CO4600634A1 - Derivados 6,5-heterobiciclicos sustituidos - Google Patents

Derivados 6,5-heterobiciclicos sustituidos

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Publication number
CO4600634A1
CO4600634A1 CO97049895A CO97049895A CO4600634A1 CO 4600634 A1 CO4600634 A1 CO 4600634A1 CO 97049895 A CO97049895 A CO 97049895A CO 97049895 A CO97049895 A CO 97049895A CO 4600634 A1 CO4600634 A1 CO 4600634A1
Authority
CO
Colombia
Prior art keywords
alkyl
nitrogen
substituted
alkylene
compounds
Prior art date
Application number
CO97049895A
Other languages
English (en)
Inventor
Liang Chen Yuhpyng
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21823717&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO4600634(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of CO4600634A1 publication Critical patent/CO4600634A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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Abstract

Esta invención se refiere a compuestos de fórmula I en la queA,B,D,E,K,T,G,R3 y R5 se definen como en la memoria descriptiva, y a las sales farmacéuticamente aceptables de tales compuestos.Un compuesto de la fórmula I:o una sal farmacéuticamente aceptable del mismo en la que la línea de trazos representa dobles enlaces opcionales; A es nitrógeno o CR7 ; B es -NR1 R2 , -CR1 R2 R10 , -C(=CR2 R11 )R1 ,-NHCR1 R2 R10 , -OCR1 R2 R10 , -SCR1 R2 R10 , -CR2 R10 NHR1 , -(CR2 R10 OR1 , -CR2 R10 SR1 ó -COR2 ;J y K son cada uno, independientemente, nitrógeno o carbono, y J y K no son a la vez nitrógenos;D y E se seleccionan, cada uno, independientemente, entre nitrógeno, CR4 , C=O, C=S, azufre, oxígeno, CR4 R6 y NR8 ;G es nitrógeno o carbono;R3 es hidrógeno, alquilo C1 -C4 , -O(alquilo C1 -C4 ), cloro, fluoro, bromo, yodo, (alquileno C1 -C2 )-O-(alquilo C1 -C2 ), (alquileno C1 -C2 )-OH ó -S(alquilo C1 -C4 );R5 es fenilo, piridilo, pirazinilo, pirimidilo, piridazinilo y donde cada uno de los grupos R5 anteriores está sustituido con uno a cuatro sustituyentes ...
CO97049895A 1996-08-28 1997-08-28 Derivados 6,5-heterobiciclicos sustituidos CO4600634A1 (es)

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US2503996P 1996-08-28 1996-08-28

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CO4600634A1 true CO4600634A1 (es) 1998-05-08

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CO97049895A CO4600634A1 (es) 1996-08-28 1997-08-28 Derivados 6,5-heterobiciclicos sustituidos

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EP (1) EP0923582B1 (es)
JP (2) JP3621706B2 (es)
KR (1) KR20000035934A (es)
CN (1) CN1227554A (es)
AP (1) AP762A (es)
AR (1) AR015103A1 (es)
AT (1) ATE340176T1 (es)
AU (1) AU735401B2 (es)
BG (1) BG103189A (es)
BR (1) BR9711970A (es)
CA (1) CA2263566C (es)
CO (1) CO4600634A1 (es)
CZ (1) CZ68199A3 (es)
DE (1) DE69736711T2 (es)
DZ (1) DZ2300A1 (es)
EA (1) EA002769B1 (es)
ES (1) ES2273369T3 (es)
GT (1) GT199700095A (es)
HR (1) HRP970454B1 (es)
HU (1) HUP9903965A3 (es)
ID (1) ID18249A (es)
IL (1) IL127566A0 (es)
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MA (1) MA26438A1 (es)
NO (1) NO313636B1 (es)
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TN (1) TNSN97145A1 (es)
TR (1) TR199900389T2 (es)
TW (1) TW575573B (es)
WO (1) WO1998008847A1 (es)
ZA (1) ZA977687B (es)

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ATE182148T1 (de) 1995-05-12 1999-07-15 Neurogen Corp Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
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HRP970454B1 (en) 2002-10-31
BR9711970A (pt) 1999-08-24
NO990927L (no) 1999-02-26
NO990927D0 (no) 1999-02-26
TNSN97145A1 (fr) 2005-03-15
SK23399A3 (en) 2000-08-14
CZ68199A3 (cs) 1999-11-17
HUP9903965A3 (en) 2002-02-28
DE69736711D1 (de) 2006-11-02
CN1227554A (zh) 1999-09-01
ZA977687B (en) 1999-03-01
HRP970454A2 (en) 1998-08-31
ES2273369T3 (es) 2007-05-01
JP2000502723A (ja) 2000-03-07
KR20000035934A (ko) 2000-06-26
HUP9903965A2 (hu) 2000-03-28
EP0923582B1 (en) 2006-09-20
DZ2300A1 (fr) 2002-12-25
GT199700095A (es) 1999-02-16
CA2263566C (en) 2003-09-09
EA002769B1 (ru) 2002-08-29
IL127566A0 (en) 1999-10-28
NZ333302A (en) 2000-08-25
PL332040A1 (en) 1999-08-16
OA10977A (en) 2001-11-02
AU735401B2 (en) 2001-07-05
JP2005047930A (ja) 2005-02-24

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