HUP0102531A2 - Új karboxi-szubsztituált aciklusos karboxamid-származékok és tachykinin receptor antagonistaként való alkalmazásuk - Google Patents
Új karboxi-szubsztituált aciklusos karboxamid-származékok és tachykinin receptor antagonistaként való alkalmazásukInfo
- Publication number
- HUP0102531A2 HUP0102531A2 HU0102531A HUP0102531A HUP0102531A2 HU P0102531 A2 HUP0102531 A2 HU P0102531A2 HU 0102531 A HU0102531 A HU 0102531A HU P0102531 A HUP0102531 A HU P0102531A HU P0102531 A2 HUP0102531 A2 HU P0102531A2
- Authority
- HU
- Hungary
- Prior art keywords
- receptor antagonists
- carboxamide derivatives
- tachykinin receptor
- group
- carboxy substituted
- Prior art date
Links
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 title abstract 2
- 239000002462 tachykinin receptor antagonist Substances 0.000 title abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- -1 1,3,4-triazolyl group Chemical group 0.000 abstract 1
- 206010011224 Cough Diseases 0.000 abstract 1
- 102000003141 Tachykinin Human genes 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 125000004122 cyclic group Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 108060008037 tachykinin Proteins 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
A találmány tárgya (1) általános képletű új karboxi-szubsztitutuáltaciklusos karboxamid-származékok: és sztereoizomerjeik, valamintgyógyászatilag alkalmazható sóik, ahol a képletben R1 jelentésehidrogénatom, 1-6 szénatomos alkil- vagy alkoxicsoport; R2 jelentésehidrogénatom vagy szubsztituált tetrazolil- vagy 1,3,4-triazolilcsoport; Ar1 jelentése adott esetben helyettesített fenil-,naftil-, piridil- vagy tienilcsoport; Ar2 jelentése adott esetbenhelyettesített fenil- vagy piridilcsoport; X jelentése pirrolidinil-,piperidinil-, morfolinil- vagy piperazinilcsoport. továbbá tachikininreceptor antagonistaként való alkalmazásuk. Ezek az antagonistáktachikinin - mediált betegségek és állapotok, így asztma, köhögés, ésbronchitis kezelésében használhatók. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7961098A | 1998-05-15 | 1998-05-15 | |
PCT/US1999/009450 WO1999059972A1 (en) | 1998-05-15 | 1999-04-30 | Carboxy substituted carboxamide derivatives as tachykinin receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0102531A2 true HUP0102531A2 (hu) | 2001-11-28 |
HUP0102531A3 HUP0102531A3 (en) | 2003-01-28 |
Family
ID=22151630
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0102531A HUP0102531A3 (en) | 1998-05-15 | 1999-04-30 | Carboxy substituted carboxamide derivatives and their use as tachykinin receptor antagonists |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP1077942B1 (hu) |
JP (1) | JP4132671B2 (hu) |
KR (1) | KR20010043598A (hu) |
CN (1) | CN1136191C (hu) |
AR (1) | AR015298A1 (hu) |
AT (1) | ATE286882T1 (hu) |
AU (1) | AU743487B2 (hu) |
DE (1) | DE69923173T2 (hu) |
DK (1) | DK200001669A (hu) |
ES (1) | ES2233042T3 (hu) |
HU (1) | HUP0102531A3 (hu) |
IL (1) | IL139262A (hu) |
MX (1) | MXPA00011204A (hu) |
NO (1) | NO319766B1 (hu) |
NZ (1) | NZ507432A (hu) |
PT (1) | PT1077942E (hu) |
SI (1) | SI1077942T1 (hu) |
TW (1) | TWI228122B (hu) |
WO (1) | WO1999059972A1 (hu) |
ZA (1) | ZA200006606B (hu) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020082421A1 (en) * | 2000-09-14 | 2002-06-27 | Abdel-Magid Ahmed F. | Novel solid salt forms of N-[2-[4-[2-(1- methylethoxy)phenyl]-1-piperazinyl]-2-oxo-1piperidineacetamide |
WO2004005256A2 (en) * | 2002-07-03 | 2004-01-15 | Glaxo Group Limited | Substituted 4-phenyl-piperidin-amides as tachykinin antagonists and serotonin reptake inhibitors |
JP2010516734A (ja) | 2007-01-24 | 2010-05-20 | グラクソ グループ リミテッド | 3,5−ジアミノ−6−(2,3−ジクロロフェニル)−1,2,4−トリアジンまたはr(−)−2,4−ジアミノ−5−(2,3−ジクロロフェニル)−6−フルオロメチルピリミジンを含む医薬組成物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9502644D0 (en) * | 1995-02-10 | 1995-03-29 | Zeneca Ltd | Heterocyclic derivatives |
FR2738245B1 (fr) * | 1995-08-28 | 1997-11-21 | Sanofi Sa | Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant |
-
1999
- 1999-04-30 ES ES99920201T patent/ES2233042T3/es not_active Expired - Lifetime
- 1999-04-30 MX MXPA00011204A patent/MXPA00011204A/es not_active IP Right Cessation
- 1999-04-30 AU AU37756/99A patent/AU743487B2/en not_active Ceased
- 1999-04-30 DE DE69923173T patent/DE69923173T2/de not_active Expired - Lifetime
- 1999-04-30 CN CNB998061891A patent/CN1136191C/zh not_active Expired - Fee Related
- 1999-04-30 IL IL13926299A patent/IL139262A/xx not_active IP Right Cessation
- 1999-04-30 KR KR1020007012743A patent/KR20010043598A/ko not_active Application Discontinuation
- 1999-04-30 AT AT99920201T patent/ATE286882T1/de not_active IP Right Cessation
- 1999-04-30 EP EP99920201A patent/EP1077942B1/en not_active Expired - Lifetime
- 1999-04-30 WO PCT/US1999/009450 patent/WO1999059972A1/en not_active Application Discontinuation
- 1999-04-30 JP JP2000549591A patent/JP4132671B2/ja not_active Expired - Lifetime
- 1999-04-30 NZ NZ507432A patent/NZ507432A/en unknown
- 1999-04-30 PT PT99920201T patent/PT1077942E/pt unknown
- 1999-04-30 HU HU0102531A patent/HUP0102531A3/hu unknown
- 1999-04-30 SI SI9930752T patent/SI1077942T1/xx unknown
- 1999-05-13 AR ARP990102258A patent/AR015298A1/es active IP Right Grant
- 1999-05-24 TW TW088107935A patent/TWI228122B/zh not_active IP Right Cessation
-
2000
- 2000-11-09 DK DK200001669A patent/DK200001669A/da not_active Application Discontinuation
- 2000-11-14 ZA ZA200006606A patent/ZA200006606B/en unknown
- 2000-11-14 NO NO20005756A patent/NO319766B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
EP1077942A1 (en) | 2001-02-28 |
ES2233042T3 (es) | 2005-06-01 |
SI1077942T1 (en) | 2005-06-30 |
PT1077942E (pt) | 2005-03-31 |
DE69923173T2 (de) | 2006-01-05 |
CN1301253A (zh) | 2001-06-27 |
NO319766B1 (no) | 2005-09-12 |
JP2002515487A (ja) | 2002-05-28 |
EP1077942B1 (en) | 2005-01-12 |
JP4132671B2 (ja) | 2008-08-13 |
NO20005756D0 (no) | 2000-11-14 |
NZ507432A (en) | 2003-08-29 |
IL139262A0 (en) | 2001-11-25 |
AR015298A1 (es) | 2001-04-18 |
DK200001669A (da) | 2000-11-09 |
WO1999059972A1 (en) | 1999-11-25 |
DE69923173D1 (en) | 2005-02-17 |
HUP0102531A3 (en) | 2003-01-28 |
CN1136191C (zh) | 2004-01-28 |
AU3775699A (en) | 1999-12-06 |
KR20010043598A (ko) | 2001-05-25 |
TWI228122B (en) | 2005-02-21 |
ATE286882T1 (de) | 2005-01-15 |
MXPA00011204A (es) | 2003-04-22 |
IL139262A (en) | 2005-06-19 |
AU743487B2 (en) | 2002-01-24 |
ZA200006606B (en) | 2002-02-14 |
NO20005756L (no) | 2001-01-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |