MA31934B1 - Formulation liquide contenant un anticorps a forte concentration - Google Patents
Formulation liquide contenant un anticorps a forte concentrationInfo
- Publication number
- MA31934B1 MA31934B1 MA32948A MA32948A MA31934B1 MA 31934 B1 MA31934 B1 MA 31934B1 MA 32948 A MA32948 A MA 32948A MA 32948 A MA32948 A MA 32948A MA 31934 B1 MA31934 B1 MA 31934B1
- Authority
- MA
- Morocco
- Prior art keywords
- high concentration
- liquid formulation
- formulation containing
- containing antibodies
- stable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention porte sur la préparation d'une solution stable contenant un anticorps, caractérisée en ce qu'elle contient de l'arginine et de la méthionine. La solution fournit un anticorps stable approprié pour une administration sous-cutanée, mais dans laquelle la formation d'un dimère et la déamidation est prévenue pendant un stockage prolongé.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007336310 | 2007-12-27 | ||
PCT/JP2008/073798 WO2009084659A1 (fr) | 2007-12-27 | 2008-12-26 | Préparation de solution contenant un anticorps à haute concentration |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31934B1 true MA31934B1 (fr) | 2010-12-01 |
Family
ID=40824372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32948A MA31934B1 (fr) | 2007-12-27 | 2010-06-25 | Formulation liquide contenant un anticorps a forte concentration |
Country Status (31)
Country | Link |
---|---|
US (8) | US8568720B2 (fr) |
EP (1) | EP2238985B2 (fr) |
JP (7) | JP4937358B2 (fr) |
KR (1) | KR101083616B1 (fr) |
CN (2) | CN106075434B (fr) |
AR (2) | AR069969A1 (fr) |
AU (1) | AU2008344292B2 (fr) |
BR (1) | BRPI0818903B8 (fr) |
CA (1) | CA2708627C (fr) |
CL (1) | CL2008003910A1 (fr) |
CO (1) | CO6450630A2 (fr) |
CR (1) | CR11594A (fr) |
CY (1) | CY1113616T1 (fr) |
DK (1) | DK2238985T4 (fr) |
EC (1) | ECSP10010370A (fr) |
ES (1) | ES2389881T5 (fr) |
HR (1) | HRP20120903T4 (fr) |
IL (2) | IL206548A (fr) |
MA (1) | MA31934B1 (fr) |
MX (1) | MX2010004399A (fr) |
MY (1) | MY159450A (fr) |
NZ (1) | NZ586378A (fr) |
PE (1) | PE20091174A1 (fr) |
PL (1) | PL2238985T5 (fr) |
PT (1) | PT2238985E (fr) |
RU (2) | RU2497544C2 (fr) |
SG (1) | SG2013049325A (fr) |
SI (1) | SI2238985T2 (fr) |
TW (1) | TWI375566B (fr) |
UA (1) | UA104134C2 (fr) |
WO (1) | WO2009084659A1 (fr) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2322216A1 (fr) | 1997-03-21 | 2011-05-18 | Chugai Seiyaku Kabushiki Kaisha | Agent thérapeutique ou préventif pour les maladies liées aux lymphocytes T sensibilisés comprenant l'antagoniste IL-6 en tant qu'ingrédient actif |
UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
EP1475101B1 (fr) | 2002-02-14 | 2010-10-27 | Chugai Seiyaku Kabushiki Kaisha | Produits pharmaceutiques en solution contenant des anticorps |
GB2401040A (en) * | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
EP1728801A4 (fr) * | 2004-03-24 | 2009-10-21 | Chugai Pharmaceutical Co Ltd | Sous-type d' anticorps humanise contre un recepteur de l'interleukine-6 |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
WO2006106905A1 (fr) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | Procede pour la production de polypeptide au moyen de la regulation d’un ensemble |
WO2007074880A1 (fr) * | 2005-12-28 | 2007-07-05 | Chugai Seiyaku Kabushiki Kaisha | Préparation stabilisatrice contenant des anticorps |
US11046784B2 (en) | 2006-03-31 | 2021-06-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
EP4218801A3 (fr) | 2006-03-31 | 2023-08-23 | Chugai Seiyaku Kabushiki Kaisha | Procédé de modification d'anticorps pour purifier un anticorps bispécifique |
SI2202245T1 (sl) | 2007-09-26 | 2016-10-28 | Chugai Seiyaku Kabushiki Kaisha | Postopek modificiranja izoelektrične točke protitelesa preko aminokislinske substitucije v CDR |
PE20091174A1 (es) * | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
DK2493922T3 (en) | 2009-10-26 | 2017-04-24 | Hoffmann La Roche | Process for preparing a glycosylated immunoglobulin |
CA2783846C (fr) * | 2009-12-21 | 2021-01-19 | Genentech, Inc. | Forme pharmaceutique a base d'anticorps |
AU2013202276B2 (en) * | 2009-12-21 | 2016-03-24 | Genentech, Inc. | Antibody formulation |
JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
PL2624865T3 (pl) * | 2010-10-06 | 2018-11-30 | Regeneron Pharmaceuticals, Inc. | Stabilizowane preparaty zawierające przeciwciała przeciwko receptorowi interleukiny-4 (IL-4R) |
KR20200059320A (ko) | 2010-11-08 | 2020-05-28 | 제넨테크, 인크. | 피하 투여용 항―il―6 수용체 항체 |
