ZA985205B - Novel n-substituted urea inhibitors of arnesyl-protein transferase - Google Patents
Novel n-substituted urea inhibitors of arnesyl-protein transferaseInfo
- Publication number
- ZA985205B ZA985205B ZA985205A ZA985205A ZA985205B ZA 985205 B ZA985205 B ZA 985205B ZA 985205 A ZA985205 A ZA 985205A ZA 985205 A ZA985205 A ZA 985205A ZA 985205 B ZA985205 B ZA 985205B
- Authority
- ZA
- South Africa
- Prior art keywords
- arnesyl
- novel
- protein transferase
- substituted urea
- urea inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87704997A | 1997-06-17 | 1997-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA985205B true ZA985205B (en) | 1998-12-15 |
Family
ID=25369144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA985205A ZA985205B (en) | 1997-06-17 | 1998-06-15 | Novel n-substituted urea inhibitors of arnesyl-protein transferase |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0989979A1 (en) |
| JP (1) | JP2002506444A (en) |
| KR (1) | KR20010013881A (en) |
| CN (1) | CN1267291A (en) |
| AR (1) | AR013094A1 (en) |
| AU (1) | AU8253598A (en) |
| CA (1) | CA2293706C (en) |
| CO (1) | CO4940458A1 (en) |
| HU (1) | HUP0002954A3 (en) |
| IL (1) | IL133389A0 (en) |
| NZ (1) | NZ501571A (en) |
| PE (1) | PE82799A1 (en) |
| WO (1) | WO1998057948A1 (en) |
| ZA (1) | ZA985205B (en) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7342016B2 (en) | 2000-08-30 | 2008-03-11 | Schering Corporation | Farnesyl protein transferase inhibitors as antitumor agents |
| AU2002211427A1 (en) * | 2000-10-05 | 2002-04-15 | Whitehead Institute For Biomedical Research | Effects of combined administration of farnesyl transferase inhibitors and signal transduction inhibitors |
| CA2424797C (en) | 2000-10-05 | 2009-12-29 | George Q. Daley | Methods of inducing cancer cell death and tumor regression |
| WO2005058823A1 (en) * | 2003-12-17 | 2005-06-30 | Takeda Pharmaceutical Company Limited | Urea derivative, process for producing the same, and use |
| US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
| JP6473133B2 (en) * | 2013-03-15 | 2019-02-20 | アラクセス ファーマ エルエルシー | Covalent inhibitor of KRASG12C |
| US9745319B2 (en) | 2013-03-15 | 2017-08-29 | Araxes Pharma Llc | Irreversible covalent inhibitors of the GTPase K-Ras G12C |
| JO3805B1 (en) | 2013-10-10 | 2021-01-31 | Araxes Pharma Llc | Inhibitors of kras g12c |
| JO3556B1 (en) | 2014-09-18 | 2020-07-05 | Araxes Pharma Llc | Combination therapies for treatment of cancer |
| US10011600B2 (en) | 2014-09-25 | 2018-07-03 | Araxes Pharma Llc | Methods and compositions for inhibition of Ras |
| JP2017528498A (en) | 2014-09-25 | 2017-09-28 | アラクセス ファーマ エルエルシー | Inhibitors of KRAS G12C mutant protein |
| CN107849022A (en) | 2015-04-10 | 2018-03-27 | 亚瑞克西斯制药公司 | Substituted quinazoline compound and its application method |
| EP3283462B1 (en) | 2015-04-15 | 2020-12-02 | Araxes Pharma LLC | Fused-tricyclic inhibitors of kras and methods of use thereof |
| US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
| WO2017058728A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| US10975071B2 (en) | 2015-09-28 | 2021-04-13 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| EP3356347A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| EP3356351A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| EP3356354A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| WO2017058792A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| US10689356B2 (en) | 2015-09-28 | 2020-06-23 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| WO2017070256A2 (en) | 2015-10-19 | 2017-04-27 | Araxes Pharma Llc | Method for screening inhibitors of ras |
| US10414757B2 (en) | 2015-11-16 | 2019-09-17 | Araxes Pharma Llc | 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof |
| US9988357B2 (en) | 2015-12-09 | 2018-06-05 | Araxes Pharma Llc | Methods for preparation of quinazoline derivatives |
| WO2017172979A1 (en) | 2016-03-30 | 2017-10-05 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use |
| US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
| CN110036010A (en) | 2016-09-29 | 2019-07-19 | 亚瑞克西斯制药公司 | The inhibitor of KRAS G12C mutain |
| CN110312711A (en) | 2016-10-07 | 2019-10-08 | 亚瑞克西斯制药公司 | Heterocyclic compound and its application method as RAS inhibitor |
| US11358959B2 (en) | 2017-01-26 | 2022-06-14 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| EP3573970A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer |
| US11279689B2 (en) | 2017-01-26 | 2022-03-22 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer |
| WO2018140512A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| CN110382482A (en) | 2017-01-26 | 2019-10-25 | 亚瑞克西斯制药公司 | Condensed miscellaneous-Heterobicyclic compounds and its application method |
| TW201906832A (en) | 2017-05-25 | 2019-02-16 | 美商亞瑞克西斯製藥公司 | Compounds for cancer treatment and methods of use thereof |
| EP3630747A1 (en) | 2017-05-25 | 2020-04-08 | Araxes Pharma LLC | Quinazoline derivatives as modulators of mutant kras, hras or nras |
| CN110869358A (en) | 2017-05-25 | 2020-03-06 | 亚瑞克西斯制药公司 | Covalent inhibitors of KRAS |
| CN111960990A (en) * | 2020-07-23 | 2020-11-20 | 宿迁联盛科技股份有限公司 | Auxiliary agent and preparation method thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Pharmaceutical compositions for inhibition of g-protein function and for treatment of proliferative diseases containing tricyclic compounds some such compounds and process for preparing part of them |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases and pharmaceutical compositions comprising them |
| JP3193725B2 (en) * | 1995-12-22 | 2001-07-30 | シェーリング コーポレイション | G-Tricyclic amides useful for inhibiting protein function and treating proliferative diseases |
| ATE286044T1 (en) * | 1996-09-13 | 2005-01-15 | Schering Corp | TRICYCLIC COMPOUNDS WITH FARNESYL PROTEIN TRANSFERASE INHIBITING ACTION |
| IL128929A0 (en) * | 1996-09-13 | 2000-02-17 | Schering Corp | Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase |
-
1998
- 1998-06-15 CA CA002293706A patent/CA2293706C/en not_active Expired - Fee Related
- 1998-06-15 NZ NZ501571A patent/NZ501571A/en unknown
- 1998-06-15 EP EP98932717A patent/EP0989979A1/en not_active Withdrawn
- 1998-06-15 PE PE1998000506A patent/PE82799A1/en not_active Application Discontinuation
- 1998-06-15 KR KR1019997011903A patent/KR20010013881A/en not_active Application Discontinuation
- 1998-06-15 IL IL13338998A patent/IL133389A0/en unknown
- 1998-06-15 AU AU82535/98A patent/AU8253598A/en not_active Abandoned
- 1998-06-15 ZA ZA985205A patent/ZA985205B/en unknown
- 1998-06-15 WO PCT/US1998/011507 patent/WO1998057948A1/en not_active Application Discontinuation
- 1998-06-15 JP JP50450299A patent/JP2002506444A/en not_active Ceased
- 1998-06-15 HU HU0002954A patent/HUP0002954A3/en unknown
- 1998-06-15 CN CN98808189A patent/CN1267291A/en active Pending
- 1998-06-16 CO CO98034144A patent/CO4940458A1/en unknown
- 1998-06-16 AR ARP980102858A patent/AR013094A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0989979A1 (en) | 2000-04-05 |
| IL133389A0 (en) | 2001-04-30 |
| JP2002506444A (en) | 2002-02-26 |
| CA2293706C (en) | 2008-11-18 |
| AR013094A1 (en) | 2000-12-13 |
| PE82799A1 (en) | 1999-08-26 |
| CN1267291A (en) | 2000-09-20 |
| WO1998057948A1 (en) | 1998-12-23 |
| CO4940458A1 (en) | 2000-07-24 |
| NZ501571A (en) | 2002-02-01 |
| AU8253598A (en) | 1999-01-04 |
| KR20010013881A (en) | 2001-02-26 |
| HUP0002954A3 (en) | 2002-11-28 |
| HUP0002954A2 (en) | 2001-06-28 |
| CA2293706A1 (en) | 1998-12-23 |
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