IL162554A0 - Microneedle devices and methods of manufacture - Google Patents

Microneedle devices and methods of manufacture

Info

Publication number
IL162554A0
IL162554A0 IL16255402A IL16255402A IL162554A0 IL 162554 A0 IL162554 A0 IL 162554A0 IL 16255402 A IL16255402 A IL 16255402A IL 16255402 A IL16255402 A IL 16255402A IL 162554 A0 IL162554 A0 IL 162554A0
Authority
IL
Israel
Prior art keywords
microneedle
methods
microneedles
microneedle devices
cover
Prior art date
Application number
IL16255402A
Other languages
English (en)
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of IL162554A0 publication Critical patent/IL162554A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150572—Pierceable protectors, e.g. shields, caps, sleeves or films, e.g. for hygienic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150694—Procedure for removing protection means at the time of piercing
    • A61B5/150717—Procedure for removing protection means at the time of piercing manually removed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Manufacturing & Machinery (AREA)
  • Optics & Photonics (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL16255402A 2002-01-15 2002-11-26 Microneedle devices and methods of manufacture IL162554A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/051,745 US6908453B2 (en) 2002-01-15 2002-01-15 Microneedle devices and methods of manufacture
PCT/US2002/037920 WO2003059431A1 (en) 2002-01-15 2002-11-26 Microneedle devices and methods of manufacture

Publications (1)

Publication Number Publication Date
IL162554A0 true IL162554A0 (en) 2005-11-20

Family

ID=21973131

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16255402A IL162554A0 (en) 2002-01-15 2002-11-26 Microneedle devices and methods of manufacture

Country Status (8)

Country Link
US (2) US6908453B2 (xx)
EP (1) EP1465698B1 (xx)
JP (1) JP4382492B2 (xx)
AT (1) ATE384549T1 (xx)
AU (1) AU2002359490A1 (xx)
DE (1) DE60224842T2 (xx)
IL (1) IL162554A0 (xx)
WO (1) WO2003059431A1 (xx)

