IL133447A0 - Compounds useful for inhibition of farnesyl protein transferase - Google Patents

Compounds useful for inhibition of farnesyl protein transferase

Info

Publication number
IL133447A0
IL133447A0 IL13344798A IL13344798A IL133447A0 IL 133447 A0 IL133447 A0 IL 133447A0 IL 13344798 A IL13344798 A IL 13344798A IL 13344798 A IL13344798 A IL 13344798A IL 133447 A0 IL133447 A0 IL 133447A0
Authority
IL
Israel
Prior art keywords
protein transferase
inhibition
farnesyl protein
compounds useful
formula
Prior art date
Application number
IL13344798A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of IL133447A0 publication Critical patent/IL133447A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
IL13344798A 1997-06-17 1998-06-15 Compounds useful for inhibition of farnesyl protein transferase IL133447A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87773997A 1997-06-17 1997-06-17
PCT/US1998/011494 WO1998057955A1 (en) 1997-06-17 1998-06-15 Compounds useful for inhibition of farnesyl protein transferase

Publications (1)

Publication Number Publication Date
IL133447A0 true IL133447A0 (en) 2001-04-30

Family

ID=25370613

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13344798A IL133447A0 (en) 1997-06-17 1998-06-15 Compounds useful for inhibition of farnesyl protein transferase

Country Status (14)

Country Link
EP (1) EP0993459B1 (de)
JP (1) JP2002504143A (de)
KR (1) KR20010013953A (de)
CN (1) CN1286690A (de)
AT (1) ATE227281T1 (de)
AU (1) AU7815198A (de)
CA (1) CA2294351C (de)
DE (1) DE69809238T2 (de)
ES (1) ES2182324T3 (de)
HK (1) HK1024686A1 (de)
HU (1) HUP0002186A3 (de)
IL (1) IL133447A0 (de)
NZ (1) NZ501617A (de)
WO (1) WO1998057955A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110483384B (zh) * 2018-05-14 2021-05-14 新发药业有限公司 一种3,5-二卤代-4-吡啶酮-1-乙酸的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
CA2174105C (en) * 1993-10-15 2002-02-12 W. Robert Bishop Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
WO1998011092A1 (en) * 1996-09-13 1998-03-19 Schering Corporation Tricyclic antitumor compounds being farnesyl protein transferase inhibitors

Also Published As

Publication number Publication date
ES2182324T3 (es) 2003-03-01
CA2294351A1 (en) 1998-12-23
EP0993459A1 (de) 2000-04-19
AU7815198A (en) 1999-01-04
CN1286690A (zh) 2001-03-07
HUP0002186A2 (hu) 2001-04-28
JP2002504143A (ja) 2002-02-05
WO1998057955A1 (en) 1998-12-23
CA2294351C (en) 2008-09-02
EP0993459B1 (de) 2002-11-06
DE69809238D1 (de) 2002-12-12
NZ501617A (en) 2001-09-28
HK1024686A1 (en) 2000-10-20
HUP0002186A3 (en) 2002-04-29
DE69809238T2 (de) 2003-09-18
KR20010013953A (ko) 2001-02-26
ATE227281T1 (de) 2002-11-15

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