JP2832979B2
(ja)
*
|
1988-02-15 |
1998-12-09 |
武田薬品工業株式会社 |
不飽和カルボン酸アミド誘導体
|
WO1990006303A1
(fr)
*
|
1988-12-02 |
1990-06-14 |
Pfizer Inc. |
Derives arylpiperidine
|
JP2777159B2
(ja)
|
1988-12-22 |
1998-07-16 |
エーザイ株式会社 |
環状アミン誘導体を含有する医薬
|
JP2969359B2
(ja)
*
|
1989-01-13 |
1999-11-02 |
武田薬品工業株式会社 |
環状アミン化合物
|
US5225402A
(en)
*
|
1989-02-10 |
1993-07-06 |
Otsuka Pharmaceutical Co., Ltd. |
Carbostyril derivatives
|
JP2931986B2
(ja)
*
|
1989-02-17 |
1999-08-09 |
武田薬品工業株式会社 |
アラルキルアミン誘導体
|
US5250528A
(en)
*
|
1989-08-02 |
1993-10-05 |
Fujisawa Pharmaceutical Co., Ltd. |
New aminopiperazine derivatives
|
US5109002A
(en)
*
|
1989-09-08 |
1992-04-28 |
Du Pont Merck Pharmaceutical Company |
Antipsychotic 1-cycloalkylpiperidines
|
US5356906A
(en)
*
|
1989-10-27 |
1994-10-18 |
The Du Pont Merck Pharmaceutical Company |
(N-phthalimidoalkyl) piperidines useful as treatments for psychosis
|
CA2069318A1
(fr)
*
|
1989-10-27 |
1991-04-28 |
Engelbert Ciganek |
(n-phthalimidoalkyl)piperidines
|
JPH03151358A
(ja)
*
|
1989-10-30 |
1991-06-27 |
Syntex Usa Inc |
ドーパミン・アゴニストとしてのベンジルピロリジン誘導体
|
US5215989A
(en)
*
|
1989-12-08 |
1993-06-01 |
Merck & Co., Inc. |
Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
|
US5032604A
(en)
*
|
1989-12-08 |
1991-07-16 |
Merck & Co., Inc. |
Class III antiarrhythmic agents
|
US5032598A
(en)
*
|
1989-12-08 |
1991-07-16 |
Merck & Co., Inc. |
Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
|
US5206240A
(en)
*
|
1989-12-08 |
1993-04-27 |
Merck & Co., Inc. |
Nitrogen-containing spirocycles
|
US5112824A
(en)
*
|
1989-12-08 |
1992-05-12 |
Merck & Co., Inc. |
Benzofuran compounds as class III antiarrhythmic agents
|
EP0507863A4
(en)
*
|
1989-12-28 |
1993-07-07 |
Virginia Commonwealth University |
Sigma receptor ligands and the use thereof
|
US5428043A
(en)
*
|
1990-02-08 |
1995-06-27 |
Pfizer Inc. |
Tricyclic-cyclic amines as novel cholinesterase inhibitors
|
US5272157A
(en)
*
|
1990-03-07 |
1993-12-21 |
Synthelabo |
Derivatives of 4-(aminomethyl) piperidine, their preparation and their therapeutic application
|
FR2659323B1
(fr)
*
|
1990-03-07 |
1992-06-12 |
Synthelabo |
Derives de 4-(aminomethyl) piperidine, leur preparation et leur application en therapeutique.
|
US5116846A
(en)
*
|
1990-03-28 |
1992-05-26 |
Du Pont Merck Pharmaceutical Company |
N-aralkyl piperidine derivatives as psychotropic drugs
|
US5173209A
(en)
*
|
1990-05-10 |
1992-12-22 |
Cyprus Foote Mineral Company |
Stable lithium cycloalkylimides
|
ATE114467T1
(de)
*
|
1990-06-01 |
1994-12-15 |
Merrell Dow Pharma |
(+)-alpha-(2,3 dimethoxyphenyl)-1-(2- (fluorophenyl)ethyl>-4-piperidinmethanol.
|
US6004980A
(en)
*
|
1990-06-01 |
1999-12-21 |
Merrell Pharmaceuticals, Inc. |
(+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
|
JP2807577B2
(ja)
*
|
1990-06-15 |
1998-10-08 |
エーザイ株式会社 |
環状アミド誘導体
|
EP0465254B1
(fr)
*
|
1990-07-06 |
1996-11-13 |
Yoshitomi Pharmaceutical Industries, Ltd. |
Composés condensés de thiophen et leur usage
|
FR2664592B1
(fr)
*
|
1990-07-10 |
1994-09-02 |
Adir |
Nouveaux derives de la piperidine, de la tetrahydropyridine et de la pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
|
TW199153B
(fr)
*
|
1990-08-07 |
1993-02-01 |
Dtsuka Seiyaku Kk |
|
US5240934A
(en)
*
|
1990-10-19 |
1993-08-31 |
Ss Pharmaceutical Co., Ltd. |
Quinoline derivatives
|
US5190951A
(en)
*
|
1990-10-19 |
1993-03-02 |
Ss Pharmaceutical Co., Ltd. |
Quinoline derivatives
|
TW197435B
(fr)
*
|
1990-11-22 |
1993-01-01 |
Takeda Pharm Industry Co Ltd |
|
DE4104870A1
(de)
*
|
1991-02-17 |
1992-08-27 |
Bayer Ag |
Verwendung von 3,(4)-substituierten pyrrolidinen als katalysatoren fuer das polyisocyanatpolyadditionsverfahren, verfahren zu ihrer herstellung sowie verfahren zur herstellung von polyurethan(harnstoff)en
|
US5162341A
(en)
*
|
1991-02-22 |
1992-11-10 |
Du Pont Merck Pharmaceutical Company |
Use of sigma receptor antagonists for treatment of amphetamine abuse
|
US5750542A
(en)
*
|
1993-09-28 |
1998-05-12 |
Pfizer |
Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
|
BR9205811A
(pt)
*
|
1991-03-28 |
1994-06-28 |
Pfizer |
Derivados heterociclicos de aminas ciclicas
|
FR2676225B1
(fr)
*
|
1991-05-03 |
1993-08-27 |
Sanofi Elf |
Nouveaux intermediaires pour la synthese de composes dialkylenepiperidino.
|
FR2676226B1
(fr)
*
|
1991-05-03 |
1993-08-27 |
Sanofi Elf |
Nouveaux intermediaires pour la synthese de composes dialkylenepiperidino.
|
CA2067475C
(fr)
*
|
1991-05-08 |
2000-10-10 |
Yasuo Oshiro |
Derives du carbostyrile et leurs utilisations
|
US5556857A
(en)
*
|
1991-05-08 |
1996-09-17 |
Otsuka Pharmaceutical Co., Ltd. |
Disturbance-of-consciousness improving agent
|
FR2677019B1
(fr)
*
|
1991-05-27 |
1994-11-25 |
Pf Medicament |
Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique.
|
US5106856A
(en)
*
|
1991-06-07 |
1992-04-21 |
Hoechst-Roussel Pharmaceuticals Inc. |
[(Arylalkylpiperidin-4-yl)methyl]-2a,3,4,5-tetrahydro-1(2H)-acenaphthylen-1-ones and related compounds
|
EP0535496A1
(fr)
*
|
1991-09-25 |
1993-04-07 |
Hoechst-Roussel Pharmaceuticals Incorporated |
(1-Indanon-2-yl)méthylpipéridines, produits intermédiaires et procédé pour leur préparation et leur utilisation comme médicaments
|
TW263504B
(fr)
|
1991-10-03 |
1995-11-21 |
Pfizer |
|
SE9103752D0
(sv)
*
|
1991-12-18 |
1991-12-18 |
Astra Ab |
New compounds
|
US5462934A
(en)
*
|
1992-03-09 |
1995-10-31 |
Takeda Chemical Industries |
Condensed heterocyclic ketone derivatives and their use
|
EP0567090B1
(fr)
|
1992-04-24 |
2000-07-26 |
Takeda Chemical Industries, Ltd. |
Dérivés de la benzoxazépine comme inhibiteurs de la cholinésterase
|
JP2932693B2
(ja)
*
|
1992-10-05 |
1999-08-09 |
宇部興産株式会社 |
ピリミジン化合物
|
US5914328A
(en)
*
|
1992-10-09 |
1999-06-22 |
Abbott Laboratories |
Heterocyclic ether compounds useful in controlling neurotransmitter release
|
US5948793A
(en)
*
|
1992-10-09 |
1999-09-07 |
Abbott Laboratories |
3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release
|
TW248556B
(fr)
*
|
1993-01-18 |
1995-06-01 |
Takeda Pharm Industry Co |
|
US5656642A
(en)
*
|
1993-04-07 |
1997-08-12 |
Otsuka Pharmaceutical Co., Ltd. |
Peripheral vasodilating agent containing piperidine derivative as active ingredient
|
US5459151A
(en)
*
|
1993-04-30 |
1995-10-17 |
American Home Products Corporation |
N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents
|
ZA944513B
(en)
*
|
1993-06-23 |
1996-01-16 |
Cambridge Neuroscience Inc |
Sigma receptor ligands
|
DK0637586T3
(da)
*
|
1993-08-05 |
1999-12-06 |
Hoechst Marion Roussel Inc |
2-(Piperidin-4-yl, pyridin-4-yl og tetrahydropyridin-4-yl)-benzofuran-7-carbamatderivater, deres fremstilling og anvendelse
|
GB9319534D0
(en)
*
|
1993-09-22 |
1993-11-10 |
Boots Co Plc |
Therapeutic agents
|
ES2108484T3
(es)
*
|
1993-11-30 |
1997-12-16 |
Pfizer |
Procedimiento para la preparacion de una tetralona asimetrica.
|
DE4439822A1
(de)
|
1994-11-08 |
1996-08-29 |
Bayer Ag |
Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen
|
US5658909A
(en)
|
1994-11-17 |
1997-08-19 |
Molecular Geriatrics Corporation |
Certain substituted 1-aryl-3-piperazin-1'-yl propanones to treat Alzheimer's Disease
|
US6214994B1
(en)
|
1997-04-21 |
2001-04-10 |
Molecular Geriatrics Corporation |
Certain substituted 1-aryl-3-piperazin-1′-yl propanones
|
US5859295A
(en)
*
|
1994-12-05 |
1999-01-12 |
University Of Kentucky Research Foundation |
Canavanine analogs and their use as chemotherapeutic agents
|
AU4483896A
(en)
*
|
1995-01-18 |
1996-08-07 |
Bayer Aktiengesellschaft |
N-substituted 1-acylaminoalkyl piperidines for treatment of cerebral disorders and depressions
|
US5889006A
(en)
*
|
1995-02-23 |
1999-03-30 |
Schering Corporation |
Muscarinic antagonists
|
IL117149A0
(en)
*
|
1995-02-23 |
1996-06-18 |
Schering Corp |
Muscarinic antagonists
|
US5703239A
(en)
*
|
1995-06-02 |
1997-12-30 |
Bristol-Myers Squibb Company |
Indanylpiperidines as melatonergic agents
|
US20100210590A1
(en)
*
|
1995-09-27 |
2010-08-19 |
Northwestern University |
Compositions and treatments for seizure-related disorders
|
SK75498A3
(en)
*
|
1995-12-15 |
1999-08-06 |
Pfizer |
Processes and intermediates for preparing 1-benzyl-4-((5,6- -dimethoxy-1-indanon)-2-yl)methylpiperidine
|
US6025355A
(en)
|
1997-05-19 |
2000-02-15 |
Cambridge Neuroscience, Inc. |
Pharmaceutically active compounds and methods of use
|
US5629325A
(en)
*
|
1996-06-06 |
1997-05-13 |
Abbott Laboratories |
3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
|
US6437138B1
(en)
|
1996-06-06 |
2002-08-20 |
Abbott Laboratories |
3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
|
TW513409B
(en)
*
|
1996-06-07 |
2002-12-11 |
Eisai Co Ltd |
Polymorphs of donepezil hydrochloride
|
AU1153097A
(en)
*
|
1996-06-07 |
1998-01-05 |
Eisai Co. Ltd. |
Stable polymorphs of donepezil (1-benzyl-4-{(5,6-dimethoxy-1-indanon)-2-yl}methylpiperidine ) hydrochloride and process for production
|
SK285312B6
(sk)
*
|
1996-06-07 |
2006-10-05 |
Eisai Co., Ltd. |
Polymorf (III) donepezil hydrochloridu, spôsob jeho výroby a terapeutický prostriedok s jeho obsahom
|
US5935958A
(en)
*
|
1996-07-01 |
1999-08-10 |
Schering Corporation |
Muscarinic antagonists
|
FR2750991A1
(fr)
*
|
1996-07-12 |
1998-01-16 |
Pf Medicament |
Nouveaux benzodioxannes et 1-(2h)-benzopyrannes, leur preparation et leur utilisation comme medicament
|
US6242198B1
(en)
|
1996-07-25 |
2001-06-05 |
Cambridge Neuroscience, Inc. |
Methods of treatment of eye trauma and disorders
|
US6756389B2
(en)
|
1996-08-09 |
2004-06-29 |
Cambridge Neuroscience, Inc. |
Pharmaceutically active compounds and methods of use
|
US5977138A
(en)
*
|
1996-08-15 |
1999-11-02 |
Schering Corporation |
Ether muscarinic antagonists
|
WO1998007703A1
(fr)
*
|
1996-08-22 |
1998-02-26 |
Meiji Seika Kaisha, Ltd. |
Derives quinoleine et agent psychotrope
|
FR2752732B1
(fr)
|
1996-08-28 |
1998-11-20 |
Pf Medicament |
Forme galenique a liberation prolongee de milnacipran
|
US6133253A