Families Citing this family (216)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
MXPA05000597A (es) 2002-07-19 2005-04-28 3M Innovative Properties Co Dispositivos de microaguja y aparatos de administracion por microaguja.
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
JP2007503268A (ja) * 2003-08-25 2007-02-22 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答修飾化合物の送達
EP1660172A1 (en) * 2003-08-26 2006-05-31 Alza Corporation Device and method for intradermal cell implantation
US7378451B2 (en) * 2003-10-17 2008-05-27 3M Innovative Properties Co Surfactant composition having stable hydrophilic character
EP1740256A4 (en) * 2003-11-10 2011-06-29 Agency Science Tech & Res MICRO NEEDLES AND MANUFACTURE OF MICRO NEEDLES
WO2005060621A2 (en) * 2003-11-21 2005-07-07 The Regents Of The University Of California Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles
US7361182B2 (en) * 2003-12-19 2008-04-22 Lightnix, Inc. Medical lancet
CA2552385C (en) * 2003-12-29 2013-07-23 3M Innovative Properties Company Medical devices and kits including same
US7150726B2 (en) * 2004-01-23 2006-12-19 Norfolk Medical Device for subcutaneous infusion of fluids
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US8551391B2 (en) * 2004-02-17 2013-10-08 Avery Dennison Corporation Method of making microneedles
JP2007523771A (ja) * 2004-02-23 2007-08-23 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイの成形方法
EP1732640A4 (en) * 2004-03-12 2010-09-01 Agency Science Tech & Res METHOD AND FORMS FOR USE IN THE MANUFACTURE OF MICRONED NEEDLES WITH SIDE OPENINGS
BRPI0509806A (pt) * 2004-04-12 2007-09-18 Allergan Inc sistema de injeção em múltiplos locais
ES2650188T3 (es) * 2004-06-10 2018-01-17 3M Innovative Properties Company Dispositivo y kit de aplicación de parches
EP1789127A2 (en) * 2004-08-05 2007-05-30 Apogee Technology, Inc. System and method for drug delivery and microfluidic applications using microneedles
WO2006016364A2 (en) * 2004-08-10 2006-02-16 Hellman De Picciotto, Tania Drug delivery devices
EP1790375A4 (en) * 2004-08-12 2009-06-17 Hisamitsu Pharmaceutical Co TRANSDERMAL MEDICINE ADMINISTRATION WITH MICRONADEL
ATE490037T1 (de) 2004-08-16 2010-12-15 Functional Microstructures Ltd Verfahren zur herstellung einer mikronadel oder eines mikroimplantats
AR050608A1 (es) * 2004-08-19 2006-11-08 Alza Corp Aparato y metodo para administracion transdermica de factores de crecimiento endotelial vascular
AU2005306372B2 (en) 2004-11-18 2011-01-06 Kindeva Drug Delivery L.P. Method of contact coating a microneedle array
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
CA2588080C (en) * 2004-11-18 2013-01-08 3M Innovative Properties Company Masking method for coating a microneedle array
CN101060882B (zh) 2004-11-18 2010-06-16 3M创新有限公司 微针阵列施放器和保持器
KR20070102669A (ko) 2004-11-18 2007-10-19 쓰리엠 이노베이티브 프로퍼티즈 컴파니 로우-프로파일 미세 바늘 어레이 인가 장치
US20080009801A1 (en) * 2004-12-02 2008-01-10 Nickel Janice H Method for dispensing material into a drug delivery device
CA2589733C (en) 2004-12-07 2014-02-11 3M Innovative Properties Company Method of molding a microneedle
MX2007006742A (es) 2004-12-10 2007-07-25 3M Innovative Properties Co Dispositivo medico.
JP4793806B2 (ja) * 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
JP2008534151A (ja) * 2005-03-28 2008-08-28 アルザ コーポレイション 毛管作用制御特徴部を有するマイクロプロジェクション及び方法
WO2006105146A2 (en) * 2005-03-29 2006-10-05 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
WO2006108185A1 (en) 2005-04-07 2006-10-12 3M Innovative Properties Company System and method for tool feedback sensing
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US7442029B2 (en) 2005-05-16 2008-10-28 Asml Netherlands B.V. Imprint lithography
US20080195035A1 (en) * 2005-06-24 2008-08-14 Frederickson Franklyn L Collapsible Patch and Method of Application
US8784363B2 (en) * 2005-06-27 2014-07-22 3M Innovative Properties Company Microneedle array applicator device and method of array application
CN101208129B (zh) 2005-06-27 2011-03-30 3M创新有限公司 微针药筒组件及其施放方法
