ATE369802T1 - Verfahren zum beschichten von mikrovorsprüngen zum durchstechen der haut - Google Patents

Verfahren zum beschichten von mikrovorsprüngen zum durchstechen der haut

Info

Publication number
ATE369802T1
ATE369802T1 AT04756456T AT04756456T ATE369802T1 AT E369802 T1 ATE369802 T1 AT E369802T1 AT 04756456 T AT04756456 T AT 04756456T AT 04756456 T AT04756456 T AT 04756456T AT E369802 T1 ATE369802 T1 AT E369802T1
Authority
AT
Austria
Prior art keywords
piercing
skin
coating microprojections
microprojections
coating
Prior art date
Application number
AT04756456T
Other languages
English (en)
Inventor
Peter Daddona
Keith Chan
John Donner
Rupal Ayer
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ATE369802T1 publication Critical patent/ATE369802T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Materials For Medical Uses (AREA)
AT04756456T 2003-06-30 2004-06-29 Verfahren zum beschichten von mikrovorsprüngen zum durchstechen der haut ATE369802T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48414203P 2003-06-30 2003-06-30

Publications (1)

Publication Number Publication Date
ATE369802T1 true ATE369802T1 (de) 2007-09-15

Family

ID=34062028

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04756456T ATE369802T1 (de) 2003-06-30 2004-06-29 Verfahren zum beschichten von mikrovorsprüngen zum durchstechen der haut

Country Status (18)

Country Link
US (1) US20040265365A1 (de)
EP (1) EP1638468B1 (de)
JP (1) JP5174347B2 (de)
KR (1) KR20060029162A (de)
CN (1) CN100586385C (de)
AR (1) AR044963A1 (de)
AT (1) ATE369802T1 (de)
AU (1) AU2004255228A1 (de)
BR (1) BRPI0412021A (de)
CA (1) CA2530520A1 (de)
DE (1) DE602004008278T2 (de)
DK (1) DK1638468T3 (de)
ES (1) ES2290738T3 (de)
MX (1) MXPA06000283A (de)
PL (1) PL1638468T3 (de)
PT (1) PT1638468E (de)
TW (1) TW200514591A (de)
WO (1) WO2005004729A1 (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
JP5456234B2 (ja) * 2003-06-30 2014-03-26 アルザ・コーポレーシヨン 非揮発性の対イオンを含有する被覆された微小突起のための製剤
JP2007503268A (ja) 2003-08-25 2007-02-22 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答修飾化合物の送達
CN100548228C (zh) * 2003-11-13 2009-10-14 阿尔扎公司 用于透皮递送的组合物和装置
KR20070011481A (ko) * 2004-04-13 2007-01-24 알자 코포레이션 다중 백신의 경피 전달용 기구 및 방법
BRPI0509788A (pt) 2004-05-13 2007-10-23 Alza Corp aparato e método para liberação transdérmica de agentes de hormÈnio paratireóides
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
US20060034903A1 (en) * 2004-08-11 2006-02-16 Yuh-Fun Maa Apparatus and method for transdermal delivery of natriuretic peptides
SE0402100D0 (sv) * 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
US8057842B2 (en) * 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
JP5015787B2 (ja) * 2004-11-18 2012-08-29 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイの接触コーティング法
AU2006206272A1 (en) * 2005-01-21 2006-07-27 Alza Corporation Therapeutic peptide formulations for coating microneedles with improved stabitity containing at least one counterion
US20060177494A1 (en) * 2005-01-31 2006-08-10 Micheal Cormier Coated microprojections having reduced variability and method for producing same
AU2006214236A1 (en) * 2005-02-16 2006-08-24 Alza Corporation Apparatus and method for transdermal delivery of erythropoetin-based agents
CA2602814A1 (en) * 2005-03-28 2006-10-05 Alza Corporation Microprojections with capillary control features and method
US20080213461A1 (en) * 2005-06-17 2008-09-04 Georgia Tech Research Corporation Coated Microstructures and Methods of Manufacture Thereof
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
EP1924364A1 (de) * 2005-09-12 2008-05-28 Alza Corporation Beschichtbare mikronadelanordnung zur transdermalen verabreichung
EP1948139A4 (de) * 2005-11-18 2012-04-04 3M Innovative Properties Co Überziehbare zusammensetzungen, daraus erhaltene überzüge und mikroanordnungen mit diesen überzügen
EP1957145A4 (de) * 2005-11-30 2011-03-23 3M Innovative Properties Co Mikronadelanordnungen und anwendungsverfahren
US8632801B2 (en) * 2005-12-28 2014-01-21 Alza Corporation Stable therapeutic formulations
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US20080039775A1 (en) * 2006-03-15 2008-02-14 Alza Corporation Apparatus and Method for Transdermal Delivery of Parathyroid Hormone Agents to Prevent or Treat Osteopenia
US20070224252A1 (en) * 2006-03-27 2007-09-27 Trautman Joseph C Microprojections with capillary control features and method
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US7918814B2 (en) * 2006-05-02 2011-04-05 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
JP5297595B2 (ja) * 2007-03-20 2013-09-25 凸版印刷株式会社 針状体および針状体製造方法
JP5090032B2 (ja) * 2007-03-20 2012-12-05 凸版印刷株式会社 針状体および針状体製造方法
AU2014200648B2 (en) * 2007-04-16 2015-09-24 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
ES2820335T3 (es) * 2007-04-16 2021-04-20 Corium Inc Matrices de microagujas coladas con disolvente que contienen agente activo
JP2008284318A (ja) * 2007-05-15 2008-11-27 Kosumedei Seiyaku Kk 生体由来物質からなる投薬用微細針
US8288142B2 (en) * 2007-06-19 2012-10-16 Uvarkina Tamara P Hyaluronidase and method of use thereof
EP2011629A1 (de) * 2007-07-03 2009-01-07 F. Hoffman-la Roche AG Verfahren zur Herstellung eines mikrofluiden Systems auf einer Polymeroberfläche
EP2197532A1 (de) 2007-08-06 2010-06-23 Serenity Pharmaceuticals Corporation Verfahren und vorrichtungen zur abgabe eines desmorpressin-arzneimittels
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP5504632B2 (ja) * 2008-03-05 2014-05-28 セイコーエプソン株式会社 電気泳動装置、電気泳動装置の駆動方法、電子機器
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
WO2009143356A1 (en) 2008-05-21 2009-11-26 Ferring International Center S.A. Orodispersible desmopressin for increasing initial period of sleep undisturbed by nocturia
CN102039000B (zh) * 2009-10-20 2015-08-26 苏州纳通生物纳米技术有限公司 一种透皮给药试剂盒
EP2566501B1 (de) 2010-05-04 2019-03-13 Corium International, Inc. Verfahren und vorrichtung zur transdermalen verabreichung von parathormon mithilfe eines mikroprojektions-arrays
CN104758118B (zh) 2010-10-15 2018-04-06 科尼尔赛德生物医学公司 用于进入眼睛的装置
CN103402496B (zh) * 2011-03-07 2016-01-20 3M创新有限公司 微针装置及方法
AU2012328448B2 (en) * 2011-10-28 2017-02-02 Sung-Yun Kwon Dissolving solid solution perforator patch for migraine treatment
KR102143435B1 (ko) * 2011-11-30 2020-08-11 쓰리엠 이노베이티브 프로퍼티즈 컴파니 펩티드 치료제 및 아미노산을 포함하는 마이크로니들 장치 및 이의 제조 및 사용 방법
JP5472771B1 (ja) 2012-09-28 2014-04-16 コスメディ製薬株式会社 段差に薬物を保持したマイクロニードル
CN104884049A (zh) 2012-11-08 2015-09-02 克莱尔塞德生物医学股份有限公司 用于在人类受试者中治疗眼部疾病的方法和装置
JP6865524B2 (ja) 2012-12-21 2021-04-28 コリウム, インコーポレイテッド 治療剤を送達するためのマイクロアレイおよび使用方法
MX2015012155A (es) 2013-03-12 2015-11-30 Corium Int Inc Aplicadores de microproyeccion.
AU2014233695A1 (en) 2013-03-15 2015-10-01 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
EP2968751B1 (de) 2013-03-15 2022-11-30 Corium, Inc. Mehrfachberührungs-mikroprojektionsapplikatoren
EP2968119B1 (de) 2013-03-15 2019-09-18 Corium International, Inc. Mikroarray zur freisetzung therapeutischer wirkstoffe, verfahren zur verwendung und verfahren zur herstellung
WO2014150293A1 (en) 2013-03-15 2014-09-25 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
CN110302004B (zh) 2013-05-03 2023-04-28 科尼尔赛德生物医学公司 用于眼部注射的设备和方法
US10188550B2 (en) 2013-06-03 2019-01-29 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using multiple reservoirs
JP6272333B2 (ja) * 2013-09-06 2018-01-31 久光製薬株式会社 マイクロニードル・シート
CN103611214A (zh) * 2013-12-03 2014-03-05 上海交通大学 针药微系统及其制备方法
US20170049695A1 (en) * 2014-02-27 2017-02-23 Hisamitsu Pharmaceutical Co., Inc. Microneedle sheet
JP2017524419A (ja) 2014-06-20 2017-08-31 クリアサイド バイオメディカル,インコーポレイテッド 薬剤送達のための挿入深さを制御するための可変径カニューレ及び方法
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
USD750223S1 (en) 2014-10-14 2016-02-23 Clearside Biomedical, Inc. Medical injector for ocular injection
TWI679997B (zh) 2014-12-05 2019-12-21 日商久光製藥股份有限公司 微針裝置系統
MX2017013802A (es) 2015-04-29 2018-08-15 Radius Pharmaceuticals Inc Métodos para tratar el cáncer.
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017139375A1 (en) 2016-02-10 2017-08-17 Clearside Biomedical, Inc. Ocular injection kit, packaging, and methods of use
CA3062845A1 (en) 2016-05-02 2017-11-09 Clearside Biomedical, Inc. Systems and methods for ocular drug delivery
WO2017204418A1 (ko) * 2016-05-23 2017-11-30 주식회사유한양행 사마귀 치료를 위한 블레오마이신을 함유하는 마이크로니들 패치 및 이의 제작방법
EP3493872A4 (de) * 2016-08-03 2020-04-08 Verndari, Inc. Mikroarrays und verfahren
CN110177527B (zh) 2016-08-12 2022-02-01 科尼尔赛德生物医学公司 用于调节药剂递送用针的插入深度的装置和方法
CN110035792A (zh) 2016-12-28 2019-07-19 考司美德制药株式会社 涂布含药成分的微针制剂
KR101947624B1 (ko) * 2016-12-29 2019-02-14 랩앤피플주식회사 멀티형 마이크로 니들
MX2019002993A (es) * 2016-12-29 2019-07-01 Labnpeople Co Ltd Arreglo de microagujas.
MX2019007748A (es) 2017-01-05 2019-09-09 Radius Pharmaceuticals Inc Formas polimorficas de rad1901-2hcl.
WO2019111959A1 (ja) * 2017-12-05 2019-06-13 古河電気工業株式会社 機能性部材及びその製造方法
KR102022968B1 (ko) * 2018-01-12 2019-09-19 주식회사 에스엔비아 마이크로 니들 시트 구조 및 그 제조방법
SG11202013177WA (en) 2018-07-04 2021-01-28 Radius Pharmaceuticals Inc Polymorphic forms of rad 1901-2hcl
JP7399295B2 (ja) * 2020-04-06 2023-12-15 イルロン カンパニー リミテッド 化粧品吸収誘導用微細針が取り付けられた化粧品注入器及びその制作方法
JP2023043192A (ja) 2021-09-15 2023-03-28 コスメディ製薬株式会社 薬剤を塗布したマイクロニードルアレイ

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3136314A (en) * 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3351059A (en) * 1964-06-02 1967-11-07 Norman Lettvin Single stable dose vaccinator
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
OA05448A (fr) * 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
FR2474856A1 (fr) * 1980-01-31 1981-08-07 Merieux Inst Dispositif scarificateur
EP0429842B1 (de) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5487726A (en) * 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
WO1996037155A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
DE69806963T2 (de) * 1997-12-11 2002-11-21 Alza Corp Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
PT1037686E (pt) * 1997-12-11 2005-10-31 Alza Corp Aparelho para potenciar o fluxo de agente transdermico
JPH11249287A (ja) * 1998-03-05 1999-09-17 Matsushita Electric Works Ltd 印刷版用材、印刷版、製版方法および印刷装置
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
CA2330207C (en) * 1998-06-10 2005-08-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
JP2000034677A (ja) * 1998-07-15 2000-02-02 Dainippon Printing Co Ltd 部分親水性シート
MXPA03003815A (es) * 2000-10-26 2004-08-12 Johnson & Johnson Dispositivos de suministro transdermico de farmaco que tienen microrresaltos recubiertos.
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
JP2004528900A (ja) * 2001-04-20 2004-09-24 アルザ・コーポレーシヨン 有益な作用物質を含有するコーティングを有する微小突起アレイ
JP5456234B2 (ja) * 2003-06-30 2014-03-26 アルザ・コーポレーシヨン 非揮発性の対イオンを含有する被覆された微小突起のための製剤

Also Published As

Publication number Publication date
DE602004008278D1 (de) 2007-09-27
BRPI0412021A (pt) 2006-08-15
PL1638468T3 (pl) 2008-01-31
DK1638468T3 (da) 2007-12-17
CN1842300A (zh) 2006-10-04
JP2007521090A (ja) 2007-08-02
CA2530520A1 (en) 2005-01-20
PT1638468E (pt) 2007-10-10
MXPA06000283A (es) 2006-07-03
US20040265365A1 (en) 2004-12-30
KR20060029162A (ko) 2006-04-04
EP1638468B1 (de) 2007-08-15
CN100586385C (zh) 2010-02-03
DE602004008278T2 (de) 2008-02-14
JP5174347B2 (ja) 2013-04-03
ES2290738T3 (es) 2008-02-16
WO2005004729A1 (en) 2005-01-20
EP1638468A1 (de) 2006-03-29
TW200514591A (en) 2005-05-01
AU2004255228A1 (en) 2005-01-20
AR044963A1 (es) 2005-10-12

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