(en)
*
|
1996-12-10 |
2000-10-17 |
Abbott Laboratories |
3-Pyridyl enantiomers and their use as analgesics
|
US5962535A
(en)
*
|
1997-01-17 |
1999-10-05 |
Takeda Chemical Industries, Ltd. |
Composition for alzheimer's disease
|
DE19707655A1
(de)
*
|
1997-02-26 |
1998-08-27 |
Hoechst Ag |
Kombinationspräparat zur Anwendung bei Demenz
|
ATE241358T1
(de)
*
|
1997-03-03 |
2003-06-15 |
Eisai Co Ltd |
Verwendung von cholinesterasehemmer zur behandlung von konzentrationsstörungen
|
WO1998056380A1
(fr)
*
|
1997-06-11 |
1998-12-17 |
Alcon Laboratories, Inc. |
Procede faisant retroceder la mydriase
|
US6028083A
(en)
*
|
1997-07-25 |
2000-02-22 |
Hoechst Marion Roussel, Inc. |
Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol
|
US5945421A
(en)
*
|
1997-08-11 |
1999-08-31 |
Warner-Lambert Company |
Dopamine D4 receptor antagonists
|
US6339087B1
(en)
|
1997-08-18 |
2002-01-15 |
Syntex (U.S.A.) Llc |
Cyclic amine derivatives-CCR-3 receptor antagonists
|
IL125658A0
(en)
|
1997-08-18 |
1999-04-11 |
Hoffmann La Roche |
Ccr-3 receptor antagonists
|
AU9454098A
(en)
*
|
1997-09-24 |
1999-04-12 |
Nova Molecular, Inc. |
Methods for increasing apoe levels for the treatment of neurodegenerative disease
|
WO1999029668A1
(fr)
*
|
1997-12-05 |
1999-06-17 |
Eisai Co., Ltd. |
Polycristaux de donepezil et leur procede de production
|
US6252081B1
(en)
|
1998-01-16 |
2001-06-26 |
Eisai Co., Ltd. |
Process for production of donepezil derivative
|
US6713627B2
(en)
|
1998-03-13 |
2004-03-30 |
Aventis Pharmaceuticals Inc. |
Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
|
US6066636A
(en)
|
1998-06-30 |
2000-05-23 |
Schering Corporation |
Muscarinic antagonists
|
US6262081B1
(en)
|
1998-07-10 |
2001-07-17 |
Dupont Pharmaceuticals Company |
Composition for and method of treating neurological disorders
|
US6218383B1
(en)
|
1998-08-07 |
2001-04-17 |
Targacept, Inc. |
Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
|
IL125809A
(en)
|
1998-08-17 |
2005-08-31 |
Finetech Lab Ltd |
Process and intermediates for production of donepezil and related compounds
|
US6184226B1
(en)
|
1998-08-28 |
2001-02-06 |
Scios Inc. |
Quinazoline derivatives as inhibitors of P-38 α
|
US20020177593A1
(en)
|
1998-09-30 |
2002-11-28 |
Yuji Ishihara |
Agents and crystals for improving excretory potency of urinary bladder
|
NZ510685A
(en)
*
|
1998-09-30 |
2003-10-31 |
Takeda Chemical Industries Ltd |
Drugs for improving vesical excretory strength
|
CN1158256C
(zh)
*
|
1998-11-20 |
2004-07-21 |
霍夫曼-拉罗奇有限公司 |
吡咯烷衍生物-ccr-3受体拮抗剂
|
BR9915735A
(pt)
|
1998-11-20 |
2001-09-04 |
Hoffmann La Roche |
Antagonistas receptores de ccr-3 de piperidina
|
EP1137412A4
(fr)
*
|
1998-12-11 |
2002-04-03 |
American Biogenetic Sciences |
Composes heterocycliques azotes substitues et leur utilisation therapeutique
|
WO2000051985A1
(fr)
|
1999-03-03 |
2000-09-08 |
Eisai Co., Ltd. |
Fluorures de derives de piperidine substitues en position 4
|
US6277866B1
(en)
*
|
1999-03-03 |
2001-08-21 |
Eisai Co., Ltd. |
1-benzyl-4[(5,6-dimethoxy-2-fluoro-1-indanon)-2-yl]methylpiperidine
|
US6833370B1
(en)
|
1999-05-21 |
2004-12-21 |
Abbott Laboratories |
Heterocycle substituted aminoazacycles useful as central nervous system agents
|
GB9914486D0
(en)
|
1999-06-21 |
1999-08-18 |
Smithkline Beecham Plc |
Medicaments
|
GB9917406D0
(en)
|
1999-07-23 |
1999-09-22 |
Smithkline Beecham Plc |
Compounds
|
ATE360612T1
(de)
|
1999-09-01 |
2007-05-15 |
Eisai R&D Man Co Ltd |
In 4-stellung substituierte piperidinderivate
|
GB0002100D0
(en)
|
2000-01-28 |
2000-03-22 |
Novartis Ag |
Organic compounds
|
US20060183776A9
(en)
*
|
2000-03-03 |
2006-08-17 |
Eisai Co., Ltd. |
Liquid dosage formulations of donepezil
|
EP1764101A1
(fr)
*
|
2000-03-03 |
2007-03-21 |
Eisai R&D Management Co., Ltd. |
Usage d'un inhibitor de cholinésterase pour la traitement de la démence et de la trouble de la perception
|
ES2275670T3
(es)
*
|
2000-03-03 |
2007-06-16 |
EISAI R&D MANAGEMENT CO., LTD. |
Metodos novedosos utilizando inhibidores de colinesterasa.
|
US20030153598A1
(en)
*
|
2000-07-25 |
2003-08-14 |
Raymond Pratt |
Methods for treating Parkinson's disease with cholinesterase inhibitors
|
US6706741B2
(en)
|
2000-04-13 |
2004-03-16 |
Eisai Co., Ltd. |
Acetylcholinesterase inhibitors containing 1-benzyl-pyridinium salts
|
CA2406383A1
(fr)
*
|
2000-04-13 |
2001-10-25 |
Mayo Foundation For Medical Education And Research |
Agents de reduction de a.beta.42
|
WO2001098271A1
(fr)
*
|
2000-06-21 |
2001-12-27 |
Eisai Co., Ltd. |
Compose piperidine 4-substitue
|
AU2001267899A1
(en)
*
|
2000-07-03 |
2002-01-14 |
Eisai Co. Ltd. |
Pharmaceutical compositions for controlling intraocular pressure
|
CN1317276C
(zh)
*
|
2000-09-29 |
2007-05-23 |
中国科学院上海药物研究所 |
一类吲哚基哌啶类化合物及其制备方法和用途
|
EP1340499A4
(fr)
*
|
2000-12-07 |
2006-05-03 |
Astellas Pharma Inc |
Nootropes
|
CA2443108A1
(fr)
*
|
2001-04-03 |
2002-10-17 |
Merck & Co. Inc. |
Antagonistes de nmda/nr2b nonaryl-heterocyclo amidyle n-substitues
|
ES2275007T3
(es)
*
|
2001-05-25 |
2007-06-01 |
Schering Corporation |
Uso de derivados de azetidinona sustitudos en el tratamiento de la enfermedad de alzeimer.