US20070004989A1 (en) * 2005-06-29 2007-01-04 Parvinder Dhillon Device for transdermal sampling
WO2007032446A1 (ja) 2005-09-15 2007-03-22 Tti Ellebeau, Inc. ロッド型イオントフォレーシス装置
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
WO2007038028A1 (en) * 2005-09-28 2007-04-05 Tti Ellebeau, Inc. Iontophoresis apparatus and method to deliver active agents to biological interfaces
CA2664589A1 (en) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Iontophoretic device and method of delivery of active agents to biological interface
JP2009509685A (ja) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 損傷組織の治癒を増強するための血管新生因子の送達のためのイオントフォレーシス装置及び方法
JP2009509677A (ja) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 小胞封入活性物質のイオントフォレーシス送達
WO2007061964A1 (en) * 2005-11-18 2007-05-31 3M Innovative Properties Company Methods for coating microneedles
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
WO2007075614A1 (en) * 2005-12-21 2007-07-05 3M Innovative Properties Company Microneedle devices
JP2009522011A (ja) * 2005-12-30 2009-06-11 Ｔｔｉ・エルビュー株式会社 活性物質を生体界面に送達するイオントフォレーシスシステム、装置及び方法
WO2011053607A1 (en) 2009-10-26 2011-05-05 Emkinetics, Inc. Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
ATE532553T1 (de) * 2006-02-10 2011-11-15 Hisamitsu Pharmaceutical Co Transdermales arzneiverabreichungsgerät mit mikronadeln
EP1820441A1 (de) * 2006-02-16 2007-08-22 Roche Diagnostics GmbH Mikronadelanordnung mit Sensor basierend auf der abgeschwächten Totalreflexion (ATR)
US7699819B2 (en) 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20080004564A1 (en) * 2006-03-30 2008-01-03 Transcutaneous Technologies Inc. Controlled release membrane and methods of use
WO2007124411A1 (en) * 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
DE102006028782A1 (de) * 2006-06-23 2007-12-27 Robert Bosch Gmbh Vorrichtung zur Aufbewahrung und Transport von Mikronadeln und ein Verfahren zur Verabreichung von Wirkstoffen mittels einer solchen Vorrichtung
US8250729B2 (en) * 2006-07-12 2012-08-28 University Of Utah Research Foundation 3D fabrication of needle tip geometry and knife blade
US20090326441A1 (en) * 2006-08-01 2009-12-31 Agency For Science ,Technology And Research Ultrasonic Enhanced Microneedles
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
ES2380226T3 (es) * 2006-09-04 2012-05-09 F. Hoffmann-La Roche Ag Embalaje para instrumentos médicos hidrófilos
US20080097352A1 (en) * 2006-09-12 2008-04-24 Beck Patricia A Methods of fabricating microneedles with bio-sensory functionality
ES2673046T3 (es) * 2006-09-26 2018-06-19 Infectious Disease Research Institute Composición de vacuna que contiene un adyuvante sintético
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
JP4954656B2 (ja) * 2006-09-28 2012-06-20 凸版印刷株式会社 針状体および針状体の製造方法
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
JP2010505471A (ja) 2006-10-02 2010-02-25 エムキネティクス， インコーポレイテッド 磁気誘導療法のための方法および装置
EP2090331A4 (en) * 2006-11-22 2012-04-18 Toppan Printing Co Ltd MICRONADEL ARRANGEMENT AND MANUFACTURING METHOD THEREFOR
TW200838576A (en) 2006-12-01 2008-10-01 Transcu Ltd Systems, devices and methods for powering and/or controlling transdermal delivery devices
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
JP5297595B2 (ja) * 2007-03-20 2013-09-25 凸版印刷株式会社 針状体および針状体製造方法
US8439861B2 (en) * 2007-04-24 2013-05-14 Velcro Industries B.V. Skin penetrating touch fasteners
TW200841866A (en) * 2007-04-25 2008-11-01 Micro Base Technology Corp Cosmetic or medical patch structure
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
US20090053673A1 (en) * 2007-08-23 2009-02-26 Zimmer, Inc. Method for localized treatment of periodontal tissue
WO2009040548A1 (en) * 2007-09-28 2009-04-02 The Queen's University Of Belfast Delivery device and method
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
EP2231257A4 (en) 2007-12-24 2013-11-06 Univ Queensland APPLICATION METHOD
AU2009212106B9 (en) 2008-02-07 2014-05-22 Vaxxas Pty Limited Patch production
US8398397B2 (en) * 2008-03-12 2013-03-19 Ultradent Products, Inc. Dental intraligamentary injection needles and related methods of manufacture
