ATE221400T1 - Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses - Google Patents

Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses

Info

Publication number
ATE221400T1
ATE221400T1 AT98964713T AT98964713T ATE221400T1 AT E221400 T1 ATE221400 T1 AT E221400T1 AT 98964713 T AT98964713 T AT 98964713T AT 98964713 T AT98964713 T AT 98964713T AT E221400 T1 ATE221400 T1 AT E221400T1
Authority
AT
Austria
Prior art keywords
increase
active ingredients
transdermal flow
transdermal
flow
Prior art date
Application number
AT98964713T
Other languages
English (en)
Inventor
Michael G Zuck
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ATE221400T1 publication Critical patent/ATE221400T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/20Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303Constructional details
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Electrotherapy Devices (AREA)
AT98964713T 1997-12-11 1998-12-09 Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses ATE221400T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6934097P 1997-12-11 1997-12-11
PCT/US1998/026158 WO1999029364A1 (en) 1997-12-11 1998-12-09 Device for enhancing transdermal agent flux

Publications (1)

Publication Number Publication Date
ATE221400T1 true ATE221400T1 (de) 2002-08-15

Family

ID=22088315

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98964713T ATE221400T1 (de) 1997-12-11 1998-12-09 Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses

Country Status (10)

Country Link
US (1) US6050988A (de)
EP (1) EP1035889B1 (de)
JP (1) JP4061022B2 (de)
KR (1) KR100572539B1 (de)
CN (1) CN1161164C (de)
AT (1) ATE221400T1 (de)
AU (1) AU739616B2 (de)
CA (1) CA2313458C (de)
DE (1) DE69806963T2 (de)
WO (1) WO1999029364A1 (de)

Families Citing this family (254)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0914178T3 (da) * 1996-06-18 2003-04-22 Alza Corp Anordning til forøgelse af transdermal afgivelse eller prøveudtagning af et middel
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
WO1999064580A1 (en) * 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
WO2000003758A1 (en) 1998-07-14 2000-01-27 Spectrx, Inc. Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport
CA2341446C (en) * 1998-08-31 2008-10-07 Johnson & Johnson Consumer Companies, Inc. Electrotransport device comprising blades
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
US6708060B1 (en) 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6597946B2 (en) 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
ATE290902T1 (de) 1999-04-16 2005-04-15 Johnson & Johnson Consumer Vorrichtung zur iontophoretischen verabreichung von medikamenten mit internen sensoren
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
ATE324922T1 (de) * 1999-06-08 2006-06-15 Altea Therapeutics Corp Vorrichtung zur mikroporation eines biologischen gewebes mittels einer filmgewebe schnittstellenvorrichtung und verfahren
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US7133717B2 (en) * 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
HK1048773B (en) * 1999-12-10 2005-10-14 Alza Corporation Skin treatment apparatus for sustained transdermal drug delivery
KR100750841B1 (ko) * 1999-12-16 2007-08-22 알자 코포레이션 채취되는 약물의 경피 유동을 강화하기 위한 장치 및 방법
US7404815B2 (en) * 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US6659982B2 (en) * 2000-05-08 2003-12-09 Sterling Medivations, Inc. Micro infusion drug delivery device
US6629949B1 (en) * 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US6540675B2 (en) 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
US6589202B1 (en) * 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6440096B1 (en) * 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6690959B2 (en) 2000-09-01 2004-02-10 Medtronic, Inc. Skin-mounted electrodes with nano spikes
BR0113749A (pt) * 2000-09-08 2004-06-22 Alza Corp Métodos para inibir a diminuição no fluxo de droga transdérmica por inibição do fechamento das vias
WO2002030506A2 (en) 2000-10-12 2002-04-18 Ink Jet Technology Ltd. Transdermal method
IL155389A0 (en) * 2000-10-13 2003-11-23 Alza Corportion Microprotrusion member retainer for impact applicator
DE60138411D1 (de) 2000-10-13 2009-05-28 Alza Corp Vorrichtung und verfahren zum durchstechen der haut mit micronadeln
AU2001296827B2 (en) 2000-10-13 2005-11-17 Alza Corporation Microblade array impact applicator
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
BR0114909A (pt) 2000-10-26 2004-02-03 Alza Corp Dispositivos de distribuição de drogas transdérmicas possuindo microprotuberâncias revestidas
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
AU2002231207A1 (en) * 2000-12-21 2002-07-01 Biovalve Technologies, Inc. Microneedle array systems
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
WO2002074173A1 (en) * 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
EP1752189A3 (de) 2001-04-20 2007-02-21 Alza Corporation Mikroprojektionsanordnung mit einem Überzug, der ein vorteilhaftes Mittel enthält
WO2002085447A2 (en) * 2001-04-20 2002-10-31 Alza Corporation Microprojection array having a beneficial agent containing coating
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
EP1425064A2 (de) * 2001-09-14 2004-06-09 The Procter & Gamble Company Mikrostrukturen für die kutane verabreichung einer komposition mit hilfe von rollen elementen
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
WO2003024507A2 (en) * 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US8920375B2 (en) * 2001-09-21 2014-12-30 Valeritas, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
EP1469903A2 (de) * 2001-09-28 2004-10-27 BioValve Technologies, Inc. Mikronadel mit membran
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
US6689100B2 (en) 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
EP1439870B1 (de) * 2001-10-29 2009-01-14 Becton, Dickinson and Company Vorrichtung für die abgabe einer substanz
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
AU2002353444A1 (en) 2001-11-07 2003-05-19 Transpharma Medical Ltd. Integrated transdermal drug delivery system
AU2002352978A1 (en) * 2001-11-30 2003-06-17 Alza Corporation Methods and apparatuses for forming microprojection arrays
AU2002357372B2 (en) * 2001-12-20 2008-11-20 Alza Corporation Skin-piercing microprojections having piercing depth control
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
US8116860B2 (en) 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
EP1483019A4 (de) 2002-03-11 2007-07-04 Altea Therapeutics Corp Transdermales arzneimittelabgabe-pflastersystem, verfahren zu seiner herstellung und anwendungsverfahren dafür
US7115108B2 (en) * 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7047070B2 (en) * 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
WO2003089043A2 (en) * 2002-04-19 2003-10-30 Transpharma Medical Ltd. Handheld transdermal drug delivery and analyte extraction
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
JP4829497B2 (ja) * 2002-06-25 2011-12-07 セラジェクト, インコーポレイテッド 薬物送達のための急速に溶解する微小穿孔器および他の適用
AR040302A1 (es) * 2002-06-28 2005-03-23 Alza Corp Dispositivos para la liberacion transdermica de farmacos, que presentan microprotrusiones recubiertas
MXPA05000597A (es) 2002-07-19 2005-04-28 3M Innovative Properties Co Dispositivos de microaguja y aparatos de administracion por microaguja.
AR040819A1 (es) * 2002-08-08 2005-04-20 Alza Corp Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
EP1531896B1 (de) * 2002-08-29 2016-07-20 Becton Dickinson and Company Microprojektionanordung zur verabreichung von stoffen in gewebe und verfahren zur verwendung
US8062573B2 (en) * 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
CA2516547A1 (en) * 2002-09-30 2004-04-15 Alza Corporation Drug delivery device having coated microprojections incorporating vasoconstrictors
US7662404B2 (en) * 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
IL152573A (en) * 2002-10-31 2009-11-18 Transpharma Medical Ltd A system for the transmission through the skin of a medical preparation against vomiting and nausea
IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
IL152575A (en) * 2002-10-31 2008-12-29 Transpharma Medical Ltd A skin-to-skin transmission system of water-insoluble drugs
US7383084B2 (en) * 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US8133505B2 (en) * 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US7045069B2 (en) * 2002-11-14 2006-05-16 Gennady Ozeryansky Microfabrication method based on metal matrix composite technology
IL152912A0 (en) * 2002-11-18 2003-06-24 Nanopass Ltd Micro needle systems
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7052652B2 (en) * 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
JP2004343275A (ja) * 2003-05-14 2004-12-02 Murata Mach Ltd 画像処理システム及びスキャナ装置
CN1321706C (zh) * 2003-05-29 2007-06-20 财团法人工业技术研究院 一种数组式微针软质基材结构及其制造方法
WO2005004842A2 (en) 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
ES2290738T3 (es) * 2003-06-30 2008-02-16 Alza Corporation Procedimiento para revestir microproyecciones de perforacion de la piel.
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
CA2530954A1 (en) * 2003-07-02 2005-01-13 Alza Corporation Microprojection array immunization patch and method
CN1863572A (zh) * 2003-08-04 2006-11-15 阿尔扎公司 提高药剂经皮流通量的方法和装置
JP2007503268A (ja) * 2003-08-25 2007-02-22 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答修飾化合物の送達
BRPI0413867A (pt) * 2003-08-26 2006-10-24 Alza Corp dispositivo e método para implantação de célula intradérmica
WO2005041871A2 (en) * 2003-10-24 2005-05-12 Alza Corporation Apparatus and method for enhancing transdermal drug delivery
CA2543086A1 (en) * 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
AU2004287412A1 (en) * 2003-10-28 2005-05-19 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
US20050106227A1 (en) * 2003-10-28 2005-05-19 Samuel Zalipsky Delivery of polymer conjugates of therapeutic peptides and proteins via coated microprojections
AU2004287414B2 (en) * 2003-10-31 2010-11-25 Alza Corporation Self-actuating applicator for microprojection array
AU2004291040A1 (en) * 2003-11-13 2005-06-02 Alza Corporation System and method for transdermal delivery
WO2005051456A2 (en) * 2003-11-13 2005-06-09 Alza Corporation Composition and apparatus for transdermal delivery
DE10353629A1 (de) * 2003-11-17 2005-06-16 Lts Lohmann Therapie-Systeme Ag Vorrichtung zur transdermalen Verabreichung von Wirkstoffen