|
JP2005502680A
(ja)
*
|
2001-08-30 |
2005-01-27 |
オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド |
抗痙攣剤およびアセチルコリンエステラーゼ阻害剤による痴呆および記憶障害の処置
|
WO2003024450A1
(fr)
*
|
2001-09-20 |
2003-03-27 |
Eisai Co., Ltd. |
Methodes de traitement des maladies a prions
|
US20050227911A1
(en)
*
|
2001-09-28 |
2005-10-13 |
Solubest Ltd. |
Hydrophilic dispersions of nanoparticles of inclusion complexes of macromolecules
|
US20050191359A1
(en)
*
|
2001-09-28 |
2005-09-01 |
Solubest Ltd. |
Water soluble nanoparticles and method for their production
|
US20050249786A1
(en)
*
|
2001-09-28 |
2005-11-10 |
Solubest Ltd. |
Hydrophilic dispersions of nanoparticles of inclusion complexes of amorphous compounds
|
US20050233003A1
(en)
*
|
2001-09-28 |
2005-10-20 |
Solubest Ltd. |
Hydrophilic dispersions of nanoparticles of inclusion complexes of salicylic acid
|
US20050226934A1
(en)
*
|
2001-09-28 |
2005-10-13 |
Solubest Ltd. |
Inclusion complexes of active compounds in acrylate (co)polymers and methods for their production
|
WO2003032914A2
(fr)
*
|
2001-10-17 |
2003-04-24 |
Eisai Co., Ltd. |
Procedes de traitement de la consommation abusive de substances psychoactives a l'aide d'inhibiteurs de la cholinesterase
|
GB0126378D0
(en)
*
|
2001-11-02 |
2002-01-02 |
Oxford Biomedica Ltd |
Antigen
|
WO2003061658A1
(fr)
*
|
2002-01-22 |
2003-07-31 |
Eisai Co., Ltd. |
Agent liant de récepteur sigma contenant un dérivé d'indanone
|
AU2003207184B2
(en)
*
|
2002-02-07 |
2008-02-14 |
Eisai R And D Management Co., Ltd. |
Hair growth stimulants, percutaneous preparations and method of stimulating hair growth
|
US20040072806A1
(en)
*
|
2002-03-15 |
2004-04-15 |
Zhi-Xing Yao |
Neuroprotective spirostenol pharmaceutical compositions
|
ATE382036T1
(de)
*
|
2002-03-29 |
2008-01-15 |
Eisai R&D Man Co Ltd |
(1-indanon)-(1,2,3,6-tetrahydropyridin)derivat
|
US20040033986A1
(en)
|
2002-05-17 |
2004-02-19 |
Protopopova Marina Nikolaevna |
Anti tubercular drug: compositions and methods
|
CN101404986B
(zh)
|
2002-05-17 |
2011-09-28 |
赛奎拉公司 |
用于诊断和治疗感染性疾病的组合物和制药方法
|
CN100375619C
(zh)
|
2002-06-14 |
2008-03-19 |
富山化学工业株式会社 |
改善脑功能的药物组合物及其用途
|
IL150509A
(en)
*
|
2002-07-01 |
2007-07-04 |
Joseph Kaspi |
Pharmaceutical preparations containing donafazil hydrochloride
|
CN1678608A
(zh)
*
|
2002-07-02 |
2005-10-05 |
先灵公司 |
新的神经肽yy5受体拮抗剂
|
US7148354B2
(en)
*
|
2002-07-24 |
2006-12-12 |
Dr. Reddy's Laboratories Limited |
Process for preparation of donepezil
|
IL150982A
(en)
|
2002-07-30 |
2007-02-11 |
Ori Lerman |
Process for making Donafzil
|
GB0218326D0
(en)
*
|
2002-08-07 |
2002-09-11 |
Glaxo Group Ltd |
Compounds
|
WO2004037234A2
(fr)
*
|
2002-10-24 |
2004-05-06 |
Merz Pharma Gmbh & Co. Kgaa |
Therapie combinee faisant appel a des derives de 1-aminocyclohexane ainsi qu'a des inhibiteurs d'acetylcholinesterase
|
US20060014801A1
(en)
*
|
2002-11-22 |
2006-01-19 |
The Johns Hopkins University |
Prevention and treatment of cognitive impairment using (R)-(-)-5-methyl-1-nicotynoyl-2-pyrazoline (MNP) and analogs
|
JP2004189706A
(ja)
*
|
2002-12-13 |
2004-07-08 |
Eisai Co Ltd |
高度アルツハイマー型痴呆治療剤
|
EP1603548A4
(fr)
*
|
2003-02-05 |
2007-10-10 |
Myriad Genetics Inc |
Composition et methode de traitement de troubles neurodegeneratifs
|
US20080057491A1
(en)
*
|
2003-02-07 |
2008-03-06 |
Mckee Patrick A |
Substrates and inhibitors of antiplasmin cleaving enzyme and methods of use
|
US20050288330A1
(en)
*
|
2004-06-29 |
2005-12-29 |
Avinash Naidu |
Process for producing a polymorphic form of (1-Benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride (donepezil hydrochloride)
|
US7186842B2
(en)
*
|
2003-02-12 |
2007-03-06 |
Usv, Ltd. |
Polymorph of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-y1] methyl piperidine hydrochloride (Donepezil hydrochloride) and a process for producing thereof
|
US6649765B1
(en)
|
2003-02-12 |
2003-11-18 |
Usv Limited, Bsd Marg. |
Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL)
|
US7439365B2
(en)
*
|
2003-11-17 |
2008-10-21 |
Usv, Ltd. |
Pharmaceutical salt of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine (Donepezil)
|
US6953856B2
(en)
*
|
2003-02-12 |
2005-10-11 |
Usv, Limited |
Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI)
|
JP2006519225A
(ja)
*
|
2003-02-27 |
2006-08-24 |
社団法人芝蘭会 |
依存症治療用医薬組成物
|
US7521481B2
(en)
|
2003-02-27 |
2009-04-21 |
Mclaurin Joanne |
Methods of preventing, treating and diagnosing disorders of protein aggregation
|
CN100422148C
(zh)
*
|
2003-02-27 |
2008-10-01 |
天津药物研究院 |
工业化生产盐酸多奈哌齐的工艺方法
|
US20060009433A1
(en)
*
|
2003-03-14 |
2006-01-12 |
Zhi-Xing Yao |
Neuroprotective spirostenol pharmaceutical compositions
|
EP1608371A1
(fr)
*
|
2003-03-21 |
2005-12-28 |
Ranbaxy Laboratories, Ltd. |
Procede de preparation de donepezil et de ses derives
|
AU2003230195A1
(en)
*
|
2003-04-02 |
2004-10-25 |
Hetero Drugs Limited |
A novel process for amorphous form of donepezil hydrochloride
|
US20040229914A1
(en)
*
|
2003-04-02 |
2004-11-18 |
Dr. Reddy's Laboratories Limited |
Novel crystalline form-VI of donepezil hydrochloride and process for the preparation thereof
|
AU2003245029A1
(en)
|
2003-04-16 |
2004-11-04 |
Hetero Drugs Limited |
Novel crystalline forms of donepezil hydrochloride
|
WO2005003092A1
(fr)
*
|
2003-07-01 |
2005-01-13 |
Hetero Drugs Limited |
Preparation d'intermediaires pour inhibiteurs de l'acetyl cholinesterase
|
EP1651195A4
(fr)
*
|
2003-07-11 |
2007-10-03 |
Myriad Genetics Inc |
Procedes pharmaceutiques, posologies et formes posologiques pour le traitement de la maladie d'alzheimer
|
GB0316915D0
(en)
|
2003-07-18 |
2003-08-20 |
Glaxo Group Ltd |
Compounds
|
AU2004262897B9
(en)
*
|
2003-07-25 |
2009-12-17 |
F. Hoffmann-La Roche Ag |
Combination of mGluR2 antagonist and ache inhibitor for treatment of acute and/or chronic neurological disorders
|
CN1280273C
(zh)
*
|
2003-11-05 |
2006-10-18 |
天津和美生物技术有限公司 |
合成多奈哌齐及其衍生物的方法
|
US7671072B2
(en)
*
|
2003-11-26 |