US20090259176A1 (en) * 2008-04-09 2009-10-15 Los Gatos Research, Inc. Transdermal patch system
US8012329B2 (en) 2008-05-09 2011-09-06 3M Innovative Properties Company Dimensional control in electroforms
AU2009250341A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection using a needle projection patch
US20110150946A1 (en) * 2008-08-22 2011-06-23 Al-Ghananeem Abeer M Transdermal Delivery of Apomorphine Using Microneedles
MX349292B (es) * 2008-11-18 2017-07-21 3M Innovative Properties Co Disposición de microagujas huecas y método.
EP2384210B1 (en) 2008-12-02 2017-08-30 Allergan, Inc. Injection device
WO2010107707A2 (en) 2009-03-17 2010-09-23 Savage Walter T External defibrillator
US8781576B2 (en) 2009-03-17 2014-07-15 Cardiothrive, Inc. Device and method for reducing patient transthoracic impedance for the purpose of delivering a therapeutic current
KR101033514B1 (ko) * 2009-06-02 2011-05-09 (주)마이티시스템 유연한 미세바늘 패치 시스템 및 그 제작방법
CN102481312B (zh) 2009-06-05 2015-07-15 传染性疾病研究院 合成的吡喃葡萄糖脂佐剂
US8062568B2 (en) * 2009-08-27 2011-11-22 Korea University Research And Business Foundation Nano pattern writer
US20110224515A1 (en) * 2009-09-08 2011-09-15 SensiVida Medical Technologies, Inc. Replaceable microneedle cartridge for biomedical monitoring
US8834423B2 (en) * 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
DE102009046581A1 (de) * 2009-11-10 2011-05-12 Robert Bosch Gmbh Herstellungsverfahren für eine poröse Mikronadelanordnung und entsprechende poröse Mikronadelanordnung und entsprechender Substratverbund
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
GB2478363A (en) * 2010-03-05 2011-09-07 Ndm Technologies Ltd Microneedle patch and method of manufacture
JP5423522B2 (ja) * 2010-03-25 2014-02-19 日本電気株式会社 モジュール及びモジュール製造方法
FR2959599B1 (fr) * 2010-04-28 2013-12-20 Commissariat Energie Atomique Dispositif et procede de texturation mecanique d'une plaquette de silicium destinee a constituer une cellule photovoltaique, plaquette de silicium obtenue
MX336139B (es) 2010-04-28 2016-01-08 Kimberly Clark Co Dispositivos medicos para la entrega de arn de interferencia corta.
KR101790815B1 (ko) 2010-04-28 2017-10-26 킴벌리-클라크 월드와이드, 인크. 세포성 상호작용이 향상된 나노패턴화 의료 기구
US9522263B2 (en) 2010-04-28 2016-12-20 Kimberly-Clark Worldwide, Inc. Device for delivery of rheumatoid arthritis medication
WO2012046149A1 (en) 2010-04-28 2012-04-12 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
WO2012048285A1 (en) * 2010-10-08 2012-04-12 Lanco Biosciences, Inc. Delivery of bisphosphonates by microinjection systems
WO2012061556A1 (en) 2010-11-03 2012-05-10 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
CA2832307A1 (en) 2011-04-08 2012-10-18 Immune Design Corp. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
US8636696B2 (en) * 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
JP2014236758A (ja) * 2011-09-30 2014-12-18 テルモ株式会社 センサ
AU2012323782B2 (en) 2011-10-12 2017-04-06 Vaxxas Pty Limited Delivery device
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
AU2012328037B2 (en) 2011-10-27 2017-11-02 Vivasor, Inc. Transdermal delivery of high viscosity bioactive agents
RS58868B1 (sr) 2012-02-07 2019-08-30 Infectious Disease Res Inst Poboljšane adjuvansne formulacije koje sadrže agoniste tlr4 i postupci upotrebe istih
CA3077452C (en) 2012-05-01 2022-08-09 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
US9555099B2 (en) 2012-05-16 2017-01-31 Immune Design Corp. Vaccines for HSV-2
JP5903016B2 (ja) * 2012-06-27 2016-04-13 コスメディ製薬株式会社 マイクロニードルパッチの保護離型シート
US20150173991A1 (en) * 2012-07-06 2015-06-25 The General Hospital Corporation Method and apparatus for dermatological treatment
EP2951560B1 (en) 2013-01-29 2019-03-20 Hewlett-Packard Development Company, L.P. Apparatus having surface-enhanced spectroscopy elements on an exterior surface
CN103157178B (zh) * 2013-02-05 2014-12-31 北京化工大学 精确控制微针插入长度的印章式工具
CA2900505C (en) 2013-02-20 2023-10-24 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
