HUP0002659A2 - Benzo-5,6-ciklohepta[1,2-b]piridin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Benzo-5,6-ciklohepta[1,2-b]piridin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk

Info

Publication number
HUP0002659A2
HUP0002659A2 HU0002659A HUP0002659A HUP0002659A2 HU P0002659 A2 HUP0002659 A2 HU P0002659A2 HU 0002659 A HU0002659 A HU 0002659A HU P0002659 A HUP0002659 A HU P0002659A HU P0002659 A2 HUP0002659 A2 HU P0002659A2
Authority
HU
Hungary
Prior art keywords
group
optionally substituted
hydrogen atom
general formula
atom
Prior art date
Application number
HU0002659A
Other languages
English (en)
Inventor
Timothy J. Guzi
Dinanath F. Rane
Original Assignee
Schering Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp. filed Critical Schering Corp.
Publication of HUP0002659A2 publication Critical patent/HUP0002659A2/hu
Publication of HUP0002659A3 publication Critical patent/HUP0002659A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

A találmány új általános képletű vegyületekre - amelyek képletében anitrogénatom vagy NO csoport: R1 és R3 halogénatom; R2 és R4 hidrogén-vagy halogénatom, azzal a megkötéssel, hogy R2 és R4 legalább egyikehidrogénatom; <-egyes vagy kettős kötés; X nitrogénatom, metincsoport,ha <-egyes kötés, vagy szénatom, ha <-kettős kötés; T jelentéseáltalános képletű csoport, amelyben R5 hidrogénatom, alkilcsoport vagykémiai kötés; b és c értéke 0, 1, 2 vagy 3; és Y adott esetbenszubsztituált 3-6 tagú cikloalkilén-, piridil-, pirazinil- vagyfenilcsoport; Z -OR7, -R7 vagy -NR8R9 csoport; R7 hidrogénatom vagyadott esetben szubsztituált alkilcsoport; R8 és R9 hidrogénatom,hidroxi- vagy adott esetben szubsztituált alkilcsoport, vagy R8 és R9az -NR8R9 általános képletű csoportban lévő nitrogénatommal együttadott esetben szubsztituált heterociklusos gyűrűrendszert képez -valamint gyógyszerészetileg elfogadható sóikra és szolvátjaikravonatkozik. A találmány szerinti vegyületek gátolják a garnezie-protein tranferázt, így alkalmasak tumorsejtek kezelésére. Ó
HU0002659A 1997-06-17 1998-06-15 Benzo-5,6-cyclohepta[1,2-b]pyridine derivatives, pharmaceutical compositions containing them and their use HUP0002659A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87650797A 1997-06-17 1997-06-17
PCT/US1998/011499 WO1998057945A1 (en) 1997-06-17 1998-06-15 Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives as farnesyl protein transferase inhibitors

Publications (2)

Publication Number Publication Date
HUP0002659A2 true HUP0002659A2 (hu) 2001-06-28
HUP0002659A3 HUP0002659A3 (en) 2002-11-28

Family

ID=25367883

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002659A HUP0002659A3 (en) 1997-06-17 1998-06-15 Benzo-5,6-cyclohepta[1,2-b]pyridine derivatives, pharmaceutical compositions containing them and their use

Country Status (13)

Country Link
EP (1) EP0991637B1 (hu)
JP (1) JP2002510308A (hu)
KR (1) KR20010013829A (hu)
CN (1) CN1272844A (hu)
AT (1) ATE218137T1 (hu)
AU (1) AU7953798A (hu)
CA (1) CA2293433C (hu)
DE (1) DE69805619T2 (hu)
ES (1) ES2174450T3 (hu)
HK (1) HK1024910A1 (hu)
HU (1) HUP0002659A3 (hu)
IL (1) IL133448A0 (hu)
WO (1) WO1998057945A1 (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03003011A (es) * 2000-10-05 2003-07-14 George Q Daley Metodos para inducir muerte de celulas cancerosas y regresion de tumores.
US20020077301A1 (en) * 2000-10-05 2002-06-20 Whitehead Institute For Biomedical Research Effects of combined administration of farnesyl transferase inhibitors and signal transduction inhibitors
TW200418825A (en) 2002-12-16 2004-10-01 Hoffmann La Roche Novel (R)-and (S) enantiomers of thiophene hydroxamic acid derivatives
KR20240035513A (ko) 2021-07-09 2024-03-15 알리고스 테라퓨틱스 인코포레이티드 항바이러스 화합물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
KR920014799A (ko) * 1991-01-18 1992-08-25 나오가따 다이도 신규벤조[5,6]시클로헵타[1,2-b]피리딘 유도체 및 이를 함유하는 항알레르기제
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them

Also Published As

Publication number Publication date
AU7953798A (en) 1999-01-04
CA2293433A1 (en) 1998-12-23
CA2293433C (en) 2009-09-29
KR20010013829A (ko) 2001-02-26
CN1272844A (zh) 2000-11-08
HK1024910A1 (en) 2000-10-27
EP0991637B1 (en) 2002-05-29
JP2002510308A (ja) 2002-04-02
DE69805619T2 (de) 2002-11-07
DE69805619D1 (en) 2002-07-04
ES2174450T3 (es) 2002-11-01
ATE218137T1 (de) 2002-06-15
IL133448A0 (en) 2001-04-30
WO1998057945A1 (en) 1998-12-23
HUP0002659A3 (en) 2002-11-28
EP0991637A1 (en) 2000-04-12

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