KR101398363B1 (ko) | 2010-11-17 | 2014-05-22 | 추가이 세이야쿠 가부시키가이샤 | 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자 |
RU2604139C2 (ru) | 2011-01-28 | 2016-12-10 | Санофи Байотекнолоджи | Фармацевтические композиции, содержащие антитела к pcsk9 человека |
EP2508525A1 (fr) | 2011-04-05 | 2012-10-10 | Bayer Pharma Aktiengesellschaft | Sels de 2,3-dihydroimidazo[1,2-C]quinazoline substitutés |
CA2832560A1 (fr) * | 2011-04-07 | 2012-10-18 | Glaxosmithkline Llc | Formulations a viscosite reduite |
CA2832556A1 (fr) * | 2011-04-07 | 2012-10-11 | Glaxosmithkline Llc | Formulations ayant une viscosite reduite |
UY34105A (es) * | 2011-06-03 | 2012-07-31 | Lg Life Sciences Ltd | Formulación líquida estable de etanercept |
JP6176849B2 (ja) | 2011-07-19 | 2017-08-09 | 中外製薬株式会社 | アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤 |
AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
SG11201400260TA (en) | 2011-09-01 | 2014-03-28 | Chugai Pharmaceutical Co Ltd | Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration |
CN104023743B (zh) | 2011-10-25 | 2017-05-03 | 普罗西纳治疗有限公司 | 抗体制剂和方法 |
EP3578203A1 (fr) | 2011-10-28 | 2019-12-11 | Integritybio Inc. | Formulations de protéine contenant des acides aminés |
US10093728B2 (en) | 2012-03-07 | 2018-10-09 | Cadila Healthcare Limited | Pharmaceutical formulations of TNF-alpha antibodies |
US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
MY188825A (en) | 2012-05-18 | 2022-01-06 | Genentech Inc | High-concentration monoclonal antibody formulations |
EP2873422A4 (fr) * | 2012-07-10 | 2015-12-30 | Takeda Pharmaceutical | Préparation pharmaceutique pour l'injection |
US8883979B2 (en) | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
HUE049282T2 (hu) | 2012-09-07 | 2020-09-28 | Coherus Biosciences Inc | Adalimumab stabil vizes formulációi |
EP2904014A4 (fr) | 2012-10-04 | 2016-09-28 | Novelmed Therapeutics Inc | Anticorps spécifiques de voies alternatives pour traiter les maladies hémolytiques |
CA2885862A1 (fr) * | 2012-10-25 | 2014-05-01 | Medimmune, Llc | Formulation d'anticorps, stable, a faible viscosite |
CN105378480B (zh) | 2013-07-04 | 2018-06-12 | 豪夫迈·罗氏有限公司 | 检测血清样品中抗药物抗体的干扰抑制性免疫测定 |
EP3808338A1 (fr) | 2013-09-11 | 2021-04-21 | Eagle Biologics, Inc. | Formulations de protéine liquides contenant des liquides ioniques |
EP3050896B1 (fr) | 2013-09-27 | 2021-07-07 | Chugai Seiyaku Kabushiki Kaisha | Procédé de production d'un hétéromultimère polypeptidique |
TWI694836B (zh) * | 2014-05-16 | 2020-06-01 | 英商葛蘭素史克智慧財產管理有限公司 | 抗體調配物 |
US11357857B2 (en) | 2014-06-20 | 2022-06-14 | Comera Life Sciences, Inc. | Excipient compounds for protein processing |
US20160074515A1 (en) | 2014-06-20 | 2016-03-17 | Reform Biologics, Llc | Viscosity-reducing excipient compounds for protein formulations |
US10478498B2 (en) | 2014-06-20 | 2019-11-19 | Reform Biologics, Llc | Excipient compounds for biopolymer formulations |
US20160137727A1 (en) | 2014-09-15 | 2016-05-19 | Genentech, Inc. | Antibody formulations |
TWI700300B (zh) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第viii凝血因子(fviii)機能替代活性的物質之抗體 |
TWI701435B (zh) | 2014-09-26 | 2020-08-11 | 日商中外製藥股份有限公司 | 測定fviii的反應性之方法 |
AU2015325055B2 (en) | 2014-10-01 | 2021-02-25 | Eagle Biologics, Inc. | Polysaccharide and nucleic acid formulations containing viscosity-lowering agents |
TWI705827B (zh) | 2014-11-07 | 2020-10-01 | 瑞士商諾華公司 | 治療眼部疾病之方法 |
CN107208025A (zh) | 2014-11-25 | 2017-09-26 | 康宁股份有限公司 | 延续细胞培养基的材料和方法 |
AR103173A1 (es) * | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
WO2016109822A1 (fr) * | 2014-12-31 | 2016-07-07 | Novelmed Therapeutics, Inc. | Formulation d'anticorps thérapeutiques aglycosylés |
JP6731953B2 (ja) * | 2015-02-11 | 2020-07-29 | ジーエムエーエックス バイオファーム エルエルシー. | Glp−1r抗体融合タンパク質の安定な医薬溶液製剤 |
AR103726A1 (es) | 2015-02-27 | 2017-05-31 | Merck Sharp & Dohme | Cristales de anticuerpos monoclonales anti-pd-1 humanos |
US11142587B2 (en) | 2015-04-01 | 2021-10-12 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide hetero-oligomer |
CA2995645A1 (fr) | 2015-08-18 | 2017-02-23 | Regeneron Pharmaceuticals, Inc. | Anticorps inhibiteurs anti-pcsk9 destines au traitement des patients atteints d'hyperlipidemie subissant une apherese de lipoproteines |
WO2017057644A1 (fr) * | 2015-09-30 | 2017-04-06 | 持田製薬株式会社 | Formulation liquide contenant une concentration élevée en anticorps |
US11229702B1 (en) | 2015-10-28 | 2022-01-25 | Coherus Biosciences, Inc. | High concentration formulations of adalimumab |
MX2018007520A (es) * | 2015-12-18 | 2018-08-01 | Astellas Pharma Inc | Composicion farmaceutica que comprende un anticuerpo receptor de linfopoyetina estromal timica antihumano. |
MX2018007781A (es) | 2015-12-28 | 2018-09-05 | Chugai Pharmaceutical Co Ltd | Metodo para promover la eficiencia de purificacion del polipeptido que contiene la region de fragmento cristalizable (fc). |
WO2017147169A1 (fr) | 2016-02-22 | 2017-08-31 | Ohio State Innovation Foundation | Chimioprévention utilisant des formulations à libération contrôlée d'agents anti-interleukine 6, d'analogues ou des métabolites synthétiques de la vitamine a et de métabolites de l'œstradiol |
AU2017222564A1 (en) * | 2016-02-24 | 2018-09-06 | Visterra, Inc. | Formulations of antibody molecules to influenza virus |
US11071782B2 (en) | 2016-04-20 | 2021-07-27 | Coherus Biosciences, Inc. | Method of filling a container with no headspace |
CN116059353A (zh) * | 2016-04-28 | 2023-05-05 | 中外制药株式会社 | 含抗体制剂 |
TWI826351B (zh) * | 2016-05-31 | 2023-12-21 | 大陸商鴻運華寧(杭州)生物醫藥有限公司 | R抗體,其藥物組合物及其應用 |
CA3029642A1 (fr) | 2016-07-05 | 2018-01-11 | Sanofi | Formule d'anticorps. |
MX2019002510A (es) | 2016-09-06 | 2019-06-24 | Chugai Pharmaceutical Co Ltd | Metodos para usar un anticuerpo biespecifico que reconoce el factor de coagulacion ix y/o el factor de coagulacion ix activado y el factor de coagulacion x y/o factor de coagulacion x activado. |
MA46334A (fr) | 2016-09-27 | 2019-08-07 | Fresenius Kabi Deutschland Gmbh | Composition pharmaceutique liquide |
HUE054858T2 (hu) | 2016-10-31 | 2021-10-28 | Fresenius Kabi Deutschland Gmbh | Folyékony gyógyszerészeti készítmény |
GEP20237513B (en) | 2016-12-23 | 2023-06-12 | Serum Institute Of India Pvt Ltd | Improved methods for enhancing antibody productivity in mammalian cell culture and minimizing aggregation during downstream, formulation processes and stable antibody formulations obtained thereof |
AU2018214554C1 (en) | 2017-02-01 | 2022-12-15 | Novo Nordisk A/S | Treatment of diuretic resistance |
US11608357B2 (en) | 2018-08-28 | 2023-03-21 | Arecor Limited | Stabilized antibody protein solutions |
GB201703063D0 (en) | 2017-02-24 | 2017-04-12 | Arecor Ltd | Stabilized antibody protein solutions |
TWI761453B (zh) | 2017-03-01 | 2022-04-21 | 英商梅迪繆思有限公司 | 抗rsv單株抗體配製物 |
EP3372241A1 (fr) | 2017-03-06 | 2018-09-12 | Ares Trading S.A. | Composition pharmaceutique liquide |
EP3372242A1 (fr) | 2017-03-06 | 2018-09-12 | Ares Trading S.A. | Composition pharmaceutique liquide |
AU2018234844B2 (en) | 2017-03-17 | 2024-01-25 | Ohio State Innovation Foundation | Nanoparticles for delivery of chemopreventive agents |
JPWO2018179138A1 (ja) * | 2017-03-29 | 2020-02-06 | 持田製薬株式会社 | 抗体含有液体製剤 |
WO2018181876A1 (fr) | 2017-03-31 | 2018-10-04 | Meiji Seikaファルマ株式会社 | Formulation aqueuse, formulation aqueuse dans un injecteur, agent de désagrégation de protéine d'anticorps et procédé de désagrégation de protéine d'anticorps |
JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
CN110913906A (zh) * | 2017-05-02 | 2020-03-24 | 默沙东公司 | 抗lag3抗体的制剂和抗lag3抗体与抗pd-1抗体的共制剂 |
EP3624846B1 (fr) | 2017-05-16 | 2024-08-07 | Bhami's Research Laboratory, Pvt. Ltd. | Formulations de protéines à haute concentration ayant une viscosité réduite incluant une mixture d'acide nicotinique et tryoptophane |
EP3672632A1 (fr) * | 2017-08-22 | 2020-07-01 | Biogen MA Inc. | Compositions pharmaceutiques et schémas posologiques contenant des anticorps anti-alpha (v) bêta (6) |
PT3672631T (pt) | 2017-08-22 | 2023-05-23 | Biogen Ma Inc | Composições farmacêuticas contendo anticorpos anti-betaamiloide |
SG11201810270SA (en) | 2017-09-29 | 2019-04-29 | Chugai Pharmaceutical Co Ltd | Multispecific antigen-binding molecules having blood coagulation factor viii (fviii) cofactor function-substituting activity and pharmaceutical formulations containing such a molecule as an active ing |
JP7395479B2 (ja) | 2018-01-05 | 2023-12-11 | ノヴォ ノルディスク アー/エス | 免疫抑制なしにil-6媒介性炎症を処置する方法 |
EP3790532A1 (fr) | 2018-05-10 | 2021-03-17 | Regeneron Pharmaceuticals, Inc. | Formulations contenant des protéines de fusion du récepteur vegf à haute concentration |
CA3111784A1 (fr) | 2018-09-12 | 2020-03-19 | Silverback Therapeutics, Inc. | Compositions pour le traitement d'une maladie avec des conjugues immunostimulants |
EP3938395A1 (fr) * | 2019-03-11 | 2022-01-19 | Biogen MA Inc. | Compositions pharmaceutiques contenant des anticorps anti-lingo-1 |
US20220177978A1 (en) | 2019-04-02 | 2022-06-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