ITMI20130586A1 (it) * 2013-04-11 2014-10-12 Azienda Ospedaliero Universitaria P Isana Microago e matrice di microaghi per uso medicale, e processo di produzione di detta matrice
KR102039520B1 (ko) 2013-04-18 2019-11-01 이뮨 디자인 코포레이션 암 치료에 이용하기 위한 gla 단일요법
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
KR20160019944A (ko) * 2013-06-13 2016-02-22 마이크로데믹스 인코퍼레이티드 금속 마이크로니들
US10279189B2 (en) 2013-06-14 2019-05-07 Cardiothrive, Inc. Wearable multiphasic cardioverter defibrillator system and method
US9656094B2 (en) 2013-06-14 2017-05-23 Cardiothrive, Inc. Biphasic or multiphasic pulse generator and method
US9616243B2 (en) 2013-06-14 2017-04-11 Cardiothrive, Inc. Dynamically adjustable multiphasic defibrillator pulse system and method
US9833630B2 (en) 2013-06-14 2017-12-05 Cardiothrive, Inc. Biphasic or multiphasic pulse waveform and method
US10149973B2 (en) 2013-06-14 2018-12-11 Cardiothrive, Inc. Multipart non-uniform patient contact interface and method of use
US9907970B2 (en) 2013-06-14 2018-03-06 Cardiothrive, Inc. Therapeutic system and method using biphasic or multiphasic pulse waveform
CA2920662A1 (en) 2013-08-09 2015-02-12 Cytrellis Biosystems, Inc. Methods and apparatuses for skin treatment using non-thermal tissue ablation
KR101511850B1 (ko) * 2013-10-10 2015-04-16 (주)엠큐어 멀티니들허브를 갖는 피부재생기
WO2015095675A1 (en) 2013-12-19 2015-06-25 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
US20160030459A1 (en) 2014-01-21 2016-02-04 Immune Design Corp. Compositions and methods for treating allergic conditions
WO2015129894A1 (ja) * 2014-02-27 2015-09-03 凸版印刷株式会社 マイクロニードルユニット、および、マイクロニードル用容器
JP5851077B1 (ja) * 2014-03-26 2016-02-03 日本写真印刷株式会社 錐体状突起シートの梱包体及びその製造方法
RU2627150C1 (ru) * 2014-04-30 2017-08-03 Кимберли-Кларк Ворлдвайд, Инк. Группа драпированных микроигл
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
US9987427B1 (en) 2014-06-24 2018-06-05 National Technology & Engineering Solutions Of Sandia, Llc Diagnostic/drug delivery “sense-respond” devices, systems, and uses thereof
US10321858B2 (en) 2014-08-18 2019-06-18 Proteadx, Inc. Apparatus and methods for transdermal sensing of analytes in interstitial fluid and associated data transmission systems
US9933387B1 (en) 2014-09-07 2018-04-03 Biolinq, Inc. Miniaturized sub-nanoampere sensitivity low-noise potentiostat system
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
JP6906885B2 (ja) 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
BR112017009805A2 (pt) 2014-11-14 2017-12-26 Cytrellis Biosystems Inc dispositivos e métodos para ablação da pele
WO2016121499A1 (ja) * 2015-01-27 2016-08-04 凸版印刷株式会社 経皮投与デバイス
US11147954B2 (en) 2015-02-02 2021-10-19 Vaxxas Pty Limited Microprojection array applicator and method
WO2016145230A1 (en) 2015-03-10 2016-09-15 Unger Jacob G Multiple needle injector
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
JP6505210B2 (ja) 2015-04-27 2019-04-24 株式会社Ｑｕａｒｒｙｍｅｎ＆Ｃｏ． シート状小片、その小片を含む発毛促進用シート、並びに、その小片を含む美白及び皺改善剤
JP6646985B2 (ja) * 2015-09-08 2020-02-14 花王株式会社 微細突起具の製造方法
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
JP6461761B2 (ja) * 2015-10-06 2019-01-30 富士フイルム株式会社 経皮吸収シートの製造方法
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
WO2017095321A1 (en) * 2015-12-04 2017-06-08 Ascilion Ab A microneedle and a chip
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
US11166743B2 (en) 2016-03-29 2021-11-09 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
WO2017176476A1 (en) 2016-04-08 2017-10-12 Allergan, Inc. Aspiration and injection device
US11147485B2 (en) 2016-05-04 2021-10-19 Midge Medical Gmbh Body fluid extraction device
US10092207B1 (en) 2016-05-15 2018-10-09 Biolinq, Inc. Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
HUE059605T2 (hu) 2016-05-16 2022-11-28 Access To Advanced Health Inst TLR agonista tartalmú készítmény és használati eljárások
WO2017200957A1 (en) 2016-05-16 2017-11-23 Infectious Disease Research Institute Pegylated liposomes and methods of use
US11173126B2 (en) 2016-06-01 2021-11-16 Infectious Disease Research Institute Nanoalum particles comprising a PAA sizing agent
JP6300864B2 (ja) * 2016-08-09 2018-03-28 ヒューレット−パッカード デベロップメント カンパニー エル．ピー．Ｈｅｗｌｅｔｔ‐Ｐａｃｋａｒｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏｍｐａｎｙ， Ｌ．Ｐ． 外面に表面増感分光法要素を有する装置
BR112019005312A2 (pt) 2016-09-21 2019-07-16 Cytrellis Biosystems Inc dispositivos e métodos para a recomposição cosmética da pele
CN110198703A (zh) 2016-11-21 2019-09-03 艾里奥治疗公司 大试剂的透皮递送
MA46885A (fr) * 2016-11-23 2019-10-02 Univ Medical Pharmaceuticals Corporation Système et procédé d'administration de micro-aiguilles
JP6977258B2 (ja) * 2016-12-20 2021-12-08 株式会社リコー 中空構造体
EP3338832A1 (en) * 2016-12-23 2018-06-27 Sanofi-Aventis Deutschland GmbH Medicament delivery device
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
CN110709250B (zh) 2017-03-31 2022-10-11 瓦克萨斯私人有限公司 用于涂覆表面的设备和方法
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
CA3066915A1 (en) 2017-06-11 2018-12-20 Molecular Express, Inc. Methods and compositions for substance use disorder vaccine formulations and uses thereof
AU2018285954A1 (en) 2017-06-13 2019-12-19 Vaxxas Pty Limited Quality control of substrate coatings
JP6931222B2 (ja) * 2017-07-18 2021-09-01 コスメディ製薬株式会社 マイクロニードルアレイの発泡支持体シート
WO2019023757A1 (en) 2017-08-04 2019-02-07 Vaxxas Pty Limited COMPACT MECHANICAL HIGH ENERGY STORAGE ACTUATOR WITH LOW TRIGGER STRENGTH FOR ADMINISTRATION OF MICROPROJECTION NETWORK (PRM) PATCHES
US11766203B2 (en) 2017-09-13 2023-09-26 National Technology & Engineering Solutions Of Sandia, Llc Coaxial microneedle assemblies and methods thereof
TWI667016B (zh) 2017-11-20 2019-08-01 研能科技股份有限公司 血糖監測控制系統
WO2019126735A1 (en) 2017-12-21 2019-06-27 Georgia Tech Research Corporation Methods and systems for improved collection of interstitial fluid
US10828500B2 (en) 2017-12-22 2020-11-10 Cardiothrive, Inc. External defibrillator
SG10201800072YA (en) * 2018-01-03 2019-08-27 Micropoint Tech Pte Ltd Microneedle Patches Comprising Corticosteroid
US10918839B2 (en) * 2018-03-13 2021-02-16 II Jaro Mayda Balloon catheter
JP7055861B2 (ja) * 2018-03-30 2022-04-18 富士フイルム株式会社 マイクロニードルアレイの製造方法
USD875254S1 (en) 2018-06-08 2020-02-11 Biolinq, Inc. Intradermal biosensor
MX2021002995A (es) 2018-09-13 2021-07-15 Eirion Therapeutics Inc Inhibidores del inhibidor 1 de activador de plasminogeno (pai-1) y usos de los mismos.
AU2019339488A1 (en) 2018-09-13 2021-04-08 Eirion Therapeutics, Inc. Uses of plasminogen activator inhibitor 1 (PAI-1) inhibitors
US20210338158A1 (en) 2018-10-02 2021-11-04 WearOptimo Pty Ltd Measurement system
WO2020069567A1 (en) 2018-10-02 2020-04-09 WearOptimo Pty Ltd Electrode arrangement
SG11202104838SA (en) 2018-12-03 2021-06-29 Eirion Therapeutics Inc Improved delivery of large agents
CN114173808A (zh) 2019-05-14 2022-03-11 艾里奥治疗公司 延迟峰值效应和/或延长反应持续时间
TWI687247B (zh) * 2019-05-15 2020-03-11 微邦科技股份有限公司 微針結構及其生物可降解微針
CN111939452A (zh) * 2019-05-15 2020-11-17 微邦科技股份有限公司 微针结构及其生物可降解微针
EP3772331A1 (fr) * 2019-08-08 2021-02-10 PKvitality Systeme de surveillance corporelle comprenant une microaiguille
CN110711312B (zh) * 2019-11-07 2021-07-30 河南大学 基于微机电系统的强促渗透皮释药微系统及其制造方法
WO2022026764A1 (en) 2020-07-29 2022-02-03 Biolinq Inc. Continuous analyte monitoring system with microneedle array
WO2022118859A1 (ja) * 2020-12-01 2022-06-09 三井化学株式会社 マイクロニードルアレイ、マイクロニードルアレイアセンブリ、及び検査チップ
JP2024501949A (ja) 2020-12-23 2024-01-17 アクセス ツー アドバンスト ヘルス インスティチュート ソラネソールワクチンアジュバント及びその調製方法
CN112858430B (zh) * 2021-01-08 2021-11-26 中山大学 一种检测植物活性小分子的传感器和制备方法
USD988160S1 (en) * 2021-03-16 2023-06-06 Biolinq Incorporated Wearable dermal sensor
WO2022240700A1 (en) 2021-05-08 2022-11-17 Biolinq Incorporated Fault detection for microneedle array based continuous analyte monitoring device
CN113499537A (zh) * 2021-09-03 2021-10-15 河南佳普医药科技有限公司 一种微针透皮给药装置
JP7141625B1 (ja) 2021-09-17 2022-09-26 リンテック株式会社 マイクロニードルパッチ及びマイクロニードル構造体
USD1013544S1 (en) * 2022-04-29 2024-02-06 Biolinq Incorporated Wearable sensor
USD996999S1 (en) * 2021-11-16 2023-08-29 Biolinq Incorporated Wearable sensor
USD1012744S1 (en) * 2022-05-16 2024-01-30 Biolinq Incorporated Wearable sensor with illuminated display

