HUP0002186A3 - Compounds useful for inhibition of farnesyl protein transferase - Google Patents
Compounds useful for inhibition of farnesyl protein transferaseInfo
- Publication number
- HUP0002186A3 HUP0002186A3 HU0002186A HUP0002186A HUP0002186A3 HU P0002186 A3 HUP0002186 A3 HU P0002186A3 HU 0002186 A HU0002186 A HU 0002186A HU P0002186 A HUP0002186 A HU P0002186A HU P0002186 A3 HUP0002186 A3 HU P0002186A3
- Authority
- HU
- Hungary
- Prior art keywords
- inhibition
- compounds useful
- protein transferase
- farnesyl protein
- farnesyl
- Prior art date
Links
- 102000004357 Transferases Human genes 0.000 title 1
- 108090000992 Transferases Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87773997A | 1997-06-17 | 1997-06-17 | |
| PCT/US1998/011494 WO1998057955A1 (en) | 1997-06-17 | 1998-06-15 | Compounds useful for inhibition of farnesyl protein transferase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0002186A2 HUP0002186A2 (hu) | 2001-04-28 |
| HUP0002186A3 true HUP0002186A3 (en) | 2002-04-29 |
Family
ID=25370613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002186A HUP0002186A3 (en) | 1997-06-17 | 1998-06-15 | Compounds useful for inhibition of farnesyl protein transferase |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0993459B1 (hu) |
| JP (1) | JP2002504143A (hu) |
| KR (1) | KR20010013953A (hu) |
| CN (1) | CN1286690A (hu) |
| AT (1) | ATE227281T1 (hu) |
| AU (1) | AU7815198A (hu) |
| CA (1) | CA2294351C (hu) |
| DE (1) | DE69809238T2 (hu) |
| ES (1) | ES2182324T3 (hu) |
| HK (1) | HK1024686A1 (hu) |
| HU (1) | HUP0002186A3 (hu) |
| IL (1) | IL133447A0 (hu) |
| NZ (1) | NZ501617A (hu) |
| WO (1) | WO1998057955A1 (hu) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110483384B (zh) * | 2018-05-14 | 2021-05-14 | 新发药业有限公司 | 一种3,5-二卤代-4-吡啶酮-1-乙酸的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| WO1995010515A1 (en) * | 1993-10-15 | 1995-04-20 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| IL128931A0 (en) * | 1996-09-13 | 2000-02-17 | Schering Corp | Tricylic antitumor compounds being farnesyl protein transferase inhibitors |
-
1998
- 1998-06-15 EP EP98926276A patent/EP0993459B1/en not_active Expired - Lifetime
- 1998-06-15 NZ NZ501617A patent/NZ501617A/en unknown
- 1998-06-15 HU HU0002186A patent/HUP0002186A3/hu unknown
- 1998-06-15 KR KR1019997011979A patent/KR20010013953A/ko not_active Application Discontinuation
- 1998-06-15 IL IL13344798A patent/IL133447A0/xx unknown
- 1998-06-15 JP JP50448999A patent/JP2002504143A/ja not_active Ceased
- 1998-06-15 AT AT98926276T patent/ATE227281T1/de not_active IP Right Cessation
- 1998-06-15 AU AU78151/98A patent/AU7815198A/en not_active Abandoned
- 1998-06-15 CA CA002294351A patent/CA2294351C/en not_active Expired - Fee Related
- 1998-06-15 CN CN98808207A patent/CN1286690A/zh active Pending
- 1998-06-15 ES ES98926276T patent/ES2182324T3/es not_active Expired - Lifetime
- 1998-06-15 WO PCT/US1998/011494 patent/WO1998057955A1/en not_active Application Discontinuation
- 1998-06-15 DE DE69809238T patent/DE69809238T2/de not_active Expired - Lifetime
-
2000
- 2000-04-20 HK HK00102386A patent/HK1024686A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1024686A1 (en) | 2000-10-20 |
| AU7815198A (en) | 1999-01-04 |
| ATE227281T1 (de) | 2002-11-15 |
| HUP0002186A2 (hu) | 2001-04-28 |
| IL133447A0 (en) | 2001-04-30 |
| DE69809238D1 (de) | 2002-12-12 |
| CA2294351C (en) | 2008-09-02 |
| JP2002504143A (ja) | 2002-02-05 |
| WO1998057955A1 (en) | 1998-12-23 |
| CN1286690A (zh) | 2001-03-07 |
| KR20010013953A (ko) | 2001-02-26 |
| CA2294351A1 (en) | 1998-12-23 |
| ES2182324T3 (es) | 2003-03-01 |
| NZ501617A (en) | 2001-09-28 |
| EP0993459A1 (en) | 2000-04-19 |
| DE69809238T2 (de) | 2003-09-18 |
| EP0993459B1 (en) | 2002-11-06 |
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