US12024553B2 (en) * | 2019-04-30 | 2024-07-02 | Medimmune Limited | Dosage regimens for and compositions including anti-RSV antibodies |
KR102169901B1 (ko) * | 2019-05-17 | 2020-10-26 | 연세대학교 산학협력단 | Dna 메틸화를 이용한 면역 항암 요법의 치료 반응에 관한 정보 제공 방법 및 이를 이용한 키트 |
KR20220035908A (ko) | 2019-06-19 | 2022-03-22 | 실버백 테라퓨틱스, 인크. | 항-메소텔린 항체 및 이의 면역접합체 |
CN112618482A (zh) * | 2019-09-24 | 2021-04-09 | 江苏恒瑞医药股份有限公司 | 新型蛋白制剂 |
JP2023514727A (ja) | 2020-02-21 | 2023-04-07 | シルバーバック セラピューティックス インコーポレイテッド | ネクチン-4抗体コンジュゲートおよびその使用 |
EP4107186A1 (fr) | 2020-03-23 | 2022-12-28 | Genentech, Inc. | Polythérapie à base de tocilizumab et de remdesivir pour une pneumonie à covid-19 |
CN115867577A (zh) | 2020-03-23 | 2023-03-28 | 基因泰克公司 | 用于预测covid-19肺炎中对il-6拮抗剂反应的生物标志物 |
JP2023518815A (ja) | 2020-03-23 | 2023-05-08 | ジェネンテック, インコーポレイテッド | Il6アンタゴニストによるcovid-19肺炎を含む肺炎の治療方法 |
AR122766A1 (es) * | 2020-06-29 | 2022-10-05 | Hanall Biopharma Co Ltd | Formulación para anticuerpos anti-fcrn |
EP4175673A1 (fr) | 2020-07-01 | 2023-05-10 | ARS Pharmaceuticals Inc. | Conjugués d'anticorps anti-asgr1 et leurs utilisations |
KR20220028972A (ko) * | 2020-08-31 | 2022-03-08 | (주)셀트리온 | 안정한 약제학적 제제 |
JP2023541921A (ja) | 2020-09-17 | 2023-10-04 | ジェネンテック, インコーポレイテッド | Covid-19肺炎を有する入院患者におけるトシリズマブの有効性及び安全性を評価するためのランダム化二重盲検プラセボ対照多施設試験(empacta)の結果 |
WO2022098750A1 (fr) * | 2020-11-03 | 2022-05-12 | La Jolla Institute For Immunology | Tcr restreints au hla de classe ii contre la mutation activant kras g12>v |
KR20230130561A (ko) * | 2022-03-02 | 2023-09-12 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | Fviii 모방 이중특이적 항체를 2주마다 1회 투여하는 방법 |
KR20230130558A (ko) * | 2022-03-02 | 2023-09-12 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | Fviii 모방 이중특이적 항체의 월 1회 투여 방법 |
KR20230130560A (ko) * | 2022-03-02 | 2023-09-12 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | Fviii 모방 이중특이적 항체의 주 1회 투여 방법 |
WO2024090488A1 (fr) * | 2022-10-26 | 2024-05-02 | 日本メジフィジックス株式会社 | Composition pharmaceutique radioactive |
US20240245779A1 (en) | 2023-01-25 | 2024-07-25 | Regeneron Pharmaceuticals, Inc. | Methods of modeling liquid protein composition stability |
Family Cites Families (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55106216A (en) | 1979-02-09 | 1980-08-14 | Hitachi Chem Co Ltd | Preparation of amino resin |
JPS58201994A (ja) | 1982-05-21 | 1983-11-25 | Hideaki Hagiwara | 抗原特異的ヒト免疫グロブリンの生産方法 |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
JPS63453A (ja) | 1986-06-20 | 1988-01-05 | Tohoku Metal Ind Ltd | 耐酸化性永久磁石材料とその製造方法 |
US6428979B1 (en) * | 1988-01-22 | 2002-08-06 | Tadamitsu Kishimoto | Receptor protein for human B cell stimulatory factor-2 |
US5670373A (en) * | 1988-01-22 | 1997-09-23 | Kishimoto; Tadamitsu | Antibody to human interleukin-6 receptor |
US5171840A (en) * | 1988-01-22 | 1992-12-15 | Tadamitsu Kishimoto | Receptor protein for human B cell stimulatory factor-2 |
US5158761A (en) * | 1989-04-05 | 1992-10-27 | Toko Yakuhin Kogyo Kabushiki Kaisha | Spray gel base and spray gel preparation using thereof |
JPH06508511A (ja) | 1990-07-10 | 1994-09-29 | ケンブリッジ アンティボディー テクノロジー リミティド | 特異的な結合ペアーの構成員の製造方法 |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
WO1994025585A1 (fr) | 1993-04-26 | 1994-11-10 | Genpharm International, Inc. | Animaux transgeniques capables de produire des anticorps heterologues |
EP0814159B1 (fr) | 1990-08-29 | 2005-07-27 | GenPharm International, Inc. | Souris transgéniques capables de produire des anticorps hétérologues |
DE69229482T2 (de) * | 1991-04-25 | 1999-11-18 | Chugai Seiyaku K.K., Tokio/Tokyo | Rekombinierte humane antikörper gegen den humanen interleukin 6-rezeptor |
DE69229477T2 (de) | 1991-09-23 | 1999-12-09 | Cambridge Antibody Technology Ltd., Melbourn | Methoden zur Herstellung humanisierter Antikörper |
ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
CA2124967C (fr) | 1991-12-17 | 2008-04-08 | Nils Lonberg | Animaux transgeniques non humains capables de produire des anticorps heterologues |
DE69333823T2 (de) | 1992-03-24 | 2006-05-04 | Cambridge Antibody Technology Ltd., Melbourn | Verfahren zur herstellung von gliedern von spezifischen bindungspaaren |
EP0652950B1 (fr) | 1992-07-24 | 2007-12-19 | Amgen Fremont Inc. | Production d'anticorps xenogeniques |
GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
US5888510A (en) * | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
WO1995015388A1 (fr) | 1993-12-03 | 1995-06-08 | Medical Research Council | Proteines et peptides de liaison recombines |
US8017121B2 (en) * | 1994-06-30 | 2011-09-13 | Chugai Seiyaku Kabushika Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
ATE340590T1 (de) | 1994-07-13 | 2006-10-15 | Chugai Pharmaceutical Co Ltd | Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper |
JP3630453B2 (ja) | 1994-09-30 | 2005-03-16 | 中外製薬株式会社 | Il−6レセプター抗体を有効成分とする未熟型骨髄腫細胞治療剤 |
CA2203182C (fr) * | 1994-10-21 | 2009-11-24 | Asao Katsume | Remede contre des maladies provoquees par la production d'il-6 |
EP0800829B2 (fr) * | 1994-12-29 | 2012-07-25 | Chugai Seiyaku Kabushiki Kaisha | Utilisation d'un anticorps pm-1 ou d'un anticorps mh 166 pour potentialiser l'effet antitumoral de la cisplatine ou de la carboplatine |
WO1996025174A1 (fr) * | 1995-02-13 | 1996-08-22 | Chugai Seiyaku Kabushiki Kaisha | Inhibiteur de decomposition des proteines musculaires contenant un anticorps du recepteur de l'interleukine-6 |
ATE390933T1 (de) | 1995-04-27 | 2008-04-15 | Amgen Fremont Inc | Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8 |
AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
WO1997049428A1 (fr) * | 1996-06-27 | 1997-12-31 | Chugai Seiyaku Kabushiki Kaisha | Remedes contre les myelomes a utiliser en combinaison avec des agents anti-tumoraux a base d'azote de la moutarde |
RU2198220C2 (ru) | 1996-09-26 | 2003-02-10 | Чугаи Сейяку Кабусики Кайся | Антитело против белка, родственного паращитовидному гормону человека, днк, вектор, способ получения и использование антитела |
UA76934C2 (en) | 1996-10-04 | 2006-10-16 | Chugai Pharmaceutical Co Ltd | Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody |
EP2322216A1 (fr) * | 1997-03-21 | 2011-05-18 | Chugai Seiyaku Kabushiki Kaisha | Agent thérapeutique ou préventif pour les maladies liées aux lymphocytes T sensibilisés comprenant l'antagoniste IL-6 en tant qu'ingrédient actif |
US6991790B1 (en) | 1997-06-13 | 2006-01-31 | Genentech, Inc. | Antibody formulation |
US20020187150A1 (en) * | 1997-08-15 | 2002-12-12 | Chugai Seiyaku Kabushiki Kaisha | Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient |
PT1074268E (pt) * | 1998-03-17 | 2008-02-28 | Chugai Pharmaceutical Co Ltd | Agentes profilácticos ou terapêuticos para doenças intestinais inflamatórias contendo anticorpos antagonistas do receptor il-6 |
DK1069185T3 (da) | 1998-04-03 | 2011-06-27 | Chugai Pharmaceutical Co Ltd | Humaniseret antistof mod human vævsfaktor (TF) og fremgangsmåde til at konstruere humaniseret antistof |
US6537782B1 (en) * | 1998-06-01 | 2003-03-25 | Chugai Seiyaku Kabushiki Kaisha | Media for culturing animal cells and process for producing protein by using the same |
US6406909B1 (en) * | 1998-07-10 | 2002-06-18 | Chugai Seiyaku Kabushiki Kaisha | Serum-free medium for culturing animal cells |
JP4711507B2 (ja) | 1998-08-24 | 2011-06-29 | 中外製薬株式会社 | Il−6アンタゴニストを有効成分として含有する膵炎の予防又は治療剤 |
JP2007204498A (ja) | 1999-03-01 | 2007-08-16 | Chugai Pharmaceut Co Ltd | 長期安定化製剤 |
JP2000247903A (ja) * | 1999-03-01 | 2000-09-12 | Chugai Pharmaceut Co Ltd | 長期安定化製剤 |
US6914128B1 (en) * | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
DE10084743T1 (de) * | 1999-06-25 | 2002-08-14 | Genentech Inc | Humanisierte Anti-ErbB2-Antikörper und Behandlung mit Anti-ErbB2-Antikörpern |
AU783306B2 (en) | 1999-10-04 | 2005-10-13 | Novartis Vaccines And Diagnostics, Inc. | Stabilized liquid polypeptide-containing pharmaceutical compositions |
AU2001236005A1 (en) | 2000-02-29 | 2001-09-12 | Chugai Seiyaku Kabushiki Kaisha | Preparations stabilized over long time |
TWI242043B (en) | 2000-03-10 | 2005-10-21 | Chugai Pharmaceutical Co Ltd | Polypeptide inducing apoptosis |
WO2002013859A1 (fr) | 2000-08-10 | 2002-02-21 | Chugai Seiyaku Kabushiki Kaisha | Methode permettant d'inhiber la coagulation ou la turbidite d'une solution contenant des anticorps |
JP5485489B2 (ja) | 2000-08-11 | 2014-05-07 | 中外製薬株式会社 | 抗体含有安定化製剤 |
AU8260701A (en) | 2000-09-01 | 2002-03-13 | Chugai Pharmaceutical Co Ltd | Solution preparations stabilized over long time |
SI1324776T2 (en) * | 2000-10-12 | 2018-06-29 | Genentech, Inc. | Concentrated protein formulations with reduced viscosity |
US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
WO2002033072A1 (fr) | 2000-10-20 | 2002-04-25 | Chugai Seiyaku Kabushiki Kaisha | Anticorps degrade, agoniste de tpo |
PT1334731E (pt) * | 2000-10-25 | 2008-03-11 | Chugai Pharmaceutical Co Ltd | Agentes preventivos ou medicamentos para a psoríase que contêm um antagonista da il-6 como ingrediente activo |
