) * 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
ATE480278T1 (de) 2005-09-12 2010-09-15 Unomedical As Einfürungssystem für ein infusionsset mit einem ersten und zweiten federeinheit
US8585377B2 (en) 2006-02-09 2013-11-19 Deka Products Limited Partnership Pumping fluid delivery systems and methods using force application assembly
WO2007047539A2 (en) * 2005-10-14 2007-04-26 Medtronic, Inc. Localized delivery to the lymphatic system
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
USD655807S1 (en) 2005-12-09 2012-03-13 Unomedical A/S Medical device
PT1962926E (pt) 2005-12-23 2009-08-27 Unomedical As Dispositivo de injecção
WO2007080596A2 (en) * 2006-01-12 2007-07-19 Nano Pass Technologies Ltd. Device for superficial abrasive treatment of the skin
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
NZ570115A (en) 2006-02-28 2010-07-30 Unomedical As Inserter for infusion part and infusion part provided with needle protector
WO2007124411A1 (en) * 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
US8439838B2 (en) 2006-06-07 2013-05-14 Unomedical A/S Inserter for transcutaneous sensor
BRPI0712361A2 (pt) 2006-06-09 2012-06-19 Unomedical As suporte de montagem
JP2009539508A (ja) 2006-06-15 2009-11-19 シーガル アイピー ピーティーワイ リミテッド 送達システム及び方法
CA2658577A1 (en) 2006-08-02 2008-02-07 Unomedical A/S Cannula and delivery device
EP1884223A1 (de) 2006-08-04 2008-02-06 IP Randwyck B.V. Wundestimulierende Einheit
US7794434B2 (en) * 2006-08-23 2010-09-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7789857B2 (en) * 2006-08-23 2010-09-07 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
US7828764B2 (en) * 2006-08-23 2010-11-09 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7811262B2 (en) * 2006-08-23 2010-10-12 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US20080051765A1 (en) * 2006-08-23 2008-02-28 Medtronic Minimed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
WO2008042902A2 (en) 2006-10-02 2008-04-10 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
EP1917990A1 (de) 2006-10-31 2008-05-07 Unomedical A/S Infusionsset
AU2008209537B2 (en) 2007-01-22 2013-01-31 Corium Pharma Solutions, Inc. Applicators for microneedle arrays
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
EP2146689B1 (de) 2007-04-16 2020-08-12 Corium, Inc. Einen wirkstoff enthaltende lösungsmittel-gegossene mikronadelanordnungen
US7959715B2 (en) 2007-04-30 2011-06-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8434528B2 (en) 2007-04-30 2013-05-07 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
US8323250B2 (en) 2007-04-30 2012-12-04 Medtronic Minimed, Inc. Adhesive patch systems and methods
JP5102350B2 (ja) 2007-04-30 2012-12-19 メドトロニック ミニメド インコーポレイテッド リザーバ充填／気泡管理／注入媒体送給システムおよび該システムを用いる方法
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
US8597243B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
RU2469751C2 (ru) 2007-06-20 2012-12-20 Уномедикал А/С Способ изготовления катетера и устройство для его осуществления
WO2009004026A1 (en) 2007-07-03 2009-01-08 Unomedical A/S Inserter having bistable equilibrium states
CA2704909A1 (en) 2007-07-10 2009-01-15 Unomedical A/S Inserter having two springs
NZ582226A (en) 2007-07-18 2011-12-22 Unomedical As Insertion device with a pivoting action from a first to a second position and longitudinal action to a third position in the direction of insertion.
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
FR2923151B1 (fr) * 2007-11-02 2010-09-03 Commissariat Energie Atomique Dispositif de prelevement sanguin comportant au moins un filtre .
