PT88230A - Processo para o isolamento de proteinas basicas a partir de proteinas que as contem - Google Patents

Processo para o isolamento de proteinas basicas a partir de proteinas que as contem

Info

Publication number
PT88230A
PT88230A PT88230A PT8823088A PT88230A PT 88230 A PT88230 A PT 88230A PT 88230 A PT88230 A PT 88230A PT 8823088 A PT8823088 A PT 8823088A PT 88230 A PT88230 A PT 88230A
Authority
PT
Portugal
Prior art keywords
proteins
isolation
basic
basic proteins
clevage
Prior art date
Application number
PT88230A
Other languages
English (en)
Other versions
PT88230B (pt
Inventor
Michael Dorschug
Rainer Obermeier
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of PT88230A publication Critical patent/PT88230A/pt
Publication of PT88230B publication Critical patent/PT88230B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT88230A 1987-08-11 1988-08-10 Processo para o isolamento de proteinas basicas a partir de proteinas que as contem PT88230B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873726655 DE3726655A1 (de) 1987-08-11 1987-08-11 Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten

Publications (2)

Publication Number Publication Date
PT88230A true PT88230A (pt) 1989-06-30
PT88230B PT88230B (pt) 1995-03-01

Family

ID=6333496

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88230A PT88230B (pt) 1987-08-11 1988-08-10 Processo para o isolamento de proteinas basicas a partir de proteinas que as contem

Country Status (19)

Country Link
US (1) US5101013A (pt)
EP (1) EP0305760B1 (pt)
JP (1) JP2587867B2 (pt)
KR (1) KR0129539B1 (pt)
AT (1) ATE96447T1 (pt)
AU (1) AU609170B2 (pt)
CA (1) CA1340237C (pt)
DE (2) DE3726655A1 (pt)
DK (1) DK173502B1 (pt)
ES (1) ES2047007T3 (pt)
FI (1) FI91875C (pt)
HU (1) HU198218B (pt)
IE (1) IE61557B1 (pt)
IL (1) IL87385A (pt)
NO (1) NO175004C (pt)
NZ (1) NZ225746A (pt)
PH (1) PH26874A (pt)
PT (1) PT88230B (pt)
ZA (1) ZA885871B (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0600372B1 (de) * 1992-12-02 1997-02-05 Hoechst Aktiengesellschaft Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken
ES2218622T3 (es) 1996-07-26 2004-11-16 Aventis Pharma Deutschland Gmbh Derivados de insulina con actividad de union al zinc incrementada.
DE19652713C2 (de) * 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
KR100341297B1 (ko) * 1997-03-29 2002-11-16 주식회사종근당 재조합활성형프로인슐린의분리.정제방법
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
WO2000055203A1 (en) * 1999-03-15 2000-09-21 Novo Nordisk A/S Ion exchange chromatographic separation of glp-1 and related peptides
US6451987B1 (en) * 1999-03-15 2002-09-17 Novo Nordisk A/S Ion exchange chromatography of proteins and peptides
US6444788B1 (en) 1999-03-15 2002-09-03 Novo Nordisk A/S Ion exchange chromatography of GLP-1, analogs and derivatives thereof
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
US7193035B2 (en) * 2002-10-29 2007-03-20 Sanofi-Aventis Deutschland Gmbh Crystals of insulin analogs and processes for their preparation
SE0300791D0 (sv) * 2003-03-20 2003-03-20 Amersham Biosciences Ab Use of ph-responsive polymers
KR20060106812A (ko) * 2003-08-21 2006-10-12 노보 노르디스크 에이/에스 라세미화 아미노산을 포함하는 폴리펩티드의 분리
AU2006276442A1 (en) * 2005-08-04 2007-02-08 Toyo Seikan Kaisha, Ltd. Method for sterilization of plastic bottle
PT3228320T (pt) 2008-10-17 2020-03-26 Sanofi Aventis Deutschland Combinação de uma insulina e de um agonista do glp-1
FR2947818B1 (fr) * 2009-07-09 2011-07-29 Inst Superieur Des Sciences Agronomiques Agroalimentaires Horticoles Et Du Paysage Agro Campus Ouest Utilisation d'un coproduit issu d'un procede d'extraction du lysozyme a partir de blanc d'oeuf, pour l'obtention d'au moins une proteine basique de blanc d'oeuf
AU2010317994B2 (en) 2009-11-13 2014-03-06 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a GLP-1 agonist and methionine
MY180661A (en) 2009-11-13 2020-12-04 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine
US20140148384A1 (en) 2010-08-30 2014-05-29 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
BR112014004726A2 (pt) 2011-08-29 2017-04-04 Sanofi Aventis Deutschland combinação farmacêutica para uso no controle glicêmico em pacientes de diabetes tipo 2
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
CN103827136B (zh) 2011-09-30 2016-07-06 通用电气健康护理生物科学股份公司 纯化裂解的胰岛素原的方法
WO2014099577A1 (en) 2012-12-17 2014-06-26 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
US10407483B2 (en) 2014-03-14 2019-09-10 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
EP3229828B1 (en) 2014-12-12 2023-04-05 Sanofi-Aventis Deutschland GmbH Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
WO2018147393A1 (ja) * 2017-02-10 2018-08-16 三菱ケミカル株式会社 ヒトインスリン精製用分離剤及びヒトインスリンの精製方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2629568C3 (de) * 1976-07-01 1981-09-10 Hoechst Ag, 6000 Frankfurt Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten
NL7713966A (nl) * 1976-12-27 1978-06-29 Univ Minnesota Werkwijze voor het behandelen van insuline.
DK311477A (da) * 1977-07-08 1979-01-09 Leo Lab Fremgangsmaade ved fremstilling af rent insulin
US4459226A (en) * 1982-02-26 1984-07-10 Eli Lilly And Company Process for recovering insulin
DD247684A1 (de) * 1983-04-14 1987-07-15 Ulrich Krabiell Verfahren zur isolierung von insulinderivaten
EP0561137B1 (en) * 1983-04-25 2002-07-03 Chiron Corporation Hybrid DNA Synthesis of Mature Insulin-like Growth Factors
DE3440988A1 (de) * 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
DE3511269A1 (de) * 1985-04-12 1986-10-09 Veb Berlin-Chemie, Ddr 1199 Berlin Verfahren zur reinigung von insulin
JPS6379591A (ja) * 1986-09-22 1988-04-09 Mitsui Toatsu Chem Inc ｔＰＡの精製方法
AU607988B2 (en) * 1987-04-21 1991-03-21 Southern Cross Biotech Pty Ltd. Production of proteins in active forms
ATE114668T1 (de) * 1988-10-26 1994-12-15 American Cyanamid Co Verfahren zur verringerung des aggregatinhaltes in wachstumshormonen gleichenden stoffen.

