ES2047007T3 - Procedimiento para el aislamiento de proteinas basicas a partir de mezclas de proteinas. - Google Patents

Procedimiento para el aislamiento de proteinas basicas a partir de mezclas de proteinas.

Info

Publication number
ES2047007T3
ES2047007T3 ES88112661T ES88112661T ES2047007T3 ES 2047007 T3 ES2047007 T3 ES 2047007T3 ES 88112661 T ES88112661 T ES 88112661T ES 88112661 T ES88112661 T ES 88112661T ES 2047007 T3 ES2047007 T3 ES 2047007T3
Authority
ES
Spain
Prior art keywords
basic proteins
isolation
procedure
protein mixtures
southern
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88112661T
Other languages
English (en)
Inventor
Michael Dr Dorschug
Rainer Dr Obermeier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2047007T3 publication Critical patent/ES2047007T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LAS PROTEINAS BASICAS SE AISLAN DE MEZCLAS PROTEICAS QUE CONTIENEN PROTEINAS BASICAS Y QUE HAN SIDO CONSEGUIDOS MEDIANTE LA DIVISION ENZIMATICA DE PROINSULINAY/O DE SUS DERIVADOS DE ORIGEN NATURAL, SEMISINTETICO O DE INGENIERIA GENETICA, MEDIANTE CROMATOGRAFIA DE INTERCAMBIADORES DE CATIONES FUERTEMENTE ACIDOS.
ES88112661T 1987-08-11 1988-08-04 Procedimiento para el aislamiento de proteinas basicas a partir de mezclas de proteinas. Expired - Lifetime ES2047007T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873726655 DE3726655A1 (de) 1987-08-11 1987-08-11 Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten

Publications (1)

Publication Number Publication Date
ES2047007T3 true ES2047007T3 (es) 1994-02-16

Family

ID=6333496

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88112661T Expired - Lifetime ES2047007T3 (es) 1987-08-11 1988-08-04 Procedimiento para el aislamiento de proteinas basicas a partir de mezclas de proteinas.

Country Status (19)

Country Link
US (1) US5101013A (es)
EP (1) EP0305760B1 (es)
JP (1) JP2587867B2 (es)
KR (1) KR0129539B1 (es)
AT (1) ATE96447T1 (es)
AU (1) AU609170B2 (es)
CA (1) CA1340237C (es)
DE (2) DE3726655A1 (es)
DK (1) DK173502B1 (es)
ES (1) ES2047007T3 (es)
FI (1) FI91875C (es)
HU (1) HU198218B (es)
IE (1) IE61557B1 (es)
IL (1) IL87385A (es)
NO (1) NO175004C (es)
NZ (1) NZ225746A (es)
PH (1) PH26874A (es)
PT (1) PT88230B (es)
ZA (1) ZA885871B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0600372B1 (de) * 1992-12-02 1997-02-05 Hoechst Aktiengesellschaft Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken
DK0821006T3 (da) 1996-07-26 2004-08-16 Aventis Pharma Gmbh Insulinderivater med öget zinkbinding
DE19652713C2 (de) * 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
KR100341297B1 (ko) * 1997-03-29 2002-11-16 주식회사종근당 재조합활성형프로인슐린의분리.정제방법
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
ATE509028T1 (de) * 1999-03-15 2011-05-15 Novo Nordisk As Ionen-austausch-chromatographische trennung von glp-1 und verwandten peptiden
US6444788B1 (en) 1999-03-15 2002-09-03 Novo Nordisk A/S Ion exchange chromatography of GLP-1, analogs and derivatives thereof
US6451987B1 (en) * 1999-03-15 2002-09-17 Novo Nordisk A/S Ion exchange chromatography of proteins and peptides
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
US7193035B2 (en) * 2002-10-29 2007-03-20 Sanofi-Aventis Deutschland Gmbh Crystals of insulin analogs and processes for their preparation
SE0300791D0 (sv) * 2003-03-20 2003-03-20 Amersham Biosciences Ab Use of ph-responsive polymers
AU2004266757A1 (en) * 2003-08-21 2005-03-03 Novo Nordisk A/S Separation of polypeptides comprising a racemized amino acid
US7906069B2 (en) * 2005-08-04 2011-03-15 Toyo Seikan Kaisha, Ltd. Method for sterilizing a plastic bottle
EP3228320B1 (de) 2008-10-17 2019-12-18 Sanofi-Aventis Deutschland GmbH Kombination von einem insulin und einem glp-1-agonisten
EP3202394A1 (de) 2009-07-06 2017-08-09 Sanofi-Aventis Deutschland GmbH Wässrige insulinzubereitungen enthaltend methionin
FR2947818B1 (fr) * 2009-07-09 2011-07-29 Inst Superieur Des Sciences Agronomiques Agroalimentaires Horticoles Et Du Paysage Agro Campus Ouest Utilisation d'un coproduit issu d'un procede d'extraction du lysozyme a partir de blanc d'oeuf, pour l'obtention d'au moins une proteine basique de blanc d'oeuf
PE20121316A1 (es) 2009-11-13 2012-10-05 Sanofi Aventis Deutschland Composicion farmaceutica que comprende un agonista de glp-1 y metionina
PT2554183T (pt) 2009-11-13 2018-07-09 Sanofi Aventis Deutschland Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina
US20140148384A1 (en) 2010-08-30 2014-05-29 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
CN108079281A (zh) 2011-08-29 2018-05-29 赛诺菲-安万特德国有限公司 用于2型糖尿病患者中的血糖控制的药物组合
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
PL2748181T3 (pl) * 2011-09-30 2016-08-31 Ge Healthcare Bioprocess R&D Ab Sposób oczyszczania rozszczepionej proinsuliny
WO2014099577A1 (en) 2012-12-17 2014-06-26 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
US10407483B2 (en) 2014-03-14 2019-09-10 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
TWI758239B (zh) 2014-12-12 2022-03-21 德商賽諾菲阿凡提斯德意志有限公司 甘精胰島素/利司那肽固定比率配製劑
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
WO2018147393A1 (ja) * 2017-02-10 2018-08-16 三菱ケミカル株式会社 ヒトインスリン精製用分離剤及びヒトインスリンの精製方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2629568C3 (de) * 1976-07-01 1981-09-10 Hoechst Ag, 6000 Frankfurt Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten
NL7713966A (nl) * 1976-12-27 1978-06-29 Univ Minnesota Werkwijze voor het behandelen van insuline.
DK311477A (da) * 1977-07-08 1979-01-09 Leo Lab Fremgangsmaade ved fremstilling af rent insulin
US4459226A (en) * 1982-02-26 1984-07-10 Eli Lilly And Company Process for recovering insulin
DE3486216T2 (de) * 1983-04-25 1994-02-17 Chiron Corp Hybrid-DNS-Synthesis von reifen insulinähnlichen Wachstumsfaktoren.
DE3440988A1 (de) * 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
DE3511269A1 (de) * 1985-04-12 1986-10-09 Veb Berlin-Chemie, Ddr 1199 Berlin Verfahren zur reinigung von insulin
JPS6379591A (ja) * 1986-09-22 1988-04-09 Mitsui Toatsu Chem Inc ｔＰＡの精製方法
AU607988B2 (en) * 1987-04-21 1991-03-21 Southern Cross Biotech Pty Ltd. Production of proteins in active forms
ATE114668T1 (de) * 1988-10-26 1994-12-15 American Cyanamid Co Verfahren zur verringerung des aggregatinhaltes in wachstumshormonen gleichenden stoffen.