CA2546443A1 (en) * 2003-11-18 2005-06-02 Nanopass Technologies Ltd. Enhanced penetration system and method for sliding microneedles
AU2004292953A1 (en) * 2003-11-21 2005-06-09 Alza Corporation Ultrasound assisted transdermal vaccine delivery method and system
CA2552385C (en) * 2003-12-29 2013-07-23 3M Innovative Properties Company Medical devices and kits including same
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
WO2005094526A2 (en) * 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
US20050271684A1 (en) * 2004-04-13 2005-12-08 Trautman Joseph C Apparatus and method for transdermal delivery of multiple vaccines
BRPI0509901A (pt) * 2004-04-13 2007-08-07 Alza Corp aparelho e método para liberação transdérmica de agentes com base em fentanila
AU2005244734A1 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US7591806B2 (en) * 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
WO2005112463A2 (en) * 2004-05-19 2005-11-24 Alza Corporation Method and formulation for transdermal delivery of immunologically active agents
US20050273049A1 (en) * 2004-06-08 2005-12-08 Peter Krulevitch Drug delivery device using microprojections
US20050273075A1 (en) * 2004-06-08 2005-12-08 Peter Krulevitch Method for delivering drugs to the adventitia using device having microprojections
ES2650188T3 (es) * 2004-06-10 2018-01-17 3M Innovative Properties Company Dispositivo y kit de aplicación de parches
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
TW200618830A (en) * 2004-08-10 2006-06-16 Alza Corp Micorprojection apparatus and system with low infection potential
US20060058602A1 (en) * 2004-08-17 2006-03-16 Kwiatkowski Krzysztof C Interstitial fluid analyzer
AR050608A1 (es) * 2004-08-19 2006-11-08 Alza Corp Aparato y metodo para administracion transdermica de factores de crecimiento endotelial vascular
US20060051403A1 (en) * 2004-09-08 2006-03-09 James Matriano Microprojection array with improved skin adhesion and compliance
AR050959A1 (es) * 2004-09-28 2006-12-06 Alza Corp Estabilizacion de agentes inmunologicamente activos adyuvados con alumbre
US20060093658A1 (en) * 2004-10-26 2006-05-04 Gayatri Sathyan Apparatus and method for transdermal delivery of desmopressin
CA2587505C (en) 2004-11-18 2013-01-08 3M Innovative Properties Company Low-profile microneedle array applicator
CN101102809B (zh) * 2004-11-18 2010-05-26 3M创新有限公司 涂敷微针阵列的遮蔽方法
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
CN101060882B (zh) * 2004-11-18 2010-06-16 3M创新有限公司 微针阵列施放器和保持器
CA2587387C (en) 2004-11-18 2013-06-25 3M Innovative Properties Company Method of contact coating a microneedle array
US8088321B2 (en) 2004-12-07 2012-01-03 3M Innovative Properties Company Method of molding a microneedle
EP1853231A2 (de) * 2005-02-16 2007-11-14 Alza Corporation Vorrichtung und verfahren zur transdermalen zuführung von agentien auf erythropoetin-basis
AU2006213994A1 (en) * 2005-02-16 2006-08-24 Alza Corporation Microprojection arrays with improved biocompatibility
EP1869414A4 (de) * 2005-03-29 2010-07-28 Arkal Medical Inc Vorrichtungen, systeme, verfahren und werkzeuge zur kontinuierlichen glucoseüberwachung
EP1871459B1 (de) 2005-04-07 2019-06-19 3M Innovative Properties Company SYSTEM ZUR ERFASSUNG DER WERKZEUGRüCKMELDUNG
US20060253078A1 (en) * 2005-04-25 2006-11-09 Wu Jeffrey M Method of treating skin disorders with stratum corneum piercing device
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US20080009802A1 (en) * 2005-04-25 2008-01-10 Danilo Lambino Method of treating acne with stratum corneum piercing device
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
AU2006252342A1 (en) * 2005-06-02 2006-12-07 Alza Corporation Method for terminal sterilization of transdermal delivery devices
US20060280645A1 (en) * 2005-06-02 2006-12-14 Scott Sellers Method for terminal sterilization of transdermal delivery devices
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
WO2007002123A2 (en) * 2005-06-21 2007-01-04 Alza Corporation Method and device for coating a continuous strip of microprojection members
WO2007002523A2 (en) * 2005-06-24 2007-01-04 3M Innovative Properties Company Collapsible patch with microneedle array
EP1901799B1 (de) 2005-06-27 2012-06-13 3M Innovative Properties Company Applikator für mikronadelanordnungen
JP2008543528A (ja) 2005-06-27 2008-12-04 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルカートリッジアセンブリ及び適用方法
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
JP5161776B2 (ja) * 2005-09-06 2013-03-13 セラジェクト, インコーポレイテッド 薬物粒子および/または薬物を吸着した粒子を含む、固溶体穿孔器
AU2006291157A1 (en) * 2005-09-12 2007-03-22 Alza Corporation Coatable transdermal delivery microprojection assembly
DE102005043496A1 (de) * 2005-09-13 2007-03-15 Daimlerchrysler Ag Verfahren und Vorrichtung zur Erhöhung der Sicherheit eines personengeführten Fahrzeugs
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
JP5147702B2 (ja) 2005-09-30 2013-02-20 インテュイティ メディカル インコーポレイテッド 完全に統合された、ウエアラブル又はハンドヘルドモニタ
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
WO2007061781A1 (en) * 2005-11-18 2007-05-31 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
EP1962942A1 (de) * 2005-12-21 2008-09-03 3M Innovative Properties Company Mikronadelvorrichtungen
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
AU2007225056A1 (en) * 2006-03-15 2007-09-20 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
US20070299388A1 (en) * 2006-04-25 2007-12-27 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
US20070293816A1 (en) * 2006-04-25 2007-12-20 Alza Corporation Microprojection Array Application with Grouped Microprojections for High Drug Loading
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
US8821446B2 (en) * 2007-01-22 2014-09-02 Corium International, Inc. Applicators for microneedles
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
CA2686093C (en) 2007-04-16 2018-05-08 Corium International, Inc. Solvent-cast microneedle arrays containing active
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
GB2448493B (en) * 2007-04-16 2009-10-14 Dewan Fazlul Hoque Chowdhury Microneedle transdermal delivery device
US8439861B2 (en) 2007-04-24 2013-05-14 Velcro Industries B.V. Skin penetrating touch fasteners
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
EP2231228A4 (de) 2007-12-17 2015-08-12 New World Pharmaceuticals Llc Integriertes intradermales verabreichungs-; diagnose- und kommunikationssystem
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
CA2728400C (en) * 2008-05-21 2014-03-25 Theraject, Inc. Method of manufacturing solid solution peforator patches and uses thereof
WO2009145920A1 (en) 2008-05-30 2009-12-03 Intuity Medical, Inc. Body fluid sampling device -- sampling site interface
WO2009148626A1 (en) 2008-06-06 2009-12-10 Intuity Medical, Inc. Medical diagnostic devices and methods
US9636051B2 (en) 2008-06-06 2017-05-02 Intuity Medical, Inc. Detection meter and mode of operation
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US20110105952A1 (en) * 2009-10-30 2011-05-05 Seventh Sense Biosystems, Inc. Relatively small devices applied to the skin, modular systems, and methods of use thereof
US20120277629A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Systems and methods for collection and/or manipulation of blood spots or other bodily fluids
EP2408369A1 (de) 2009-03-02 2012-01-25 Seventh Sense Biosystems, Inc. Vorrichtungen und verfahren zur analyse eines extrahierbaren mediums
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
CA2759850C (en) * 2009-04-24 2019-10-22 Corium International, Inc. Methods for manufacturing microprojection arrays
WO2011005894A1 (en) * 2009-07-07 2011-01-13 Naya Touch, Inc. Dermal roller with therapeutic microstructures
EP2493537B1 (de) * 2009-10-30 2017-12-06 Seventh Sense Biosystems, Inc. Systeme und verfahren zur behandlung, desinfektion und/oder abschirmung der haut oder von auf der haut angebrachten vorrichtungen
CA2782047C (en) 2009-11-30 2019-10-29 Intuity Medical, Inc. Calibration material delivery devices and methods
ES2719595T3 (es) 2010-05-04 2019-07-11 Corium Int Inc Método y dispositivo para la administración transdérmica de la hormona paratiroidea usando una matriz de microproyección
EP2584964B1 (de) 2010-06-25 2021-08-04 Intuity Medical, Inc. Analytüberwachungsvorrichtungen
CN103068308B (zh) 2010-07-16 2016-03-16 第七感生物系统有限公司 用于流体传输装置的低压环境
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
EP2637562B1 (de) 2010-11-09 2016-01-27 Seventh Sense Biosystems, Inc. Systeme und schnittstellen zur blutabnahme
CA2833571A1 (en) * 2011-04-22 2012-10-26 Radius Health, Inc. Method of drug delivery for pth, pthrp and related peptides
CN103874460B (zh) 2011-04-29 2016-06-22 第七感生物系统有限公司 一种用于从受验者的皮肤接收血液或其它物质的装置
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
EP3106092A3 (de) 2011-04-29 2017-03-08 Seventh Sense Biosystems, Inc. Systeme und verfahren zur flüssigkeitsentnahme aus einer person
WO2013020103A1 (en) 2011-08-03 2013-02-07 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US9522267B2 (en) * 2012-02-08 2016-12-20 Derma Dream Group Ltd Transdermal delivery device
BR112015014969B1 (pt) 2012-12-21 2021-12-07 Corium, Inc Aparelho de microestruturas e método de fabricar um aparelho de microestruturas
JP6387338B2 (ja) * 2013-02-13 2018-09-05 久光製薬株式会社 マイクロニードル・アレイ
JP6487899B2 (ja) 2013-03-12 2019-03-20 コリウム インターナショナル, インコーポレイテッド 微小突起アプリケータ
BR112015022625B1 (pt) 2013-03-15 2023-01-31 Corium, Inc Aparelho de microestrutura para entrega de agente terapêutico
WO2014144973A1 (en) 2013-03-15 2014-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
AU2014237357B2 (en) 2013-03-15 2019-11-28 Corium Pharma Solutions, Inc. Multiple impact microprojection applicators and methods of use
JP2016514133A (ja) 2013-03-15 2016-05-19 コリウム インターナショナル, インコーポレイテッド ポリマーを含まない微細構造物を含むマイクロアレイ、製造方法および使用方法
AU2014262382A1 (en) * 2013-05-06 2015-11-19 Mupharma Pty Ltd Non-invasive agent applicator
CN103263727B (zh) * 2013-05-22 2015-09-30 清华大学 金属微针阵列、经皮给药贴片、微针滚轮及微针电极阵列
CA2912283A1 (en) 2013-06-21 2014-12-21 Intuity Medical, Inc. Analyte monitoring system with audible feedback
GB201314902D0 (en) * 2013-08-20 2013-10-02 Chowdhury Dewan F H Microneedle device and method of preparation
ES2708996T3 (es) 2013-08-22 2019-04-12 Zp Opco Inc Formulaciones estables de péptido glucagón
US9782344B2 (en) 2013-08-22 2017-10-10 Zp Opco, Inc. Stable glucagon peptide formulations
JP6215343B2 (ja) * 2013-11-05 2017-10-18 久光製薬株式会社 アプリケータ
JP6265774B2 (ja) * 2014-02-18 2018-01-24 久光製薬株式会社 貼付剤
EP3111987B1 (de) * 2014-02-27 2022-04-20 Hisamitsu Pharmaceutical Co., Inc. Mikronadelblech
EP4035664A3 (de) 2014-03-28 2022-11-30 Duke University Behandlung von krebs unter verwendung von selektiven östrogenrezeptormodulatoren
WO2015168738A1 (en) 2014-05-06 2015-11-12 Mupharma Pty Ltd Non-invasive agent applicator
EP3188714A1 (de) 2014-09-04 2017-07-12 Corium International, Inc. Mikrostrukturanordnung, verfahren zur herstellung und verfahren zur verwendung
JP2017537690A (ja) 2014-11-12 2017-12-21 ミューファーマ ピーティーワイ リミテッド 非侵襲性の薬剤塗布具
MX393599B (es) 2015-04-29 2025-03-19 Radius Pharmaceuticals Inc Rad1901 para usarse en el tratamiento de cancer en sujetos con cancer positivo a receptor de estrogeno alfa resistente a farmaco
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017079611A1 (en) 2015-11-02 2017-05-11 Zp Opco, Inc. Stable glucagon peptide formulations
WO2017130793A1 (ja) * 2016-01-28 2017-08-03 株式会社リコー マイクロニードルアレイ、マイクロニードルシート
US9918932B2 (en) 2016-02-19 2018-03-20 Zosano Pharma Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines
JP2019205484A (ja) * 2016-09-29 2019-12-05 国立大学法人東北大学 マイクロニードルアレイ及びその製造方法
KR101837449B1 (ko) 2016-10-28 2018-03-12 삼성전자주식회사 마이크로 니들 패치, 마이크로 니들을 제조하는 방법 및 장치
DK3565542T3 (da) 2017-01-05 2024-07-01 Radius Pharmaceuticals Inc Polymorphic forms of rad1901-2hcl
CN111050749A (zh) 2017-08-23 2020-04-21 佐萨诺制药公司 快速实现佐米曲坦的治疗性浓度以用于治疗偏头痛和丛集性头痛的方法
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
KR102119675B1 (ko) * 2017-12-11 2020-06-05 랩앤피플주식회사 고밀도 마이크로 니들
KR102291392B1 (ko) * 2018-03-30 2021-08-20 랩앤피플주식회사 멀티형 마이크로 니들
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
KR102792490B1 (ko) 2018-07-04 2025-04-04 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태
WO2020115224A1 (en) * 2018-12-06 2020-06-11 Bausch Health Ireland Limited Microblade structure and method of treating tissue
MX2021009569A (es) 2019-02-12 2021-09-08 Radius Pharmaceuticals Inc Procesos y compuestos.
CN119033429A (zh) 2019-04-10 2024-11-29 腹腔解决方案医疗公司 闭合腹疝和减少复发的腹部闭合方法和器械的变型
US11696851B2 (en) * 2019-04-25 2023-07-11 Alcon Inc. Cannula system with retention feature
US12144505B2 (en) 2020-01-13 2024-11-19 Absolutions Med, Inc. Abdominal approximation device and method
CA3180057A1 (en) * 2020-05-25 2021-12-02 Ying-Shu Quan High-performance micro-needle array
AU2021281307A1 (en) * 2020-05-29 2022-12-15 Georgia Tech Research Corporation Devices, systems, and methods for facilitating tissue delivery of drug
US20230047828A1 (en) * 2021-08-16 2023-02-16 Absolutions Med, Inc. Nipple areolar grafting methods and apparatus

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US25637A (en) * 1859-10-04 Cooking-stove
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3322121A (en) * 1965-11-26 1967-05-30 Oscar H Banker Skin-puncturing unit with a collapsible protective cover
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
DE2250293A1 (de) * 1972-10-13 1974-04-25 Bayern Freistaat Impfstempel zur cutanen pockenimpfung mittels trockenimpfstoff
FR2232331B1 (de) * 1973-06-06 1978-03-24 Guerin A Ets
US4379454A (en) * 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
US4340048A (en) * 1981-03-28 1982-07-20 Alza Corporation Self-driven hypodermic injector
US4753651A (en) * 1982-08-30 1988-06-28 Alza Corporation Self-driven pump
US4725439A (en) * 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
US4588580B2 (en) * 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4655766A (en) * 1985-08-01 1987-04-07 Alza Corporation Fluid imbibing pump with self-regulating skin patch
US4756314A (en) * 1985-10-28 1988-07-12 Alza Corporation Sweat collection patch
US4698062A (en) * 1985-10-30 1987-10-06 Alza Corporation Medical device for pulsatile transdermal delivery of biologically active agents
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US4832953A (en) * 1987-08-13 1989-05-23 Alza Corporation Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
KR970011449B1 (ko) * 1988-01-29 1997-07-11 더 리전트 오브 디 유니버시티 오브 캘리포니아 이온전기 영동형 비침입 검체 채취 또는 이송 장치 및 방법
US5362307A (en) * 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5438984A (en) * 1988-09-08 1995-08-08 Sudor Partners Apparatus and method for the collection of analytes on a dermal patch
US5147296A (en) * 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5169382A (en) * 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
EP0429842B1 (de) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5077104A (en) * 1989-12-21 1991-12-31 Alza Corporation Nicotine packaging materials
US5108819A (en) * 1990-02-14 1992-04-28 Eli Lilly And Company Thin film electrical component
ES2082973T3 (es) * 1990-03-30 1996-04-01 Alza Corp Dispositivo para administracion iontoforetica de farmacos.
US5242406A (en) * 1990-10-19 1993-09-07 Sil Medics Ltd. Liquid delivery device particularly useful for delivering drugs
MX9101782A (es) * 1990-10-29 1992-06-05 Alza Corp Dispositivo de suministro iontoforetico y metodo para hidratar el mismo
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5312456A (en) * 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5310404A (en) * 1992-06-01 1994-05-10 Alza Corporation Iontophoretic delivery device and method of hydrating same
US5391250A (en) * 1994-03-15 1995-02-21 Minimed Inc. Method of fabricating thin film sensors
CA2149836C (en) * 1994-05-23 1999-07-06 Sang Bae Choi Perforating device for dermal administration
FR2720003B1 (fr) * 1994-05-23 1998-06-26 Samsung Electro Mech Dispositif servant à inciser la peau pour une médication transcutanée.
AU4256496A (en) * 1994-12-09 1996-06-26 Novartis Ag Transdermal system
AU5740496A (en) * 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
AU5869796A (en) * 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
ES2536459T3 (es) * 1995-08-29 2015-05-25 Nitto Denko Corporation Microporación de piel humana para administración de fármacos y aplicaciones de supervisión
DK0914178T3 (da) 1996-06-18 2003-04-22 Alza Corp Anordning til forøgelse af transdermal afgivelse eller prøveudtagning af et middel

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CN1161164C (zh) 2004-08-11
CA2313458C (en) 2007-04-17
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