Also Published As

Publication number Publication date
FI91875C (fi) 1994-08-25
NO175004B (no) 1994-05-09
NO883554L (no) 1989-02-13
KR0129539B1 (ko) 1998-04-04
EP0305760B1 (de) 1993-10-27
ATE96447T1 (de) 1993-11-15
CA1340237C (en) 1998-12-15
KR890003799A (ko) 1989-04-18
US5101013A (en) 1992-03-31
DK447688D0 (da) 1988-08-10
IE61557B1 (en) 1994-11-16
IL87385A0 (en) 1989-01-31
NZ225746A (en) 1990-11-27
PH26874A (en) 1992-11-16
DK173502B1 (da) 2001-01-08
JP2587867B2 (ja) 1997-03-05
DE3726655A1 (de) 1989-02-23
IE882441L (en) 1989-02-11
IL87385A (en) 1993-08-18
NO175004C (no) 1994-08-17
NO883554D0 (no) 1988-08-10
FI91875B (fi) 1994-05-13
ZA885871B (en) 1989-04-26
EP0305760A3 (en) 1990-06-06
AU609170B2 (en) 1991-04-26
HUT47958A (en) 1989-04-28
FI883708A0 (fi) 1988-08-09
HU198218B (en) 1989-08-28
DK447688A (da) 1989-02-12
EP0305760A2 (de) 1989-03-08
AU2059188A (en) 1989-02-16
JPS6486896A (en) 1989-03-31
PT88230B (pt) 1995-03-01
ES2047007T3 (es) 1994-02-16
DE3885214D1 (de) 1993-12-02
FI883708A (fi) 1989-02-12

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FG3A Patent granted, date of granting

Effective date: 19940809

PC3A Transfer or assignment

Free format text: 20010322 AVENTIS PHARMA DEUTSCHLAND GMBH DE

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

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Effective date: 20090809