Also Published As

Publication number Publication date
AU609170B2 (en) 1991-04-26
IL87385A (en) 1993-08-18
JP2587867B2 (ja) 1997-03-05
EP0305760A2 (de) 1989-03-08
FI883708A0 (fi) 1988-08-09
FI91875B (fi) 1994-05-13
EP0305760B1 (de) 1993-10-27
NO175004B (no) 1994-05-09
HU198218B (en) 1989-08-28
NZ225746A (en) 1990-11-27
ATE96447T1 (de) 1993-11-15
ZA885871B (en) 1989-04-26
US5101013A (en) 1992-03-31
JPS6486896A (en) 1989-03-31
FI883708L (fi) 1989-02-12
DK447688A (da) 1989-02-12
PT88230A (pt) 1989-06-30
NO883554L (no) 1989-02-13
EP0305760A3 (en) 1990-06-06
KR0129539B1 (ko) 1998-04-04
IL87385A0 (en) 1989-01-31
PT88230B (pt) 1995-03-01
DE3726655A1 (de) 1989-02-23
KR890003799A (ko) 1989-04-18
IE61557B1 (en) 1994-11-16
PH26874A (en) 1992-11-16
NO883554D0 (no) 1988-08-10
NO175004C (no) 1994-08-17
AU2059188A (en) 1989-02-16
DE3885214D1 (de) 1993-12-02
DK447688D0 (da) 1988-08-10
FI91875C (fi) 1994-08-25
DK173502B1 (da) 2001-01-08
CA1340237C (en) 1998-12-15
HUT47958A (en) 1989-04-28
IE882441L (en) 1989-02-11

Similar Documents

Publication Publication Date Title
ES2047007T3 (es) Procedimiento para el aislamiento de proteinas basicas a partir de mezclas de proteinas.
NO880842L (no) Fremgangsmaate for flytendegjoering av naturgass.
EP0212474A3 (en) Bone morphogenetic peptides
ES2061512T3 (es) Polipeptidos de nor-estatina y nor-cicloestatina.
FI873364A0 (fi) Foerfarande foer framstaellning av ett sytotoxiskt laekemedel.
NO885670D0 (no) Fortilsetning og for som inneholder denne tilsetning.
NO880713D0 (no) Reguleringsanordning for gassturbiner.
SE8801701D0 (sv) Production technology based on enzymic method
ES2059436T3 (es) Proteina de la membrana exterior f de pseudomonas aeruginosa.
DE3876769D1 (de) Mikrobiologische herstellung von 9-alpha-hydroxy-17-keto-steroiden.
DE3887690D1 (de) Bewegliche gekühlte zelle für lebensmittel.
IL90220A0 (en) Anticoagulant peptide alcohols
DE3782560D1 (de) Hefestaemme zur expression fremder gene.
FI895844A0 (fi) Koagulation foerhindrande peptider.
ATE107361T1 (de) Gen des hüllproteins des gurkenmosaikvirus.
DE3865825D1 (de) Gasfeuerzeug.
DK623188A (da) Fremgangsmaade til inkubation af rekombinante proteinekspressionsceller
AU3186189A (en) Isolation of 24-R scymnol
AU8111091A (en) Analogs of hirudin having antiplatelet activity
IT1198443B (it) Espressione genetica di polipeptidi ibridi contenenti la sequenza della somatostatina
ES2182324T3 (es) Compuestos utiles para inhibir la farnesil-protein-transferasa.
KR890003215U (ko) 가스용기용 밸브의 물기 제거기
PT88764A (pt) Liquified gas lighter
DE3676725D1 (de) Schwefelhaltige pfropfprodukte.
KR890001041U (ko) 가스 콕장치

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 305760

Country of ref document: ES