WO2002036164A1 (fr) * | 2000-10-27 | 2002-05-10 | Chugai Seiyaku Kabushiki Kaisha | Agent abaissant le taux sanguin de vegf contenant un antagoniste de il-6 en tant que principe actif |
WO2002036165A1 (fr) * | 2000-10-27 | 2002-05-10 | Chugai Seiyaku Kabushiki Kaisha | Agent à base d'antagoniste d'il-6, faisant baisser le niveau des mmp-3 dans le sang |
WO2002072615A1 (fr) * | 2001-03-09 | 2002-09-19 | Chugai Seiyaku Kabushiki Kaisha | Methode de purification de proteines |
UA80091C2 (en) * | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
KR100913714B1 (ko) | 2001-11-08 | 2009-08-24 | 패시트 바이오테크 코포레이션 | Igg 항체의 안정한 액상 약학 제형물 |
ES2624547T3 (es) * | 2001-11-14 | 2017-07-14 | Janssen Biotech, Inc. | Anticuerpos anti il 6, composiciones, métodos y usos |
US20030138416A1 (en) * | 2001-12-03 | 2003-07-24 | Jesper Lau | Use of glucokinase activator in combination with a glucagon antagonist for treating type 2 diabetes |
EP1475101B1 (fr) | 2002-02-14 | 2010-10-27 | Chugai Seiyaku Kabushiki Kaisha | Produits pharmaceutiques en solution contenant des anticorps |
ES2311094T3 (es) * | 2002-02-27 | 2009-02-01 | Immunex Corporation | Composicion estabilizada de tnfr-fc que comprende arginina. |
JP3822137B2 (ja) | 2002-05-20 | 2006-09-13 | 中外製薬株式会社 | 動物細胞培養用培地の添加剤およびそれを用いたタンパク質の製造方法 |
AU2003259995B2 (en) | 2002-08-28 | 2009-07-02 | Immunex Corporation | Compositions and methods for treating cardiovascular disease |
JP5525118B2 (ja) * | 2002-09-11 | 2014-06-18 | 中外製薬株式会社 | タンパク質精製方法 |
DE10255508A1 (de) | 2002-11-27 | 2004-06-17 | Forschungszentrum Jülich GmbH | Verfahren zur Kultivierung von Zellen zur Produktion von Substanzen |
WO2004055164A2 (fr) * | 2002-12-13 | 2004-07-01 | Abgenix, Inc. | Systeme et methode de stabilisation d'anticorps au moyen d'histidine |
AU2004212843B2 (en) * | 2003-02-24 | 2009-06-25 | Chugai Seiyaku Kabushiki Kaisha | Remedy for spinal injury containing interleukin-6 antagonist |
AU2004229335C1 (en) | 2003-04-04 | 2010-06-17 | Genentech, Inc. | High concentration antibody and protein formulations |
US20050158303A1 (en) | 2003-04-04 | 2005-07-21 | Genentech, Inc. | Methods of treating IgE-mediated disorders comprising the administration of high concentration anti-IgE antibody formulations |
GB2401040A (en) * | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
CA2532966C (fr) | 2003-07-15 | 2012-12-04 | Chugai Seiyaku Kabushiki Kaisha | Production d'igm par des cellules transformees et methodes de quantification de cette production |
TWI350175B (en) * | 2003-10-17 | 2011-10-11 | Chugai Pharmaceutical Co Ltd | Mesothelioma therapeutic agent |
EP1532983A1 (fr) * | 2003-11-18 | 2005-05-25 | ZLB Bioplasma AG | Preparation d'immunoglobulines à stabilité élevée |
DE10355251A1 (de) * | 2003-11-26 | 2005-06-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung enthaltend einen Antikörper gegen den EGF-Rezeptor |
US8617550B2 (en) * | 2003-12-19 | 2013-12-31 | Chugai Seiyaku Kabushiki Kaisha | Treatment of vasculitis with IL-6 antagonist |
AR048210A1 (es) | 2003-12-19 | 2006-04-12 | Chugai Pharmaceutical Co Ltd | Un agente preventivo para la vasculitis. |
US20070184050A1 (en) | 2003-12-25 | 2007-08-09 | Kirin Beer Kabushiki Kaisha | Stable water-based medicinal preparation containing antibody |
CA2555791A1 (fr) | 2004-02-12 | 2005-08-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Formulations liquides fortement concentrees d'anticorps anti-egfr |
WO2005089503A2 (fr) | 2004-03-19 | 2005-09-29 | Progenics Pharmaceuticals, Inc. | Formulations de cd4-igg2 |
AR048335A1 (es) * | 2004-03-24 | 2006-04-19 | Chugai Pharmaceutical Co Ltd | Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo |
EP1728801A4 (fr) | 2004-03-24 | 2009-10-21 | Chugai Pharmaceutical Co Ltd | Sous-type d' anticorps humanise contre un recepteur de l'interleukine-6 |
PL1778723T3 (pl) | 2004-08-17 | 2013-03-29 | Regeneron Pharma | Preparaty antagonisty IL-1 |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
KR20130101161A (ko) * | 2005-01-05 | 2013-09-12 | 추가이 세이야쿠 가부시키가이샤 | 세포의 배양 방법 및 그 이용 |
SV2008002394A (es) * | 2005-01-28 | 2008-02-08 | Wyeth Corp | Formulaciones liquidas estabilizadas de polipeptido ref. ahn- 072sv |
NZ599176A (en) | 2005-08-03 | 2014-04-30 | Immunogen Inc | Immunoconjugate formulations |
JP5014143B2 (ja) * | 2005-10-14 | 2012-08-29 | 学校法人福岡大学 | 膵島移植における移植膵島障害抑制剤 |
AR058135A1 (es) * | 2005-10-21 | 2008-01-23 | Chugai Pharmaceutical Co Ltd | Agentes para el tratamiento de cardiopatias |
AR057582A1 (es) * | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
EP1967209B1 (fr) * | 2005-11-25 | 2012-06-06 | Keio University | Agent thérapeutique pour le cancer de la prostate |
WO2007074880A1 (fr) | 2005-12-28 | 2007-07-05 | Chugai Seiyaku Kabushiki Kaisha | Préparation stabilisatrice contenant des anticorps |
US8771686B2 (en) * | 2006-01-27 | 2014-07-08 | Chugai Seiyaku Kabushiki Kaisha | Methods for treating a disease involving choroidal neovascularization by administering an IL-6 receptor antibody |
KR20080098504A (ko) | 2006-02-03 | 2008-11-10 | 메디뮨 엘엘씨 | 단백질 제제 |
JP4902674B2 (ja) | 2006-03-09 | 2012-03-21 | エフ.ホフマン−ラ ロシュ アーゲー | 抗薬物抗体アッセイ法 |
TW200806317A (en) | 2006-03-20 | 2008-02-01 | Wyeth Corp | Methods for reducing protein aggregation |
JP5754875B2 (ja) * | 2006-04-07 | 2015-07-29 | 国立大学法人大阪大学 | 筋再生促進剤 |
KR101317235B1 (ko) † | 2006-04-21 | 2013-10-15 | 조마 테크놀로지 리미티드 | 길항제 항-cd40 항체 제약 조성물 |
JP5330829B2 (ja) | 2006-08-04 | 2013-10-30 | 憲弘 西本 | 関節リウマチ患者の治療予後予測方法 |
JP2010095445A (ja) | 2006-12-27 | 2010-04-30 | Tokyo Medical & Dental Univ | Il−6アンタゴニストを有効成分とする炎症性筋疾患治療剤 |
MX2009007406A (es) | 2007-01-09 | 2010-01-25 | Wyeth Corp | Formulaciones de anticuerpo anti-il-13 y usos de las mismas. |
TWI438208B (zh) * | 2007-01-23 | 2014-05-21 | Chugai Pharmaceutical Co Ltd | 抑制慢性排斥反應之藥劑 |
WO2009014263A1 (fr) * | 2007-07-26 | 2009-01-29 | Osaka University | Agent pour le traitement de l'ophtalmie contenant un inhibiteur du récepteur de l'interleukine 6 en tant qu'ingrédient actif |
MX2010003329A (es) | 2007-09-26 | 2010-04-27 | Chugai Pharmaceutical Co Ltd | Anticuerpo anti-receptor de il-6. |
CN101815532B (zh) * | 2007-10-02 | 2012-08-15 | 中外制药株式会社 | 以白细胞介素6受体抑制剂为有效成分的移植物抗宿主病治疗剂 |
JP2009092508A (ja) | 2007-10-09 | 2009-04-30 | Norihiro Nishimoto | リウマチ治療剤の効果の予測方法 |
EP2573568B1 (fr) * | 2007-12-15 | 2015-01-14 | F. Hoffmann-La Roche AG | Analyse de distinction |
PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
CN104906581A (zh) * | 2008-06-05 | 2015-09-16 | 国立研究开发法人国立癌症研究中心 | 神经浸润抑制剂 |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
WO2011013786A1 (fr) * | 2009-07-31 | 2011-02-03 | Maeda Shin | Inhibiteur de métastases cancéreuses |
DK2493922T3 (en) * | 2009-10-26 | 2017-04-24 | Hoffmann La Roche | Process for preparing a glycosylated immunoglobulin |
AR080428A1 (es) | 2010-01-20 | 2012-04-11 | Chugai Pharmaceutical Co Ltd | Formulaciones liquidas estabilizadas contentivas de anticuerpos |
WO2011128096A1 (fr) * | 2010-04-16 | 2011-10-20 | Roche Diagnostics Gmbh | Marqueurs de polymorphisme destinés à prédire la réponse à un traitement par un médicament anticorps monoclonal inhibant les récepteurs de l'interleukine-6 |
JP6051049B2 (ja) | 2010-05-28 | 2016-12-21 | 中外製薬株式会社 | 抗腫瘍t細胞応答増強剤 |
JP5904552B2 (ja) | 2010-05-28 | 2016-04-13 | 国立研究開発法人国立がん研究センター | 膵癌治療剤 |
CN103119176A (zh) * | 2010-06-07 | 2013-05-22 | 霍夫曼-拉罗奇有限公司 | 用于预测对白介素-6受体抑制性单克隆抗体药物治疗的响应的基因表达标记 |
KR20200059320A (ko) | 2010-11-08 | 2020-05-28 | 제넨테크, 인크. | 피하 투여용 항―il―6 수용체 항체 |
SG11201400260TA (en) | 2011-09-01 | 2014-03-28 | Chugai Pharmaceutical Co Ltd | Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration |
CN105378480B (zh) | 2013-07-04 | 2018-06-12 | 豪夫迈·罗氏有限公司 | 检测血清样品中抗药物抗体的干扰抑制性免疫测定 |
US10349940B2 (en) | 2015-08-24 | 2019-07-16 | Ethicon Llc | Surgical stapler buttress applicator with state indicator |
MA46334A (fr) | 2016-09-27 | 2019-08-07 | Fresenius Kabi Deutschland Gmbh | Composition pharmaceutique liquide |
HUE054858T2 (hu) | 2016-10-31 | 2021-10-28 | Fresenius Kabi Deutschland Gmbh | Folyékony gyógyszerészeti készítmény |
CA3083971A1 (fr) | 2017-11-30 | 2019-06-06 | Bio-Thera Solutions, Ltd. | Preparation liquide d'anticorps humanise pour le traitement d'une maladie liee a l'il-6 |
-
2008
- 2008-12-22 PE PE2008002174A patent/PE20091174A1/es active IP Right Grant
- 2008-12-23 AR ARP080105706A patent/AR069969A1/es not_active Application Discontinuation
- 2008-12-26 TW TW097151029A patent/TWI375566B/zh active
- 2008-12-26 BR BRPI0818903A patent/BRPI0818903B8/pt active IP Right Grant
- 2008-12-26 SI SI200830806T patent/SI2238985T2/sl unknown
- 2008-12-26 EP EP08866971.8A patent/EP2238985B2/fr active Active
- 2008-12-26 KR KR1020107016322A patent/KR101083616B1/ko active IP Right Grant
- 2008-12-26 AU AU2008344292A patent/AU2008344292B2/en active Active
- 2008-12-26 DK DK08866971.8T patent/DK2238985T4/da active
- 2008-12-26 ES ES08866971T patent/ES2389881T5/es active Active
- 2008-12-26 RU RU2010131179/15A patent/RU2497544C2/ru active
- 2008-12-26 CL CL2008003910A patent/CL2008003910A1/es unknown
- 2008-12-26 NZ NZ586378A patent/NZ586378A/en unknown
