HUP0003048A2 - Farnezil-protein transzferáz gátlására alkalmazható benzo[5,6]ciklohepta[1,2-b]piridin-származékok - Google Patents
Farnezil-protein transzferáz gátlására alkalmazható benzo[5,6]ciklohepta[1,2-b]piridin-származékokInfo
- Publication number
- HUP0003048A2 HUP0003048A2 HU0003048A HUP0003048A HUP0003048A2 HU P0003048 A2 HUP0003048 A2 HU P0003048A2 HU 0003048 A HU0003048 A HU 0003048A HU P0003048 A HUP0003048 A HU P0003048A HU P0003048 A2 HUP0003048 A2 HU P0003048A2
- Authority
- HU
- Hungary
- Prior art keywords
- protein transferase
- farnesyl protein
- cyclohepta
- benzo
- inhibition
- Prior art date
Links
- 102000004357 Transferases Human genes 0.000 title abstract 3
- 108090000992 Transferases Proteins 0.000 title abstract 3
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 title abstract 3
- VVJQGUSMDLABEG-UHFFFAOYSA-N 11h-benzo[1,2]cyclohepta[3,4-b]pyridine Chemical class C1=CC2=CC=CN=C2CC2=CC=CC=C21 VVJQGUSMDLABEG-UHFFFAOYSA-N 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 241000251468 Actinopterygii Species 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
A találmány új (1.0) általános képletű vegyületekre - ahol a jelentésenitrogénatom vagy NO-csoport, R1 és R3 jelentése hal, R2 és R4jelentése egymástól függetlenül hidrogén- vagy halogénatom, azzal amegkötéssel, hogy legalább egyikük jelentése hidrogénatom, X jelentéseszénatom, metincsoport vagy nitrogénatom, és T jelentése öt- vagyhattagú, heteroatomként egy vagy két oxigén- és/vagy kénatomottartalmazó heterocikloalkilcsoport - és gyógyszerészetileg elfogadhatósóikra, tumorsejtek kezelési eljárására, farnezil-protein transzferázgátlási eljárására, a vegyületeket tartalmazó gyógyszerkészítményekreés a vegyületek tumorsejtek kezelésére, farnezil-protein transzferázgátlására, valamint ilyen célra szolgáló gyógyszerkészítményekelőállítására történő alkalmazására vonatkozik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87749897A | 1997-06-17 | 1997-06-17 | |
| PCT/US1998/011409 WO1998057968A1 (en) | 1997-06-17 | 1998-06-15 | Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives useful for inhibition of farnesyl protein transferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0003048A2 true HUP0003048A2 (hu) | 2001-06-28 |
Family
ID=25370103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0003048A HUP0003048A2 (hu) | 1997-06-17 | 1998-06-15 | Farnezil-protein transzferáz gátlására alkalmazható benzo[5,6]ciklohepta[1,2-b]piridin-származékok |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1019398B1 (hu) |
| JP (1) | JP2002504142A (hu) |
| KR (1) | KR20010013944A (hu) |
| CN (1) | CN1267300A (hu) |
| AT (1) | ATE276250T1 (hu) |
| AU (1) | AU8253298A (hu) |
| CA (1) | CA2293368C (hu) |
| DE (1) | DE69826301T2 (hu) |
| ES (1) | ES2224413T3 (hu) |
| HU (1) | HUP0003048A2 (hu) |
| IL (1) | IL133392A0 (hu) |
| NZ (1) | NZ501612A (hu) |
| WO (1) | WO1998057968A1 (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
| CN111868031B (zh) * | 2018-01-19 | 2023-10-03 | 有机合成药品工业株式会社 | N-烷氧基羰基哌啶衍生物的制备方法及其中间体 |
| UY39661A (es) | 2021-03-09 | 2022-10-31 | Fmc Corp | Amidas bicíclicas para controlar plagas de invertebrados |
| WO2024170339A1 (en) | 2023-02-13 | 2024-08-22 | Syngenta Crop Protection Ag | Pesticidally active bicyclic compounds |
| WO2023097341A2 (en) | 2023-03-20 | 2023-06-01 | Fmc Corporation | Bicyclic amides and esters for controlling invertebrate pests |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| JP2001521489A (ja) * | 1996-09-13 | 2001-11-06 | シェーリング コーポレイション | ファルネシルタンパク質トランスフェラーゼインヒビターである三環式抗腫瘍性化合物 |
-
1998
- 1998-06-15 NZ NZ501612A patent/NZ501612A/en unknown
- 1998-06-15 AU AU82532/98A patent/AU8253298A/en not_active Abandoned
- 1998-06-15 DE DE69826301T patent/DE69826301T2/de not_active Expired - Lifetime
- 1998-06-15 IL IL13339298A patent/IL133392A0/xx unknown
- 1998-06-15 ES ES98932714T patent/ES2224413T3/es not_active Expired - Lifetime
- 1998-06-15 AT AT98932714T patent/ATE276250T1/de not_active IP Right Cessation
- 1998-06-15 HU HU0003048A patent/HUP0003048A2/hu unknown
- 1998-06-15 CA CA002293368A patent/CA2293368C/en not_active Expired - Fee Related
- 1998-06-15 WO PCT/US1998/011409 patent/WO1998057968A1/en active IP Right Grant
- 1998-06-15 JP JP50448499A patent/JP2002504142A/ja not_active Ceased
- 1998-06-15 CN CN98808200A patent/CN1267300A/zh active Pending
- 1998-06-15 KR KR1019997011969A patent/KR20010013944A/ko not_active Application Discontinuation
- 1998-06-15 EP EP98932714A patent/EP1019398B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69826301T2 (de) | 2005-10-13 |
| DE69826301D1 (de) | 2004-10-21 |
| NZ501612A (en) | 2001-11-30 |
| EP1019398B1 (en) | 2004-09-15 |
| AU8253298A (en) | 1999-01-04 |
| WO1998057968A1 (en) | 1998-12-23 |
| CN1267300A (zh) | 2000-09-20 |
| KR20010013944A (ko) | 2001-02-26 |
| IL133392A0 (en) | 2001-04-30 |
| JP2002504142A (ja) | 2002-02-05 |
| ES2224413T3 (es) | 2005-03-01 |
| EP1019398A1 (en) | 2000-07-19 |
| ATE276250T1 (de) | 2004-10-15 |
| CA2293368C (en) | 2009-01-20 |
| CA2293368A1 (en) | 1998-12-23 |
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