2010-03-02 |
Pfizer Inc. |
Aminopyrazole derivatives as GSK-3 inhibitors
|
CA2552221A1
(fr)
*
|
2003-12-31 |
2005-07-21 |
Actavis Group Hf |
Formulations de donepezil
|
CN1300112C
(zh)
*
|
2004-01-06 |
2007-02-14 |
浙江大学 |
N-苄基-4-哌啶基甲醛的合成方法
|
WO2005072713A2
(fr)
|
2004-01-27 |
2005-08-11 |
The Feinstein Institute For Medical Research |
Inhibiteurs de la cholinesterase pour traiter l'inflammation
|
MY142362A
(en)
*
|
2004-01-29 |
2010-11-30 |
Otsuka Pharma Co Ltd |
Pharmaceutical composition for promoting angiogenesis
|
US20080312189A1
(en)
*
|
2004-03-05 |
2008-12-18 |
Eisai Co., Ltd. |
Cadasil Treatment with Cholinesterase Inhibitors
|
US20070293538A1
(en)
*
|
2004-04-13 |
2007-12-20 |
Myriad Genetics, Incorporated |
Pharmaceutical Composition And Methods For Treating Neurodegenerative Disorders
|
US7795438B2
(en)
*
|
2004-04-28 |
2010-09-14 |
Eisai R&D Management Co., Ltd |
Processes for producing 1-benzyl-4-[(5,6-dimethoxy-1indanon)-2-yl]methylpiperidine and hydrochloride
|
AU2005241023A1
(en)
*
|
2004-04-29 |
2005-11-17 |
Keystone Retaining Wall Systems, Inc. |
Veneers for walls, retaining walls and the like
|
WO2005112946A1
(fr)
*
|
2004-05-14 |
2005-12-01 |
The Johns Hopkins University |
Methode pour ameliorer la fonction cognitive faisant appel a une co-administration d'un antagoniste du recepteur gabab et d'un inhibiteur d'acetylcholinesterase
|
JPWO2006004201A1
(ja)
*
|
2004-07-01 |
2008-04-24 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
神経再生促進剤
|
EP1773339A4
(fr)
*
|
2004-07-30 |
2009-07-29 |
Reddys Lab Ltd Dr |
Forme cristalline d'hydrochlorure de donepezil
|
WO2006020852A2
(fr)
*
|
2004-08-11 |
2006-02-23 |
Myriad Genetics, Inc. |
Composition pharmaceutique et technique de traitement de troubles neurodegeneratifs
|
CA2618985A1
(fr)
*
|
2004-08-11 |
2006-02-23 |
Myriad Genetics, Inc. |
Composition pharmaceutique et methode de traitement de troubles neurodegeneratifs
|
WO2006020850A2
(fr)
*
|
2004-08-11 |
2006-02-23 |
Myriad Genetics, Inc. |
Composition pharmaceutique et technique de traitement de troubles neurodegeneratifs
|
HUP0401850A3
(en)
*
|
2004-09-15 |
2008-03-28 |
Egis Gyogyszergyar Nyilvanosan |
Donepezil salts for producing pharmaceutical composition
|
US7718674B2
(en)
|
2004-09-27 |
2010-05-18 |
Bridge Pharma, Inc. |
Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine
|
JP2008514691A
(ja)
*
|
2004-09-29 |
2008-05-08 |
ケマジス リミティド |
薬学的に純粋な非晶質塩酸ドネペジルを製造するための精製されたマレイン酸ドネペジルの使用
|
EP2008660A1
(fr)
*
|
2004-10-12 |
2008-12-31 |
Ernir Snorrason |
Procédé de traitement de maladies de la peau
|
GB2419093A
(en)
*
|
2004-10-12 |
2006-04-19 |
Ernir Snorrason |
Acetylcholinesterase inhibitors for the treatment of skin
|
JP2008518955A
(ja)
*
|
2004-11-02 |
2008-06-05 |
ノースウェスタン ユニバーシティ |
ピリダジン化合物および方法
|
MX2007005137A
(es)
*
|
2004-11-23 |
2007-06-22 |
Warner Lambert Co |
Derivados del acido 7-(2h-pyrazol-3-il)-3, 5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de lipidemia.
|
US7619007B2
(en)
|
2004-11-23 |
2009-11-17 |
Adamas Pharmaceuticals, Inc. |
Method and composition for administering an NMDA receptor antagonist to a subject
|
US20060122226A1
(en)
|
2004-12-08 |
2006-06-08 |
Itai Adin |
Crystalline forms of Donepezil base
|
WO2006070396A1
(fr)
*
|
2004-12-30 |
2006-07-06 |
Jubilant Organosys Limited |
Procédé de synthèse de la 1-benzyl-4-[(5,6-diméthoxy-1-indanon-2-yl)méthyl]pipéridine ou de son sel via un nouvel intermédiaire
|
EP1881756B1
(fr)
|
2005-02-11 |
2016-08-10 |
Stephen Wills |
Traitement de maladies microvasculaires au moyen d'inhibiteurs de l'acetyle cholinesterase
|
EP1858848A1
(fr)
*
|
2005-03-17 |
2007-11-28 |
Synthon B.V. |
Procede de preparation du monohydrate d'hydrochlorure de donepezil cristallin
|
US20090131480A1
(en)
*
|
2005-04-04 |
2009-05-21 |
Eisai Co., Ltd. |
Dihydropyridine Compounds for Neurodegenerative Diseases and Dementia
|
CA2604052C
(fr)
*
|
2005-04-06 |
2014-07-08 |
Adamas Pharmaceuticals, Inc. |
Methode et compositions de traitement des affections du snc
|
US20080188510A1
(en)
*
|
2005-05-23 |
2008-08-07 |
Eisai R & D Management Co., Ltd. |
Novel methods using zonisamide
|
US20070015832A1
(en)
*
|
2005-07-14 |
2007-01-18 |
Myriad Genetics, Incorporated |
Methods of treating overactive bladder and urinary incontinence
|
WO2007010910A1
(fr)
*
|
2005-07-15 |
2007-01-25 |
Eisai R & D Management Co., Ltd. |
1-benzyl-4-[(5, 6-dimethoxy-1-indanon)-2-yl]-methylpiperidine p-toluenesulfonate ou son cristal
|
WO2007014124A2
(fr)
*
|
2005-07-22 |
2007-02-01 |
Myriad Genetics, Inc. |
Formes posologiques et preparations a charge medicamenteuse elevee
|
WO2007013395A1
(fr)
*
|
2005-07-25 |
2007-02-01 |
Eisai R & D Management Co., Ltd. |
Procédé servant à produire de la 1-benzyl-4-[(5,6-diméthoxy-1-indanone)-2-ylidène]méthylpipéridine
|
US20070026075A1
(en)
*
|
2005-07-28 |
2007-02-01 |
Jutaro Shudo |
Gelled donepezil compositions and methods for making and using the same
|
CN100436416C
(zh)
*
|
2005-07-29 |
2008-11-26 |
西南合成制药股份有限公司 |
盐酸多奈哌齐合成工艺
|
GB0515803D0
(en)
|
2005-07-30 |
2005-09-07 |
Pliva Hrvatska D O O |
Intermediate compounds
|
JPWO2007043440A1
(ja)
*
|
2005-10-14 |
2009-04-16 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
1−ベンジル−4−[(5,6−ジメトキシ−1−インダノン)−2−イル]メチルピペリジンまたはその塩酸塩の製造法
|
WO2007043440A1
(fr)
|
2005-10-14 |
2007-04-19 |
Eisai R & D Management Co., Ltd. |
Procédé de production de la 1-benzyl-4-[(5,6-diméthoxy-1indanon)-2-yl]méthylpipéridine ou de son chlorhydrate
|
CA2628074C
(fr)
|
2005-10-25 |
2014-01-14 |
Shionogi & Co., Ltd. |
Derive aminodihydrothiazine
|
JP2008280248A
(ja)
*
|
2005-11-02 |
2008-11-20 |
Eisai R & D Management Co Ltd |
アルツハイマー型痴呆症治療薬塩酸ドネペジルのプロドラッグ
|
AR057910A1
(es)
|
2005-11-18 |
2007-12-26 |
Synthon Bv |
Proceso para preparar donepezilo
|
HU227474B1
(en)
*
|
2005-12-20 |
2011-07-28 |
Richter Gedeon Nyrt |
Process for industrial scale production of high purity donepezil hydrochloride polymorph i.