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
GB0802447D0 (en) * 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
CA2713485A1 (en) 2008-02-13 2009-08-20 Unomedical A/S Sealing between a cannula part and a fluid path
US9566384B2 (en) 2008-02-20 2017-02-14 Unomedical A/S Insertion device with horizontally moving part
EP2296557B1 (de) * 2008-05-21 2018-07-11 Theraject, Inc. Verfahren zur Herstellung von Mikronadel-Matrizen
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
WO2010033878A2 (en) 2008-09-19 2010-03-25 David Brown Solute concentration measurement device and related methods
JP2012513224A (ja) 2008-12-22 2012-06-14 ウノメディカル アクティーゼルスカブ 接着剤パッドを含む医療デバイス
US9119578B2 (en) 2011-04-29 2015-09-01 Seventh Sense Biosystems, Inc. Plasma or serum production and removal of fluids under reduced pressure
WO2010101620A2 (en) 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Systems and methods for creating and using suction blisters or other pooled regions of fluid within the skin
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
WO2011012465A1 (en) 2009-07-30 2011-02-03 Unomedical A/S Inserter device with horizontal moving part
EP3284494A1 (de) 2009-07-30 2018-02-21 Tandem Diabetes Care, Inc. Tragbares infusionspumpensystem
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
AU2010280713A1 (en) 2009-08-07 2012-02-02 Unomedical A/S Delivery device with sensor and one or more cannulas
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
CA2778963A1 (en) 2009-10-26 2011-05-05 Emkinetics, Inc. Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
AU2010332400B2 (en) 2009-12-16 2016-08-04 Chrontech Pharma Ab Injection Needle and Device
US8900181B2 (en) 2009-12-18 2014-12-02 Srgi Holdings, Llc Skin treatment and drug delivery device
WO2011094573A1 (en) 2010-01-28 2011-08-04 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
WO2011121023A1 (en) 2010-03-30 2011-10-06 Unomedical A/S Medical device
WO2011135530A2 (en) 2010-04-28 2011-11-03 Kimberly-Clark Worldwide, Inc. Device for delivery of rheumatoid arthritis medication
EP2563455A4 (de) 2010-04-28 2014-02-19 Kimberly Clark Co Verfahren zur erhöhung der durchlässigkeit einer epithelialbarriere
WO2011135531A2 (en) 2010-04-28 2011-11-03 Kimberly-Clark Worldwide, Inc. MEDICAL DEVICES FOR DELIVERY OF siRNA
WO2011135533A2 (en) 2010-04-28 2011-11-03 Kimberly-Clark Worldwide, Inc. Nanopatterned medical device with enhanced cellular interaction
EP2566501B1 (de) 2010-05-04 2019-03-13 Corium International, Inc. Verfahren und vorrichtung zur transdermalen verabreichung von parathormon mithilfe eines mikroprojektions-arrays
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
WO2012009613A1 (en) 2010-07-16 2012-01-19 Seventh Sense Biosystems, Inc. Low-pressure environment for fluid transfer devices
EP2600901B1 (de) 2010-08-06 2019-03-27 ModernaTX, Inc. Pharmazeutische zusammensetzungen enthaltenbearbeitete nukleinsäuren und ihre medizinische verwendung
WO2012021801A2 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
EP2433663A1 (de) 2010-09-27 2012-03-28 Unomedical A/S Einführsystem
CN104531671A (zh) 2010-10-01 2015-04-22 现代治疗公司 设计核酸及其使用方法
EP2436412A1 (de) 2010-10-04 2012-04-04 Unomedical A/S Sprinklerkanüle
CN103370007B (zh) 2010-11-09 2018-12-18 第七感生物系统有限公司 用于采血的系统和界面
EP2460553A1 (de) * 2010-12-02 2012-06-06 Debiotech S.A. Vorrichtung für das Einsetzen von Nadeln
US10695546B2 (en) 2010-12-17 2020-06-30 Srgi Holdings, Llc Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal
US11278309B2 (en) 2010-12-17 2022-03-22 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10335190B2 (en) 2013-12-06 2019-07-02 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10661063B2 (en) 2010-12-17 2020-05-26 Srgi Holdings, Llc Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal
US10702684B2 (en) 2010-12-17 2020-07-07 Srgi Holdings, Llc Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal
US20160317170A1 (en) 2013-12-06 2016-11-03 Edward KNOWLTON Pixel array medical systems, devices and methods
US11103275B2 (en) 2010-12-17 2021-08-31 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US11612410B2 (en) 2010-12-17 2023-03-28 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10736653B2 (en) 2013-12-06 2020-08-11 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10321948B2 (en) 2010-12-17 2019-06-18 Srgi Holdings, Llc Pixel array medical devices and methods
US11000310B2 (en) 2010-12-17 2021-05-11 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10368904B2 (en) 2013-12-06 2019-08-06 Srgi Holdings, Llc Pixel array medical systems, devices and methods
ES2718651T3 (es) 2011-01-28 2019-07-03 Massachusetts Gen Hospital Método y aparato para dermoabrasión discontinua
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
CA2831613A1 (en) 2011-03-31 2012-10-04 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
KR102013466B1 (ko) 2011-04-29 2019-08-22 세븐쓰 센스 바이오시스템즈, 인크. 유체들의 전달 및/또는 수용
WO2012149155A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US9457183B2 (en) 2011-06-15 2016-10-04 Tripep Ab Injection needle and device
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP3682905B1 (de) 2011-10-03 2021-12-01 ModernaTX, Inc. Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
CN103957962B (zh) 2011-10-05 2017-07-07 犹诺医药有限公司 用于同时插入多个经皮部分的插入物
EP2583715A1 (de) 2011-10-19 2013-04-24 Unomedical A/S Infusionsschlauchsystem und Herstellungsverfahren
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
EP3542851B1 (de) 2011-10-27 2021-12-15 Sorrento Therapeutics, Inc. Implantierbare vorrichtungen zur freisetzung bioaktiver wirkstoffe
JP6100271B2 (ja) 2011-10-27 2017-03-22 キンバリー クラーク ワールドワイド インコーポレイテッド 高粘性生理活性薬剤の経皮的送達
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
ES2923757T3 (es) 2011-12-16 2022-09-30 Modernatx Inc Composiciones de ARNm modificado
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
AU2013243953A1 (en) 2012-04-02 2014-10-30 Modernatx, Inc. Modified polynucleotides for the production of nuclear proteins
US9303079B2 (en) 2012-04-02 2016-04-05 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
JP6145249B2 (ja) * 2012-05-25 2017-06-07 学校法人 関西大学 中空微細針及びその作製方法
WO2013191025A1 (ja) * 2012-06-22 2013-12-27 凸版印刷株式会社 針状体及び針状体製造方法
WO2014064534A2 (en) 2012-10-05 2014-05-01 Chrontech Pharma Ab Injection needle, device, immunogenic compositions and method of use
DK2922554T3 (en) 2012-11-26 2022-05-23 Modernatx Inc Terminalt modificeret rna
MX2015007227A (es) 2012-12-06 2016-02-18 Srgi Holdings Llc Dispositivos médicos de arreglo de pixeles y métodos.
CA2896188C (en) 2012-12-21 2021-02-23 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
BR112015019440A8 (pt) 2013-02-20 2019-11-12 Cytrellis Biosystems Inc curativo regulável, kit, uso e método para fortalecimento da pele
ES2921481T3 (es) 2013-03-12 2022-08-26 Corium Inc Aplicadores para microproyecciones
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
AU2014237279B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
AU2014233695A1 (en) 2013-03-15 2015-10-01 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
WO2014144973A1 (en) 2013-03-15 2014-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
EP2968751B1 (de) 2013-03-15 2022-11-30 Corium, Inc. Mehrfachberührungs-mikroprojektionsapplikatoren
CN104056345B (zh) * 2013-03-22 2017-04-19 北京神州汉方医药科技有限公司 一种经皮给药装置
AU2014262382A1 (en) * 2013-05-06 2015-11-19 Mupharma Pty Ltd Non-invasive agent applicator
KR20230119266A (ko) 2013-08-09 2023-08-16 사이트렐리스 바이오시스템즈, 인크. 비-열적 조직 절제를 사용한 피부 치료를 위한 방법및 기구
ES2827049T3 (es) 2013-10-02 2021-05-19 Srgi Holdings Llc Dispositivos médicos de conjunto de píxeles
SG11201602636PA (en) 2013-10-02 2016-05-30 Srgi Holdings Llc Pixel array medical devices and methods
WO2015051214A1 (en) 2013-10-03 2015-04-09 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
US11229452B2 (en) 2013-12-06 2022-01-25 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US11937846B2 (en) 2013-12-06 2024-03-26 Srgi Holdings Llc Pixel array medical systems, devices and methods
US10953143B2 (en) 2013-12-19 2021-03-23 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
WO2015138207A1 (en) * 2014-03-10 2015-09-17 3M Innovative Properties Company Micro-needle device
US20160279401A1 (en) 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
WO2015159525A1 (ja) * 2014-04-14 2015-10-22 凸版印刷株式会社 注入器具
EP3139990A4 (de) * 2014-05-06 2018-01-17 Mupharma Pty Ltd Nichtinvasiver wirkstoffapplikator
CA2959512A1 (en) * 2014-08-29 2016-03-03 Srgi Holdings, Llc Pixel array medical devices and methods
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
WO2016074040A2 (en) * 2014-11-12 2016-05-19 Mupharma Pty Ltd Non-invasive agent applicator
JP2017533774A (ja) 2014-11-14 2017-11-16 サイトレリス バイオシステムズ，インコーポレーテッド 皮膚のアブレーションのためのデバイス及び方法
US9730625B2 (en) 2015-03-02 2017-08-15 Verily Life Sciences Llc Automated blood sampling device
US10765361B2 (en) * 2015-03-02 2020-09-08 Verily Life Sciences Llc Automated sequential injection and blood draw
JP2018507771A (ja) * 2015-03-10 2018-03-22 アラーガン ファーマシューティカルズ ホールディングス （アイルランド） アンリミテッド カンパニー 多針注入器
WO2016147476A1 (ja) * 2015-03-18 2016-09-22 凸版印刷株式会社 薬剤投与装置および薬剤投与装置の製造方法
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US11751904B2 (en) 2015-08-31 2023-09-12 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US11490952B2 (en) 2015-08-31 2022-11-08 Srgi Holdings, Llc Pixel array medical devices and methods
US11564706B2 (en) 2019-10-28 2023-01-31 Srgi Holdings, Llc Pixel array medical systems, devices and methods
AU2017218014B2 (en) * 2016-02-11 2020-12-17 Edward Knowlton Pixel array medical systems, devices and methods
EP3435890A1 (de) 2016-03-29 2019-02-06 Cytrellis Biosystems, Inc. Vorrichtungen und verfahren zur kosmetischen hauterneuerung
KR102627434B1 (ko) * 2016-08-08 2024-01-18 주식회사 엘지생활건강 흡착 마이크로니들
AU2017330298B2 (en) 2016-09-21 2022-09-29 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
CN106725894B (zh) * 2017-01-22 2020-06-05 袁晓辉 一种间歇式负压吸引皮肤扩张装置及其使用方法
US10765426B2 (en) * 2017-02-17 2020-09-08 Ethicon Llc Systems for coupling adjuncts to an end effector
WO2018151832A1 (en) 2017-02-17 2018-08-23 Allergan, Inc. Microneedle array with active ingredient
WO2020086915A2 (en) 2017-05-03 2020-04-30 Srgi Holdings Llc Handed spiral slotted scalpet array
TWI778065B (zh) 2017-07-25 2022-09-21 瑞典商艾瑟莉恩公司 吸力施加裝置以及用於取樣體液的裝置
US11213667B2 (en) * 2018-07-11 2022-01-04 Santa Clara University 3D printed microneedles for microencapsulated mammalian cell extrusion
JP1632957S (de) 2018-10-30 2019-06-03
CN113329707A (zh) 2018-12-19 2021-08-31 克利里特有限责任公司 用于使用所施加的电场去除纹身的系统和方法
CN109938777B (zh) * 2019-04-02 2020-02-07 汕头大学医学院第一附属医院 一种皮肤辅助检查机械
JP7491551B2 (ja) * 2019-04-25 2024-05-28 コスメディ製薬株式会社 水溶性シート状製剤のアプリケータ２
WO2021216761A1 (en) * 2020-04-22 2021-10-28 Paul Gilbert Fluid characteristic indicator
FR3110382B1 (fr) * 2020-05-20 2022-05-13 Pkvitality Capteur pour système de surveillance corporelle monté en surface
FR3113578B1 (fr) * 2020-08-28 2023-02-10 Pkvitality Procede d’alignement de composant(s) d’un systeme de surveillance corporelle
CN115227957A (zh) * 2022-07-26 2022-10-25 空芯微医疗科技(上海)有限责任公司 空心微针的制备方法及其制品

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3167073A (en) * 1962-01-16 1965-01-26 Rosenthal Sol Roy Transcutaneous injection device
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
EP0429842B1 (de) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5466465A (en) * 1993-12-30 1995-11-14 Harrogate Holdings, Limited Transdermal drug delivery system
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
JP2713255B2 (ja) * 1995-08-11 1998-02-16 日本電気株式会社 浸出液吸引装置
ES2195151T3 (es) 1996-06-18 2003-12-01 Alza Corp Dispositivo de mejora de aporte o de muestreo de agentes transdermicos.
US6183434B1 (en) * 1996-07-03 2001-02-06 Spectrx, Inc. Multiple mechanical microporation of skin or mucosa
ATE231015T1 (de) * 1996-09-17 2003-02-15 Deka Products Lp System zur medikamentenabgabe durch transport
US5993412A (en) * 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
EP1037687B8 (de) * 1997-12-11 2008-10-22 Alza Corporation Vorrichtung zur verbesserung des transdermalen flusses von medikamenten
ATE221400T1 (de) * 1997-12-11 2002-08-15 Alza Corp Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
US6126637A (en) * 1998-04-15 2000-10-03 Science Incorporated Fluid delivery device with collapsible needle cover
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
CA2393537C (en) * 1999-12-10 2009-02-03 Alza Corporation Skin treatment apparatus for sustained transdermal drug delivery

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EP1301237A2 (de) 2003-04-16
EP1301237B1 (de) 2006-11-29
US20020183688A1 (en) 2002-12-05
WO2002005890A3 (en) 2002-04-25
ES2276805T3 (es) 2007-07-01
AU2001273340A1 (en) 2002-01-30
DE60124917T2 (de) 2007-06-06
JP4892166B2 (ja) 2012-03-07

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