CY1113616T1 - Υγρη συνταγοποιηση που περιεχει υψηλη συγκεντρωση αντισωματος - Google Patents

Υγρη συνταγοποιηση που περιεχει υψηλη συγκεντρωση αντισωματος

Info

Publication number
CY1113616T1
CY1113616T1 CY20121101082T CY121101082T CY1113616T1 CY 1113616 T1 CY1113616 T1 CY 1113616T1 CY 20121101082 T CY20121101082 T CY 20121101082T CY 121101082 T CY121101082 T CY 121101082T CY 1113616 T1 CY1113616 T1 CY 1113616T1
Authority
CY
Cyprus
Prior art keywords
coclusion
liquid
high concentration
containing high
antibody
Prior art date
Application number
CY20121101082T
Other languages
English (en)
Inventor
Toshiyuki Morichika
Daisuke Kameoka
Yoshimi Imaeda
Terutoshi Maeda
Oliver Boris Stauch
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40824372&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1113616(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Publication of CY1113616T1 publication Critical patent/CY1113616T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Το πρόβλημα που θα επιλυθεί είναι να παρέχεται μια συνταγοποίηση που περιέχει αντίσωμα, η οποία είναι σταθερή και κατάλληλη για υποδόρια χορήγηση, όπου ο διμερισμός και η αποαμίδωση αποτρέπεται κατά τη διάρκεια μακροχρόνιας αποθήκευσης. Η παρούσα δήλωση κατευθύνεται σε μία σταθερή υγρή συνταγοποίηση που περιέχει αντίσωμα που χαρακτηρίζεται από το ότι περιέχει αργινίνη και μεθειονίνη.
CY20121101082T 2007-12-27 2012-11-13 Υγρη συνταγοποιηση που περιεχει υψηλη συγκεντρωση αντισωματος CY1113616T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007336310 2007-12-27
EP08866971.8A EP2238985B2 (en) 2007-12-27 2008-12-26 High concentration antibody-containing liquid formulation

Publications (1)

Publication Number Publication Date
CY1113616T1 true CY1113616T1 (el) 2016-06-22

Family

ID=40824372

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121101082T CY1113616T1 (el) 2007-12-27 2012-11-13 Υγρη συνταγοποιηση που περιεχει υψηλη συγκεντρωση αντισωματος

Country Status (31)

Country Link
US (8) US8568720B2 (el)
EP (1) EP2238985B2 (el)
JP (7) JP4937358B2 (el)
KR (1) KR101083616B1 (el)
CN (2) CN101883588B (el)
AR (2) AR069969A1 (el)
AU (1) AU2008344292B2 (el)
BR (1) BRPI0818903B8 (el)
CA (1) CA2708627C (el)
CL (1) CL2008003910A1 (el)
CO (1) CO6450630A2 (el)
CR (1) CR11594A (el)
CY (1) CY1113616T1 (el)
DK (1) DK2238985T4 (el)
EC (1) ECSP10010370A (el)
ES (1) ES2389881T5 (el)
HR (1) HRP20120903T4 (el)
IL (2) IL206548A (el)
MA (1) MA31934B1 (el)
MX (1) MX2010004399A (el)
MY (1) MY159450A (el)
NZ (1) NZ586378A (el)
PE (1) PE20091174A1 (el)
PL (1) PL2238985T5 (el)
PT (1) PT2238985E (el)
RU (2) RU2497544C2 (el)
SG (1) SG2013049325A (el)
SI (1) SI2238985T2 (el)
TW (1) TWI375566B (el)
UA (1) UA104134C2 (el)
WO (1) WO2009084659A1 (el)

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RU2701181C2 (ru) 2019-09-25
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US20220281988A1 (en) 2022-09-08
IL238896A0 (en) 2015-07-30
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US20200079857A1 (en) 2020-03-12
JP2021155453A (ja) 2021-10-07
CN106075434A (zh) 2016-11-09
KR20100095474A (ko) 2010-08-30
RU2010131179A (ru) 2012-02-10
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US20230167183A1 (en) 2023-06-01
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AU2008344292B2 (en) 2012-11-08
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MA31934B1 (fr) 2010-12-01
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BRPI0818903B1 (pt) 2021-04-06
CL2008003910A1 (es) 2009-07-03
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JPWO2009084659A1 (ja) 2011-05-19
SI2238985T2 (sl) 2022-09-30
MY159450A (en) 2017-01-13
EP2238985B1 (en) 2012-08-29
US20100285011A1 (en) 2010-11-11
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AR122312A2 (es) 2022-08-31
BRPI0818903B8 (pt) 2021-05-25
JP2023055780A (ja) 2023-04-18
EP2238985A1 (en) 2010-10-13
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US11359026B2 (en) 2022-06-14
JP6567024B2 (ja) 2019-08-28
RU2013137740A (ru) 2015-02-20
US20160090419A1 (en) 2016-03-31
WO2009084659A1 (ja) 2009-07-09
PE20091174A1 (es) 2009-08-03
BRPI0818903A2 (pt) 2015-05-12
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AR069969A1 (es) 2010-03-03
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JP6259436B2 (ja) 2018-01-10
UA104134C2 (ru) 2014-01-10
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RU2497544C2 (ru) 2013-11-10
US11008394B2 (en) 2021-05-18

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