- 2008-12-26 CA CA2708627A patent/CA2708627C/fr active Active
- 2008-12-26 US US12/810,938 patent/US8568720B2/en active Active
- 2008-12-26 PL PL08866971.8T patent/PL2238985T5/pl unknown
- 2008-12-26 CN CN201610505769.8A patent/CN106075434B/zh active Active
- 2008-12-26 PT PT08866971T patent/PT2238985E/pt unknown
- 2008-12-26 MX MX2010004399A patent/MX2010004399A/es active IP Right Grant
- 2008-12-26 UA UAA201009396A patent/UA104134C2/ru unknown
- 2008-12-26 JP JP2009548102A patent/JP4937358B2/ja active Active
- 2008-12-26 SG SG2013049325A patent/SG2013049325A/en unknown
- 2008-12-26 WO PCT/JP2008/073798 patent/WO2009084659A1/fr active Application Filing
- 2008-12-26 MY MYPI2010003035A patent/MY159450A/en unknown
- 2008-12-26 CN CN200880119066.5A patent/CN101883588B/zh active Active
-
2010
- 2010-06-22 IL IL206548A patent/IL206548A/en active Protection Beyond IP Right Term
- 2010-06-25 MA MA32948A patent/MA31934B1/fr unknown
- 2010-07-26 CR CR11594A patent/CR11594A/es unknown
- 2010-07-27 EC EC2010010370A patent/ECSP10010370A/es unknown
- 2010-07-27 CO CO10091445A patent/CO6450630A2/es not_active Application Discontinuation
-
2011
- 2011-11-25 JP JP2011257255A patent/JP5906067B2/ja active Active
-
2012
- 2012-11-09 HR HRP20120903TT patent/HRP20120903T4/hr unknown
- 2012-11-13 CY CY20121101082T patent/CY1113616T1/el unknown
-
2013
- 2013-08-12 RU RU2013137740A patent/RU2701181C2/ru active
- 2013-09-03 US US14/017,013 patent/US20140005367A1/en not_active Abandoned
-
2015
- 2015-05-19 IL IL238896A patent/IL238896A/en active IP Right Grant
- 2015-11-13 JP JP2015223070A patent/JP6259436B2/ja active Active
- 2015-12-09 US US14/963,414 patent/US20160090419A1/en not_active Abandoned
-
2017
- 2017-12-07 JP JP2017234971A patent/JP6567024B2/ja active Active
-
2019
- 2019-04-22 US US16/390,197 patent/US11008394B2/en active Active
- 2019-07-30 JP JP2019139465A patent/JP2019206559A/ja active Pending
-
2020
- 2020-09-30 AR ARP200102716A patent/AR122312A2/es not_active Application Discontinuation
-
2021
- 2021-04-27 US US17/242,199 patent/US11359026B2/en active Active
- 2021-07-01 JP JP2021109852A patent/JP7256234B2/ja active Active
-
2022
- 2022-05-25 US US17/752,978 patent/US11584798B2/en active Active
-
2023
- 2023-01-25 JP JP2023009289A patent/JP2023055780A/ja active Pending
- 2023-01-31 US US18/162,368 patent/US11767363B2/en active Active
- 2023-06-15 US US18/335,789 patent/US20230340134A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA31934B1 (fr) | Formulation liquide contenant un anticorps a forte concentration | |
JP7159277B2 (ja) | 即効型インスリン組成物 | |
BR0213143A (pt) | Composições lìquidas para administração oral contendo guaifenesina e um copolìmero de bloco polioxialquileno | |
PH12017500844A1 (en) | Stable protein solution formulation containing high concentration of an anti-vegf antibody | |
BR112014027116A2 (pt) | formulação de anticorpo | |
MA35430B1 (fr) | Procédés de réduction du taux de lipoprotéine(a) par l'administration d'un inhibiteur de proprotéine convertase subtilisine/kexine-9 (pcsk9) | |
CO5660273A2 (es) | Formulaciones de proteina y anticuerpo de alta concentracion | |
MY165156A (en) | Stabilized formulations containing anti-pcsk9 antibodies | |
RU2006122638A (ru) | Фармацевтический препарат, включающий антитело против рецептора egf | |
MX2010009031A (es) | Composicion farmaceutica de un solo liquido estabilizada que contiene docetaxel. | |
EA200701923A1 (ru) | Лекарственная форма для перорального введения витамина | |
EA201101706A1 (ru) | Лекарственное средство на основе дииндолилметана(dim) с повышенной биодоступностью и его использование в лечении гиперпластических и воспалительных заболеваний человека | |
JP2017200909A (ja) | ロキソプロフェン配合皮膚用外用剤 | |
EA202193240A1 (ru) | Стабилизированные составы, содержащие анти-angptl3 антитела | |
NZ702342A (en) | Pharmaceutical formulation | |
RU2010138650A (ru) | Комбинация, включающая паклитаксел, для лечения рака яичников | |
Stephens et al. | Olanzapine-related fatality | |
MX2021007393A (es) | Formulacion de solucion de proteinas que contiene una alta concentracion de un anticuerpo anti-vegf. | |
JP4715515B2 (ja) | (2r)−2−プロピルオクタン酸を有効成分とする薬剤 | |
JP2007291070A (ja) | 催眠用医薬組成物 | |
RU2007133661A (ru) | КОМПОЗИЦИИ АНТИТЕЛ К MAdCAM | |
MXPA06003605A (es) | Preparacion de infusion que contiene acido (2r)-2-propiloctanoico como ingrediente activo. | |
JP2017039694A (ja) | ナルフラフィン塩酸塩含有カプセル製剤 | |
MA20150424A1 (fr) | Compositions liquides orales pédiatriques contenant du nepadutant | |
JP2010047482A (ja) | エダラボン注射液 |