DE60138411D1 - Vorrichtung und verfahren zum durchstechen der haut mit micronadeln - Google Patents
Vorrichtung und verfahren zum durchstechen der haut mit micronadelnInfo
- Publication number
- DE60138411D1 DE60138411D1 DE60138411T DE60138411T DE60138411D1 DE 60138411 D1 DE60138411 D1 DE 60138411D1 DE 60138411 T DE60138411 T DE 60138411T DE 60138411 T DE60138411 T DE 60138411T DE 60138411 D1 DE60138411 D1 DE 60138411D1
- Authority
- DE
- Germany
- Prior art keywords
- impact
- skin
- microned
- pins
- microprotrusion member
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 210000000434 stratum corneum Anatomy 0.000 abstract 3
- 210000003491 skin Anatomy 0.000 abstract 2
- 238000005070 sampling Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150274—Manufacture or production processes or steps for blood sampling devices
- A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150801—Means for facilitating use, e.g. by people with impaired vision; means for indicating when used correctly or incorrectly; means for alarming
- A61B5/150824—Means for facilitating use, e.g. by people with impaired vision; means for indicating when used correctly or incorrectly; means for alarming by visual feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150977—Arrays of piercing elements for simultaneous piercing
- A61B5/150984—Microneedles or microblades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15103—Piercing procedure
- A61B5/15107—Piercing being assisted by a triggering mechanism
- A61B5/15113—Manually triggered, i.e. the triggering requires a deliberate action by the user such as pressing a drive button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
- A61B5/15117—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15142—Devices intended for single use, i.e. disposable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
- A61B5/15188—Constructional features of reusable driving devices
- A61B5/1519—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for propelling the piercing unit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Manufacturing & Machinery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Optics & Photonics (AREA)
- Anesthesiology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Perforating, Stamping-Out Or Severing By Means Other Than Cutting (AREA)
- Surgical Instruments (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Massaging Devices (AREA)
- Medicinal Preparation (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24030700P | 2000-10-13 | 2000-10-13 | |
PCT/US2001/031936 WO2002030301A1 (en) | 2000-10-13 | 2001-10-12 | Apparatus and method for piercing skin with microprotrusions |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60138411D1 true DE60138411D1 (de) | 2009-05-28 |
Family
ID=22906027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60138411T Expired - Lifetime DE60138411D1 (de) | 2000-10-13 | 2001-10-12 | Vorrichtung und verfahren zum durchstechen der haut mit micronadeln |
Country Status (22)
Country | Link |
---|---|
US (2) | US7131960B2 (de) |
EP (1) | EP1341453B1 (de) |
JP (1) | JP4659332B2 (de) |
KR (1) | KR20030068136A (de) |
CN (1) | CN1250171C (de) |
AT (1) | ATE428357T1 (de) |
AU (2) | AU2001296828B2 (de) |
BR (1) | BR0114629A (de) |
CA (1) | CA2425315C (de) |
CZ (1) | CZ20031037A3 (de) |
DE (1) | DE60138411D1 (de) |
ES (1) | ES2324461T3 (de) |
HU (1) | HUP0303558A2 (de) |
IL (1) | IL155374A0 (de) |
MA (1) | MA26057A1 (de) |
MX (1) | MXPA03003299A (de) |
NO (1) | NO20031681L (de) |
NZ (1) | NZ525294A (de) |
PL (1) | PL360998A1 (de) |
RU (1) | RU2275871C2 (de) |
WO (1) | WO2002030301A1 (de) |
ZA (1) | ZA200303633B (de) |
Families Citing this family (138)
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ATE234129T1 (de) * | 1996-06-18 | 2003-03-15 | Alza Corp | Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten |
US6918901B1 (en) * | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
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US7419481B2 (en) * | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
CA2425312C (en) * | 2000-10-13 | 2010-02-16 | Alza Corporation | Microprotrusion member retainer for impact applicator |
US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
EP1333880B1 (de) | 2000-10-26 | 2009-04-15 | Alza Corporation | Transdermales arzneistoffverabreichungssytem mit beschichteten mikrovorsprüngen |
US6855372B2 (en) * | 2001-03-16 | 2005-02-15 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
DE60233939D1 (de) * | 2001-04-20 | 2009-11-19 | Alza Corp | Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält |
US20020193729A1 (en) * | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
AU2002352978A1 (en) * | 2001-11-30 | 2003-06-17 | Alza Corporation | Methods and apparatuses for forming microprojection arrays |
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KR20060115716A (ko) * | 2003-08-04 | 2006-11-09 | 알자 코포레이션 | 경피 약물 플럭스를 개선시키기 위한 방법 및 장치 |
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JP5562138B2 (ja) † | 2010-06-24 | 2014-07-30 | シスメックス株式会社 | 微細孔形成装置 |
EP2399635A1 (de) | 2010-06-28 | 2011-12-28 | Sanofi-Aventis Deutschland GmbH | Automatischer Injektor |
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CN1250171C (zh) | 2006-04-12 |
ES2324461T3 (es) | 2009-08-07 |
EP1341453A1 (de) | 2003-09-10 |
NO20031681D0 (no) | 2003-04-11 |
MA26057A1 (fr) | 2004-04-01 |
CA2425315A1 (en) | 2002-04-18 |
PL360998A1 (en) | 2004-09-20 |
AU9682801A (en) | 2002-04-22 |
RU2275871C2 (ru) | 2006-05-10 |
ZA200303633B (en) | 2004-05-12 |
WO2002030301A1 (en) | 2002-04-18 |
US7131960B2 (en) | 2006-11-07 |
BR0114629A (pt) | 2004-01-20 |
ATE428357T1 (de) | 2009-05-15 |
CA2425315C (en) | 2010-01-12 |
JP4659332B2 (ja) | 2011-03-30 |
HUP0303558A2 (en) | 2004-01-28 |
US20020123675A1 (en) | 2002-09-05 |
US20050234401A1 (en) | 2005-10-20 |
EP1341453B1 (de) | 2009-04-15 |
MXPA03003299A (es) | 2004-12-13 |
IL155374A0 (en) | 2003-11-23 |
JP2004510535A (ja) | 2004-04-08 |
NO20031681L (no) | 2003-06-13 |
CZ20031037A3 (cs) | 2003-10-15 |
CN1479590A (zh) | 2004-03-03 |
KR20030068136A (ko) | 2003-08-19 |
NZ525294A (en) | 2005-02-25 |
AU2001296828B2 (en) | 2005-11-24 |
US7798987B2 (en) | 2010-09-21 |
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