DE69809238T2 - Verbindungen als farnesyl-protein transferase inhibitoren - Google Patents
Verbindungen als farnesyl-protein transferase inhibitorenInfo
- Publication number
- DE69809238T2 DE69809238T2 DE69809238T DE69809238T DE69809238T2 DE 69809238 T2 DE69809238 T2 DE 69809238T2 DE 69809238 T DE69809238 T DE 69809238T DE 69809238 T DE69809238 T DE 69809238T DE 69809238 T2 DE69809238 T2 DE 69809238T2
- Authority
- DE
- Germany
- Prior art keywords
- protein transferase
- connections
- farnesyl protein
- transferase inhibitor
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87773997A | 1997-06-17 | 1997-06-17 | |
PCT/US1998/011494 WO1998057955A1 (en) | 1997-06-17 | 1998-06-15 | Compounds useful for inhibition of farnesyl protein transferase |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69809238D1 DE69809238D1 (de) | 2002-12-12 |
DE69809238T2 true DE69809238T2 (de) | 2003-09-18 |
Family
ID=25370613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69809238T Expired - Lifetime DE69809238T2 (de) | 1997-06-17 | 1998-06-15 | Verbindungen als farnesyl-protein transferase inhibitoren |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0993459B1 (de) |
JP (1) | JP2002504143A (de) |
KR (1) | KR20010013953A (de) |
CN (1) | CN1286690A (de) |
AT (1) | ATE227281T1 (de) |
AU (1) | AU7815198A (de) |
CA (1) | CA2294351C (de) |
DE (1) | DE69809238T2 (de) |
ES (1) | ES2182324T3 (de) |
HK (1) | HK1024686A1 (de) |
HU (1) | HUP0002186A3 (de) |
IL (1) | IL133447A0 (de) |
NZ (1) | NZ501617A (de) |
WO (1) | WO1998057955A1 (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110483384B (zh) * | 2018-05-14 | 2021-05-14 | 新发药业有限公司 | 一种3,5-二卤代-4-吡啶酮-1-乙酸的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
DK0723538T3 (da) * | 1993-10-15 | 2002-03-18 | Schering Corp | Tricykliske carbamatforbindelser, der er nyttige til inhibition af funktion af G-protein og til behandling af proliferative sygdomme |
IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
KR20000036111A (ko) * | 1996-09-13 | 2000-06-26 | 둘락 노먼 씨. | 파네실 단백질 트랜스페라제 억제제인 트리사이클릭 항종양성화합물 |
-
1998
- 1998-06-15 KR KR1019997011979A patent/KR20010013953A/ko not_active Application Discontinuation
- 1998-06-15 IL IL13344798A patent/IL133447A0/xx unknown
- 1998-06-15 HU HU0002186A patent/HUP0002186A3/hu unknown
- 1998-06-15 NZ NZ501617A patent/NZ501617A/en unknown
- 1998-06-15 ES ES98926276T patent/ES2182324T3/es not_active Expired - Lifetime
- 1998-06-15 AU AU78151/98A patent/AU7815198A/en not_active Abandoned
- 1998-06-15 CA CA002294351A patent/CA2294351C/en not_active Expired - Fee Related
- 1998-06-15 JP JP50448999A patent/JP2002504143A/ja not_active Ceased
- 1998-06-15 EP EP98926276A patent/EP0993459B1/de not_active Expired - Lifetime
- 1998-06-15 DE DE69809238T patent/DE69809238T2/de not_active Expired - Lifetime
- 1998-06-15 CN CN98808207A patent/CN1286690A/zh active Pending
- 1998-06-15 AT AT98926276T patent/ATE227281T1/de not_active IP Right Cessation
- 1998-06-15 WO PCT/US1998/011494 patent/WO1998057955A1/en not_active Application Discontinuation
-
2000
- 2000-04-20 HK HK00102386A patent/HK1024686A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0993459B1 (de) | 2002-11-06 |
EP0993459A1 (de) | 2000-04-19 |
HK1024686A1 (en) | 2000-10-20 |
DE69809238D1 (de) | 2002-12-12 |
CA2294351A1 (en) | 1998-12-23 |
WO1998057955A1 (en) | 1998-12-23 |
JP2002504143A (ja) | 2002-02-05 |
NZ501617A (en) | 2001-09-28 |
AU7815198A (en) | 1999-01-04 |
IL133447A0 (en) | 2001-04-30 |
HUP0002186A2 (hu) | 2001-04-28 |
ATE227281T1 (de) | 2002-11-15 |
KR20010013953A (ko) | 2001-02-26 |
CN1286690A (zh) | 2001-03-07 |
ES2182324T3 (es) | 2003-03-01 |
HUP0002186A3 (en) | 2002-04-29 |
CA2294351C (en) | 2008-09-02 |
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Publication | Publication Date | Title |
---|---|---|
NO991234D0 (no) | Trisykliske inhibitorer av farnesylproteintransferase | |
ATE242216T1 (de) | Tricyclische verbindungen als inhibitoren von farnesyl protein transferase | |
DE69709774D1 (de) | Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren | |
NO991235D0 (no) | Forbindelser anvendelige for inhibering av farnesylproteintransferase | |
DE69809238T2 (de) | Verbindungen als farnesyl-protein transferase inhibitoren | |
IL133392A0 (en) | Benzo (5, 6) cyclohepta (1, 2b) pyridine derivatives useful for inhibition of farnesyl protein transferase | |
DE69805619D1 (en) | Benzo[5,6]cyclohepta[1,2-b]pyridin derivate als farnesyl protein transferase inhibitoren | |
ATE281450T1 (de) | Verbindungen als inhibitoren von farnesylprotein- transferase | |
DE69724130D1 (de) | Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl protein transferase inhibitoren |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |