ATE286044T1 - Trizyklische verbindungen mit farnesyl protein transferase inhibierender wirkung - Google Patents
Trizyklische verbindungen mit farnesyl protein transferase inhibierender wirkungInfo
- Publication number
- ATE286044T1 ATE286044T1 AT97946875T AT97946875T ATE286044T1 AT E286044 T1 ATE286044 T1 AT E286044T1 AT 97946875 T AT97946875 T AT 97946875T AT 97946875 T AT97946875 T AT 97946875T AT E286044 T1 ATE286044 T1 AT E286044T1
- Authority
- AT
- Austria
- Prior art keywords
- protein transferase
- farnesyl protein
- inhibiting action
- tricyclic compounds
- transferase inhibiting
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 102000004357 Transferases Human genes 0.000 title abstract 2
- 108090000992 Transferases Proteins 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- JXBSHSBNOVLGHF-BUJBXKITSA-N (6E,10E)-2,6,10-trimethyldodeca-2,6,10-triene Chemical compound C\C=C(/C)CC\C=C(/C)CCC=C(C)C JXBSHSBNOVLGHF-BUJBXKITSA-N 0.000 title 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71329796A | 1996-09-13 | 1996-09-13 | |
| US87745397A | 1997-06-17 | 1997-06-17 | |
| PCT/US1997/019976 WO1998011091A2 (en) | 1996-09-13 | 1997-09-11 | Tricyclic compounds useful for inhibition of farnesyl protein transferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE286044T1 true ATE286044T1 (de) | 2005-01-15 |
Family
ID=27108965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97946875T ATE286044T1 (de) | 1996-09-13 | 1997-09-11 | Trizyklische verbindungen mit farnesyl protein transferase inhibierender wirkung |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0934303B1 (de) |
| JP (1) | JP2001500515A (de) |
| KR (1) | KR20000036110A (de) |
| CN (1) | CN1237164A (de) |
| AT (1) | ATE286044T1 (de) |
| AU (1) | AU5196698A (de) |
| BR (1) | BR9712980A (de) |
| CA (1) | CA2266014A1 (de) |
| CZ (1) | CZ84599A3 (de) |
| DE (1) | DE69732123T2 (de) |
| ES (1) | ES2234036T3 (de) |
| ID (1) | ID21577A (de) |
| IL (1) | IL128951A0 (de) |
| NO (1) | NO991235L (de) |
| NZ (1) | NZ334454A (de) |
| PL (1) | PL332192A1 (de) |
| SK (1) | SK33699A3 (de) |
| TR (1) | TR199901275T2 (de) |
| WO (1) | WO1998011091A2 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6524832B1 (en) | 1994-02-04 | 2003-02-25 | Arch Development Corporation | DNA damaging agents in combination with tyrosine kinase inhibitors |
| CN1267291A (zh) * | 1997-06-17 | 2000-09-20 | 先灵公司 | 新的n－取代的脲的法呢基蛋白转移酶抑制剂 |
| US5939416A (en) | 1997-06-17 | 1999-08-17 | Schering Corporation | Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors |
| US6358968B1 (en) | 1997-06-17 | 2002-03-19 | Schering Corporation | N-substituted urea inhibitors of farnesyl-protein transferase |
| JP2002519376A (ja) | 1998-07-02 | 2002-07-02 | メルク エンド カムパニー インコーポレーテッド | プレニル蛋白トランスフェラーゼ阻害薬 |
| US6410534B1 (en) | 1998-07-02 | 2002-06-25 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| US6316462B1 (en) | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
| WO2001051128A1 (en) | 2000-01-12 | 2001-07-19 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| WO2001051126A1 (en) | 2000-01-12 | 2001-07-19 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| AU2001227756A1 (en) | 2000-01-12 | 2001-07-24 | Merck And Co., Inc. | Inhibitors of prenyl-protein transferase |
| AU2001251445A1 (en) | 2000-04-10 | 2001-10-23 | Merck And Co., Inc. | Inhibitors of prenyl-protein transferase |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| KR920014799A (ko) * | 1991-01-18 | 1992-08-25 | 나오가따 다이도 | 신규벤조[5,6]시클로헵타[1,2-b]피리딘 유도체 및 이를 함유하는 항알레르기제 |
| ES2164717T3 (es) * | 1993-10-15 | 2002-03-01 | Schering Corp | Compuestos triciclicos de sulfonamida utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas. |
| EP0723538B1 (de) * | 1993-10-15 | 2001-12-12 | Schering Corporation | Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| US5700806A (en) * | 1995-03-24 | 1997-12-23 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| WO1997023478A1 (en) * | 1995-12-22 | 1997-07-03 | Schering Corporation | Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases |
-
1997
- 1997-09-11 AU AU51966/98A patent/AU5196698A/en not_active Abandoned
- 1997-09-11 BR BR9712980-1A patent/BR9712980A/pt unknown
- 1997-09-11 EP EP97946875A patent/EP0934303B1/de not_active Expired - Lifetime
- 1997-09-11 AT AT97946875T patent/ATE286044T1/de not_active IP Right Cessation
- 1997-09-11 WO PCT/US1997/019976 patent/WO1998011091A2/en not_active Ceased
- 1997-09-11 JP JP10514032A patent/JP2001500515A/ja not_active Ceased
- 1997-09-11 SK SK336-99A patent/SK33699A3/sk unknown
- 1997-09-11 ES ES97946875T patent/ES2234036T3/es not_active Expired - Lifetime
- 1997-09-11 CN CN97199597A patent/CN1237164A/zh active Pending
- 1997-09-11 NZ NZ334454A patent/NZ334454A/xx unknown
- 1997-09-11 DE DE69732123T patent/DE69732123T2/de not_active Expired - Lifetime
- 1997-09-11 PL PL97332192A patent/PL332192A1/xx unknown
- 1997-09-11 TR TR1999/01275T patent/TR199901275T2/xx unknown
- 1997-09-11 IL IL12895197A patent/IL128951A0/xx unknown
- 1997-09-11 KR KR1019997002133A patent/KR20000036110A/ko not_active Withdrawn
- 1997-09-11 ID IDW990085A patent/ID21577A/id unknown
- 1997-09-11 CZ CZ99845A patent/CZ84599A3/cs unknown
- 1997-09-11 CA CA002266014A patent/CA2266014A1/en not_active Abandoned
-
1999
- 1999-03-12 NO NO991235A patent/NO991235L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL128951A0 (en) | 2000-02-17 |
| AU5196698A (en) | 1998-04-02 |
| EP0934303A2 (de) | 1999-08-11 |
| ID21577A (id) | 1999-06-24 |
| WO1998011091A3 (en) | 1998-06-11 |
| WO1998011091A2 (en) | 1998-03-19 |
| CN1237164A (zh) | 1999-12-01 |
| EP0934303B1 (de) | 2004-12-29 |
| NZ334454A (en) | 2000-08-25 |
| SK33699A3 (en) | 2000-03-13 |
| CZ84599A3 (cs) | 1999-07-14 |
| BR9712980A (pt) | 2000-04-18 |
| TR199901275T2 (xx) | 1999-09-21 |
| PL332192A1 (en) | 1999-08-30 |
| DE69732123T2 (de) | 2005-12-08 |
| KR20000036110A (ko) | 2000-06-26 |
| CA2266014A1 (en) | 1998-03-19 |
| NO991235D0 (no) | 1999-03-12 |
| ES2234036T3 (es) | 2005-06-16 |
| NO991235L (no) | 1999-05-10 |
| DE69732123D1 (de) | 2005-02-03 |
| JP2001500515A (ja) | 2001-01-16 |
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| Publication | Publication Date | Title |
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| NO991234D0 (no) | Trisykliske inhibitorer av farnesylproteintransferase | |
| DE69731544D1 (de) | Trizyklische antitumor verbindungen mit farnesyl protein transferase inhibierender wirkung | |
| ATE286044T1 (de) | Trizyklische verbindungen mit farnesyl protein transferase inhibierender wirkung | |
| DE69709774D1 (de) | Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren | |
| NO991231D0 (no) | Forbindelser for inhibering av farnesylproteintransferase | |
| ID22002A (id) | Derivatif benzosikloheptapiridin tersubstitusi yang berguna untuk penghalangan transferase protein farnesil |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |