DE69809238D1 - Verbindungen als farnesyl-protein transferase inhibitoren - Google Patents

Verbindungen als farnesyl-protein transferase inhibitoren

Info

Publication number
DE69809238D1
DE69809238D1 DE69809238T DE69809238T DE69809238D1 DE 69809238 D1 DE69809238 D1 DE 69809238D1 DE 69809238 T DE69809238 T DE 69809238T DE 69809238 T DE69809238 T DE 69809238T DE 69809238 D1 DE69809238 D1 DE 69809238D1
Authority
DE
Germany
Prior art keywords
protein transferase
connections
farnesyl protein
transferase inhibitor
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69809238T
Other languages
English (en)
Other versions
DE69809238T2 (de
Inventor
W Remiszewski
J Doll
Carmen Alvarez
Tarik Lalwani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69809238D1 publication Critical patent/DE69809238D1/de
Application granted granted Critical
Publication of DE69809238T2 publication Critical patent/DE69809238T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Materials For Medical Uses (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69809238T 1997-06-17 1998-06-15 Verbindungen als farnesyl-protein transferase inhibitoren Expired - Lifetime DE69809238T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87773997A 1997-06-17 1997-06-17
PCT/US1998/011494 WO1998057955A1 (en) 1997-06-17 1998-06-15 Compounds useful for inhibition of farnesyl protein transferase

Publications (2)

Publication Number Publication Date
DE69809238D1 true DE69809238D1 (de) 2002-12-12
DE69809238T2 DE69809238T2 (de) 2003-09-18

Family

ID=25370613

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69809238T Expired - Lifetime DE69809238T2 (de) 1997-06-17 1998-06-15 Verbindungen als farnesyl-protein transferase inhibitoren

Country Status (14)

Country Link
EP (1) EP0993459B1 (de)
JP (1) JP2002504143A (de)
KR (1) KR20010013953A (de)
CN (1) CN1286690A (de)
AT (1) ATE227281T1 (de)
AU (1) AU7815198A (de)
CA (1) CA2294351C (de)
DE (1) DE69809238T2 (de)
ES (1) ES2182324T3 (de)
HK (1) HK1024686A1 (de)
HU (1) HUP0002186A3 (de)
IL (1) IL133447A0 (de)
NZ (1) NZ501617A (de)
WO (1) WO1998057955A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110483384B (zh) * 2018-05-14 2021-05-14 新发药业有限公司 一种3,5-二卤代-4-吡啶酮-1-乙酸的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
TW308594B (de) * 1993-10-15 1997-06-21 Schering Corp
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
KR20000036111A (ko) * 1996-09-13 2000-06-26 둘락 노먼 씨. 파네실 단백질 트랜스페라제 억제제인 트리사이클릭 항종양성화합물

Also Published As

Publication number Publication date
KR20010013953A (ko) 2001-02-26
JP2002504143A (ja) 2002-02-05
DE69809238T2 (de) 2003-09-18
ATE227281T1 (de) 2002-11-15
HUP0002186A2 (hu) 2001-04-28
CA2294351C (en) 2008-09-02
WO1998057955A1 (en) 1998-12-23
ES2182324T3 (es) 2003-03-01
EP0993459B1 (de) 2002-11-06
HK1024686A1 (en) 2000-10-20
NZ501617A (en) 2001-09-28
IL133447A0 (en) 2001-04-30
CA2294351A1 (en) 1998-12-23
EP0993459A1 (de) 2000-04-19
CN1286690A (zh) 2001-03-07
AU7815198A (en) 1999-01-04
HUP0002186A3 (en) 2002-04-29

Similar Documents

Publication Publication Date Title
NO991234D0 (no) Trisykliske inhibitorer av farnesylproteintransferase
ATE242216T1 (de) Tricyclische verbindungen als inhibitoren von farnesyl protein transferase
DE69709774D1 (de) Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl-protein transferase inhibitoren
NO991235L (no) Forbindelser anvendelige for inhibering av farnesylproteintransferase
DE69809238D1 (de) Verbindungen als farnesyl-protein transferase inhibitoren
IL133392A0 (en) Benzo (5, 6) cyclohepta (1, 2b) pyridine derivatives useful for inhibition of farnesyl protein transferase
DE69805619D1 (en) Benzo[5,6]cyclohepta[1,2-b]pyridin derivate als farnesyl protein transferase inhibitoren
DE69731481D1 (de) Verbindungen als inhibitoren von farnesylprotein-transferase
DE69724130D1 (de) Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl protein transferase inhibitoren

Legal Events

Date Code Title Description
8364 No opposition during term of opposition