|
WO2007077443A1
(fr)
*
|
2006-01-04 |
2007-07-12 |
Cipla Limited |
Procede et intermediaire pour la preparation de donepezil
|
US7994328B2
(en)
|
2006-02-16 |
2011-08-09 |
Aurobindo Pharma Ltd. |
Process for the preparation of donepezil hydrochloride
|
EP2520567A3
(fr)
|
2006-02-23 |
2012-12-12 |
Shionogi & Co., Ltd. |
Dérivés d'hétérocycle contenant de l'azote substitués avec un groupe cyclique
|
WO2007108011A2
(fr)
*
|
2006-03-20 |
2007-09-27 |
Ind-Swift Laboratories Limited |
Procede de preparation de donepezile de grande purete
|
CA2650711A1
(fr)
*
|
2006-04-28 |
2007-11-08 |
Northwestern University |
Compositions et traitements utilisant des pyridazines et des inhibiteurs de cholinesterase
|
WO2007131804A1
(fr)
|
2006-05-17 |
2007-11-22 |
Synthon B.V. |
Composition en comprimé pour la libération prolongée de la tamsulosine
|
US8933201B2
(en)
*
|
2006-06-07 |
2015-01-13 |
The Board Of Regents Of The University Of Oklahoma |
Substrates and inhibitors of antiplasmin cleaving enzyme and fibroblast activation protein and methods of use
|
US20080033045A1
(en)
*
|
2006-07-07 |
2008-02-07 |
Myriad Genetics, Incorporated |
Treatment of psychiatric disorders
|
CL2007002070A1
(es)
|
2006-07-14 |
2008-02-08 |
Ac Immune S A Genentech Inc |
Anticuerpo quimerico o humanizado, o fragmentos de ellos, que se adhieren especificamente a por lo menos un epitopo en la proteina beta-amiloide; molecula de acido nucleico que lo codifica; composicion que lo comprende; su uso para tratar enfermedade
|
WO2008010235A2
(fr)
*
|
2006-07-19 |
2008-01-24 |
Torrent Pharmaceuticals Limited |
Procédé amélioré pour la préparation de donépézil
|
US7592458B2
(en)
|
2006-07-21 |
2009-09-22 |
Wright George E |
Dermal anesthetic compounds and pharmaceutical compositions for inducing local anesthesia and mitigating neuropathic pain
|
WO2008019431A1
(fr)
*
|
2006-08-14 |
2008-02-21 |
Brc Operations Pty Limited |
Procédé et compositions pour réguler simultanément la mémoire et l'humeur
|
WO2008033466A2
(fr)
*
|
2006-09-14 |
2008-03-20 |
Combinatorx (Singapore) Pre. Ltd. |
Compositions et procédés pour le traitement de maladies virales
|
AU2007309390A1
(en)
|
2006-10-27 |
2008-05-02 |
Medivation Neurology, Inc. |
Methods and combination therapies for treating Alzheimer's disease
|
WO2008073452A1
(fr)
*
|
2006-12-11 |
2008-06-19 |
Reviva Pharmaceuticals, Inc. |
Compositions, synthèse et procédés d'utilisation d'inhibiteurs de cholinestérase à base d'indanone
|
EP2131828A2
(fr)
*
|
2007-03-05 |
2009-12-16 |
Eisai R&D Management Co., Ltd. |
Antagonistes des récepteurs ampa et nmda pour maladies neurodégénératives
|
KR20080092515A
(ko)
*
|
2007-04-12 |
2008-10-16 |
동화약품공업주식회사 |
도네페질 중간체의 제조방법
|
WO2008133273A1
(fr)
*
|
2007-04-24 |
2008-11-06 |
Shionogi & Co., Ltd. |
Composition pharmaceutique pour le traitement de la maladie d'alzheimer
|
KR20100017255A
(ko)
*
|
2007-04-24 |
2010-02-16 |
시오노기 앤드 컴파니, 리미티드 |
환식기로 치환된 아미노다이하이드로싸이아진 유도체
|
WO2008139984A1
(fr)
*
|
2007-04-26 |
2008-11-20 |
Eisai R & D Management Co., Ltd. |
Composés de cinnamide destinés au traitement de la démence
|
EP2481735A1
(fr)
*
|
2007-05-09 |
2012-08-01 |
Pfizer Inc. |
Dérivés hétérocycliques substitués et leur utilisation pharmaceutique et compositions
|
WO2008143361A1
(fr)
|
2007-05-22 |
2008-11-27 |
Otsuka Pharmaceutical Co., Ltd. |
Médicament comprenant un dérivé de carbostyrile et de donépézil destiné à traiter la maladie d'alzheimer
|
US8048420B2
(en)
|
2007-06-12 |
2011-11-01 |
Ac Immune S.A. |
Monoclonal antibody
|
US8613923B2
(en)
|
2007-06-12 |
2013-12-24 |
Ac Immune S.A. |
Monoclonal antibody
|
EP2574345A1
(fr)
*
|
2007-06-12 |
2013-04-03 |
AC Immune S.A. |
Anticorps humanisés à amyloïde bêta
|
JP2010533126A
(ja)
*
|
2007-07-13 |
2010-10-21 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
神経因性疼痛の治療ためのampa受容体アンタゴニストとアセチルコリンエステラーゼ阻害剤との併用
|
DE102007037932A1
(de)
|
2007-08-11 |
2009-02-12 |
Alfred E. Tiefenbacher Gmbh & Co.Kg |
Donepezilhydrochlorid in amorpher Form enthaltende Tablette
|
US8304435B2
(en)
|
2007-09-12 |
2012-11-06 |
Deuteria Pharmaceuticals Inc. |
Deuterium-enriched donepezil
|
CN102603612A
(zh)
|
2007-09-28 |
2012-07-25 |
天津和美生物技术有限公司 |
多奈哌齐盐的多晶型物及其制备和应用
|
TWI432195B
(zh)
|
2007-10-03 |
2014-04-01 |
Kowa Co |
神經細胞死亡抑制劑
|
EP2650308A3
(fr)
*
|
2007-10-05 |
2014-11-12 |
Genentech, Inc. |
Utilisation d'anticorps anti-beta amyloide aux maladies oculaires
|
WO2009048539A2
(fr)
*
|
2007-10-05 |
2009-04-16 |
Genentech, Inc. |
Anticorps monoclonal
|
JP5566004B2
(ja)
|
2007-11-14 |
2014-08-06 |
株式会社Dnpファインケミカル宇都宮 |
アルコキシインダノン誘導体の製造方法
|
EP2278970B1
(fr)
|
2008-03-25 |
2015-04-22 |
Cipla Limited |
Procédé de préparation de chlorhydrate de donépézil
|
WO2009128058A1
(fr)
|
2008-04-18 |
2009-10-22 |
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al |
Produits psycho-pharmaceutiques
|
WO2009128057A2
(fr)
|
2008-04-18 |
2009-10-22 |
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al |
Produits psycho-pharmaceutiques
|
US20090291127A1
(en)
*
|
2008-05-21 |
2009-11-26 |
Jianye Wen |
Transdermal anti-dementia active agent formulations and methods for using the same
|
US8637504B2
(en)
|
2008-06-13 |
2014-01-28 |
Shionogi & Co., Ltd. |
Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
|
WO2010019560A1
(fr)
*
|
2008-08-12 |
2010-02-18 |
Concert Pharmaceuticals Inc. |
Dérivés deutérés de donépézil
|
WO2010039381A1
(fr)
*
|
2008-09-30 |
2010-04-08 |
Teikoku Pharma Usa, Inc. |
Compositions de donépézil à administration transdermique étendue et leurs procédés d'utilisation
|
US8703785B2
(en)
*
|
2008-10-22 |
2014-04-22 |
Shionogi & Co., Ltd. |
2-aminopyrimidin-4-one and 2-aminopyridine derivatives both having BACE1-inhibiting activity
|
US20100105916A1
(en)
*
|
2008-10-29 |
2010-04-29 |
Sterling Biotech Limited |
Processes for Preparing Donepezil
|
EP2352730A4
(fr)
*
|
2008-11-07 |
2012-04-25 |
Lundbeck & Co As H |
Amides biologiquement actifs
|
WO2010077730A2
(fr)
*
|
2008-12-09 |
2010-07-08 |
Auspex Pharmaceutical, Inc |
Inhibiteurs indanones de l'acétylcholinestérase
|
US8247405B2
(en)
|
2008-12-10 |
2012-08-21 |
Conopco, Inc. |
Skin lightening compositions with acetylcholinesterase inhibitors
|
WO2010071216A1
(fr)
|
2008-12-17 |
2010-06-24 |
Eisai R&D Management Co., Ltd. |
Cristal polymorphique de donépézil et son procédé de production
|
US8465770B2
(en)
*
|
2008-12-24 |
2013-06-18 |
Synthon Bv |
Low dose controlled release tablet
|
EP2674150A1
(fr)
|
2009-01-28 |
2013-12-18 |
Labtec GmbH |
Préparation pharmaceutique ayant une stabilité dýagent actif améliorée
|
JP4666093B2
(ja)
*
|
2009-03-13 |
2011-04-06 |
ユニマテック株式会社 |
ポリフルオロアルキルホスホン酸エステルの製造法
|
CA2766277C
(fr)
*
|
2009-07-10 |
2014-02-18 |
Unimatec Co., Ltd. |
Ester d'acide polyfluoroalkyle phosphonique et procede de production de celui-ci
|
US8361215B2
(en)
*
|
2009-11-04 |
2013-01-29 |
Unimatec Co., Ltd. |
Polyfluoroalkylphosphonic acid salt emulsifier and mold-releasing agent comprising the same as active ingredient
|
WO2011061591A1
(fr)
|
2009-11-18 |
2011-05-26 |
Jubilant Life Sciences Limited |
Procédé amélioré de préparation de la forme iii de chlorhydrate de 1-benzyl-4-(5,6-diméthoxy-1-indanone)-2-yl)méthyl pipéridine
|
CA2773409C
(fr)
|
2009-11-18 |
2015-06-16 |
Suven Life Sciences Limited |
Composes bicycliques en tant que ligands du recepteur .alpha.4.beta.2 nicotinique de l'acetycholine
|
US8999980B2
(en)
|
2009-12-11 |
2015-04-07 |
Shionogi & Co., Ltd. |
Oxazine derivatives
|
EP2519514B1
(fr)
|
2009-12-29 |
2015-08-26 |
Suven Life Sciences Limited |
Ligands du récepteur nicotinique neuronal de l'acétylcholine alpha4beta2
|
US20100178307A1
(en)
*
|
2010-01-13 |
2010-07-15 |
Jianye Wen |
Transdermal anti-dementia active agent formulations and methods for using the same
|
US20110212928A1
(en)
|
2010-02-09 |
2011-09-01 |
The Johns Hopkins University |
Methods and compositions for improving cognitive function
|
WO2011127235A1
(fr)
|
2010-04-07 |
2011-10-13 |
Eisai Inc. |
Polythérapie pour le traitement de la démence
|
GR1007368B
(el)
|
2010-05-27 |
2011-08-02 |
Alapis Α.Β.Ε.Ε., |
Ποσιμα φαρμακευτικα διαλυματα για τη θεραπεια των συμπτωματων της ανοιας
|
WO2011151359A1
(fr)
|
2010-06-02 |
2011-12-08 |
Noscira, S.A. |
Traitement combiné comprenant un inhibiteur de la cholinestérase et un dérivé de thiadiazolidinedione
|
FR2962335B1
(fr)
|
2010-07-12 |
2013-01-18 |
Cll Pharma |
Utilisation du nonapeptide pat dans le traitement et la prevention des maladies neurodegeneratives
|
NZ606357A
(en)
|
2010-07-30 |
2015-05-29 |
Genentech Inc |
Safe and functional humanized anti beta-amyloid antibody
|
TR201007110A2
(tr)
|
2010-08-25 |
2012-03-21 |
Bi̇lgi̇ç Mahmut |
Sinerjik etki gösteren kombinasyonlar
|
TR201007109A2
(tr)
|
2010-08-25 |
2012-03-21 |
Bi̇lgi̇ç Mahmut |
Tek birim dozaj formları.
|
WO2012038966A1
(fr)
|
2010-09-22 |
2012-03-29 |
Tyche Industries Ltd. |
Procédé de préparation d'un intermédiaire du donépézil
|
EP2634186A4
(fr)
|
2010-10-29 |
2014-03-26 |
Shionogi & Co |
Dérivé de naphtyridine
|
JP5766198B2
(ja)
|
2010-10-29 |
2015-08-19 |
塩野義製薬株式会社 |
縮合アミノジヒドロピリミジン誘導体
|
MX346185B
(es)
|
2010-11-15 |
2017-03-10 |
Agenebio Inc |
Derivados de piridazina, composiciones y metodos para tratar deterioro cognitivo.
|
WO2012071369A2
(fr)
|
2010-11-24 |
2012-05-31 |
The Trustees Of Columbia University In The City Of New York |
Antagoniste rbp4 non rétinoïde pour le traitement de la dégénérescence maculaire liée à l'âge et de la maladie de stargardt
|
EP2703399A4
(fr)
|
2011-04-26 |
2014-10-15 |
Shionogi & Co |
Dérivé d'oxazine et inhibiteur de bace 1 le contenant
|
EP2543792A3
(fr)
|
2011-05-16 |
2013-12-11 |
Weitzer Holding GmbH |
Système de revêtement de sol et mural doté d'unités de pose à isolation acoustique
|
EP2565186A1
(fr)
|
2011-09-02 |
2013-03-06 |
Hybrigenics S.A. |
Inhibiteurs sélectifs et réversibles de la protéase 7 spécifique de l'ubiquitine
|
US9428506B2
(en)
|
2012-04-14 |
2016-08-30 |
Intra-Cellular Therapies, Inc. |
Substituted pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines for the treatment of nervous system disorders
|
CN103524515B
(zh)
*
|
2012-07-03 |
2016-07-06 |
浙江海正药业股份有限公司 |
具有乙酰胆碱酯酶抑制活性的苯并间二氧杂环戊烯衍生物及其制备方法和用途
|
WO2014065434A1
(fr)
|
2012-10-24 |
2014-05-01 |
Shionogi & Co., Ltd. |
Dérivés de dihydrooxazine ou d'oxazépine ayant une activité inhibitrice de bace1
|
CN103787954B
(zh)
|
2012-10-26 |
2016-01-20 |
中国科学院上海药物研究所 |
一类氟取代的环状胺类化合物及其制备方法、药物组合物和用途
|
EP2919788A4
(fr)
|
2012-11-14 |
2016-05-25 |
Univ Johns Hopkins |
Méthodes et compositions pour le traitement de la schizophrénie
|
JPWO2014076965A1
(ja)
*
|
2012-11-16 |
2017-01-05 |
学校法人北里研究所 |
抗原虫活性を示す1−インダン誘導体
|
EP2759536A1
(fr)
|
2013-01-25 |
2014-07-30 |
INSA (Institut National des Sciences Appliquees) de Rouen |
Dérivés de pyridine oxydables, leur préparation et leur utilisation en tant qu'agents anti-Alzheimer
|
US10806717B2
(en)
|
2013-03-15 |
2020-10-20 |
The Johns Hopkins University |
Methods and compositions for improving cognitive function
|
ES2881081T3
(es)
|
2013-03-15 |
2021-11-26 |
Agenebio Inc |
Procedimientos y composiciones para mejorar la función cognitiva
|
US20160067306A1
(en)
|
2013-04-19 |
2016-03-10 |
National University Corporation Hokkaido University |
Treatment agent for cognitive impairment induced by amyloid beta-protein, therapeutic agent for alzheimer's disease, and treatment method and pathological analysis method related to these
|
WO2015022418A1
(fr)
|
2013-08-16 |
2015-02-19 |
Takeda Gmbh |
Traitement d'une déficience cognitive à l'aide d'un inhibiteur de pde4
|
US9359315B2
(en)
*
|
2013-09-10 |
2016-06-07 |
Arrien Pharmaceuticals Llc |
Substituted 2,3-dihydro-1H-inden-1-one retinoic acid-related orphan nuclear receptor antagonists for treating multiple sclerosis
|
US10329301B2
(en)
|
2013-12-20 |
2019-06-25 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
FR3018689B1
(fr)
*
|
2014-03-20 |
2017-04-28 |
Centre Hospitalier Univ De Clermont Ferrand |
Inhibiteurs de l'acetylcholinesterase d'action centrale pour la prevention et/ou le traitement des neuropathies chimio-induites et leurs symptomes, compositions, utilisations, methodes et trousse correspondantes.
|
CN105753768B
(zh)
*
|
2014-12-15 |
2020-11-27 |
北京恒瑞新霖科技有限公司 |
一种含单个氮杂环化合物的生产方法
|
TWI770525B
(zh)
|
2014-12-30 |
2022-07-11 |
美商瓦洛健康公司 |
作為泛素特異性蛋白酶7抑制劑之吡咯并及吡唑并嘧啶
|
MA41291A
(fr)
|
2014-12-30 |
2017-11-07 |
Forma Therapeutics Inc |
Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer
|
JP2018504432A
(ja)
|
2015-02-05 |
2018-02-15 |
フォーマ セラピューティクス,インコーポレイテッド |
ユビキチン特異的プロテアーゼ7阻害物質としてのイソチアゾロピリミジノン、ピラゾロピリミジノン及びピロロピリミジノン
|
US9932351B2
(en)
|
2015-02-05 |
2018-04-03 |
Forma Therapeutics, Inc. |
Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors
|
JP2018504430A
(ja)
|
2015-02-05 |
2018-02-15 |
フォーマ セラピューティクス,インコーポレイテッド |
ユビキチン特異的プロテアーゼ7阻害物質としてのキナゾリノン及びアザキナゾリノン
|
JP6899043B2
(ja)
|
2015-05-22 |
2021-07-07 |
エージンバイオ, インコーポレイテッド |
レベチラセタムの持続放出性医薬組成物
|
US10815242B2
(en)
|
2015-06-19 |
2020-10-27 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
CN108135860A
(zh)
|
2015-06-22 |
2018-06-08 |
考里安国际公司 |
包含难溶性治疗剂的透皮粘合剂组合物
|
CN105367483B
(zh)
*
|
2015-11-20 |
2017-12-26 |
山东淄博新达制药有限公司 |
盐酸多奈哌齐的制备方法
|
EP3468948A1
(fr)
|
2016-06-08 |
2019-04-17 |
GlaxoSmithKline Intellectual Property Development Limited |
Composés chimiques
|
CN109922796B
(zh)
|
2016-06-23 |
2023-04-07 |
考里安有限责任公司 |
具有亲水和疏水域的粘合剂基质和治疗剂
|
KR101829631B1
(ko)
|
2016-07-20 |
2018-02-19 |
주식회사 엔솔바이오사이언스 |
신규 펩타이드 및 그 용도
|
US10016372B2
(en)
|
2016-07-27 |
2018-07-10 |
Corium International, Inc. |
Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery
|
US10300025B2
(en)
|
2016-07-27 |
2019-05-28 |
Corium, Inc. |
Donepezil transdermal delivery system
|
AU2017301929B2
(en)
|
2016-07-27 |
2023-03-02 |
Corium Pharma Solutions, Inc. |
Memantine transdermal delivery systems
|
US11505555B2
(en)
|
2016-12-19 |
2022-11-22 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
US20180170941A1
(en)
|
2016-12-19 |
2018-06-21 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
US10369187B2
(en)
|
2017-02-09 |
2019-08-06 |
Vanderbilt University |
Peptide regulators of JNK family kinases
|
WO2019118782A1
(fr)
|
2017-12-13 |
2019-06-20 |
Corium, Inc. |
Méthode de création de dépôt pendant l'administration transdermique de médicament
|
WO2019126531A1
(fr)
|
2017-12-20 |
2019-06-27 |
Corium, Inc. |
Composition adhésive transdermique comprenant un agent thérapeutique liquide volatil à bas point de fusion
|
WO2019246300A1
(fr)
|
2018-06-19 |
2019-12-26 |
Agenebio, Inc. |
Dérivés de benzodiazépine, compositions, et méthodes de traitement de déficience cognitive
|
MX2021014673A
(es)
|
2019-05-31 |
2022-01-11 |
Tecnimede Soc Tecnico Medicinal Sa |
Combinacion de dosis fija de liberacion inmediata de memantina y donepezil.
|
JP7452810B2
(ja)
*
|
2019-06-17 |
2024-03-19 |
東和薬品株式会社 |
固定化触媒を用いたフロー反応によるドネペジルの製造方法
|
KR20220059300A
(ko)
*
|
2020-11-02 |
2022-05-10 |
주식회사 종근당 |
인덴 유도체 프로드럭의 산부가염 및 이의 제조방법
|
KR102451185B1
(ko)
|
2021-08-05 |
2022-10-07 |
환인제약 주식회사 |
도네페질 함유 지속방출형 미립구
|
US20240132513A1
(en)
|
2022-08-19 |
2024-04-25 |
Agenebio, Inc. |
Benzazepine derivatives, compositions, and methods for treating cognitive impairment
|