PL2748181T3 - Sposób oczyszczania rozszczepionej proinsuliny - Google Patents

Sposób oczyszczania rozszczepionej proinsuliny

Info

Publication number
PL2748181T3
PL2748181T3 PL12837180T PL12837180T PL2748181T3 PL 2748181 T3 PL2748181 T3 PL 2748181T3 PL 12837180 T PL12837180 T PL 12837180T PL 12837180 T PL12837180 T PL 12837180T PL 2748181 T3 PL2748181 T3 PL 2748181T3
Authority
PL
Poland
Prior art keywords
insulin
purification
cleaved pro
cleaved
pro
Prior art date
Application number
PL12837180T
Other languages
English (en)
Inventor
Eggert Brekkan
Kjell Eriksson
Bo-Lennart Johansson
Jamil Shanagar
Original Assignee
Ge Healthcare Bioprocess R&D Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Bioprocess R&D Ab filed Critical Ge Healthcare Bioprocess R&D Ab
Publication of PL2748181T3 publication Critical patent/PL2748181T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/288—Polar phases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3291—Characterised by the shape of the carrier, the coating or the obtained coated product
    • B01J20/3293—Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL12837180T 2011-09-30 2012-09-28 Sposób oczyszczania rozszczepionej proinsuliny PL2748181T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1100722 2011-09-30
EP12837180.4A EP2748181B1 (en) 2011-09-30 2012-09-28 Method for purification of cleaved pro-insulin
PCT/SE2012/051040 WO2013048330A1 (en) 2011-09-30 2012-09-28 Method for purification of cleaved pro-insulin

Publications (1)

Publication Number Publication Date
PL2748181T3 true PL2748181T3 (pl) 2016-08-31

Family

ID=47996093

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12837180T PL2748181T3 (pl) 2011-09-30 2012-09-28 Sposób oczyszczania rozszczepionej proinsuliny

Country Status (7)

Country Link
US (1) US9409967B2 (pl)
EP (1) EP2748181B1 (pl)
JP (1) JP6093364B2 (pl)
CN (1) CN103827136B (pl)
DK (1) DK2748181T3 (pl)
PL (1) PL2748181T3 (pl)
WO (1) WO2013048330A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10864512B2 (en) * 2016-04-06 2020-12-15 Cytiva Bioprocess R&D Ab Chromatography matrix
WO2018147393A1 (ja) * 2017-02-10 2018-08-16 三菱ケミカル株式会社 ヒトインスリン精製用分離剤及びヒトインスリンの精製方法
US20240116029A1 (en) * 2021-02-02 2024-04-11 Biocon Biologies Limied A process for the regeneration of silica based reverse phase chromatography material
KR20240120721A (ko) * 2021-12-07 2024-08-07 씨티바 바이오프로세스 알＆디 에이비 분리 매트릭스 및 표적 분자를 분리하는 방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1054523A (pl) * 1965-11-17 1900-01-01
GB1285024A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Process of purifying insulin
DE2629568C3 (de) 1976-07-01 1981-09-10 Hoechst Ag, 6000 Frankfurt Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten
AU5397579A (en) * 1978-12-26 1980-07-03 Eli Lilly And Company Purifying insulin
DE3511270A1 (de) * 1985-03-28 1986-10-09 Veb Berlin-Chemie, Ddr 1199 Berlin Insulin aus pankreasextrakten
DE3511269A1 (de) 1985-04-12 1986-10-09 Veb Berlin-Chemie, Ddr 1199 Berlin Verfahren zur reinigung von insulin
DE3726655A1 (de) 1987-08-11 1989-02-23 Hoechst Ag Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
DE19652713C2 (de) * 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
SE9700768D0 (sv) * 1997-03-04 1997-03-04 Pharmacia Biotech Ab Förfarande för att introducera funktionalitet
DE19838097A1 (de) * 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen
JP5643642B2 (ja) * 2007-07-25 2014-12-17 ジーイー・ヘルスケア・バイオ−サイエンシズ・アーベー 分離マトリクス
WO2010005364A1 (en) * 2008-07-08 2010-01-14 Ge Healthcare Bio-Sciences Ab Separation medium for chromatography of various biomolecules
IN2012DN06243A (pl) * 2010-02-19 2015-09-25 Ge Healthcare Bio Sciences Ab

Also Published As

Publication number Publication date
EP2748181B1 (en) 2016-03-30
CN103827136A (zh) 2014-05-28
US20140243498A1 (en) 2014-08-28
JP2014530211A (ja) 2014-11-17
US9409967B2 (en) 2016-08-09
JP6093364B2 (ja) 2017-03-08
EP2748181A4 (en) 2015-04-15
CN103827136B (zh) 2016-07-06
EP2748181A1 (en) 2014-07-02
WO2013048330A1 (en) 2013-04-04
DK2748181T3 (en) 2016-05-23

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