HUP0002186A2 - Farnezil-protein transzferáz gátlására alkalmazható vegyületek - Google Patents

Farnezil-protein transzferáz gátlására alkalmazható vegyületek

Info

Publication number
HUP0002186A2
HUP0002186A2 HU0002186A HUP0002186A HUP0002186A2 HU P0002186 A2 HUP0002186 A2 HU P0002186A2 HU 0002186 A HU0002186 A HU 0002186A HU P0002186 A HUP0002186 A HU P0002186A HU P0002186 A2 HUP0002186 A2 HU P0002186A2
Authority
HU
Hungary
Prior art keywords
protein transferase
farnesyl protein
compounds
inhibition
compounds useful
Prior art date
Application number
HU0002186A
Other languages
English (en)
Inventor
Carmen Alvarez
Ronald J. Doll
Tarik Lalwani
Stacy W. Remiszewski
Original Assignee
Schering Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp. filed Critical Schering Corp.
Publication of HUP0002186A2 publication Critical patent/HUP0002186A2/hu
Publication of HUP0002186A3 publication Critical patent/HUP0002186A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A találmány új (1.0) általános képletű vegyületekre -, amelyekképletében a jelentése nitrogénatom vagy NO csoport; R1 és R3 jelentése halogénatom; R2 és R4 jelentése egymástól függetlenül hidrogén- vagy halogénatom,azzal a megkötéssel, hogy legalább egyikük jelentése hidrogénatom; X jelentése szénatom, metincsoport vagy nitrogénatom; és R jelentése adott esetben szubsztituált cikloalkil- vagyheterocikloalkilcsoport -, valamint gyógyszerészetileg elfogadhatósóikra és szolvátjaikra, tumorsejtek kezelési eljárására, farnezil-protein-transzferáz gátlási eljárására, a vegyületeket tartalmazógyógyszerkészítményekre és a vegyületek tumorsejtek kezelésére,farnezil-protein-transzferáz gátlására, valamint ilyen célra szolgálógyógyszerkészítmények előállítására történő alkalmazására vonatkozik. Ó
HU0002186A 1997-06-17 1998-06-15 Compounds useful for inhibition of farnesyl protein transferase HUP0002186A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87773997A 1997-06-17 1997-06-17
PCT/US1998/011494 WO1998057955A1 (en) 1997-06-17 1998-06-15 Compounds useful for inhibition of farnesyl protein transferase

Publications (2)

Publication Number Publication Date
HUP0002186A2 true HUP0002186A2 (hu) 2001-04-28
HUP0002186A3 HUP0002186A3 (en) 2002-04-29

Family

ID=25370613

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002186A HUP0002186A3 (en) 1997-06-17 1998-06-15 Compounds useful for inhibition of farnesyl protein transferase

Country Status (14)

Country Link
EP (1) EP0993459B1 (hu)
JP (1) JP2002504143A (hu)
KR (1) KR20010013953A (hu)
CN (1) CN1286690A (hu)
AT (1) ATE227281T1 (hu)
AU (1) AU7815198A (hu)
CA (1) CA2294351C (hu)
DE (1) DE69809238T2 (hu)
ES (1) ES2182324T3 (hu)
HK (1) HK1024686A1 (hu)
HU (1) HUP0002186A3 (hu)
IL (1) IL133447A0 (hu)
NZ (1) NZ501617A (hu)
WO (1) WO1998057955A1 (hu)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110483384B (zh) * 2018-05-14 2021-05-14 新发药业有限公司 一种3,5-二卤代-4-吡啶酮-1-乙酸的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
WO1995010515A1 (en) * 1993-10-15 1995-04-20 Schering Corporation Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
IL128931A0 (en) * 1996-09-13 2000-02-17 Schering Corp Tricylic antitumor compounds being farnesyl protein transferase inhibitors

Also Published As

Publication number Publication date
HK1024686A1 (en) 2000-10-20
AU7815198A (en) 1999-01-04
ATE227281T1 (de) 2002-11-15
IL133447A0 (en) 2001-04-30
DE69809238D1 (de) 2002-12-12
CA2294351C (en) 2008-09-02
JP2002504143A (ja) 2002-02-05
WO1998057955A1 (en) 1998-12-23
CN1286690A (zh) 2001-03-07
KR20010013953A (ko) 2001-02-26
CA2294351A1 (en) 1998-12-23
HUP0002186A3 (en) 2002-04-29
ES2182324T3 (es) 2003-03-01
NZ501617A (en) 2001-09-28
EP0993459A1 (en) 2000-04-19
DE69809238T2 (de) 2003-09-18
EP0993459B1 (en) 2002-11-06

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