CY1125154T1 - Ενωσεις και συνθεσεις για ενδοκυτταρικη χορηγηση θεραπευτικων παραγοντων - Google Patents

Ενωσεις και συνθεσεις για ενδοκυτταρικη χορηγηση θεραπευτικων παραγοντων

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Publication number
CY1125154T1
CY1125154T1 CY20221100215T CY221100215T CY1125154T1 CY 1125154 T1 CY1125154 T1 CY 1125154T1 CY 20221100215 T CY20221100215 T CY 20221100215T CY 221100215 T CY221100215 T CY 221100215T CY 1125154 T1 CY1125154 T1 CY 1125154T1
Authority
CY
Cyprus
Prior art keywords
compositions
lipids
compounds
therapeutic agents
intracellular delivery
Prior art date
Application number
CY20221100215T
Other languages
English (en)
Inventor
Kerry E. BENENATO
Ellalahewage Sathyajith Kumarasinghe
Mark Cornebise
Original Assignee
Modernatx, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Modernatx, Inc. filed Critical Modernatx, Inc.
Publication of CY1125154T1 publication Critical patent/CY1125154T1/el

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    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
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Abstract

Η αποκάλυψη παρουσιάζει νέα λιπίδια και συνθέσεις που περιλαμβάνουν αυτά. Οι συνθέσεις νανοσωματιδίων περιλαμβάνουν ένα νέο λιπίδιο καθώς και πρόσθετα λιπίδια όπως φωσφολιπίδια, δομικά λιπίδια και PEG λιπίδια. Συνθέσεις νανοσωματιδίων που περιλαμβάνουν περαιτέρω θεραπευτικά και/ή προφυλακτικά μέσα όπως RNA είναι χρήσιμες στην παροχή θεραπευτικών και/ή προφυλακτικών μέσων σε κύτταρα ή όργανα θηλαστικών, παραδείγματος χάριν, για την ρύθμιση της έκφρασης πολυπεπτιδίου, πρωτεΐνης ή γονιδίου.
CY20221100215T 2015-09-17 2022-03-15 Ενωσεις και συνθεσεις για ενδοκυτταρικη χορηγηση θεραπευτικων παραγοντων CY1125154T1 (el)

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US201562220091P 2015-09-17 2015-09-17
US201562252316P 2015-11-06 2015-11-06
US201562253433P 2015-11-10 2015-11-10
US201562266460P 2015-12-11 2015-12-11
US201662333557P 2016-05-09 2016-05-09
US201662382740P 2016-09-01 2016-09-01
US201662393940P 2016-09-13 2016-09-13
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