ES2182324T3 - Compuestos utiles para inhibir la farnesil-protein-transferasa. - Google Patents

Compuestos utiles para inhibir la farnesil-protein-transferasa.

Info

Publication number
ES2182324T3
ES2182324T3 ES98926276T ES98926276T ES2182324T3 ES 2182324 T3 ES2182324 T3 ES 2182324T3 ES 98926276 T ES98926276 T ES 98926276T ES 98926276 T ES98926276 T ES 98926276T ES 2182324 T3 ES2182324 T3 ES 2182324T3
Authority
ES
Spain
Prior art keywords
sup
transferasa
farnesil
inhibit
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98926276T
Other languages
English (en)
Inventor
Stacy W Remiszewski
Ronald J Doll
Carmen Alvarez
Tarik Lalwani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2182324T3 publication Critical patent/ES2182324T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Materials For Medical Uses (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se presenta nuevos compuestos de la fórmula (1.0). En la fórmula (1.0) a representa N o NO, R{sup, 1} y R{sup, 3} son halo, R{sup, 2} y R{sup, 4} son independientemente H y halo teniendo en cuenta que una sea H, X es C, CH o N, y R representa un cicloalquilo o un anillo de heterocicloalquilo que está sustituido. También se presentan procedimientos para inhibir la transferasa de la proteína farnesil y procedimientos para el tratamiento de las células tumorales.
ES98926276T 1997-06-17 1998-06-15 Compuestos utiles para inhibir la farnesil-protein-transferasa. Expired - Lifetime ES2182324T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87773997A 1997-06-17 1997-06-17

Publications (1)

Publication Number Publication Date
ES2182324T3 true ES2182324T3 (es) 2003-03-01

Family

ID=25370613

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98926276T Expired - Lifetime ES2182324T3 (es) 1997-06-17 1998-06-15 Compuestos utiles para inhibir la farnesil-protein-transferasa.

Country Status (14)

Country Link
EP (1) EP0993459B1 (es)
JP (1) JP2002504143A (es)
KR (1) KR20010013953A (es)
CN (1) CN1286690A (es)
AT (1) ATE227281T1 (es)
AU (1) AU7815198A (es)
CA (1) CA2294351C (es)
DE (1) DE69809238T2 (es)
ES (1) ES2182324T3 (es)
HK (1) HK1024686A1 (es)
HU (1) HUP0002186A3 (es)
IL (1) IL133447A0 (es)
NZ (1) NZ501617A (es)
WO (1) WO1998057955A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110483384B (zh) * 2018-05-14 2021-05-14 新发药业有限公司 一种3,5-二卤代-4-吡啶酮-1-乙酸的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
ES2164716T3 (es) * 1993-10-15 2002-03-01 Schering Corp Compuestos triciclicos de carbamato utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas.
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
HUP0001109A2 (hu) * 1996-09-13 2001-04-28 Schering Corporation Triciklusos farnezil-protein transzferáz inhibitorok mint tumorellenes vegyületek

Also Published As

Publication number Publication date
JP2002504143A (ja) 2002-02-05
DE69809238T2 (de) 2003-09-18
CA2294351C (en) 2008-09-02
HUP0002186A3 (en) 2002-04-29
EP0993459A1 (en) 2000-04-19
HUP0002186A2 (hu) 2001-04-28
HK1024686A1 (en) 2000-10-20
CN1286690A (zh) 2001-03-07
NZ501617A (en) 2001-09-28
ATE227281T1 (de) 2002-11-15
IL133447A0 (en) 2001-04-30
DE69809238D1 (de) 2002-12-12
AU7815198A (en) 1999-01-04
KR20010013953A (ko) 2001-02-26
EP0993459B1 (en) 2002-11-06
WO1998057955A1 (en) 1998-12-23
CA2294351A1 (en) 1998-12-23

Similar Documents

Publication Publication Date Title
FI873364A (fi) Foerfarande foer framstaellning av ett sytotoxiskt laekemedel.
ATE221069T1 (de) Pentafluorophenylazolopyrimidine
MX9302932A (es) Nuevas 4-aza-5&-androstan-3-onas 7b-substituidas como inhibidores de la5&-reductasa.
ATE286046T1 (de) Trizyklische inhibitoren der farnesyl protein transferase
ES2186300T3 (es) Oligopeptidos con actividad fungicida.
ES2047007T3 (es) Procedimiento para el aislamiento de proteinas basicas a partir de mezclas de proteinas.
ES2174989T3 (es) Pirido(3,2-e)pirazinonas con antiasmatica y procedimiento para su preparacion.
DE69106586D1 (de) Verwendung von Baclofen zur Herstellung von Arzneimitteln zur Behandlung von Angina pectoris.
ES2056180T3 (es) Nuevos derivados de 2'-halometiliden, 2'-eteniliden y 2'-etinil citidina.
MX9303466A (es) Derivados de bifenilo, medicamentos que contienen estos compuestos y procedimiento para su preparacion.
ES2059301T3 (es) Utilizacion de inhibidores de la enzima convertidora de angiotensina para el tratamiento de la aterosclerosis, trombosis y de la enfermedad vascular periferica.
PL257730A1 (en) Insecticide
BG96171A (bg) Амидинофенилаланинови производни,метод за получаването им, приложението им и средства,които ги съдържат
DE3776391D1 (de) Fluessige zubereitungen von 1,2-benzisothiazolin-3-on, ihre herstellung und verwendung.
DE3580132D1 (de) Aromatische verbindungen.
ES8609271A1 (es) Procedimiento para preparar derivados de carbamoilimidazol fungicidas
ES2060689T3 (es) Alcoholes peptidicos anticoagulantes.
ATE286044T1 (de) Trizyklische verbindungen mit farnesyl protein transferase inhibierender wirkung
ES2182324T3 (es) Compuestos utiles para inhibir la farnesil-protein-transferasa.
ES2042726T3 (es) Beta-alquilmelatoninas.
ATE70182T1 (de) Therapeutische mittel zur behandlung von magengeschwueren.
MX9301863A (es) Morfolin y tiomorfolin 4-ilamidas
ATE41927T1 (de) Phenylalkylamine - bioregulatoren.
DE69016693D1 (de) Züchtung von transformierten Mikroorganismen.
ES2043778T3 (es) Procedimiento para preparar oxiindanos y tetrahidronaftalenos herbicidas.