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123212A (en) * 1964-03-03 Multiple disposable intracutaneous injector package
NL113697C (xx) * 1954-04-27
US3034507A (en) * 1960-05-10 1962-05-15 American Cyanamid Co Intracutaneous injection device
US3074403A (en) * 1960-05-17 1963-01-22 American Cyanamid Co Intracutaneous injector with capillary gap
US3136314A (en) * 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3246647A (en) * 1962-07-23 1966-04-19 American Cyanamid Co Disposable intracutaneous injector
US3466131A (en) * 1967-09-07 1969-09-09 Becton Dickinson Co Dispensing applicator package
US3675766A (en) * 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3688764A (en) * 1970-08-20 1972-09-05 Bard Hamilton Co Inc Intracutaneous injection system
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) * 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
DE2250293A1 (de) * 1972-10-13 1974-04-25 Bayern Freistaat Impfstempel zur cutanen pockenimpfung mittels trockenimpfstoff
OA05448A (fr) * 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
US4473083A (en) * 1981-12-14 1984-09-25 Maganias Nicholas H Device and method for allergy testing
US4921475A (en) * 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
GB2221394B (en) 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
US6090790A (en) * 1989-12-14 2000-07-18 Eriksson; Elof Gene delivery by microneedle injection
US5402798A (en) * 1991-07-18 1995-04-04 Swierczek; Remi Disposable skin perforator and blood testing device
US5342737A (en) * 1992-04-27 1994-08-30 The United States Of America As Represented By The Secretary Of The Navy High aspect ratio metal microstructures and method for preparing the same
JP3553933B2 (ja) * 1992-06-18 2004-08-11 アメリカ合衆国 高められた活性を有する組換シュードモナス外毒素
JP3211525B2 (ja) 1993-04-22 2001-09-25 オムロン株式会社 薄材メッシュ、その製造方法及びその製造装置
US5620095A (en) 1993-06-11 1997-04-15 Minnesota Mining And Manufacturing Company Orthopedic casting material and hermetic package
US5611806A (en) * 1994-05-23 1997-03-18 Samsung Electro-Mechanics Co., Ltd. Skin perforating device for transdermal medication
EP0822881B1 (en) 1995-04-26 2009-08-12 Minnesota Mining And Manufacturing Company Laser imaging ablation method
AU5740496A (en) * 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
JP2725637B2 (ja) * 1995-05-31 1998-03-11 日本電気株式会社 電子回路装置およびその製造方法
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5658515A (en) * 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5657516A (en) * 1995-10-12 1997-08-19 Minnesota Mining And Manufacturing Company Dual structured fastener elements
US6219574B1 (en) * 1996-06-18 2001-04-17 Alza Corporation Device and method for enchancing transdermal sampling
DK0921840T3 (da) * 1996-07-03 2003-09-22 Altea Therapeutics Corp Multipel mekanisk mikroperforering af hud eller slimhinde
US6797276B1 (en) * 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
EP0957972B1 (en) * 1996-12-20 2003-03-19 Alza Corporation Device and method for enhancing transdermal agent flux
US6605332B2 (en) * 1997-07-29 2003-08-12 3M Innovative Properties Company Unitary polymer substrate having napped surface of frayed end microfibers
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
EP1037686B1 (en) * 1997-12-11 2005-08-17 Alza Corporation Device for enhancing transdermal agent flux
EP1035889B1 (en) * 1997-12-11 2002-07-31 Alza Corporation Device for enhancing transdermal agent flux
US6099682A (en) 1998-02-09 2000-08-08 3M Innovative Properties Company Corporation Of Delaware Cold seal package and method for making the same
WO1999064580A1 (en) 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
GB9815820D0 (en) 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
ATE280615T1 (de) * 1998-08-31 2004-11-15 Johnson & Johnson Consumer Elektrotransportvorrichtung mit klingen
WO2000035530A1 (en) * 1998-12-18 2000-06-22 Minimed Inc. Insertion sets with micro-piercing members for use with medical devices and methods of using the same
CA2372409C (en) * 1999-01-28 2005-03-29 Alan D. King Delivery of macromolecules into cells
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) * 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
DE60044084D1 (de) 1999-06-04 2010-05-12 Georgia Tech Res Inst Vorrichtungen zur vergrösserten penetration von mikronadeln in biologischen hautschichten
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6551849B1 (en) * 1999-11-02 2003-04-22 Christopher J. Kenney Method for fabricating arrays of micro-needles
MXPA02004863A (es) * 1999-11-15 2003-01-28 Velcro Ind Miembro de sujecion dermica.
US6558361B1 (en) * 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
WO2001066065A2 (en) 2000-03-09 2001-09-13 Nanopass Ltd. Systems and methods for fluid transport through dermal barriers
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
AU2001275138A1 (en) * 2000-06-02 2001-12-17 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6537242B1 (en) * 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6589202B1 (en) * 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6440096B1 (en) * 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6749575B2 (en) * 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
MXPA03002122A (es) * 2000-09-08 2004-09-10 Johnson & Johnson Metodos para inhibir disminucion en flujo de farmaco transdermico mediante inhibicion de cierre de trayectoria.
CN1479589A (zh) * 2000-10-13 2004-03-03 用于冲击敷贴器的微凸起构件保持器
US6821281B2 (en) * 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
BR0114909A (pt) * 2000-10-26 2004-02-03 Alza Corp Dispositivos de distribuição de drogas transdérmicas possuindo microprotuberâncias revestidas
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US7027478B2 (en) * 2000-12-21 2006-04-11 Biovalve Technologies, Inc. Microneedle array systems
US20020099356A1 (en) * 2001-01-19 2002-07-25 Unger Evan C. Transmembrane transport apparatus and method
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
AU2002312315A1 (en) * 2001-06-08 2002-12-23 The Regents Of The University Of California Microfabricated surgical devices and methods of making the same
US6686299B2 (en) * 2001-06-21 2004-02-03 Carlo D. Montemagno Nanosyringe array and method
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US6746590B2 (en) * 2001-09-05 2004-06-08 3M Innovative Properties Company Ultrasonically-enhanced electroplating apparatus and methods
WO2003024507A2 (en) * 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
AU2002337788A1 (en) * 2001-09-28 2003-04-07 Biovalve Technologies, Inc. Microneedle with membrane
US6689100B2 (en) * 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
DE60230894D1 (xx) * 2001-10-29 2009-03-05 Becton Dickinson Co
WO2003046508A2 (en) * 2001-11-09 2003-06-05 Biomicroarrays, Inc. High surface area substrates for microarrays and methods to make same
ES2297056T3 (es) * 2001-12-20 2008-05-01 Alza Corporation Micro-proyecciones para perforacion de la piel que tienen control de la profundidad de perforacion.
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US20040060902A1 (en) * 2002-02-05 2004-04-01 Evans John D. Microprotrusion array and methods of making a microprotrusion
EP2319578B1 (en) * 2002-03-11 2016-11-02 Nitto Denko Corporation Transdermal drug delievery patch system, method of making same and method of using same
US6780171B2 (en) * 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US6899838B2 (en) * 2002-07-12 2005-05-31 Becton, Dickinson And Company Method of forming a mold and molding a micro-device
JP4691445B2 (ja) * 2002-07-22 2011-06-01 ベクトン・ディキンソン・アンド・カンパニー パッチ状注入装置
US7422567B2 (en) * 2002-08-29 2008-09-09 Becton, Dickinson And Company Microabrader with controlled abrasion features
AU2003277306A1 (en) * 2002-10-07 2004-05-04 Biovalve Technologies, Inc. Microneedle array patch
AU2004251699A1 (en) * 2003-06-04 2005-01-06 Georgia Tech Research Corporation Drilling microneedle device
AU2004253571A1 (en) * 2003-07-02 2005-01-13 Alza Corporation Microprojection array immunization patch and method
MXPA06001414A (es) * 2003-08-04 2006-08-25 Johnson & Johnson Metodo y dispositivo para incrementar el flujo de agente transdermico.
SG145737A1 (en) * 2003-08-12 2008-09-29 Becton Dickinson Co Patch-like infusion device
EP1660172A1 (en) * 2003-08-26 2006-05-31 Alza Corporation Device and method for intradermal cell implantation
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
AU2004285484A1 (en) * 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
EP1680057A4 (en) * 2003-10-24 2007-10-31 Alza Corp DEVICE AND METHOD FOR IMPROVING TRANSDERMAL DRUG DELIVERY
EP1677687A4 (en) * 2003-10-28 2008-09-17 Alza Corp ADMINISTRATION OF POLYMERIC CONJUGATES OF PEPTIDES AND THERAPEUTIC PROTEINS THROUGH COATED MICROPROTUBERANCES

Also Published As

Publication number Publication date
DE60224842T2 (de) 2009-01-22
AU2002359490A1 (en) 2003-07-30
JP4382492B2 (ja) 2009-12-16
DE60224842D1 (de) 2008-03-13
EP1465698B1 (en) 2008-01-23
US20030135161A1 (en) 2003-07-17
EP1465698A1 (en) 2004-10-13
US20050187521A1 (en) 2005-08-25
US6908453B2 (en) 2005-06-21
ATE384549T1 (de) 2008-02-15
WO2003059431A1 (en) 2003-07-24
JP2005514179A (ja) 2005-05-19

Similar Documents

Publication Publication Date Title
IL162554A0 (en) Microneedle devices and methods of manufacture
ES2612779T3 (es) Sistema de parches transdérmicos de administración de fármacos, método de fabricación del mismo y método de uso del mismo
ES2314995T3 (es) Dispositivo para mejorar el flujo de agentes tansdermicos.
US8579862B2 (en) Applicator for microneedle array
TW200613029A (en) System and method for drug delivery and microfluidic applications using microneedles
JP2012523265A (ja) 流体伝達を調節することができるマイクロニードルユニット
WO2002085447A8 (en) Microprojection array having a beneficial agent containing coating
DE60106261D1 (de) Abgabevorrichtung mit mikronadeln zur transdermalen verabreichung von einer substanz
WO2005000382A3 (en) Drilling microneedle device
IL183606A (en) Medical device
JP2005501615A5 (xx)
WO2005042054A3 (en) Pretreatment method and system for enhancing transdermal drug delivery
PL1684846T3 (pl) Urządzenie do transdermalnego podawania substancji czynnych
CN203436688U (zh) 金属微针阵列、经皮给药贴片、微针给药印章、微针美容印章、微针滚轮及微针电极阵列
US20200230389A1 (en) Micropenetrator device for penetrating a biological barrier
CN107913458B (zh) 一种液体定量储存系统
CN105381536A (zh) 自行载药的长时透皮给药及取样装置
CN211461763U (zh) 一种方便按压的可溶性微针贴片
KR102535229B1 (ko) 광치료용 니들 패치 및 이의 제조 방법